Interactions of a novel inhibitor from an extremophilic Bacillus sp. with HIV-1 protease. Implications for the mechanism of inactivation

Journal of Biological Chemistry

Volumn 276, Issue 4, 2001, Pages 2487-2493

  Dash, Chandravanu ^b   Rao, Mala ^a  

^a NATIONAL CHEMICAL LABORATORY   (India)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BINDING ENERGY; CATALYST ACTIVITY; CHEMICAL ACTIVATION; ENZYME INHIBITION; FLUORESCENCE;

ENZYME INACTIVATION;

BIOCHEMISTRY;

ALANYLGLYCYLLYSYLLYSYLASPARTYLASPARTYLPROLYLPROLYLGLUTAMINE; AMINO ACID; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; ALANYL GLYCYL LYSYL LYSYL ASPARTYL ASPARTYL ASPARTYL ASPARTYL PROLYL PROLYL 2 AMINOADIPIC ACID; ALANYL-GLYCYL-LYSYL-LYSYL-ASPARTYL-ASPARTYL-ASPARTYL-ASPARTYL-PROLYL-PROLYL-2-AMINOADIPIC ACID; BACTERIAL PROTEIN; OLIGOPEPTIDE; PROTEINASE;

AMINO ACID SEQUENCE; ARTICLE; BACILLUS; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INACTIVATION; ENZYME INHIBITOR INTERACTION; ENZYME KINETICS; ENZYME SUBSTRATE COMPLEX; FLUORESCENCE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYDROPHILICITY; IC 50; NONHUMAN; PRIORITY JOURNAL; PROTEINASE INHIBITION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; STRUCTURE ANALYSIS; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; ENZYMOLOGY; MASS SPECTROMETRY; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE;

BACILLUS SP.; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

AMINO ACID SEQUENCE; BACILLUS; BACTERIAL PROTEINS; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; MASS SPECTROMETRY; MODELS, BIOLOGICAL; MODELS, MOLECULAR; OLIGOPEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SEQUENCE ANALYSIS, PROTEIN;

EID: 0035951768     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M005662200     Document Type: Article

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