Human immunodeficiency virus type 1 viral background plays a major role in development of resistance to protease inhibitors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 4, 1996, Pages 1648-1653

  Rose, Ronald E ^a   Gong, Yi Fei ^a   Greytok, Jill A ^a   Bechtold, Clifford M ^a   Terry, Brian J ^a   Robinson, Brett S ^a   Alam, Masud ^a   Colonno, Richard J ^a   Lin, Pin Fang ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

A 77003; BMS 186318; combination therapy; saquinavir

Indexed keywords

A 77003; ANTIVIRUS AGENT; BMS 186318; INDINAVIR; PROTEINASE INHIBITOR; RITONAVIR; SAQUINAVIR; TELINAVIR; UNCLASSIFIED DRUG;

ARTICLE; CLINICAL TRIAL; DNA SEQUENCE; ENZYME INHIBITION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; VIRUS REPLICATION; VIRUS RESISTANCE;

AMINO ACID SEQUENCE; CARBAMATES; CLONE CELLS; DNA MUTATIONAL ANALYSIS; DNA, RECOMBINANT; DNA, VIRAL; DRUG ADMINISTRATION SCHEDULE; DRUG RESISTANCE, MICROBIAL; DRUG THERAPY, COMBINATION; ETHANOLAMINES; HELA CELLS; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; INDINAVIR; ISOQUINOLINES; METHYLUREA COMPOUNDS; MOLECULAR SEQUENCE DATA; POINT MUTATION; PROVIRUSES; PYRIDINES; QUINOLINES; REASSORTANT VIRUSES; RECOMBINANT FUSION PROTEINS; SAQUINAVIR; T-LYMPHOCYTES; UREA;

EID: 0029869305     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.4.1648     Document Type: Article

References (36)

1. Richman, D. D. (1993) Antimicrob. Agents Chemother. 37, 1207-1213.
2. Connolly, K.J. & Hammer, S. M. (1992) Antimicrob. Agents Chemother. 36, 245-254.
3. Larder, B. A. (1994) J. Gen. Virol. 75, 951-957.
4. Debouck, C. (1992) AIDS Res. Hum. Retroviruses 8, 153-164.
5. Kempf, D. J., Marsh, K. C., Denissen, J. F., McDonald, E., Vasavanonda, S., et al. (1995) Proc. Natl. Acad. Sci. USA 92, 2484-2488.
6. West, L. M. & Fairlie, D. P. (1995) Trends Pharmacol. Sci. 16, 67-75.
7. Kempf, D. J., Codacovi, C., Wang, X. C., Kohlbrenner, W. E., Wideburg, N. E., Saldivar, A., Vasavanonda, S., Marsh, K. C., Bryant, P., Sham, H. L., Green, B. E., Betebenner, D. A., Erickson, J. & Norbeck, D. W. (1993) J. Med. Chem. 36, 320-330.
8. Kageyama, S., Weinstein, J. N., Shirasaka, T., Kempf, D. J., Norbeck, D. W., Plattner, J. J., Erickson, J. & Mitsuya, H. (1992) Antimicrob. Agents Chemother. 36, 926-933.
9. Roberts, N. A., Martin, J. A., Kinchington, D., Broadhurst, A. V., Craig, J. C., Duncan, I. B., Galpin, S. A., Handa, B. K., Kay, J., Kröhu, A., Lambert, R. W., Merrett, J. H., Mills, J. S., Yarkes, K. E. B., Redshaw, S., Ritchie, A. J., Taylor, D. L., Thomas, G. J. & Machin, P. J. (1990) Science 248, 358-361.
10. Getman, D. P., DeCrescenzo, G. A., Heintz, R. M., Reed, K. L., Talley, J. J., Bryant, M. L., Clare, M., Houseman, K. A., Marr, J. J., Mueller, R. A., Vazquez, M. L., Shieh, H.-S., Stallings, W. C. & Stegeman, R. A. (1993) J. Med. Chem. 36, 288-291.
11. Vacca, J. P., Dorsey, B.D., Schleif, W. A., Levin, R. B., McDaniel, S. L., et al. (1994) Proc. Natl. Acad. Sci. USA 91, 4096-4100.
12. Dorsey, B. D., Levin, R. B., McDaniel, S. L., Vacca, J. P., Guare, J. P., Darke, P. L., Zugay, J. A., Emmini, E. A., Schleif, W. A., Quintero, J. C., Lin, J. H., Chen, I.-W., Holloway, M. K., Fitgerald, M. D., Axel, M. G., Ostovic, D., Anderson, P. S. & Huff, J. R. (1994) J. Med. Chem. 37, 3443-3451.
13. Barrish, J. E., Gordon, E., Alam, M., Lin, P.-F., Bisacchi, G. S., et al. (1994) J. Med. Chem. 37, 1758-1768.
14. Condra, J. H., Schleif, W. A., Blahy, O. M., Gabryelski, L. J., Graham, D. J., Quintero, J. C, Rhodes, A., Robbins, H. L., Roth, E., Shivaprakash, M., Titus, D., Yang, T., Teppler, H., Squires, K. E., Deutsch, P. J. & Emini, E. A. (1995) Nature (London) 374, 569-571.
15. Ho, D. D., Neumann, A. U., Perelson, A. S., Chen, W., Leonard, J. M. & Markowitz, M. (1995) Nature (London) 373, 123-126.
16. Otto, M. J., Garber, S., Winslow, D. L., Reid, C. D., Aldrich, P., Jadhav, P. K., Patterson, C. E., Hodge, C. N. & Cheng, Y.-S. (1993) Proc. Natl. Acad. Sci. USA 90, 7543-7547.
17. Craig, J. C., Whittaker, L., Duncan, I. B. & Roberts, N. A. (1993) Antiviral Chem. Chemother. 4, 335-339.
18. Dianzani, F., Antonelli, G., Turriziani, O., Riva, E., Dong, G. & Bellarosa, D. (1993) Antiviral Chem. Chemother. 4, 329-333.
19. Jacobsen, H., Yasargil, K., Winslow, D. L., Craig, J. C., Kröhn, A., Duncan, I. B. & Mous, J. (1995) Virology 206, 527-534.
20. El-Farrash, M. A., Kuroda, M. J., Kitazaki, T., Masuda, T., Kato, K., Hatanaka, M. & Harada, S. (1994) J. Virol. 68, 233-239.
21. Ho, D. D., Toyoshima, T., Mo, H., Kempf, D. J., Norbeck, D., Chen, C-M., Wideburg, N. E., Burt, S. K., Erickson, J. W. & Sigh, M. K. (1994) J. Virol. 68, 2016-2020.
22. Kaplan, A. H., Michael, S. F., Wehbie, R. S., Knigge, M. F., Paul, D. A., Everitt, L., Kempf, D. J., Norbeck, D. W., Erickson, J. W. & Swanstrom, R. (1994) Proc. Natl. Acad. Sci. USA 91, 5597-5601.
23. Markowitz, M., Mo, H., Kempf, D. J., Norbeck, D. W., Baht, T. N., Erickson, J. W. & Ho. D. D. (1995) J. Virol 69, 701-706.
24. Mellors, J. W., Larder, B. A. & Schinazi, R. F. (1995) Int. Antiviral News 3, 8-13.
25. Patick, A. K., Rose, R., Greytock, J., Bechtold, C. M., Hermsmeier, M. A., Chen, P. T., Barrish, J. C., Zahler, R., Colonno, R. J. & Lin, P.-F. (1995) J. Virol. 69, 2148-2152.
26. Mazzulli, T., Rusconi, S., Merrill, D. P., D'Aquila, R. T., Moonis, M., Chou, T.-C. & Hirsch, M.S. (1994) Antimicrob. Agents Chemother. 38, 656-661.
27. Hammer, S. M., Kessler, H. A. & Saag, M. S. (1994) J. Acquired Immune Defic. Syndr. 7, S24-S37.
28. Loeb, D. D., Swanstrom, R., Everitt, L., Manchester, M., Stamper, S. E. & Hutchinson, C. A., III (1989) Nature (London) 340, 397-400.
29. Louis, J. M., McDonald, R. A., Nashed, N. T., Wondrak, E. M., Jerina, D. M., Oroszlan, S. & Mora, P. T. (1991) Eur. J. Biochem. 199, 361-369.
30. Heimbach, J. C., Garsky, V. M., Michelson, S. R., Dixon, R. A. F., Sigal, I. S. & Darke, P. L. (1989) Biochem. Biophys. Res. Commun. 164, 955-960.
31. Dixon, M. & Webb, E. C. (1979) in Enzymes (Academic, New York), 3rd Ed., pp. 361-365.
32. Nara, P. L. (1990) in Techniques in HIV Research, eds. Aldovini, A. & Walker, B. D. (Stockton, New York), pp. 77-86.
33. Johnson, V. A. & Byington, R. E. (1990) in Techniques in HIV Research, eds. Aldovini, A. & Walker, B. D. (Stockton, New York), pp. 71-76.
34. Potts, B. J. (1990) in Techniques in HIV Research, eds. Aldovini, A. & Walker, B. D. (Stockton, New York), pp. 103-106.
35. Wei, X., Ghosh, S. K., Taylor, M. E., Johnson, V. A., Emini, E. A., Deutsch, P., Lifson, J. D., Bonhoeffer, S., Nowak, M. A., Hahn, B. H., Saag, M. S. & Shaw, G. M. (1995) Nature (London) 373, 117-122.
36. Larder, B. A., Kellam, P. & Kemp, S. D. (1993) Nature (London) 365, 451-453.