Escape mutants of HIV-1 proteinase: Enzymatic efficiency and susceptibility to inhibition

Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology

Volumn 1339, Issue 1, 1997, Pages 113-125

  Wilson, Sara I ^a   Phylip, Lowri H ^a   Mills, John S ^b   Gulnik, Sergei V ^c   Erickson, John W ^c   Dunn, Ben M ^d   Kay, John ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b ROCHE PRODUCTS LTD   (United Kingdom)

^c NATIONAL CANCER INSTITUTE   (United States)

^d UNIVERSITY OF FLORIDA HEALTH   (United States)

Author keywords

E. coli; HIV proteinase; Inhibitor binding; Mutant HIV proteinase; Substrate specificity

Indexed keywords

4,7 DIBENZYL 2,3,4,5,6,7 HEXAHYDRO 5,6 DIHYDROXY 1,3 BIS[4 (HYDROXYMETHYL)BENZYL] 2H 1,3 DIAZEPIN 2 ONE; A 77003; ANTIVIRUS AGENT; HBY 793; INDINAVIR; NELFINAVIR; PROTEINASE; RITONAVIR; RO 31 6624; RO 31 8344; RO 31 8458; RO 31 8875; SAQUINAVIR; UNCLASSIFIED DRUG;

ARTICLE; ENZYME SPECIFICITY; ESCHERICHIA COLI; HUMAN IMMUNODEFICIENCY VIRUS 1; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS MUTANT; VIRUS REPLICATION;

ANTI-HIV AGENTS; ASPARTIC ENDOPEPTIDASES; CLONING, MOLECULAR; ESCHERICHIA COLI; GENE PRODUCTS, GAG; HIV PROTEASE INHIBITORS; HIV-1; MUTATION; RITONAVIR; SAQUINAVIR;

ESCHERICHIA COLI; HIV 1; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0030938867     PISSN: 01674838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4838(96)00224-5     Document Type: Article

References (40)

1. Jacobsen, H., Hanggi, M., Ott, M., Duncan, I.B., Owen, S., Andreoni, M., Vella, S. and Mous, J. (1996) J. Infect. Dis. 173, 1379-1287.
2. Wlodawer, A. and Erickson, J.E. (1993) Annu. Rev. Biochem. 62, 543-85.
3. Roberts, N.A., Martin, J.A., Kinchington, D., Broadhurst, A.V., Craig, J.C., Duncan, I.B., Galpin, S.A., Handa, B.K., Kay, J., Krohn, A., Lambert, R.W., Merritt, J.H., Mills, J.S., Parkes, K.E.B., Redshaw, S., Ritchie, A.J., Taylor, D.L., Thomas, G.J. and Machin, P.J. (1990) Science 248, 358-361.
4. MacDougall, D.S. (1996) J. Int. Assoc. Physicians AIDS Care 2, 25-31.
5. Kempf, D.J., Marsh, K.C., Denissen, J.F., McDonald, E., Vasavanonda, S., Flentge, C.A., Green, B.E., Fino, L., Park, C.H., Kong, X-P., Wideburg, N.B., Saldivar, A., Ruiz, L., Kati, W.M., Sham, H.L., Robins, T., Stewart, K.D., Hsu, A., Plattner, J.J., Leonard, J.M. and Norbeck, D.W. (1995) Proc. Natl. Acad. Sci. USA 92, 2484-2488.
6. Vacca, J.P., Dorsey, B.D., Schleif, W.A., Levin, R.B., McDaniel, S.L., Darke, P.L., Zugay, J., Quintero, J.C., Blahy, O.M., Roth, E., Sardana, V.V., Schlabach, A.J., Graham, P.I., Condra, J.H., Gotlib, L., Holloway, M.K., Lin, J., Chen, I.-W., Vastag, K., Ostovic, D., Anderson, P.S., Emini, E.A. and Huff, J.R. (1994) Proc. Natl. Acad. Sci. USA 91, 4096-4100.
7. Ho, D.D., Neumann, A.U., Perelson, A.S., Chen, W., Leonard, J.M. and Markowitz, M. (1995) Nature 373, 123-126.
8. Wei, X., Ghosh, S.K., Taylor, M.E., Johnson, V.A., Emini, E.A., Deutsch, P., Lifson, J., Bonhoeffer, S., Nowak, M.A., Hahn, B.H., Saag, M.S. and Shaw, G.M. (1995) Nature 373, 117-122.
9. Jacobsen, H., Yasargil, K., Winslow, D.L., Craig, J.C., Kröhn, A., Duncan, I.A. and Mous, J. (1995) Virology 206, 527-534.
10. Condra, J.H., Schleif, W.A., Blahy, O.M., Gabryelski, L.J., Graham, D.J., Quintero, J.C., Rhodes, A., Robbins, H.L., Roth, E., Shivaprakash, M., Titus, D., Yang, T., Teppler, H., Squires, K.E., Deutsch, P.J. and Emini, E.A. (1995) Nature 374, 569-571.
11. Molla, A., Korneyeva, M., Gao, Q., Vasavanonda, S., Schipper, P.J., Mo, H.-M., Markowitz, M., Chernyavskiy, T., Niu, P., Lyons, N., Hsu, A., Granneman, G.R., Ho, D.D., Boucher, C.A.B., Leonard, J.M., Norbeck, D.W. and Kempf, D.J. (1996) Nature Med. 2, 760-765.
12. Le Grice, S.F.J., Ette, R., Mills, J. and Mous, J. (1989) J. Biol. Chem. 264, 14902-14908.
13. Dunn, B.M., Gustchina, A., Wlodawer, A. and Kay, J. (1994) Methods Enzymol. 241, 254-286.
14. Griffiths, J.T., Phylip, L.H., Konvalinka, J., Strop, P., Gustchina, A., Wlodawer, A., Davenport, R.J., Briggs, R., Dunn, B.M. and Kay, J. (1992) Biochemistry 31, 5193-5200.
15. Schechter, I. and Berger, A. (1967) Biochem. Biophys. Res. Commun. 27, 157-162.
16. Jupp, R.A., Dunn, B.M., Jacobs, J.W., Vlasuk, G., Arcuri, K.E., Veber, D.F., Perlow, D.S., Payne, L.S., Rogers, J., De Laszlo, S., Chakravarty, P.K., Ten Broeke, J., Hangauer, D.G., Ondeyka, D., Greenlee, W.J. and Kay, J. (1990) Biochem J. 265, 871-878.
17. Powell, D.J., Bur, D., Wlodawer, A., Gustchina, A., Payne, S.L., Dunn, B.M. and Kay, J. (1996) Eur. J. Biochem. 241, 664-674.
18. Jupp, R., Hoffmann, S., Depto, A., Stenberg, R.M., Ghazal, P. and Nelson, J.A. (1993) J. Virol. 67, 5595-5604.
19. Certa, U., Bannwarth, W., Stueber, D., Gentz, R., Lanzer, M., Le Grice, S.F.J., Guillot, F., Wendler, I., Hunsmann, G., Bujard, H. and Mous, J. (1986) EMBO J. 5, 3051-3056.
20. Gulnik, S.V., Suvorov, L.I., Liu, B., Yu, B., Anderson, B., Mitsuya, H. and Erickson, J.W. (1995) Biochemistry 34, 9282-9287.
21. Pettitl, S.C., Moody, M.D., Wehbie, R.S., Kaplan, A.H., Nantermet, P.V., Klein, C.A. and Swanstrom, R. (1994) J. Virol. 68, 8017-8027.
22. Konvalinka, J., Heuser, A.-M., Hruskova-Heidingsfeldova, O., Vogt, V.M., Sedlacek, J., Strop, P. and Kräusslich, H.-G. (1995) Eur. J. Biochem. 228, 191-198.
23. Griffiths, J.T., Tomchak, L.A., Mills, J.S., Graves, M.C., Cook, N.D., Dunn, B.M. and Kay, J. (1994) J. Biol. Chem. 269, 4787-4793.
24. Phylip, L.H., Richards, A.D., Kay, J., Konvalinka, J., Strop, P., Blaha, I., Velek, J., Kostka, V., Ritchie, A.J., Broadhurst, A.V., Farmerie, W.G., Scarborough, P.E. and Dunn, B.M. (1990) Biochem. Biophys. Res. Commun. 171, 439-444.
25. Dunn, B.M. and Kay, J. (1990) Antiviral Chem. Chemother. 1, 3-8.
26. Cook, N.D., Jessop, R.A., Robinson, P.S., Richards, A.D. and Kay, J. (1991) in Structure and Function of the Aspartic Proteinases (Dunn, B.M., ed.), pp. 525-529, Plenum Press, New York.
27. Maschera, B., Furfine, E. and Blair, E.D. (1995) J. Virol. 69, 5431-5436.
28. Lech, W.J., Wang, G., Yang, Y.L., Chee, Y., Dorman, K., McCrae, D., Lazzeroni, L.C., Erickson, J.W., Sinsheimer, J.S. and Kaplan, A.H. (1996) J. Virol. 70, 2038-2043.
29. Kozal, M.J., Shah, N., Shen, N., Yang, R., Fucini, R., Merigan, T.C., Richman, D.D., Morris, D., Hubbell, E., Chee, M. and Gingeras, T.R. (1996) Nature Med. 2, 753-759.
30. Barrie, K.A., Perez, E.E., Lamers, S.L., Farmerie, W.G., Dunn, B.M., Sleasman, J.W. and Goodenow, M.M. (1996) Virology 219, 407-416.
31. Erickson, J.W. (1995) Nature Struct. Biol. 2, 523-529.
32. Darke, P.L., Jordan, S.P., Hall, D.L., Zugay, J.A., Shafer, J.A. and Kuo, L.C. (1994) Biochemistry 33, 98-105.
33. Kuzmic, P., García-Eccheverría, C. and Rieh, D.H. (1993) Biochem. Biophys. Res. Commun. 194, 301-305.
34. Patick, A.K., Mo, H., Markowitz, M., Appelt, K., Wu, B., Musick, L., Kalish, V., Kaldor, S., Reich, S., Ho, D. and Webber, S. (1996) Antimicrob. Agents Chemother. 40, 293-297.
35. Lam, P.Y.S., Jadhav, P.K., Eyermann, C.J., Hodge, C.N., Ru, Y., Bacheler, L.T., Meek, J.L., Otto, M.J., Rayner, M.M., Wong, Y.N., Chang, C.-H., Weber, P.C., Jackson, D.A., Sharpe, T.R. and Erickson-Vittanen, S. (1994) Science 263, 380-384.
36. Gustchina, A., Kervinen, J., Powell, D.J., Zdanov, A., Kay, J. and Wlodawer, A. (1996) Protein Sci. 5, 1453-1465.
37. Markowitz, M., Mo, H., Kempf, D.J., Norbeck, D.W., Bhat, T.N., Erickson, J.W. and Ho, D.D. (1995) J. Virol. 69, 701-706.
38. Tisdale, M., Myers, R.E., Maschera, B., Parry, N.R., Oliver, N.M. and Blair, E.D. (1995) Antimicrobial Agents Chemother. 39, 1704-1710.
39. Leis, J., Baltimore, D., Bishop, J.M., Coffin, J., Fleissner, E., Goff, S.P., Oroszlan, S., Robinson, H., Skalka, A.M., Temin, H.M. and Vogt, V. (1988) Virology 62, 1808-1809.
40. Lin, Y., Lin, X., Hong, L., Foundling, S., Heinrikson, R.L., Thaisrivongs, S., Leelamanit, W., Raterman, D., Shah, M., Dunn, B.M. and Tang, J. (1995) Biochemistry 34, 1143-1152.