Molecular basis of HIV-1 protease drug resistance: Structural analysis of mutant proteases complexed with cyclic urea inhibitors

Biochemistry

Volumn 36, Issue 7, 1997, Pages 1573-1580

  Ala, Paul J ^a   Huston, Edward E ^a   Klabe, Ronald M ^a   McCabe, Denise D ^a   Duke, Jodie L ^a   Rizzo, Christopher J ^a   Korant, Brace D ^a   DeLoskey, Richard J ^a   Lam, Patrick Y S ^a   Nicholas Hodge, C ^a   Chang, Chong Hvvan ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE; PROTEINASE INHIBITOR;

ARTICLE; CONFORMATIONAL TRANSITION; ENZYME CONFORMATION; ENZYME SUBSTRATE COMPLEX; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEINASE INHIBITION; STRUCTURE ACTIVITY RELATION; VIRUS MUTATION; VIRUS RESISTANCE;

AZEPINES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, MICROBIAL; HIV PROTEASE; HIV PROTEASE INHIBITORS; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0031027901     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi962234u     Document Type: Article

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