메뉴 건너뛰기




Volumn 71, Issue 2, 1997, Pages 1089-1096

Impaired fitness of human immunodeficiency virus type 1 variants with high-level resistance to protease inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

PROTEINASE; PROTEINASE INHIBITOR; VIRUS ENZYME;

EID: 0031015475     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.2.1089-1096.1997     Document Type: Article
Times cited : (224)

References (43)
  • 1
    • 0022495870 scopus 로고
    • Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone
    • Adachi, A., H. E. Gendelman, S. Koenig, T. Folks, R. Willey, A. Rabson, and M. A. Martin. 1986. Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone. J. Virol. 59:284-291.
    • (1986) J. Virol. , vol.59 , pp. 284-291
    • Adachi, A.1    Gendelman, H.E.2    Koenig, S.3    Folks, T.4    Willey, R.5    Rabson, A.6    Martin, M.A.7
  • 4
    • 0028248489 scopus 로고
    • HIV protease as an inhibitor target for the treatment of AIDS
    • Darke, P. L., and J. R. Huff. 1994. HIV protease as an inhibitor target for the treatment of AIDS. Adv. Pharmocol. 25:399-454.
    • (1994) Adv. Pharmocol. , vol.25 , pp. 399-454
    • Darke, P.L.1    Huff, J.R.2
  • 6
    • 0026523623 scopus 로고
    • HIV inhibitors targeted at the reverse transcriptase
    • De Clerq, E. 1992. HIV inhibitors targeted at the reverse transcriptase. AIDS Res. Hum. Retroviruses 8:119-134.
    • (1992) AIDS Res. Hum. Retroviruses , vol.8 , pp. 119-134
    • De Clerq, E.1
  • 7
    • 0029899093 scopus 로고    scopus 로고
    • Second locus involved in human immunodeficiency virus type 1 resistance to protease inhibitors
    • Doyon, L., G. Croteau, D. Thibeault, F. Poulin, L. Pilote, and D. Lamarre. 1996. Second locus involved in human immunodeficiency virus type 1 resistance to protease inhibitors. J. Virol 70:3763-3769.
    • (1996) J. Virol , vol.70 , pp. 3763-3769
    • Doyon, L.1    Croteau, G.2    Thibeault, D.3    Poulin, F.4    Pilote, L.5    Lamarre, D.6
  • 8
    • 0028158211 scopus 로고
    • Resistance of human immunodeficiency virus type 1 to antiretroviral agents: A review
    • Erice, A., and H. H. Balfour, Jr. 1994. Resistance of human immunodeficiency virus type 1 to antiretroviral agents: a review. Clin. Infect. Dis. 18: 149-156.
    • (1994) Clin. Infect. Dis. , vol.18 , pp. 149-156
    • Erice, A.1    Balfour Jr., H.H.2
  • 9
    • 0029157399 scopus 로고
    • The not-so-great escape
    • Erickson, J. W. 1995. The not-so-great escape. Nat. Struct. Biol. 2:523-529.
    • (1995) Nat. Struct. Biol. , vol.2 , pp. 523-529
    • Erickson, J.W.1
  • 10
    • 0029151345 scopus 로고
    • Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure
    • Gulnik, S. V., L. I. Suvorov, B. Liu, B. Yu, B. Anderson, H. Mitsuya, and J, W. Erickson. 1995. Kinetic characterization and cross-resistance patterns of HIV-1 protease mutants selected under drug pressure. Biochemistry 34: 9282-9287.
    • (1995) Biochemistry , vol.34 , pp. 9282-9287
    • Gulnik, S.V.1    Suvorov, L.I.2    Liu, B.3    Yu, B.4    Anderson, B.5    Mitsuya, H.6    Erickson, J.W.7
  • 11
    • 0028874048 scopus 로고
    • Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
    • Ho, D. D., A. U. Neumann, A. S. Perelson, W. Chen, J. M. Leonard, and M. Markowitz. 1995. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373:123-126.
    • (1995) Nature , vol.373 , pp. 123-126
    • Ho, D.D.1    Neumann, A.U.2    Perelson, A.S.3    Chen, W.4    Leonard, J.M.5    Markowitz, M.6
  • 12
    • 0028014288 scopus 로고
    • Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor
    • Ho, D. D., T. Toyoshima, H. Mo, D. J. Kempt, D. Norbeck, C. M. Chen, N. E. Wideburg, S. K. Burt, J. W. Erickson, and M. K. Singh. 1994. Characterization of human immunodeficiency virus type 1 variants with increased resistance to a C2-symmetric protease inhibitor. J. Virol 68:2016-2020.
    • (1994) J. Virol , vol.68 , pp. 2016-2020
    • Ho, D.D.1    Toyoshima, T.2    Mo, H.3    Kempt, D.J.4    Norbeck, D.5    Chen, C.M.6    Wideburg, N.E.7    Burt, S.K.8    Erickson, J.W.9    Singh, M.K.10
  • 17
    • 0024310253 scopus 로고
    • Multiple mutations in the HIV-1 reverse transcriptase confer high-level resistance to Zidovudine (AZT)
    • Larder, B. A., and S. D. Kemp. 1989. Multiple mutations in the HIV-1 reverse transcriptase confer high-level resistance to Zidovudine (AZT). Science 246:1155-1158.
    • (1989) Science , vol.246 , pp. 1155-1158
    • Larder, B.A.1    Kemp, S.D.2
  • 19
    • 0026635623 scopus 로고
    • A basic computer program for analyzing endpoint assays
    • Lynn, D. E. 1992. A basic computer program for analyzing endpoint assays. BioTechniques 12:880-881.
    • (1992) BioTechniques , vol.12 , pp. 880-881
    • Lynn, D.E.1
  • 20
    • 0028854676 scopus 로고
    • Selection analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor
    • Markowitz, M., H. Mo, D. J. Kempf, D. W. Norbeck, T. N. Bhat. J. W. Erickson, and D. D. Ho. 1995. Selection analysis of human immunodeficiency virus type 1 variants with increased resistance to ABT-538, a novel protease inhibitor. J. Virol. 69:701-706.
    • (1995) J. Virol. , vol.69 , pp. 701-706
    • Markowitz, M.1    Mo, H.2    Kempf, D.J.3    Norbeck, D.W.4    Bhat, T.N.5    Erickson, J.W.6    Ho, D.D.7
  • 21
    • 0028855166 scopus 로고
    • Mutations in HIV-1 reverse transcriptase and protease associated with drug resistance
    • Mellors, J. W., B. A. Larder, and R. F. Schinazi. 1995. Mutations in HIV-1 reverse transcriptase and protease associated with drug resistance. Int. Antiviral News 3:8-13.
    • (1995) Int. Antiviral News , vol.3 , pp. 8-13
    • Mellors, J.W.1    Larder, B.A.2    Schinazi, R.F.3
  • 23
    • 0023728105 scopus 로고
    • The behavior and significance of slow-binding enzyme inhibitors
    • Morrison, J. F., and C. T. Walsh. 1988. The behavior and significance of slow-binding enzyme inhibitors. Adv. Enzymol. 61:201-301.
    • (1988) Adv. Enzymol. , vol.61 , pp. 201-301
    • Morrison, J.F.1    Walsh, C.T.2
  • 24
    • 0028046926 scopus 로고
    • Determination of kinetic rate constants for the binding of inhibitors to HIV-1 protease and for the association and dissociation of active homodimer
    • Pargellis, C. A., M. M. Morelock, E. T. Graham, P. Kinkade, S. Pav, K. Lubbe, D. Lamarre, and P. C. Anderson. 1994. Determination of kinetic rate constants for the binding of inhibitors to HIV-1 protease and for the association and dissociation of active homodimer. Biochemistry 33:12527-12534.
    • (1994) Biochemistry , vol.33 , pp. 12527-12534
    • Pargellis, C.A.1    Morelock, M.M.2    Graham, E.T.3    Kinkade, P.4    Pav, S.5    Lubbe, K.6    Lamarre, D.7    Anderson, P.C.8
  • 27
    • 0028025318 scopus 로고
    • Microtube batch protein crystallization: Applications to human immunodeficiency virus type 2 (HIV-2) protease and human renin
    • Pav, S., K. Lubbe, F. Dô, D. Lamarre, C. Pargellis, and L. Tong. 1994. Microtube batch protein crystallization: applications to human immunodeficiency virus type 2 (HIV-2) protease and human renin. Protein Struct. Funct. Genet. 20:98-102.
    • (1994) Protein Struct. Funct. Genet. , vol.20 , pp. 98-102
    • Pav, S.1    Lubbe, K.2    Dô, F.3    Lamarre, D.4    Pargellis, C.5    Tong, L.6
  • 28
    • 0024334170 scopus 로고
    • Role of human immunodeficiency virus type 1-specific protease in core maturation and viral infectivity
    • Peng, C., B. K. Ho. T. W. Chang, and N. T. Chang. 1989. Role of human immunodeficiency virus type 1-specific protease in core maturation and viral infectivity. J. Virol. 63:2550-2556.
    • (1989) J. Virol. , vol.63 , pp. 2550-2556
    • Peng, C.1    Ho, B.K.2    Chang, T.W.3    Chang, N.T.4
  • 30
    • 0021707158 scopus 로고
    • T4 positive human neoplastic cell lines susceptible to and permissice for HTLV-III
    • Popovic, M., E. Read-Connole, and R. C. Gallo. 1984. T4 positive human neoplastic cell lines susceptible to and permissice for HTLV-III. Lancet ii:1472-1473.
    • (1984) Lancet , vol.2 , pp. 1472-1473
    • Popovic, M.1    Read-Connole, E.2    Gallo, R.C.3
  • 31
    • 0021237243 scopus 로고
    • Detection, isolation and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS
    • Popovic, M., M. G. Sarngadharan, E. Read, and R. C. Gallo. 1984. Detection, isolation and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS. Science 224:497-500.
    • (1984) Science , vol.224 , pp. 497-500
    • Popovic, M.1    Sarngadharan, M.G.2    Read, E.3    Gallo, R.C.4
  • 32
    • 0024267430 scopus 로고
    • Fidelity of HIV-1 reverse transcriptase
    • Preston, B. D., B. J. Poiesz, and L. A. Loeb. 1988. Fidelity of HIV-1 reverse transcriptase. Science 242:1168-1171.
    • (1988) Science , vol.242 , pp. 1168-1171
    • Preston, B.D.1    Poiesz, B.J.2    Loeb, L.A.3
  • 34
    • 0028969065 scopus 로고
    • Defining the level of human immunodeficiency virus type 1 (HIV-1 ) protease activity required for HIV-1 particle maturation and intectivity
    • Rosé, J. R., L. M. Babe, and C. S. Craik. 1995. Defining the level of human immunodeficiency virus type 1 (HIV-1 ) protease activity required for HIV-1 particle maturation and intectivity. J. Virol. 69:2751-2758.
    • (1995) J. Virol. , vol.69 , pp. 2751-2758
    • Rosé, J.R.1    Babe, L.M.2    Craik, C.S.3
  • 38
    • 0029643790 scopus 로고
    • Crystal structures of HIV-2 protease in complex with inhibitors containing the hydroxyethylamine dipeptidyl isostere
    • Tong, L., S. Pav, S. Mui, D. Lamarre, C. Yoakim, P. Beaulieu, and P. C. Anderson. 1995. Crystal structures of HIV-2 protease in complex with inhibitors containing the hydroxyethylamine dipeptidyl isostere. Structure 3:33-40.
    • (1995) Structure , vol.3 , pp. 33-40
    • Tong, L.1    Pav, S.2    Mui, S.3    Lamarre, D.4    Yoakim, C.5    Beaulieu, P.6    Anderson, P.C.7
  • 39
    • 0025663423 scopus 로고
    • A simple, continuous fluorometric assay for HIV protease
    • Toth, M. V., and G. R. Marshall. 1990. A simple, continuous fluorometric assay for HIV protease. Int. J. Peptide Protein Res. 36:544-550.
    • (1990) Int. J. Peptide Protein Res. , vol.36 , pp. 544-550
    • Toth, M.V.1    Marshall, G.R.2
  • 40
    • 0025980395 scopus 로고
    • Comparison of the HIV-1 and HIV-2 proteinases using oligopeptide substrates representing cleavage sites in Gag and Gag-Pol polyproteins
    • Tozser, J., I. Blahah, T. D. Copeland, E. M. Wondrak, and S. Oroszlan. 1991. Comparison of the HIV-1 and HIV-2 proteinases using oligopeptide substrates representing cleavage sites in Gag and Gag-Pol polyproteins. FEBS Lett. 281:77-80.
    • (1991) FEBS Lett. , vol.281 , pp. 77-80
    • Tozser, J.1    Blahah, I.2    Copeland, T.D.3    Wondrak, E.M.4    Oroszlan, S.5
  • 42
    • 0028986487 scopus 로고
    • Targeting HIV-1 protease: A test of drug-design methodologies
    • West, M. L., and D. P. Fairlie. 1995. Targeting HIV-1 protease: a test of drug-design methodologies. Trends Pharmacol. Sci. 16:67-75.
    • (1995) Trends Pharmacol. Sci. , vol.16 , pp. 67-75
    • West, M.L.1    Fairlie, D.P.2
  • 43
    • 0027491307 scopus 로고
    • The Gag precursor contains a specific HIV-1 protease cleavage site between the NC (p7) and p1 proteins
    • Wondrak, E. M., J. M. Louis, H. de Rocquigny, J. C. Chermann, and B. P. Roques. 1993. The Gag precursor contains a specific HIV-1 protease cleavage site between the NC (p7) and p1 proteins. FEBS Lett. 333:21-24.
    • (1993) FEBS Lett. , vol.333 , pp. 21-24
    • Wondrak, E.M.1    Louis, J.M.2    De Rocquigny, H.3    Chermann, J.C.4    Roques, B.P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.