Threonine 41 in β-catenin serves as a key phosphorylation relay residue in β-catenin degradation

Biochemistry

Volumn 45, Issue 16, 2006, Pages 5319-5323

  Wu, Geng ^a   He, Xi ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; BIODEGRADATION; ENZYME KINETICS; ENZYMES; PROTEINS;

CATENIN DEGRADATIONS; GLYCOGEN SYNTHASE KINASE 3; PHOSPHORYLATION; PHOSPHORYLATION-DEGRADATION;

GENETIC ENGINEERING;

BETA CATENIN; CASEIN KINASE I; F BOX PROTEIN; GLYCOGEN SYNTHASE KINASE 3; MUTANT PROTEIN; SERINE; THREONINE; UBIQUITIN PROTEIN LIGASE; WNT PROTEIN;

ARTICLE; CANCER; HUMAN; HUMAN CELL; MOLECULAR RECOGNITION; MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; BETA CATENIN; GENE DELETION; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SERINE; THREONINE;

EID: 33646001713     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0601149     Document Type: Article

References (33)

1. Wodarz, A., and Nusse, PR. (1998) Mechanisms of Wnt signaling in development, Annu. Rev. Cell Dev. Biol. 14, 59-88.
2. Moon, R. T., Bowerman, B., Boutros, M., and Perrimon, N. (2002) The promise and perils of Wnt signaling through beta-catenin, Science 296, 1644-1646.
3. van Es, J. H., Barker, N., and Clevers, H. (2003) You Wnt some, you lose some: oncogenes in the Wnt signaling pathway, Curr. Opin. Genet. Dev. 13, 28-33.
4. Polakis, P. (2000) Wnt signaling and cancer, Genes Dev. 14, 1837-1851.
5. Zeng, L., Fagotto, F., Zhang, T., Hsu, W., Vasicek, T. J., Perry, W. L., III, Lee, J. J., Tilghman, S. M., Gumbiner, B. M., and Costantini, F. (1997) The mouse fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation, Cell 90, 181-192.
6. Behrens, J., Jerchow, B. A., Wurtele, M., Grimm, J., Asbrand, C., Wirtz, R., Kuhl, M., Wedlich, D., and Birchmeier, W. (1998) Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta, Science 280, 596-599.
7. Hart, M. J., de los Santos, R., Albert, I. N., Rubinfeld, B., and Polakis, P. (1998) Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta, Curr. Biol. 8, 573-581.
8. Ikeda, S., Kishida, S., Yamamoto, H., Murai, H., Koyama, S., and Kikuchi, A. (1998) Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin, EMBO J. 17, 1371-1384.
9. Sakanaka, C., Weiss, J. B., and Williams, L. T. (1998) Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription, Proc. Natl. Acad. Sci. U.S.A. 95, 3020-3023.
10. Itoh, K., Krupnik, V. E., and Sokol, S. Y. (1998) Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and beta-catenin, Curr. Biol. 8, 591-594.
11. Salic, A., Lee, E., Mayer, L., and Kirschner, M. W. (2000) Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts, Mol. Cell 5, 523-532.
12. Liu, C., Li, Y., Semenov, M., Han, C., Baeg, G. H., Tan, Y., Zhang, Z., Lin, X., and He, X. (2002) Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism, Cell 108, 837-847.
13. Amit, S., Hatzubai, A., Birman, Y., Andersen, J. S., Ben-Shushan, E., Mann, M., Ben-Nerianh, Y., and Alkalay, I. (2002) Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway, Genes Dev. 16, 1066-1076.
14. Yanagawa, S., Matsuda, Y., Lee, J. S., Matsubayashi, H., Sese, S., Kadowaki, T., and Ishimoto, A. (2002) Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila, EMBO J. 21, 1733-1742.
15. Yost, C., Torres, M., Miller, J. R., Huang, E., Kimelman, D., and Moon, R. T. (1996) The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3, Genes Dev. 10, 1443-1454.
16. Peifer, M., Pai, L. M., and Casey, M. (1994) Phosphorylation of the Drosophila adherens junction protein Armadillo: roles for wingless signal and zeste-white 3 kinase, Dev. Biol. 166, 543-556.
17. Winston, J. T., Strack, P., Beer-Romero, P., Chu, C. Y., Elledge, S. J., and Harper, J. W. (1999) The SCFbeta-TrCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro, Genes Dev. 13, 270-283.
18. Liu, C., Kato, Y., Zhang, Z., Do, V. M., Yankner, B. A., and He, X. (1999) beta-TrCP couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation, Proc. Natl. Acad. Sci. U.S.A. 96, 6273-6278.
19. Hart, M., Concordet, J. P., Lassot, I., Albert, I., del los Santos, R., Durand, H., Perret, C., Rubinfeld, B., Margottin, F., Benarous, R., and Polakis, P. (1999) The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell, Curr. Biol. 9, 207-210.
20. Kitagawa, M., Hatakeyama, S., Shirane, M., Matsumoto, M., Ishida, N., Hattori, K., Nakamichi, I., Kikuchi, A., Nakayama, K., and Nakayama, K. (1999) An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin, EMBO J. 18, 2401-2410.
21. Latres, E., Chiaur, D. S., and Pagano, M. (1999) The human F box protein beta-TrCP associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin, Oncogene 18, 849-854.
22. Wu, G., Xu, G., Schulman, B. A., Jeffrey, P. D., Harper, J. W., and Pavletich, N. P. (2003) Ozz; a new name on the long list of beta-catenin's nemeses, Mol. Cell 11, 1445-1456.
23. Aberle, H., Bauer, A., Stappert, J., Kispert, A., and Kemler, R. (1997) beta-catenin is a target for the ubiquitin-proteasome pathway, EMBO J. 16, 3797-3804.
24. Orford, K., Crockett, C., Jensen, J. P., Weissman, A. M., and Byers, S. W. (1997) Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin, J. Biol. Chem. 272, 24735-24738.
25. He, X., Semenov, M., Tamai, K., and Zeng, X. (2004) LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way, Development 131, 1663-1677.
26. Behrens, J., von Kries, J. P., Kuhl, M., Bruhn, L., Wedlich, D., Grosschedl, R., and Birchmeier, W. (1996) Functional interaction of beta-catenin with the transcription factor LEF-1, Nature 382, 638-642.
27. Huber, O., Korn, R., McLaughlin, J., Ohsugi, M., Herrmann, B. G., and Kemler, R. (1996) Nuclear localization of beta-catenin by interaction with transcription factor LEF-1, Mech. Dev. 59, 3-10.
28. Molenaar, M., van der Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destree, O., and Clevers, H. (1996) XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos, Cell 86, 391-399.
29. He, T. C., Sparks, A. B., Rago, C., Hermeking, H., Zawel, L., da Costa, L. T., Morin, P. J., Vogelstein, B., and Kinzler, K. W. (1998) Identification of c-MYC as a target of the APC pathway, Science 281, 1509-1512.
30. Tetsu, O., and McCormick, F. (1999) Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells, Nature 398, 422-426.
31. Mao, B., Wu, W., Li, Y., Hoppe, D., Stannek, P., Glinka, A., and Niehrs, C. (2001) LDL-receptor-related protein 6 is a receptor for Dickkopf proteins, Nature 411, 321-325.
32. Tamai, K., Zeng, X., Liu, C., Zhang, X., Harada, Y., Chang, Z., and He, X. (2004) A mechanism for Wnt coreceptor activation, Mol. Cell 13, 149-156.
33. Dajani, R., Fraser, E., Roe, S. M., Young, N., Good, V., Dale, T. C., and Pearl, L. H. (2001) Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition, Cell 105, 721-732.