A comparative study of the central effects of specific proopiomelancortin (POMC)-derived melanocortin peptides on food intake and body weight in Pomc null mice

Endocrinology

Volumn 147, Issue 12, 2006, Pages 5940-5947

  Tung, Y C Loraine ^a   Piper, Sarah J ^a   Yeung, Debra ^a   O'Rahilly, Stephen ^a   Coll, Anthony P ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INTERMEDIN DERIVATIVE; LIPOTROPIN; MELANOCORTIN; PROOPIOMELANOCORTIN;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; ENERGY; FOOD INTAKE; HEMOSTASIS; LEAN BODY WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ALPHA-MSH; ANIMALS; APPETITE REGULATION; BODY WEIGHT; CENTRAL NERVOUS SYSTEM; DRUG ADMINISTRATION ROUTES; EATING; MALE; MELANOCORTINS; MICE; MICE, KNOCKOUT; PLACEBOS; PRO-OPIOMELANOCORTIN; WEIGHT LOSS;

EID: 33751548654     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2006-0866     Document Type: Article

References (40)

1. Cone RD 1999 The central melanocortin system and energy homeostasis. Trends Endocrinol Metab 10:211-216
2. Coll AP, Farooqi IS, Challis BG, Yeo GS, O'Rahilly S 2004 Proopiomelanocortin and energy balance: insights from human and murine genetics. J Clin Endocrinol Metab 89:2557-2562
3. Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, Gu W, Kesterson RA, Boston BA, Cone RD, Smith FJ, Campfield LA, Burn P, Lee F 1997 Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88:131-141
4. Farooqi IS, Keogh JM, Yeo GS, Lank EJ, Cheetham T, O'Rahilly S 2003 Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med 348:1085-1095
5. Butler AA, Kesterson RA, Khong K, Cullen MJ, Pelleymounter MA, Dekoning J, Baetscher M, Cone RD 2000 A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. Endocrinology 141:3518-3521
6. Chen AS, Marsh DJ, Trumbauer ME, Frazier EG, Guan XM, Yu H, Rosenblum CI, Vongs A, Feng Y, Cao L, Metzger JM, Strack AM, Camacho RE, Mellin TN, Nunes CN, Min W, Fisher J, Gopal-Truter S, MacIntyre DE, Chen HY, Van der Ploeg LH 2000 Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet 26:97-102
7. Feng N, Young SF, Aguilera G, Puricelli E, Adler-Wailes DC, Sebring NG, Yanovski JA 2005 Co-occurrence of two partially inactivating polymorphisms of MC3R is associated with pediatric-onset obesity. Diabetes 54:2663-2667
8. Raffin-Sanson ML, de Keyzer Y, Bertagna X 2003 Proopiomelanocortin, a polypeptide precursor with multiple functions: from physiology to pathological conditions. Eur J Endocrinol 149:79-90
9. Pritchard LE, Turnbull AV, White A 2002 Pro-opiomelanocortin processing in the hypothalamus: impact on melanocortin signalling and obesity. J Endocrinol 172:411-421
10. Krude H, Biebermann H, Luck W, Horn R, Brabant G, Gruters A 1998 Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 19:155-157
11. Challis BG, Coll AP, Yeo GS, Pinnock SB, Dickson SL, Thresher RR, Dixon J, Zahn D, Rochford JJ, White A, Oliver RL, Millington G, Aparicio SA, Colledge WH, Russ AP, Carlton MB, O'Rahilly S 2004 Mice lacking proopiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36). Proc Natl Acad Sci USA 101:4695-4700
12. Jackson RS, Creemers JW, Ohagi S, Raffin-Sanson ML, Sanders L, Montague CT, Hutton JC, O'Rahilly S 1997 Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nat Genet 16:303-306
13. Lloyd DJ, Bohan S, Gekakis N 2006 Obesity, hyperphagia and increased metabolic efficiency in Pc1 mutant mice. Hum Mol Genet 15:1884-1893
14. Bertagna X 1994 Proopiomelanocortin-derived peptides. Endocrinol Metab Clin North Am 23:467-485
15. Hadley ME, Hruby VJ, Jiang J, Sharma SD, Fink JL, Haskell-Luevano C, Bentley DL, al-Obeidi F, Sawyer TK 1996 Melanocortin receptors: identification and characterization by melanotropic peptide agonists and antagonists. Pigment Cell Res 9:213-234
16. Schioth HB, Muceniece R, Wikberg JE 1996 Characterisation of the melanocortin 4 receptor by radioligand binding. Pharmacol Toxicol 79:161-165
17. Harrold JA, Widdowson PS, Williams G 2003 β-MSH: a functional ligand that regulated energy homeostasis via hypothalamic MC4-R? Peptides 24:397-405
18. Roselli-Rehfuss L, Mountjoy KG, Robbins LS, Mortrud MT, Low MJ, Tatro JB, Entwistle ML, Simerly RB, Cone RD 1993 Identification of a receptor for γ melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system. Proc Natl Acad Sci USA 90:8856-8860
19. Xiang Z, Litherland SA, Sorensen NB, Proneth B, Wood MS, Shaw AM, Millard WJ, Haskell-Luevano C 2006 Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin- derived agonists and the agouti-related protein (AGRP) antagonist. Biochemistry 45:7277-7288
20. Kask A, Rago L, Wikberg JE, Schioth HB 2000 Differential effects of melanocortin peptides on ingestive behaviour in rats: evidence against the involvement of MC(3) receptor in the regulation of food intake. Neurosci Lett 283:1-4
21. Abbott CR, Rossi M, Kim M, AlAhmed SH, Taylor GM, Ghatei MA, Smith DM, Bloom SR 2000 Investigation of the melanocyte stimulating hormones on food intake. Lack Of evidence to support a role for the melanocortin-3-receptor. Brain Res 869:203-210
22. 2-melanocyte- stimulating hormones on hypothalamic neuronal activation and feeding in the fasted rat. Neuroscience 108:437-445
23. -/- mice reduces food intake and weight but does not affect adrenal growth or corticosterone production. J Endocrinol 190:515-525
24. Coll AP, Challis BG, Lopez M, Piper S, Yeo GS, O'Rahilly S 2005 Proopiomelanocortin-deficient mice are hypersensitive to the adverse metabolic effects of glucocorticoids. Diabetes 54:2269-2276
25. Grill HJ, Ginsberg AB, Seeley RJ, Kaplan JM 1998 Brainstem application of melanocortin receptor ligands produces long-lasting effects on feeding and body weight. J Neurosci 18:10128-10135
26. Hwa JJ, Ghibaudi L, Gao J, Parker EM 2001 Central melanocortin system modulates energy intake and expenditure of obese and lean Zucker rats. Am J Physiol Regul Integr Comp Physiol 281:R444-R451
27. Pierroz DD, Ziotopoulou M, Ungsunan L, Moschos S, Flier JS, Mantzoros CS 2002 Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity. Diabetes 51:1337-1345
28. Li G, Zhang Y, Wilsey JT, Scarpace PJ 2004 Unabated anorexic and enhanced thermogenic responses to melanotan II in diet-induced obese rats despite reduced melanocortin 3 and 4 receptor expression. J Endocrinol 182:123-132
29. Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD 1997 Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385:165-168
30. Hadley ME, Hruby VJ, Blanchard J, Dorr RT, Levine N, Dawson BV, al-Obeidi F, Sawyer TK 1998 Discovery and development of novel melanogenic drugs. Melanotan-I and -II. Pharm Biotechnol 11:575-595
31. Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, Williams T, Ferreira M, Tang V, McGovern RA, Kenny CD, Christiansen LM, Edelstein E, Choi B, Boss O, Aschkenasi C, Zhang CY, Mountjoy K, Kishi T, Elmquist JK, Lowell BB 2005 Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123:493-505
32. Lee YS, Challis BG, Thompson DA, Yeo GS, Keogh JM, Madonna ME, Wraight V, Sims M, Vatin V, Meyre D, Shield J, Burren C, Ibrahim Z, Cheetham T, Swift P, Blackwood A, Hung CC, Wareham NJ, Froguel P, Millhauser GL, O'Rahilly S, Farooqi IS 2006 A POMC variant implicates β-melanocyte-stimulating hormone in the control of human energy balance. Cell Metab 3:135-140
33. Biebermann H, Castaneda TR, van Landeghem F, von Deimling A, Escher F, Brabant G, Hebebrand J, Hinney A, Tschop MH, Gruters A, Krude H 2006 A role for β-melanocyte-stimulating hormone in human body-weight regulation. Cell Metab 3:141-146
34. Humphreys MH 2004 γ-MSH, sodium metabolism, and salt-sensitive hypertension. Am J Physiol Regul Integr Comp Physiol 286:R417-R430
35. Ni XP, Pearce D, Butler AA, Cone RD, Humphreys MH 2003 Genetic disruption of γ-melanocyte-stimulating hormone signaling leads to salt-sensitive hypertension in the mouse. J Clin Invest 111:1251-1258
36. Marks DL, Hruby V, Brookhart G, Cone RD 2006 The regulation of food intake by selective stimulation of the type 3 melanocortin receptor (MC3R). Peptides 27:259-264
37. Dunbar JC, Lu H 1999 Leptin-induced increase in sympathetic nervous and cardiovascular tone is mediated by proopiomelanocortin (POMC) products. Brain Res Bull 50:215-221
38. Song CK, Jackson RM, Harris RB, Richard D, Bartness TJ 2005 Melanocortin-4 receptor mRNA is expressed in sympathetic nervous system outflow neurons to white adipose tissue. Am J Physiol Regul Integr Comp Physiol 289:R1467-R1476
39. Guo L, Munzberg H, Stuart RC, Nillni EA, Bjorbaek C 2004 N-acetylation of hypothalamic α-melanocyte-stimulating hormone and regulation by leptin. Proc Natl Acad Sci USA 101:11797-11802
40. Obici S, Rossetti L 2003 Minireview: nutrient sensing and the regulation of insulin action and energy balance. Endocrinology 144:5172-5178