-
1
-
-
0032577309
-
The search for human obesity genes
-
Comuzzie AG, Allison DB. The search for human obesity genes. Science 1998;280:1374-7.
-
(1998)
Science
, vol.280
, pp. 1374-1377
-
-
Comuzzie, A.G.1
Allison, D.B.2
-
2
-
-
0004318660
-
Obesity: Preventing and managing the global epidemic: Report of a WHO consultation
-
Obesity: preventing and managing the global epidemic: report of a WHO consultation. WHO Tech Rep Set 1999;894:1-253.
-
(1999)
WHO Tech Rep Set
, vol.894
, pp. 1-253
-
-
-
3
-
-
0035514934
-
Partial leptin deficiency and human adiposity
-
Farooqi IS, Keogh JM, Kamath S, et al. Partial leptin deficiency and human adiposity. Nature 2001;414:34-5.
-
(2001)
Nature
, vol.414
, pp. 34-35
-
-
Farooqi, I.S.1
Keogh, J.M.2
Kamath, S.3
-
4
-
-
0030878110
-
Congenital leptin deficiency is associated with severe early-onset obesity in humans
-
Montague CT, Farooqi IS, Whitehead JP, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997;387:903-8.
-
(1997)
Nature
, vol.387
, pp. 903-908
-
-
Montague, C.T.1
Farooqi, I.S.2
Whitehead, J.P.3
-
5
-
-
0033861080
-
Soluble leptin receptor in serum of subjects with complete resistance to leptin: Relation to fat mass
-
Lahlou N, Clement K, Carel JC, et al. Soluble leptin receptor in serum of subjects with complete resistance to leptin: relation to fat mass. Diabetes 2000;49:1347-52.
-
(2000)
Diabetes
, vol.49
, pp. 1347-1352
-
-
Lahlou, N.1
Clement, K.2
Carel, J.C.3
-
6
-
-
0030928715
-
Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus
-
Cheung CC, Clifton DK, Steiner RA. Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology 1997;138:4489-92.
-
(1997)
Endocrinology
, vol.138
, pp. 4489-4492
-
-
Cheung, C.C.1
Clifton, D.K.2
Steiner, R.A.3
-
7
-
-
0028134706
-
Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain
-
Mountjoy KG,Mortrud MT, Low MJ, Simerly RB, Cone RD. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol Endocrinol 1994;8:1298-308.
-
(1994)
Mol Endocrinol
, vol.8
, pp. 1298-1308
-
-
Mountjoy, K.G.1
Mortrud, M.T.2
Low, M.J.3
Simerly, R.B.4
Cone, R.D.5
-
8
-
-
0032014836
-
A leptin missense mutation associated with hypogonadism and morbid obesity
-
Strobel A, Issad T, Camoin L, Ozata M, Strosberg AD. A leptin missense mutation associated with hypogonadism and morbid obesity. Nat Genet 1998;18:213-5.
-
(1998)
Nat Genet
, vol.18
, pp. 213-215
-
-
Strobel, A.1
Issad, T.2
Camoin, L.3
Ozata, M.4
Strosberg, A.D.5
-
9
-
-
0344450708
-
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
-
Clement K, Vaisse C, Lahlou N, et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998;392:398-401.
-
(1998)
Nature
, vol.392
, pp. 398-401
-
-
Clement, K.1
Vaisse, C.2
Lahlou, N.3
-
10
-
-
0031838353
-
Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
-
Krude H, Biebermann H, Luck W, Horn R, Brabant G, Grüters A. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 1998;19:155-7.
-
(1998)
Nat Genet
, vol.19
, pp. 155-157
-
-
Krude, H.1
Biebermann, H.2
Luck, W.3
Horn, R.4
Brabant, G.5
Grüters, A.6
-
11
-
-
0033927916
-
Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity
-
Vaisse C, Clement K, Durand E, Hercberg S, Guy-Grand B, Froguel P. Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. J Clin Invest 2000;106:253-62.
-
(2000)
J Clin Invest
, vol.106
, pp. 253-262
-
-
Vaisse, C.1
Clement, K.2
Durand, E.3
Hercberg, S.4
Guy-Grand, B.5
Froguel, P.6
-
12
-
-
0030889192
-
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
-
Huszar D, Lynch CA, Fairchild-Huntress V, et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 1997;88:131-41.
-
(1997)
Cell
, vol.88
, pp. 131-141
-
-
Huszar, D.1
Lynch, C.A.2
Fairchild-Huntress, V.3
-
13
-
-
0032829033
-
Monogenic disorders of obesity and body fat distribution
-
Chen D, Garg A. Monogenic disorders of obesity and body fat distribution. J Lipid Res 1999;40:1735-46.
-
(1999)
J Lipid Res
, vol.40
, pp. 1735-1746
-
-
Chen, D.1
Garg, A.2
-
14
-
-
12944331892
-
A metabolic defect promotes obesity in mice lacking melanocortin- 4 receptors
-
Ste Marie L, Miura GI, Marsh DJ, Yagaloff K, Palmiter RD. A metabolic defect promotes obesity in mice lacking melanocortin- 4 receptors. Proc Natl Acad Sci U S A 2000;97:12339-44.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 12339-12344
-
-
Ste Marie, L.1
Miura, G.I.2
Marsh, D.J.3
Yagaloff, K.4
Palmiter, R.D.5
-
15
-
-
0031668219
-
A frameshift mutation in MC4R associated with dominantly inherited human obesity
-
Yeo GSH, Farooqi IS, Aminian S, Halsall DJ, Stanhope RG, O'Rahilly S. A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nat Genet 1998;20:111-2.
-
(1998)
Nat Genet
, vol.20
, pp. 111-112
-
-
Yeo, G.S.H.1
Farooqi, I.S.2
Aminian, S.3
Halsall, D.J.4
Stanhope, R.G.5
O'Rahilly, S.6
-
16
-
-
0031662163
-
A flameshift mutation in human MC4R is associated with a dominant form of obesity
-
Vaisse C, Clement K, Guy-Grand B, Froguel P. A flameshift mutation in human MC4R is associated with a dominant form of obesity. Nat Genet 1998;20:113-4.
-
(1998)
Nat Genet
, vol.20
, pp. 113-114
-
-
Vaisse, C.1
Clement, K.2
Guy-Grand, B.3
Froguel, P.4
-
17
-
-
0033343736
-
Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans
-
Hinney A, Schmidt A, Nottebom K, et al. Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans. J Clin Endocrinol Metab 1999;84:1483-6.
-
(1999)
J Clin Endocrinol Metab
, vol.84
, pp. 1483-1486
-
-
Hinney, A.1
Schmidt, A.2
Nottebom, K.3
-
18
-
-
0033362016
-
Phenotypes in three pedigrees with autosomal dominant obesity caused by haploinsufficiency mutations in the melanocortin-4 receptor gene
-
SinaM, Hinney A, Ziegler A, et al. Phenotypes in three pedigrees with autosomal dominant obesity caused by haploinsufficiency mutations in the melanocortin-4 receptor gene. Am J Hum Genet 1999;65:1501-7.
-
(1999)
Am J Hum Genet
, vol.65
, pp. 1501-1507
-
-
Sina, M.1
Hinney, A.2
Ziegler, A.3
-
19
-
-
0033010326
-
Identification and functional analysis of novel human melanocortin-4 receptor variants
-
Gu W, Tu Z, Kleyn PW, et al. Identification and functional analysis of novel human melanocortin-4 receptor variants. Diabetes 1999;48:635-9.
-
(1999)
Diabetes
, vol.48
, pp. 635-639
-
-
Gu, W.1
Tu, Z.2
Kleyn, P.W.3
-
20
-
-
0343953074
-
Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency
-
Farooqi IS, Yeo GSH, Keogh JM, et al. Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency. J Clin Invest 2000;106:271-9.
-
(2000)
J Clin Invest
, vol.106
, pp. 271-279
-
-
Farooqi, I.S.1
Yeo, G.S.H.2
Keogh, J.M.3
-
21
-
-
0034913118
-
A novel melanocortin 4 receptor (MC4R) gene mutation associated with morbid obesity
-
Mergen M, Mergen H, Ozata M, Oner R, Oner C. A novel melanocortin 4 receptor (MC4R) gene mutation associated with morbid obesity. J Clin Endocrinol Metab 2001;86:3448.
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 3448
-
-
Mergen, M.1
Mergen, H.2
Ozata, M.3
Oner, R.4
Oner, C.5
-
22
-
-
0034905674
-
Mutational analysis of melanocortin-4 receptor, agouti-related protein, and alpha-melanocyte-stimulating hormone genes in severely obese children
-
Dubern B, Clément K, Pelloux V, et al. Mutational analysis of melanocortin-4 receptor, agouti-related protein, and alpha-melanocyte-stimulating hormone genes in severely obese children. J Pediatr 2001;139:204-9.
-
(2001)
J Pediatr
, vol.139
, pp. 204-209
-
-
Dubern, B.1
Clément, K.2
Pelloux, V.3
-
23
-
-
0034771191
-
A missense mutation in the human melanocortin-4 receptor gene in relation to abdominal obesity and salivary cortisol
-
Rosmond R, Chagnon M, Bouchard C, Bjomtorp P. A missense mutation in the human melanocortin-4 receptor gene in relation to abdominal obesity and salivary cortisol. Diabetologia 2001;44:1335-8.
-
(2001)
Diabetologia
, vol.44
, pp. 1335-1338
-
-
Rosmond, R.1
Chagnon, M.2
Bouchard, C.3
Bjomtorp, P.4
-
24
-
-
0036094522
-
A novel homozygous missense mutation of melanocortin-4 receptor (MC4R) in a Japanese woman with severe obesity
-
Kobayashi H, Ogawa Y, Shintani M, et al. A novel homozygous missense mutation of melanocortin-4 receptor (MC4R) in a Japanese woman with severe obesity. Diabetes 2002;51:243-6.
-
(2002)
Diabetes
, vol.51
, pp. 243-246
-
-
Kobayashi, H.1
Ogawa, Y.2
Shintani, M.3
-
25
-
-
0036512889
-
The human obesity gene map: The 2001 update
-
Rankinen T, Pérusse L, Weisnagel SJ, Synder EE, Chagnon YC, Bouchard C. The human obesity gene map: the 2001 update. Obes Res 2002;10:196-243.
-
(2002)
Obes Res
, vol.10
, pp. 196-243
-
-
Rankinen, T.1
Pérusse, L.2
Weisnagel, S.J.3
Synder, E.E.4
Chagnon, Y.C.5
Bouchard, C.6
-
26
-
-
18644363563
-
Melanocortin 4 receptor sequence variations are seldom a cause of human obesity: The Swedish Obese Subjects, the HERITAGE Family Study, and a Memphis cohort
-
Jacobsen P, Ukkola O, Rankinen T, et al. Melanocortin 4 receptor sequence variations are seldom a cause of human obesity: the Swedish Obese Subjects, the HERITAGE Family Study, and a Memphis cohort. J Clin Endocrinol Metab 2002;87:4442-6.
-
(2002)
J Clin Endocrinol Metab
, vol.87
, pp. 4442-4446
-
-
Jacobsen, P.1
Ukkola, O.2
Rankinen, T.3
-
27
-
-
0036263843
-
Mutations in the human leptin and leptin receptor genes as models of serum leptin receptor regulation
-
Lahlou N, Issad T, Lebouc Y, et al. Mutations in the human leptin and leptin receptor genes as models of serum leptin receptor regulation. Diabetes 2002;51:1980-5.
-
(2002)
Diabetes
, vol.51
, pp. 1980-1985
-
-
Lahlou, N.1
Issad, T.2
Lebouc, Y.3
-
28
-
-
0012429494
-
Criteria sets and axes provided for further study
-
DSM-IV. Washington, D.C.: American Psychiatric Association
-
Criteria sets and axes provided for further study. In: Diagnostic and statistical manual of mental disorders, 4th ed.: DSM-IV. Washington, D.C.: American Psychiatric Association, 1994:703-61.
-
(1994)
Diagnostic and Statistical Manual of Mental Disorders, 4th Ed.
, pp. 703-761
-
-
-
29
-
-
0026534579
-
Binge eating disorder: A multisite field trial of the diagnostic criteria
-
Spitzer RL, Devlin M, Walsh BT, et al. Binge eating disorder: a multisite field trial of the diagnostic criteria. Int J Eat Disord 1992;11:191-203.
-
(1992)
Int J Eat Disord
, vol.11
, pp. 191-203
-
-
Spitzer, R.L.1
Devlin, M.2
Walsh, B.T.3
-
30
-
-
0027417254
-
Binge eating disorder: Its further validation in a multisite study
-
Spitzer RL, Yanovski S, Wadden T, et al. Binge eating disorder: its further validation in a multisite study. Int J Eat Disord 1993;13:137-53.
-
(1993)
Int J Eat Disord
, vol.13
, pp. 137-153
-
-
Spitzer, R.L.1
Yanovski, S.2
Wadden, T.3
-
31
-
-
0026589982
-
Is there another binge eating disorder? A review of the literature on overeating in the absence of bulimia nervosa
-
Devlin MJ, Walsh BT, Spitzer RL, Hasin D. Is there another binge eating disorder? A review of the literature on overeating in the absence of bulimia nervosa. Int J Eat Disord 1992;11:333-40.
-
(1992)
Int J Eat Disord
, vol.11
, pp. 333-340
-
-
Devlin, M.J.1
Walsh, B.T.2
Spitzer, R.L.3
Hasin, D.4
-
32
-
-
0034835938
-
Morbidity of severe obesity
-
Kral JG. Morbidity of severe obesity. Surg Clin North Am 2001;8:1039-61.
-
(2001)
Surg Clin North Am
, vol.8
, pp. 1039-1061
-
-
Kral, J.G.1
-
34
-
-
0032874203
-
Imipramine and diet counseling with psychological support in the treatment of obese binge eaters: A randomized, placebo-controlled double-blind study
-
Laederach-Hofmann K, GrafC, Horber F, et al. Imipramine and diet counseling with psychological support in the treatment of obese binge eaters: a randomized, placebo-controlled double-blind study. Int J Eat Disord 1999;26:231-44.
-
(1999)
Int J Eat Disord
, vol.26
, pp. 231-244
-
-
Laederach-Hofmann, K.1
Graf, C.2
Horber, F.3
-
35
-
-
0030757857
-
Effect of sex and age on bone mass, body composition and fuel metabolism in humans
-
Horber FF, Gruber B, Thomi F, Jensen EX, Jaeger P. Effect of sex and age on bone mass, body composition and fuel metabolism in humans. Nutrition 1997;13:524-34.
-
(1997)
Nutrition
, vol.13
, pp. 524-534
-
-
Horber, F.F.1
Gruber, B.2
Thomi, F.3
Jensen, E.X.4
Jaeger, P.5
-
36
-
-
0029084864
-
Use of dual-energy X-ray absorptiometry in obese individuals
-
Tataranni PA, Ravussin E. Use of dual-energy X-ray absorptiometry in obese individuals. Am J Clin Nutr 1995;62:730-4.
-
(1995)
Am J Clin Nutr
, vol.62
, pp. 730-734
-
-
Tataranni, P.A.1
Ravussin, E.2
-
37
-
-
0030872838
-
PolyPhred: Automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing
-
Nickerson DA, Tobe VO, Taylor SL. PolyPhred: automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing. Nucleic Acids Res 1997;25:2745-51.
-
(1997)
Nucleic Acids Res
, vol.25
, pp. 2745-2751
-
-
Nickerson, D.A.1
Tobe, V.O.2
Taylor, S.L.3
-
38
-
-
0036255811
-
Candidate-gene approaches for studying complex genetic traits: Practical considerations
-
Tabor HK, Risch NJ, Myers RM. Candidate-gene approaches for studying complex genetic traits: practical considerations. Nat Rev Genet 2002;3:391-7.
-
(2002)
Nat Rev Genet
, vol.3
, pp. 391-397
-
-
Tabor, H.K.1
Risch, N.J.2
Myers, R.M.3
-
39
-
-
0032148845
-
Are leptin levels dependent on body fat distribution in obese men and women?
-
Wauters M, Mertens I, Considine R, De Leeuw I, Van Gaal L. Are leptin levels dependent on body fat distribution in obese men and women? Eat Weight Disord 1998;3:124-30.
-
(1998)
Eat Weight Disord
, vol.3
, pp. 124-130
-
-
Wauters, M.1
Mertens, I.2
Considine, R.3
De Leeuw, I.4
Van Gaal, L.5
-
40
-
-
0032721802
-
Leptin concentrations and their relation to body fat distribution and weight loss - A prospective study in individuals with impaired glucose tolerance
-
Eriksson J, Valle T, Lindstrom S, et al. Leptin concentrations and their relation to body fat distribution and weight loss - a prospective study in individuals with impaired glucose tolerance. Horm Metab Res 1999;31:616-9.
-
(1999)
Horm Metab Res
, vol.31
, pp. 616-619
-
-
Eriksson, J.1
Valle, T.2
Lindstrom, S.3
-
41
-
-
0036778260
-
Binge size increases with body mass index in women with binge-eating disorder
-
Guss JL, Kissileff HR, Devlin MJ, Zimmerli E, Walsh BT. Binge size increases with body mass index in women with binge-eating disorder. Obes Res 2002;10:1021-9.
-
(2002)
Obes Res
, vol.10
, pp. 1021-1029
-
-
Guss, J.L.1
Kissileff, H.R.2
Devlin, M.J.3
Zimmerli, E.4
Walsh, B.T.5
-
42
-
-
0036235653
-
Binge eating among gastric bypass patients at longterm follow-up
-
Kalarchian MA, Marcus MD, Wilson GT, Labouvie EW, Brolin RE, LaMarca LB. Binge eating among gastric bypass patients at longterm follow-up. Obes Surg 2002;12:270-5.
-
(2002)
Obes Surg
, vol.12
, pp. 270-275
-
-
Kalarchian, M.A.1
Marcus, M.D.2
Wilson, G.T.3
Labouvie, E.W.4
Brolin, R.E.5
LaMarca, L.B.6
-
43
-
-
0036515969
-
Chronic application of MTII in a rat model ofobesity results in sustained weight loss
-
Hamilton BS, Doods HN. Chronic application of MTII in a rat model ofobesity results in sustained weight loss. Obes Res 2002;10:182-7.
-
(2002)
Obes Res
, vol.10
, pp. 182-187
-
-
Hamilton, B.S.1
Doods, H.N.2
|