Direct reversal of DNA damage mutant methyltransferase protein protects mice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells

Cancer Research

Volumn 60, Issue 18, 2000, Pages 5187-5195

  Ragg, S ^a   Xu Welliver, M ^a   Bailey, J ^a   D'Souza, M ^a   Cooper, R ^a   Chandra, S ^a   Seshadri, R ^a   Pegg, A E ^a   Williams, D A ^a  

^a INDIANA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 O BENZYLGUANINE; CARMUSTINE; CELL DNA; DNA METHYLTRANSFERASE; MUTANT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW TOXICITY; CELL PROTECTION; CELL SELECTION; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFICACY; GENE TRANSFER; HEMATOPOIETIC STEM CELL; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL;

3T3 CELLS; ANIMAL; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BONE MARROW TRANSPLANTATION; CARMUSTINE; COMPARATIVE STUDY; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GUANINE; HEMATOPOIETIC STEM CELLS; HUMAN; MICE; MICE, INBRED C57BL; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; POINT MUTATION; RATS; RETROVIRIDAE; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TRANSDUCTION, GENETIC;

EID: 0034665336     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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