Potential oncogene activity of the woodchuck hepatitis post-transcriptional regulatory element (WPRE)

Gene Therapy

Volumn 12, Issue 1, 2005, Pages 3-4

  Kingsman, S M ^a   Mitrophanous, K ^a   Olsen, J C ^b  

^a OXFORD BIOMEDICA UK LTD   (United Kingdom)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; LENTIVIRUS VECTOR; MESSENGER RNA; POSTTRANSCRIPTIONAL REGULATORY ELEMENT PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS VECTOR; X PROTEIN;

ADENO ASSOCIATED VIRUS; CELL PROLIFERATION; ENHANCER REGION; EQUINE INFECTIOUS ANEMIA VIRUS; GENE DELETION; GENE EXPRESSION REGULATION; GENE MUTATION; GENETIC CODE; HEPATITIS B VIRUS; HEPATITIS VIRUS; HUMAN; LETTER; LIVER CANCER; LIVER CELL CARCINOMA; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS CARCINOGENESIS; VIRUS DNA CELL DNA INTERACTION; VIRUS TRANSCRIPTION; WILD TYPE;

ANIMALS; GENETIC VECTORS; HEPATITIS B VIRUS, WOODCHUCK; HUMANS; NEOPLASMS; REGULATORY SEQUENCES, NUCLEIC ACID; RNA PROCESSING, POST-TRANSCRIPTIONAL; TRANS-ACTIVATORS;

ADENO-ASSOCIATED VIRUS; EQUIDAE; EQUINE INFECTIOUS ANEMIA VIRUS; HEPATITIS B VIRUS; LENTIVIRUS; MARMOTA MONAX;

EID: 11844288284     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3302417     Document Type: Letter

References (15)

1. Donello JE et al. Woodchuck hepatitis virus contains a tripartite posttranscriptional regulatory element. J Vir 1998; 72: 5085-5092.
2. Zuffrey R et al. Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. J Vir 1999; 73: 886-892.
3. Loeb JE et al. Enhanced expression of transgenes from adeno-associated virus vectors with the woodchuck hepatitis virus posttranscriptional regulatory element: implications for gene therapy. Hum Gene Ther 1999; 10: 2295-2305.
4. O'Rourke JP et al. Analysis of gene transfer and expression in skeletal muscle using enhanced EIAV lentivirus vectors. Mol Ther 2003; 7: 632-639.
5. Bienemann AS et al. Long-term replacement of a mutated nonfunctional CNS gene: reversal of hypothalmic diabetes insipidus using an EIAV-based lentiviral vector expressing arginine vasopressin. Mol Ther 2003; 7: 588-596.
6. Kim H et al. X-gene product of hepatitis B virus induces apoptosis in liver cells. J Biol Chem 273; 1998: 381-385.
7. Höhne M et al. Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA. EMBO J 9; 1990: 1137-1145.
8. Schuster R et al. Induction of apoptosis by the transactivating domains of the hepatitis B virus X gene leads to suppression of oncogenic transformation of primary rat embryo fibroblasts. Oncogene 2000; 19: 1173-1180.
9. Flajolet M et al. Woodchuck hepatitis virus enhancer I and enhancer II are both involved in N-myc2 activation in woodchuck liver tumours. J Vir 1998; 72: 6175-6180.
10. Nash KL et al. Hepatocyte-specific gene expression from integrated lentiviral vectors. J Gene Med 2004; 6: 974-983.
11. Terradillos O et al. The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic mice. Oncogene 1997; 14: 395-404.
12. Tu H et al. Biological impact of natural COOH-terminal deletions of hepatitis B virus X protein in hepatocellular carcinoma tissues. Cancer Res 2001; 61: 7803-7810.
13. Sirma H et al. Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx. Oncogene 1999; 18: 4848-4859.
14. Murakami S et al. Human hepatitis virus X gene encodes a regulatory domain that represses transactivation of X protein. J Biol Chem 1994; 269: 15118-15123.
15. Azzouz M et al. Neuroprotection of dopamine neurons by non-primate EIAV lentiviral-mediated expression of GDNF in the rat model of Parkinson's disease. Neuroreport 2004; 15: 985-990.