NMDA antagonist inhibits the extracellular signal-regulated kinase pathway and suppresses cancer growth

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 43, 2005, Pages 15605-15610

  Stepulak, Andrzej ^a,b   Sifringer, Marco ^a   Rzeski, Wojciech ^c,d   Endesfelder, Stefanie ^a   Gratopp, Alexander ^e   Pohl, Elena E ^e   Bittigau, Petra ^e   Felderhoff Mueser, Ursula ^e   Kaindl, Angela M ^e   Bührer, Christoph ^f   Hansen, Henrik H ^e   Stryjecka Zimmer, Marta ^b   Turski, Lechoslaw ^g   Ikonomidou, Chrysanthy ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b MEDICAL UNIVERSITY OF LUBLIN   (Poland)

^c MARIA CURIE SK ODOWSKA UNIVERSITY   (Poland)

^d INSTITUTE OF AGRICULTURAL MEDICINE   (Poland)

^e HUMBOLDT UNIVERSITY   (Germany)

^f UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^g Solvay Pharmaceuticals Inc   (Netherlands)

Author keywords

Cell cycle; Growth factors; Lung cancer; Signal transduction

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; BETA ACTIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIN D1; DIZOCILPINE; EPIDERMAL GROWTH FACTOR; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PROTEIN BCL 2; PROTEIN C FOS; PROTEIN C JUN; PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN P21; PROTEIN P53; SMALL INTERFERING RNA; SOMATOMEDIN; TUMOR SUPPRESSOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IN VITRO STUDY; IN VIVO STUDY; LUNG ADENOCARCINOMA; MOUSE; NEUROBLASTOMA; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHABDOMYOSARCOMA; SIGNAL TRANSDUCTION; SURVIVAL TIME; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CELLS, CULTURED; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; HUMANS; LUNG NEOPLASMS; MAP KINASE SIGNALING SYSTEM; PHOSPHORYLATION; RECEPTORS, N-METHYL-D-ASPARTATE;

ANIMALIA;

EID: 27344452342     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0507679102     Document Type: Article

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