Further evidence for the presence of cannabinoid CB1 receptors in guinea-pig small intestine

British Journal of Pharmacology

Volumn 118, Issue 8, 1996, Pages 2199-2205

  Pertwee, Roger G ^a   Fernando, Susanthi R ^a   Nash, Joanne E ^a   Coutts, Angela A ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Acetylcholine release; AM 630; Cannabinoid receptor agonists; Cannabinoid receptor antagonist; Guinea pig small intestine; Myenteric plexus; SR141716A; 9 tetrahydrocannabinol

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; ACETYLCHOLINE; CANNABINOID RECEPTOR; CANNABINOL; CLONIDINE; LEVONANTRADOL; NABILONE; NALOXONE; NORMORPHINE; PRAVADOLINE; RECEPTOR SUBTYPE; RIMONABANT; TETRAHYDROCANNABINOL; YOHIMBINE;

ACETYLCHOLINE RELEASE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROSTIMULATION; GUINEA PIG; INTESTINE MUSCLE; MALE; MYENTERIC PLEXUS; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR BLOCKING; SMALL INTESTINE; SMOOTH MUSCLE CONTRACTION;

EID: 0029786781     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15663.x     Document Type: Article

References (23)

1. ARUNLAKSHANA, O. & SCHILD, H.O. (1959). Some quantitative uses of drug antagonists. Br. J. Pharmacol., 14, 48-58.
2. COLQUHOUN, D. (1971). Lectures on Biostatistics. Oxford: Oxford University Press.
3. 1 cannabinoid receptors and possibly also a cannabinoid receptor ligand. Br. J. Pharmacol., 116, 46p.
4. DEADWYLER, S.A., HAMPSON, R.E. & CHILDERS, S.R. (1995). Functional significance of cannabinoid receptors in brain. In Cannabinoid Receptors, ed. Pertwee, R.G., pp. 205-231. London: Academic Press.
5. DEVANE, W.A., HANUS, L., BREUER, A., PERTWEE, R.G., STEVENSON, L.A., GRIFFIN, G., GIBSON, D., MANDELBAUM, A., ETINGER, A. & MECHOULAM, R. (1992). Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science, 258, 1946-1949.
6. HERKENHAM, M., LYNN, A.B., LITTLE, M.D., JOHNSON, M.R., MELVIN, L.S., DE COSTA, B.R. & RICE, K.C. (1990). Cannabinoid receptor localization in brain. Proc. Natl. Acad. Sci. U.S.A., 87, 1932-1936.
7. KENAKIN, T.P., BOND, R.A. & BONNER, T.I. (1992). Definition of pharmacological receptors. Pharmacol. Rev., 44, 351-362.
8. 1-tetrahydrocannabinol and cannabidiol at cholinergic junctions. Br. J. Pharmacol., 41, 379P.
9. LEFF, P. (1995). The two-state model of receptor activation. Trends Pharmacol. Sci., 16, 89-97.
10. MECHOULAM, R., BEN-SHABAT, S., HANUS, L., LIGUMSKY, M., KAMINSKI, N.E., SCHATZ, A.R., GOPHER, A., ALMOG, S., MARTIN, B.R., COMPTON, D.R., PERTWEE, R.G., GRIFFIN, G., BAYEWITCH, M., BARG, J. & VOGEL, Z. (1995). Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem. Pharmacol., 50, 83-90.
11. PATERSON, S.J. & PERTWEE, R.G. (1993). Characterization of the cannabinoid binding site in the guinea-pig. Br. J. Pharmacol. (Proc. suppl.), 109, 82P.
12. PATON, W.D.M. & ZAR, M.A. (1968). The origin of acetylcholine released from guinea-pig intestine and longitudinal muscle strips. J. Physiol., 194, 13-33.
13. PATON, W.D.M., PERTWEE, R.G. & TEMPLE, D. (1972). The general pharmacology of cannabinoids. In Cannabis and its Derivatives, ed. Paton, W.D.M. & Crown, J., pp. 50-75. London: Oxford University Press.
14. PERTWEE, R.G. (1990). The central neuropharmacology of psychotropic cannabinoids. In Psychotropic Drugs of Abuse., ed. Balfour, D.J.K., pp. 355-429. New York: Pergamon Press.
15. PERTWEE, R.G. (1995). Pharmacological, physiological and clinical implications of the discovery of cannabinoid receptors: an overview. In Cannabinoid Receptors, ed. Pertwee, R.G. pp. 1-34. London: Academic Press.
16. PERTWEE, R.G., GRIFFIN, G., LAINTON, J.A.H. & HUFFMAN, J.W. (1995a). Pharmacological characterization of three novel cannabinoid receptor agonists in the mouse isolated vas deferens. Eur. J. Pharmacol., 284, 241-247.
17. PERTWEE, R., GRIFFIN, G., FERNANDO, S., LI, X., HILL, A. & MAKRIYANNIS, A. (1995b). AM630, a competitive cannabinoid receptor antagonist. Life Sci., 56, 1949-1955.
18. PERTWEE, R.G., STEVENSON, L.A., ELRICK, D.B., MECHOULAM, R. & CORBETT, A.D. (1992). Inhibitory effects of certain enantiomeric cannabinoids in the mouse vas deferens and the myenteric plexus preparation of guinea-pig small intestine. Br. J. Pharmacol., 105, 980-984.
19. RINALDI-CARMONA, M., BARTH, F., HEAULME, M., SHIRE, D., CALANDRA, B., CONGY, C., MARTINEZ, S., MARUANI, J., NELIAT, G., CAPUT, D., FERRARA, P., SOUBRIE, P., BRELIERE, J.C. & LEFUR, G. (1994). SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Letts., 350, 240-244.
20. 35 S]thio]triphosphate binding. Proc. Natl. Acad. Sci. U.S.A., 92, 7242-7246.
21. 2 and receptor differentiation: a statistical analysis of competitive antagonism. Life. Sci., 25, 637-654.
22. WATERFIELD, A.A. (1973). Factors affecting acetylcholine release from the myenteric plexus of the ileum. PhD Thesis, University of Aberdeen.
23. WATSON, S. & GIRDLESTONE, D. (1995). 1995 receptor and ion channel nomenclature supplement. Trends Pharmacol. Sci., 6th Edition, Cambridge: Elsevier.