SR141716, a central cannabinoid (CB1) receptor antagonist, blocks the motivational and dopamine-releasing effects of nicotine in rats

Behavioural Pharmacology

Volumn 13, Issue 5-6, 2002, Pages 451-463

  Cohen, C ^a   Perrault, G ^a   Voltz, C ^a   Steinberg, R ^a   Soubrie P ^a  

^a SANOFI   (France)

Author keywords

Cannabinoid receptors; Drug discrimination; Ethanol; Mesolimbic dopaminergic system; Microdialysis; Nicotine; Rat; Self administration

Indexed keywords

ALCOHOL; CANNABINOID; CANNABINOID RECEPTOR; DEXAMPHETAMINE; DOPAMINE; NICOTINE; RIMONABANT;

ALCOHOL CONSUMPTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOPAMINE RELEASE; DOPAMINERGIC SYSTEM; DOSE RESPONSE; DRUG ANTAGONISM; DRUG DISCRIMINATION; DRUG SELF ADMINISTRATION; LIMBIC CORTEX; MALE; MICRODIALYSIS; MOTIVATION; NONHUMAN; NUCLEUS ACCUMBENS; RAT; REWARD; SMOKING CESSATION; STRIA TERMINALIS;

EID: 0036748948     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008877-200209000-00018     Document Type: Article

References (83)

1. Arnone M, Maruani J, Chaperon F, Thiebot MH, Poncelet M, Soubrie P, Le Fur G (1997). Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors. Psychopharmacology (Berl) 132:104-106.
2. Berridge K C, Robinson TE (1998). What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?. Brain Res Rev 28:309-369.
3. Brioni JD, Decker MW, Sullivan JP, Arneric SP (1997). The pharmacology of (-)-nicotine and novel cholinergic channel modulators. Adv Pharmacol 37:153-214.
4. Carboni E, Silvagni A, Rolando MTP, DiChiara G (2000). Stimulation of in vivo dopamine transmission in the bed nucleus of stria terminalis by reinforcing drugs. J Neurosci 20:U6-U10.
5. Chaperon F, Soubrie P, Puech AJ, Thiebot MH (1998). Involvement of central cannabinoid (CB1) receptors in the establishment of place conditioning in rats. Psychopharmacology 135:324-332.
6. Cheer JF, Kendall DA, Marsden CA (2000). Cannabinoid receptors and reward in the rat: a conditioned place preference study. Psychopharmacology (Berl) 151:25-30.
7. Chen JP, Paredes W, Li J, Smith D, Lowinson J, Gardner EL (1990). Delta 9-tetrahydrocannabinol produces naloxone-blockable enhancement of presynaptic basal dopamine efflux in nucleus accumbens of conscious, freely-moving rats as measured by intracerebral microdialysis. Psychopharmacology (Berl) 102:156-162.
8. Cohen C, Sanger DJ, Perrault G (1997). Characterization of the discriminative stimulus produced by the dopamine antagonist tiapride. J Pharmacol Exp Ther 283:566-573.
9. Cohen C, Perrault G, Sanger DJ (1998). Preferential involvement of D3 versus D2 dopamine receptors in the effects of dopamine receptor ligands on oral ethanol self-administration in rats. Psychopharmacology (Berlin) 140:478-485.
10. Cohen C, Perrault G, Sanger DJ (1999a). Effects of D-1 dopamine receptor agonists on oral ethanol self administration in rats: comparison with their efficacy to produce grooming and hyperactivity. Psychopharmacology (Berlin) 142:102-110.
11. Cohen C, Perrault G, Sanger DJ (1999b). Nicotine and D-amphetamine produce common discriminative stimulus effects in rats. NIDA Research Monograph, US Department of Health and Human Services 180:197.
12. Colombo G, Agabio R, Fa M, Guano L, Lobina C, Loche A et al. (1998). Reduction of voluntary ethanol intake in ethanol-preferring sP rats by the cannabinoid antagonist SR-141716. Alcohol Alcohol 33:126-130.
13. Corrigall WA, Coen KM (1989). Nicotine maintains robust self-administration in rats on a limited-access schedule. Psychopharmacology (Berlin) 99:473-478.
14. Corrigall WA, Coen KM (1991). Selective dopamine antagonists reduce nicotine self-administration. Psychopharmacology (Berlin) 104:171-176.
15. Corrigall WA, Coen KM (1994). Dopamine mechanisms play at best a small role in the nicotine discriminative stimulus. Pharmacol Biochem Behav 48:817-820.
16. Corrigall WA, Franklin KB, Coen KM, Clarke PB (1992). The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine. Psychopharmacology (Berlin) 107:285-289.
17. Corrigall WA, Coen KM, Adamson KL (1994). Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area. Brain Res 653:278-284.
18. Cossu G, Ledent C, Fattore L, Imperato A, Bohme GA, Parmentier M, Fratta W (2001). Cannabinoid CB1 receptor knockout mice fail to self-administer morphine but not other drugs of abuse. Behav Brain Res 118:61-65.
19. Curet O, Damoiseau G, Aubin N, Sontag N, Rovei V, Jarreau FX (1996). Befloxatone, a new reversible and selective monoamine oxidase-A inhibitor. I. Biochemical profile. J Pharmacol Exp Ther 277:253-264.
20. deFonseca FR, Roberts AJ, Bilbao A, Koob GF, Navarro M (1999). Cannabinoid receptor antagonist SR141716A decreases operant ethanol self administration in rats exposed to ethanol-vapor chambers. Acta Pharmacol Sin 20:1109-1114.
21. Deminiere JM, Piazza PV, Le Moal M, Simon H (1989). Experimental approach to individual vulnerability to psycho-stimulant addiction. Neurosci Biobehav Rev 13:141-147.
22. Depoortère RY, Li DH, Lane JD, Emmet-Oglesby MW (1993). Parameters of self-administration of cocaine in rats under a progressive-ratioschedule. Pharmacol Biochem Behav 45:539-545.
23. Deroche-Gamonet V, Le Moal M, Piazza PV, Soubrié P. (2001). SR141716, a CB1 receptor antagonist, decreases the sensitivity to the reinforcing effects of electrical brain stimulation in rats. Psychopharmacology 157:254-259.
24. De Vries TJ, Shaham Y, Homberg JR, Crombag H, Schuurman K, Dieben J et al. (2001). A cannabinoid mechanism in relapse to cocaine seeking. Nature 7:1511-1154.
25. Epping-Jordan MP, Markou A, Koob GF (1998). The dopamine D-1 receptor antagonist SCH 23390 injected into the dorsolateral bed nucleus of the stria terminalis decreased cocaine reinforcement in the rat. Brain Res 784:105-115.
26. Erb S, Stewart J (1999). A role for the bed nucleus of the stria terminalis, but not the amygdala, in the effects of corticotropin-releasing factor on stress-induced reinstatement of cocaine seeking. J Neurosci 19:C1-C6.
27. Fattore L, Martellotta MC, Cossu G, Mascia MS, Fratta W (1999). CB1 cannabinoid receptor agonist WIN 55,212-2 decreases intravenous cocaine self-administration in rats. Behav Brain Res 104:141-146.
28. Fattore L, Cossu G, Martellotta M, Fratta W (2001). Intravenous self-administration of the cannabinoid CB1 receptor agonist WIN 55,212-2 in rats. Psychopharmacology 156:410-416.
29. Freedland CS, Sharpe AL, Samson HH, Porrino LJ (2001). Effects of SR141716A on ethanol and sucrose self-administration. Alcohol Clin Exp Res 25:277-282.
30. 9-Tetrahydrocannabinol excites rat VTA dopamine neurons through activation of cannabinoid CB1 but not opioid receptors. Neurosci Lett 226:159-162.
31. French ED, Dillon K, Wu X (1997). Cannabinoids excite dopamine neurons in the ventral tegmentum and substantia nigra. Neuroreport 8:649-652.
32. Fu Y, Matta SG, Gao W, Brower VG, Sharp BM (2000). Systemic nicotine stimulates dopamine release in nucleus accumbens: re-evaluation of the role of N-methyl-D-aspartate receptors in the ventral tegmental area. J Pharmacol Exp Ther 294:458-465.
33. Gallate JE, McGregor IS (1999). The motivation for beer in rats: effects of ritanserin, naloxone and SR 141716. Psychopharmacology (Berlin) 142:302-308.
34. Gaoni Y, Mechoulam R (1964). Isolation, structure and partial synthesis of an active component of hashish. J Am Chem Sec 86:1646-1647.
35. Gardner EL (1999). Cannabinoid interaction with brain reward systems. In: Marihuana and Medicine. Nahas GG, Sutin KM, Harvey D, Agurell S, Pace N, Cancro R, (editors). Totowa: Humana Press, pp. 187-205.
36. Gasior M, Shoaib M, Yasar S, Jaszyna M, Goldberg SR (1999). Acquisition of nicotine discrimination and discriminative stimulus effects of nicotine in rats chronically exposed to caffeine. J Pharmacol Exp Ther 288:1053-1073.
37. George SR, Fan T, Ng GY, Jung SY, O'Dowd BF, Naranjo CA (1995). Low endogenous dopamine function in brain predisposes to high alcohol preference and consumption: reversal by increasing synaptic dopamine. J Pharmacol Exp Ther 273:373-379.
38. Goldberg SR, Spealman RD, Risner ME, Henningfield JE (1983). Control of behavior by intravenous nicotine injections in laboratory animals. Pharmacol Biochem Behav 19:1011-1020.
39. Harris RT, Waters W, McLendon D (1974). Evaluation of reinforcing capability of delta-9-tetrahydrocannabinol in rhesus monkeys. Psychopharmacologia 37:23-29.
40. Henningfield JE, Cohen C, Slade JD (1991). Is nicotine more addictive than cocaine? Br J Addict 86:565-569.
41. Herkenham M, Lynn AB, de Costa BR, Richfield EK (1991). Neuronal localization of cannabinoid receptors in the basal ganglia of the rat. Brain Res 547:267-274.
42. Hungund BL, Basavarajappa BS (2000). Are anandamide and cannabinoid receptors involved in ethanol tolerance? A review of the evidence. Alcohol Alcohol 35:126-133.
43. Ikemoto S, Panksepp J (1999). The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking. Brain Res Rev 31:6-41.
44. Imperato A, Mulas A, Di Chiara G (1986). Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats. Eur J Pharmacol 132:337-338.
45. Ledent C, Valverde O, Cossu C, Petitet F, Aubert LF, Beslot F et al. (1999). Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Science 283:401-404.
46. Lepore M, Vorel SR, Lowinson J, Gardner EL (1995). Conditioned place preference induced by delta 9-tetrahydrocannabinol: comparison with cocaine, morphine, and food reward. Life Sci 56:2073-2080.
47. Mailleux P, Vanderhaeghen JJ (1992). Distribution of neuronal cannabinoid receptor in the adult rat brain: a comparative receptor binding radioautography and in situ hybridization histochemistry. Neuroscience 48:655-668.
48. 9-tetrahydrocannabinol and CP 55,940 to maintain intravenous self-administration under a fixed-interval schedule in rhesus monkeys. Behav Pharmacol 5:219-225.
49. Mansbach RS, Rovetti CC, Freedland CS (1998). The role of monoamine neurotransmitter systems in the nicotine discriminative stimulus. Drug and Alcohol Depend 52:125-134.
50. Markou A, Weiss F, Gold LH, Caine SB, Schulteis G, Koob GF (1993). Animal models of drug craving. Psychopharmacology (Berlin) 112:163-182.
51. Martellotta MC, Cossu G, Fattore L, Gessa GL, Fratta W (1998). Self-administration of the cannabinoid receptor agonist WIN 55,212-2 in drug-naive mice. Neuroscience 85:327-330.
52. Mascia MS, Obinu MC, Ledent C, Parmentier M, Bohme GA, Imperato A, Fratta W (1999). Lack of morphine-induced dopamine release in the nucleus accumbens of cannabinoid CB1 receptor knockout mice. Eur J Pharmacol 383:R1-R2.
53. Matsuda LA, Lolait SJ, Brownstein MJ, Young AC, Bonner TI (1990). Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346:561-564.
54. McGregor IS, Issakidis CN, Prior G (1996). Aversive effects of the synthetic cannabinoid CP 55,940 in rats. Pharmacol Biochem Behav 53:657-664.
55. Morrison CF, Stephenson JA (1969). Nicotine injections as the conditioned stimulus in discrimination learning. Psychopharmacologia 15:351-360.
56. Navarro M, Carrera MR, Fratta W, Valverde O, Cossu G, Fattore L et al. (2001). Functional interaction between opioid and cannabinoid receptors in drug self-administration. J Neurosci 21:5344-5350.
57. Nisell M, Nomikos GG, Svensson TH (1994). Infusion of nicotine in the ventral tegmental area or the nucleus accumbens of the rat differentially affects accumbal dopamine release. Pharmacol Toxicol 75:348-352.
58. O'Neill MF, Dourish CT, Iversen SD (1991). Evidence for an involvement of D1 and D2 dopamine receptors in mediating nicotine-induced hyperactivity in rats. Psychopharmacology 104:343-350.
59. Pagliusi SR, Tessari M, DeVevey S, Chiamulera C, Pich EM (1996). The reinforcing properties of nicotine are associated with a specific patterning of c-fos expression in the rat brain. Eur J Neurosci 8:2247-2256.
60. Parker LA, Gillies T (1995). THC-induced place and taste aversions in Lewis and Sprague-Dawley rats. Behav Neurosci 109:71-78.
61. Paxinos G, Watson C (1986). The Rat Brain in Stereotaxic Coordinates. 2nd ed. Sydney: Academic Press.
62. Pério A, Barnouin MC, Poncelet M, Soubrié P (2001). Activity of SR141716 on post-reinforcement pauses in operant responding for sucrose reward in rats. Behav Pharmacol 12:641-645.
63. Peters H, Nahas GG (1999). A brief history of four millennia (B.C. 2000-A.D. 1974). In: Marihuana and Medicine. Nahas GG, Sutin KM, Harvey D, Agurell S, Pace N, Cancro R, (editors). Totowa: Humana Press; pp. 187-205.
64. Pontieri FE, Tanda G, Orzi F, Di Chiara G (1996). Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs. Nature 382:255-257.
65. Pontieri FE, Conti G, Zocchi A, Fieschi C, Orzi F (1999). Metabolic mapping of the effects of WIN 55212-2 intravenous administration in the rat. Neuropsychopharmacology 21:773-776.
66. Rasmussen T, Swedberg MD (1998). Reinforcing effects of nicotinic compounds: intravenous self-administration in drug-naive mice. Pharmacol Biochem Behav 60:567-573.
67. Reavill C, Stolerman IP (1987). Interaction of nicotine with dopaminergic mechanisms assessed through drug discrimination and rotational behaviour in rats. J Psychopharmacol 1:264-273.
68. Rinaldi-Carmona M, Barth F, Heaulme M, Shire D, Calandra B, Congy C et al. (1994). SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett 350:240-244.
69. Samson HH, Hodge CW (1996). Neurobehavioral regulation of ethanol intake. In: Pharmacological Effects of Ethanol on the Nervous System. Deitrich RA, Erwin VG, (editors). Boca Raton USA: CRC Press, pp. 203-226.
70. 3 receptors. In: Interactive Monoaminergic Disorders, Strategies for Studying Brain Disorders 4. Palomo T, Beninger RJ, Archer T, (editors). Madrid: Editorial Sintesis, pp. 481-498.
71. Sanudo-Pena MC, Tsou K, Delay ER, Hohman AG, Force M, Walker JM (1997). Endogenous cannabinoids as an aversive or counter-rewarding system in the rat. Neurosci Lett 223: 125-128.
72. Schaefer GJ, Michael RP (1986). Task-specific effects of nicotine in rats. Intracranial self-stimulation and locomotor activity. Neuropharmacology 25:125-131.
73. Schechter MD, Cook PG (1975). Dopaminergic mediation of the interoceptive cue produced by D-amphetamine in rats. Psychopharmacologia 42:185-193.
74. Schilstrom B, Nomikos GG, Nisell M, Hertel P, Svensson TH (1998). N-methyl-D-aspartate receptor antagonism in the ventral tegmental area diminishes the systemic nicotine-induced dopamine release in the nucleus accumbens. Neuroscience 82:781-789.
75. Schlicker E, Kathmann M (2001). Modulation of transmitter release via presynaptic cannabinoid receptors. Trends Pharmacol Sci 22:565-572.
76. Stolerman IP, Naylor C, Elmer GI, Goldberg SR (1999). Discrimination and self administration of nicotine by inbred strains of mice. Psychopharmacology (Berlin) 141:297-306.
77. Takada K, Hagen TJ, Cook JM, Goldberg SR, Katz JL (1988). Discriminative stimulus effects of intravenous nicotine in squirrel monkeys. Pharmacol Biochem Behav 30:243-247.
78. Tanda G, Pontieri FE, Di Chiara G (1997). Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mul opioid receptor mechanism. Science 276:2048-2050.
79. Tanda G, Munzar P, Goldberg SR (2000). Self-administration behavior is maintained by the psychoactive ingredient of marijuana in squirrel monkeys. Nature Neurosci 3:1073-1074.
80. Tsou K, Brown S, Sanudo-Pena MC, Mackie K, Walker JM (1998). Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system. Neuroscience 83: 393-411.
81. Valjent E, Maldonado R (2000). A behavioural model to reveal place preference to delta-9-tetrahydrocannabinol in mice. Psychopharmacology (Berlin) 147:436-438.
82. 9-tetrahydrocannabinol and nicotine. Br J Pharmacol 135:564-578.
83. Weiss F, Parsons LH, Schulteis G, Hyytia P, Lorang MT, Bloom FE, Koob GF (1996). Ethanol self-administration restores withdrawal-associated deficiencies in accumbal dopamine and 5-hydroxytryptamine release in dependent rats. J Neurosci 16:3474-3485.