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Volumn 12, Issue 11, 2007, Pages 4168-4178

P53 in breast cancer: Mutation and countermeasures

Author keywords

Breast cancer; MDM2; Mutation; Nutlin; P53; Review; Therapy

Indexed keywords

MAMMALIA;

EID: 34347233807     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/2378     Document Type: Article
Times cited : (21)

References (150)
  • 2
    • 2342478955 scopus 로고    scopus 로고
    • Global genechip profiling to identify genes responsive to p53-induced growth arrest and apoptosis in human lung carcinoma cells
    • M. Robinson, P. Jiang, J. Cui, J. Li, Y. Wang, M. Swaroop, S. Madore, T. S. Lawrence, and Y. Sun: Global genechip profiling to identify genes responsive to p53-induced growth arrest and apoptosis in human lung carcinoma cells. Cancer Biol. Ther. 2, 406-415 (2003)
    • (2003) Cancer Biol. Ther , vol.2 , pp. 406-415
    • Robinson, M.1    Jiang, P.2    Cui, J.3    Li, J.4    Wang, Y.5    Swaroop, M.6    Madore, S.7    Lawrence, T.S.8    Sun, Y.9
  • 5
    • 0033387525 scopus 로고    scopus 로고
    • Structure and function in the p53 family
    • C. H. Arrowsmith: Structure and function in the p53 family. Cell Death. Differ. 6, 1169-1173 (1999) (Pubitemid 30047893)
    • (1999) Cell Death and Differentiation , vol.6 , Issue.12 , pp. 1169-1173
    • Arrowsmith, C.H.1
  • 6
    • 0037377060 scopus 로고    scopus 로고
    • Ubiquitination, phosphorylation and acetylation: The molecular basis for p53 regulation
    • DOI 10.1016/S0955-0674(03)00003-6
    • C. L. Brooks and W. Gu: Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr. Opin. Cell Biol. 15, 164-171 (2003) (Pubitemid 36332191)
    • (2003) Current Opinion in Cell Biology , vol.15 , Issue.2 , pp. 164-171
    • Brooks, C.L.1    Gu, W.2
  • 8
    • 0037377060 scopus 로고    scopus 로고
    • Ubiquitination, phosphorylation and acetylation: The molecular basis for p53 regulation
    • DOI 10.1016/S0955-0674(03)00003-6
    • C. L. Brooks and W. Gu: Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr. Opin. Cell Biol. 15, 164-171 (2003) (Pubitemid 36332191)
    • (2003) Current Opinion in Cell Biology , vol.15 , Issue.2 , pp. 164-171
    • Brooks, C.L.1    Gu, W.2
  • 9
    • 33644990074 scopus 로고    scopus 로고
    • Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking
    • Y. Kawaguchi, A. Ito, E. Appella, and T. P. Yao: Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. J. Biol. Chem. 281, 1394-1400 (2006)
    • (2006) J. Biol. Chem , vol.281 , pp. 1394-1400
    • Kawaguchi, Y.1    Ito, A.2    Appella, E.3    Yao, T.P.4
  • 12
    • 3142570737 scopus 로고    scopus 로고
    • Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity
    • DOI 10.1016/j.cell.2004.06.016, PII S0092867404005859
    • D. P. Xirodimas, M. K. Saville, J. C. Bourdon, R. T. Hay, and D. P. Lane: Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity. Cell 118, 83-97 (2004) (Pubitemid 38902816)
    • (2004) Cell , vol.118 , Issue.1 , pp. 83-97
    • Xirodimas, D.P.1    Saville, M.K.2    Bourdon, J.-C.3    Hay, R.T.4    Lane, D.P.5
  • 13
    • 0031583962 scopus 로고    scopus 로고
    • Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
    • DOI 10.1016/S0014-5793(97)01480-4, PII S0014579397014804
    • R. Honda, H. Tanaka, and H. Yasuda: Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett. 420, 25-27 (1997) (Pubitemid 28037193)
    • (1997) FEBS Letters , vol.420 , Issue.1 , pp. 25-27
    • Honda, R.1    Tanaka, H.2    Yasuda, H.3
  • 14
    • 0027244853 scopus 로고
    • The p53-mdm-2 autoregulatory feedback loop
    • X. Wu, J. H. Bayle, D. Olson, and A. J. Levine: The p53-mdm-2 autoregulatory feedback loop. Genes Dev. 7, 1126-1132 (1993) (Pubitemid 23207405)
    • (1993) Genes and Development , vol.7 , Issue.7 A , pp. 1126-1132
    • Wu, X.1    Bayle, J.H.2    Olson, D.3    Levine, A.J.4
  • 15
    • 0032191393 scopus 로고    scopus 로고
    • Tumor surveillance via the ARF-p53 pathway
    • C. J. Sherr: Tumor surveillance via the ARF-p53 pathway. Genes Dev. 12, 2984-2991 (1998) (Pubitemid 28469300)
    • (1998) Genes and Development , vol.12 , Issue.19 , pp. 2984-2991
    • Sherr, C.J.1
  • 16
    • 0035279162 scopus 로고    scopus 로고
    • Human ARF binds E2F1 and inhibits its transcriptional activity
    • DOI 10.1038/sj.onc.1204220
    • B. Eymin, L. Karayan, P. Seite, C. Brambilla, E. Brambilla, C. J. Larsen, and S. Gazzeri: Human ARF binds E2F1 and inhibits its transcriptional activity. Oncogene 20, 1033-1041 (2001) (Pubitemid 32238852)
    • (2001) Oncogene , vol.20 , Issue.9 , pp. 1033-1041
    • Eymin, B.1    Karayan, L.2    Seite, P.3    Brambilla, C.4    Brambilla, E.5    Larsen, C.-J.6    Gazzeri, S.7
  • 17
    • 0030728468 scopus 로고    scopus 로고
    • Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19(ARF)
    • T. Kamijo, F. Zindy, M. F. Roussel, D. E. Quelle, J. R. Downing, R. A. Ashmun, G. Grosveld, and C. J. Sherr: Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 91, 649-659 (1997) (Pubitemid 27513656)
    • (1997) Cell , vol.91 , Issue.5 , pp. 649-659
    • Kamijo, T.1    Zindy, F.2    Roussel, M.F.3    Quelle, D.E.4    Downing, J.R.5    Ashmun, R.A.6    Grosveld, G.7    Sherr, C.J.8
  • 19
    • 0032148385 scopus 로고    scopus 로고
    • The human p19(ARF) protein encoded by the β transcript of the p16(INK4a) gene is frequently lost in small cell lung cancer
    • S. Gazzeri, V. Della, V. L. Chaussade, C. Brambilla, C. J. Larsen, and E. Brambilla: The human p19ARF protein encoded by the beta transcript of the p16INK4a gene is frequently lost in small cell lung cancer. Cancer Res. 58, 3926-3931 (1998) (Pubitemid 28405650)
    • (1998) Cancer Research , vol.58 , Issue.17 , pp. 3926-3931
    • Gazzeri, S.1    Della Valle, V.2    Chaussade, L.3    Brambilla, C.4    Larsen, C.-J.5    Brambilla, E.6
  • 21
    • 33645769536 scopus 로고    scopus 로고
    • A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network
    • F. Toledo, K. A. Krummel, C. J. Lee, C. W. Liu, L. W. Rodewald, M. Tang, and G. M. Wahl: A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network. Cancer Cell 9, 273-285 (2006)
    • (2006) Cancer Cell , vol.9 , pp. 273-285
    • Toledo, F.1    Krummel, K.A.2    Lee, C.J.3    Liu, C.W.4    Rodewald, L.W.5    Tang, M.6    Wahl, G.M.7
  • 23
    • 33645769536 scopus 로고    scopus 로고
    • A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network
    • F. Toledo, K. A. Krummel, C. J. Lee, C. W. Liu, L. W. Rodewald, M. Tang, and G. M. Wahl: A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network. Cancer Cell 9, 273-285 (2006)
    • (2006) Cancer Cell , vol.9 , pp. 273-285
    • Toledo, F.1    Krummel, K.A.2    Lee, C.J.3    Liu, C.W.4    Rodewald, L.W.5    Tang, M.6    Wahl, G.M.7
  • 24
    • 33747884339 scopus 로고    scopus 로고
    • DNA damage-induced cell death by apoptosis
    • DOI 10.1016/j.molmed.2006.07.007, PII S1471491406001687
    • W. P. Roos and B. Kaina: DNA damage-induced cell death by apoptosis. Trends Mol. Med. 12, 440-450 (2006) (Pubitemid 44291571)
    • (2006) Trends in Molecular Medicine , vol.12 , Issue.9 , pp. 440-450
    • Roos, W.P.1    Kaina, B.2
  • 28
    • 11344252796 scopus 로고    scopus 로고
    • Reassessment of the TP53 mutation database in human disease by data mining with a library of TP53 missense mutations
    • DOI 10.1002/humu.20114
    • T. Soussi, S. Kato, P. P. Levy, and C. Ishioka: Reassessment of the TP53 mutation database in human disease by data mining with a library of TP53 missense mutations. Hum. Mutat. 25, 6-17 (2005) (Pubitemid 40075908)
    • (2005) Human Mutation , vol.25 , Issue.1 , pp. 6-17
    • Soussi, T.1    Kato, S.2    Levy, P.P.3    Ishioka, C.4
  • 31
    • 33749039966 scopus 로고    scopus 로고
    • The CHEK2 gene and inherited breast cancer susceptibility
    • DOI 10.1038/sj.onc.1209877, PII 1209877
    • H. Nevanlinna and J. Bartek: The CHEK2 gene and inherited breast cancer susceptibility. Oncogene 25, 5912-5919 (2006) (Pubitemid 44453447)
    • (2006) Oncogene , vol.25 , Issue.43 , pp. 5912-5919
    • Nevanlinna, H.1    Bartek, J.2
  • 32
    • 33845345621 scopus 로고    scopus 로고
    • LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation
    • DOI 10.1158/0008-5472.CAN-06-0999
    • P. Y. Zeng and S. L. Berger: LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation. Cancer Res. 66, 10701-10708 (2006) (Pubitemid 44876965)
    • (2006) Cancer Research , vol.66 , Issue.22 , pp. 10701-10708
    • Zeng, P.-Y.1    Berger, S.L.2
  • 35
    • 0036052930 scopus 로고    scopus 로고
    • Mutations in the p53 tumor suppressor gene and early onset breast cancer
    • H. Lai, L. Lin, M. Nadji, S. Lai, E. Trapido, and L. Meng: Mutations in the p53 tumor suppressor gene and early onset breast cancer. Cancer Biol. Ther. 1, 31-36 (2002)
    • (2002) Cancer Biol. Ther , vol.1 , pp. 31-36
    • Lai, H.1    Lin, L.2    Nadji, M.3    Lai, S.4    Trapido, E.5    Meng, L.6
  • 36
    • 1842862755 scopus 로고    scopus 로고
    • TP53 mutation spectra and load: A tool for generating hypotheses on the etiology of cancer
    • M. Olivier, S. P. Hussain, F. C. Caron de, P. Hainaut, and C. C. Harris: TP53 mutation spectra and load: a tool for generating hypotheses on the etiology of cancer. IARC Sci. Publ., 247-270 (2004)
    • (2004) IARC Sci. Publ. , pp. 247-270
    • Olivier, M.1    Hussain, S.P.2    De Caron, F.C.3    Hainaut, P.4    Harris, C.C.5
  • 37
    • 1842536849 scopus 로고    scopus 로고
    • Mutant p53 exerts a dominant negative effect by preventing wild-type p53 from binding to the promoter of its target genes
    • DOI 10.1038/sj.onc.1207396
    • A. Willis, E. J. Jung, T. Wakefield, and X. Chen: Mutant p53 exerts a dominant negative effect by preventing wild-type p53 from binding to the promoter of its target genes. Oncogene 23, 2330-2338 (2004) (Pubitemid 38496788)
    • (2004) Oncogene , vol.23 , Issue.13 , pp. 2330-2338
    • Willis, A.1    Jung, E.J.2    Wakefield, T.3    Chen, X.4
  • 40
    • 0030021748 scopus 로고    scopus 로고
    • Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant
    • S. Rowan, R. L. Ludwig, Y. Haupt, S. Bates, X. Lu, M. Oren, and K. H. Vousden: Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant. EMBO J. 15, 827-838 (1996) (Pubitemid 26064289)
    • (1996) EMBO Journal , vol.15 , Issue.4 , pp. 827-838
    • Rowan, S.1    Ludwig, R.L.2    Haupt, Y.3    Bates, S.4    Lu, X.5    Oren, M.6    Vousden, K.H.7
  • 41
    • 0346455759 scopus 로고    scopus 로고
    • Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice
    • DOI 10.1038/ng1282
    • G. Liu, J. M. Parant, G. Lang, P. Chau, A. Chavez-Reyes, A. K. El-Naggar, A. Multani, S. Chang, and G. Lozano: Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice. Nat. Genet. 36, 63-68 (2004) (Pubitemid 38056209)
    • (2004) Nature Genetics , vol.36 , Issue.1 , pp. 63-68
    • Liu, G.1    Parant, J.M.2    Lang, G.3    Chau, P.4    Chavez-Reyes, A.5    El-Naggar, A.K.6    Multani, A.7    Chang, S.8    Lozano, G.9
  • 42
    • 0037221767 scopus 로고    scopus 로고
    • TP53 and breast cancer
    • A. L. Borresen-Dale: TP53 and breast cancer. Hum. Mutat. 21, 292-300 (2003)
    • (2003) Hum. Mutat , vol.21 , pp. 292-300
    • Borresen-Dale, A.L.1
  • 47
    • 33645216608 scopus 로고    scopus 로고
    • The serine-threonine protein phosphatase PPM1D is frequently activated through amplification in aggressive primary breast tumours
    • J. Rauta, E. L. Alarmo, P. Kauraniemi, R. Karhu, T. Kuukasjarvi, and A. Kallioniemi: The serine-threonine protein phosphatase PPM1D is frequently activated through amplification in aggressive primary breast tumours. Breast Cancer Res. Treat. 95, 257-263 (2006)
    • (2006) Breast Cancer Res. Treat , vol.95 , pp. 257-263
    • Rauta, J.1    Alarmo, E.L.2    Kauraniemi, P.3    Karhu, R.4    Kuukasjarvi, T.5    Kallioniemi, A.6
  • 48
    • 0034744224 scopus 로고    scopus 로고
    • ARF without relocation of MDM2 to the nucleolus
    • DOI 10.1038/35074506
    • S. Llanos, P. A. Clark, J. Rowe, and G. Peters: Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus. Nat. Cell Biol. 3, 445-452 (2001) (Pubitemid 32422079)
    • (2001) Nature Cell Biology , vol.3 , Issue.5 , pp. 445-452
    • Llanos, S.1    Clark, P.A.2    Rowe, J.3    Peters, G.4
  • 49
    • 0032169516 scopus 로고    scopus 로고
    • The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2
    • DOI 10.1093/emboj/17.17.5001
    • F. J. Stott, S. Bates, M. C. James, B. B. McConnell, M. Starborg, S. Brookes, I. Palmero, K. Ryan, E. Hara, K. H. Vousden, and G. Peters: The alternative product from the human CDKN2A locus, p14 (ARF), participates in a regulatory feedback loop with p53 and MDM2. EMBO J. 17, 5001-5014 (1998) (Pubitemid 28408466)
    • (1998) EMBO Journal , vol.17 , Issue.17 , pp. 5001-5014
    • Stott, F.J.1    Bates, S.2    James, M.C.3    McConnell, B.B.4    Starborg, M.5    Brookes, S.6    Palmero, I.7    Ryan, K.8    Hara, E.9    Vousden, K.H.10    Peters, G.11
  • 52
    • 0030728468 scopus 로고    scopus 로고
    • Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19(ARF)
    • T. Kamijo, F. Zindy, M. F. Roussel, D. E. Quelle, J. R. Downing, R. A. Ashmun, G. Grosveld, and C. J. Sherr: Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 91, 649-659 (1997) (Pubitemid 27513656)
    • (1997) Cell , vol.91 , Issue.5 , pp. 649-659
    • Kamijo, T.1    Zindy, F.2    Roussel, M.F.3    Quelle, D.E.4    Downing, J.R.5    Ashmun, R.A.6    Grosveld, G.7    Sherr, C.J.8
  • 53
    • 0030778842 scopus 로고    scopus 로고
    • Splicing into senescence: The curious case of p16 and p19(ARF)
    • D. A. Haber: Splicing into senescence: the curious case of p16 and p19ARF. Cell 91, 555-558 (1997) (Pubitemid 27513645)
    • (1997) Cell , vol.91 , Issue.5 , pp. 555-558
    • Haber, D.A.1
  • 54
    • 0029028881 scopus 로고
    • Cytotoxic effects of adenovirusmediated wild-type p53 protein expression in normal and tumor mammary epithelial cells
    • D. Katayose, J. Gudas, H. Nguyen, S. Srivastava, K. H. Cowan, and P. Seth: Cytotoxic effects of adenovirusmediated wild-type p53 protein expression in normal and tumor mammary epithelial cells. Clin. Cancer Res. 1, 889-897 (1995)
    • (1995) Clin. Cancer Res , vol.1 , pp. 889-897
    • Katayose, D.1    Gudas, J.2    Nguyen, H.3    Srivastava, S.4    Cowan, K.H.5    Seth, P.6
  • 56
    • 33846937033 scopus 로고    scopus 로고
    • Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
    • DOI 10.1038/nature05529, PII NATURE05529
    • W. Xue, L. Zender, C. Miething, R. A. Dickins, E. Hernando, V. Krizhanovsky, C. Cordon-Cardo, and S. W. Lowe: Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 445, 656-660 (2007) (Pubitemid 46232886)
    • (2007) Nature , vol.445 , Issue.7128 , pp. 656-660
    • Xue, W.1    Zender, L.2    Miething, C.3    Dickins, R.A.4    Hernando, E.5    Krizhanovsky, V.6    Cordon-Cardo, C.7    Lowe, S.W.8
  • 57
    • 33845611951 scopus 로고    scopus 로고
    • Modeling the Therapeutic Efficacy of p53 Restoration in Tumors
    • DOI 10.1016/j.cell.2006.12.007, PII S0092867406015972
    • C. P. Martins, L. Brown-Swigart, and G. I. Evan: Modeling the therapeutic efficacy of p53 restoration in tumors. Cell 127, 1323-1334 (2006) (Pubitemid 44960417)
    • (2006) Cell , vol.127 , Issue.7 , pp. 1323-1334
    • Martins, C.P.1    Brown-Swigart, L.2    Evan, G.I.3
  • 58
    • 0031583962 scopus 로고    scopus 로고
    • Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
    • DOI 10.1016/S0014-5793(97)01480-4, PII S0014579397014804
    • R. Honda, H. Tanaka, and H. Yasuda: Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett. 420, 25-27 (1997) (Pubitemid 28037193)
    • (1997) FEBS Letters , vol.420 , Issue.1 , pp. 25-27
    • Honda, R.1    Tanaka, H.2    Yasuda, H.3
  • 59
    • 0034624678 scopus 로고    scopus 로고
    • Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase
    • R. Honda and H. Yasuda: Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase. Oncogene 19, 1473-1476 (2000) (Pubitemid 30171179)
    • (2000) Oncogene , vol.19 , Issue.11 , pp. 1473-1476
    • Honda, R.1    Yasuda, H.2
  • 60
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • J. Momand, G. P. Zambetti, D. C. Olson, D. George, and A. J. Levine: The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69, 1237-1245 (1992)
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 61
    • 0027673764 scopus 로고
    • The p53-mdm2 autoregulatory feedback loop: A paradigm for the regulation of growth control by p53?
    • S. M. Picksley and D. P. Lane: The p53-mdm2 autoregulatory feedback loop: a paradigm for the regulation of growth control by p53? Bioessays 15, 689-690 (1993)
    • (1993) Bioessays , vol.15 , pp. 689-690
    • Picksley, S.M.1    Lane, D.P.2
  • 62
    • 0027325132 scopus 로고
    • Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
    • DOI 10.1038/362857a0
    • J. D. Oliner, J. A. Pietenpol, S. Thiagalingam, J. Gyuris, K. W. Kinzler, and B. Vogelstein: Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature 362, 857-860 (1993) (Pubitemid 23132165)
    • (1993) Nature , vol.362 , Issue.6423 , pp. 857-860
    • Oliner, J.D.1    Pietenpol, J.A.2    Thiagalingam, S.3    Gyuris, J.4    Kinzler, K.W.5    Vogelstein, B.6
  • 63
    • 0027222956 scopus 로고
    • Mapping of the p53 and mdm-2 interaction domains
    • J. Chen, V. Marechal, and A. J. Levine: Mapping of the p53 and mdm-2 interaction domains. Mol. Cell Biol. 13, 4107-4114 (1993) (Pubitemid 23187639)
    • (1993) Molecular and Cellular Biology , vol.13 , Issue.7 , pp. 4107-4114
    • Chen, J.1    Marechal, V.2    Levine, A.J.3
  • 64
    • 0028303752 scopus 로고
    • Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein
    • J. Lin, J. Chen, B. Elenbaas, and A. J. Levine: Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein. Genes Dev. 8, 1235-1246 (1994) (Pubitemid 24163450)
    • (1994) Genes and Development , vol.8 , Issue.10 , pp. 1235-1246
    • Lin, J.1    Chen, J.2    Elenbaas, B.3    Levine, A.J.4
  • 65
    • 0027964904 scopus 로고
    • Immunochemical analysis of the interaction of p53 with MDM2; - Fine mapping of the MDM2 binding site on p53 using synthetic peptides
    • S. M. Picksley, B. Vojtesek, A. Sparks, and D. P. Lane: Immunochemical analysis of the interaction of p53 with MDM2;-fine mapping of the MDM2 binding site on p53 using synthetic peptides. Oncogene 9, 2523-2529 (1994) (Pubitemid 24254027)
    • (1994) Oncogene , vol.9 , Issue.9 , pp. 2523-2529
    • Picksley, S.M.1    Vojtesek, B.2    Sparks, A.3    Lane, D.P.4
  • 66
    • 0037048646 scopus 로고    scopus 로고
    • Study of the cytotoxic effect of a peptidic inhibitor of the p53-hdm2 interaction in tumor cells
    • P. Chene, J. Fuchs, I. Carena, P. Furet, and C. Garcia-Echeverria: Study of the cytotoxic effect of a peptidic inhibitor of the p53-hdm2 interaction in tumor cells. FEBS Lett. 529, 293-297 (2002)
    • (2002) FEBS Lett , vol.529 , pp. 293-297
    • Chene, P.1    Fuchs, J.2    Carena, I.3    Furet, P.4    Garcia-Echeverria, C.5
  • 67
    • 0036822698 scopus 로고    scopus 로고
    • Transducible peptide therapy for uveal melanoma and retinoblastoma
    • J. W. Harbour, L. Worley, D. Ma, and M. Cohen: Transducible peptide therapy for uveal melanoma and retinoblastoma. Arch. Ophthalmol. 120, 1341-1346 (2002) (Pubitemid 36105439)
    • (2002) Archives of Ophthalmology , vol.120 , Issue.10 , pp. 1341-1346
    • Harbour, J.W.1    Worley, L.2    Ma, D.3    Cohen, M.4
  • 68
    • 4344610526 scopus 로고    scopus 로고
    • Small-molecule antagonists of p53-MDM2 binding: Research tools and potential therapeutics
    • L. T. Vassilev: Small-molecule antagonists of p53-MDM2 binding: research tools and potential therapeutics. Cell Cycle 3, 419-421 (2004) (Pubitemid 40278226)
    • (2004) Cell Cycle , vol.3 , Issue.4 , pp. 419-421
    • Vassilev, L.T.1
  • 69
    • 33746646758 scopus 로고    scopus 로고
    • Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia
    • DOI 10.1182/blood-2005-12-5148
    • K. Kojima, M. Konopleva, T. McQueen, S. O'Brien, W. Plunkett, and M. Andreeff: Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia. Blood 108, 993-1000 (2006) (Pubitemid 44154636)
    • (2006) Blood , vol.108 , Issue.3 , pp. 993-1000
    • Kojima, K.1    Konopleva, M.2    McQueen, T.3    O'Brien, S.4    Plunkett, W.5    Andreeff, M.6
  • 70
    • 33748586754 scopus 로고    scopus 로고
    • Small molecule inhibition of HDM2 leads to p53-mediated cell death in retinoblastoma cells
    • DOI 10.1001/archopht.124.9.1269
    • J. R. Elison, D. Cobrinik, N. Claros, D. H. Abramson, and T. C. Lee: Small molecule inhibition of HDM2 leads to p53-mediated cell death in retinoblastoma cells. Arch. Ophthalmol. 124, 1269-1275 (2006) (Pubitemid 44379861)
    • (2006) Archives of Ophthalmology , vol.124 , Issue.9 , pp. 1269-1275
    • Elison, J.R.1    Cobrinik, D.2    Claros, N.3    Abramson, D.H.4    Lee, T.C.5
  • 72
    • 33846703114 scopus 로고    scopus 로고
    • Nutlin3 blocks vascular endothelial growth factor induction by preventing the interaction between hypoxia inducible factor 1α and Hdm2
    • DOI 10.1158/0008-5472.CAN-06-2710
    • G. A. LaRusch, M. W. Jackson, J. D. Dunbar, R. S. Warren, D. B. Donner, and L. D. Mayo: Nutlin3 blocks vascular endothelial growth factor induction by preventing the interaction between hypoxia inducible factor 1alpha and Hdm2. Cancer Res. 67, 450-454 (2007) (Pubitemid 46192180)
    • (2007) Cancer Research , vol.67 , Issue.2 , pp. 450-454
    • LaRusch, G.A.1    Jackson, M.W.2    Dunbar, J.D.3    Warren, R.S.4    Donner, D.B.5    Mayo, L.D.6
  • 73
    • 0037044103 scopus 로고    scopus 로고
    • The initial evaluation of non-peptidic small-molecule HDM2 inhibitors based on p53-HDM2 complex structure
    • DOI 10.1016/S0304-3835(02)00084-8, PII S0304383502000848
    • J. Zhao, M. Wang, J. Chen, A. Luo, X. Wang, M. Wu, D. Yin, and Z. Liu: The initial evaluation of non-peptidic small-molecule HDM2 inhibitors based on p53-HDM2 complex structure. Cancer Lett. 183, 69-77 (2002) (Pubitemid 34607353)
    • (2002) Cancer Letters , vol.183 , Issue.1 , pp. 69-77
    • Zhao, J.1    Wang, M.2    Chen, J.3    Luo, A.4    Wang, X.5    Wu, M.6    Yin, D.7    Liu, Z.8
  • 75
    • 0037784028 scopus 로고    scopus 로고
    • Design, synthesis, and evaluation of novel boronic-chalcone derivatives as antitumor agents
    • DOI 10.1021/jm030213+
    • S. K. Kumar, E. Hager, C. Pettit, H. Gurulingappa, N. E. Davidson, and S. R. Khan: Design, synthesis, and evaluation of novel boronic-chalcone derivatives as antitumor agents. J. Med. Chem. 46, 2813-2815 (2003) (Pubitemid 36775907)
    • (2003) Journal of Medicinal Chemistry , vol.46 , Issue.14 , pp. 2813-2815
    • Kumar, S.K.1    Hager, E.2    Pettit, C.3    Gurulingappa, H.4    Davidson, N.E.5    Khan, S.R.6
  • 76
    • 0034710708 scopus 로고    scopus 로고
    • Discovery of potent antagonists of the interaction between human double minute 2 and tumor suppressor p53
    • C. Garcia-Echeverria, P. Chene, M. J. Blommers, and P. Furet: Discovery of potent antagonists of the interaction between human double minute 2 and tumor suppressor p53. J. Med. Chem. 43, 3205-3208 (2000)
    • (2000) J. Med. Chem , vol.43 , pp. 3205-3208
    • Garcia-Echeverria, C.1    Chene, P.2    Blommers, M.J.3    Furet, P.4
  • 79
    • 1642430704 scopus 로고    scopus 로고
    • Antisense oligonucleotide-based therapeutics for cancer
    • DOI 10.1038/sj.onc.1207231, Apoptosis - Part 2
    • N. M. Dean and C. F. Bennett: Antisense oligonucleotide-based therapeutics for cancer. Oncogene 22, 9087-9096 (2003) (Pubitemid 38121709)
    • (2003) Oncogene , vol.22 , Issue.56 REV. ISS. 8 , pp. 9087-9096
    • Dean, N.M.1    Frank Bennett, C.2
  • 80
    • 14644410433 scopus 로고    scopus 로고
    • Novel antisense anti-MDM2 mixed-backbone oligonucleotides: Proof of principle, in vitro and in vivo activities, and mechanisms
    • DOI 10.2174/1568009053332663
    • R. Zhang, H. Wang, and S. Agrawal: Novel antisense anti-MDM2 mixed-backbone oligonucleotides: proof of principle, in vitro and in vivo activities, and mechanisms. Curr. Cancer Drug Targets. 5, 43-49 (2005) (Pubitemid 40321799)
    • (2005) Current Cancer Drug Targets , vol.5 , Issue.1 , pp. 43-49
    • Zhang, R.1    Wang, H.2    Agrawal, S.3
  • 82
    • 0032975130 scopus 로고    scopus 로고
    • Ubiquitous induction of p53 in tumor cells by antisense inhibition of MDM2 expression
    • L. Chen, W. Lu, S. Agrawal, W. Zhou, R. Zhang, and J. Chen: Ubiquitous induction of p53 in tumor cells by antisense inhibition of MDM2 expression. Mol. Med. 5, 21-34 (1999) (Pubitemid 29282094)
    • (1999) Molecular Medicine , vol.5 , Issue.1 , pp. 21-34
    • Chen, L.1    Lu, W.2    Agrawal, S.3    Zhou, W.4    Zhang, R.5    Chen, J.6
  • 83
    • 0037942897 scopus 로고    scopus 로고
    • Antisense oligonucleotide inhibitors of MDM2 oncogene expression
    • R. Zhang and H. Wang: Antisense oligonucleotide inhibitors of MDM2 oncogene expression. Methods Mol. Med. 85, 205-222 (2003)
    • (2003) Methods Mol. Med , vol.85 , pp. 205-222
    • Zhang, R.1    Wang, H.2
  • 84
    • 0036548741 scopus 로고    scopus 로고
    • Antisense anti-MDM2 mixed-backbone oligonucleotides enhance therapeutic efficacy of topoisomerase I inhibitor irinotecan in nude mice bearing human cancer xenografts: In vivo activity and mechanisms
    • H. Wang, S. Wang, L. Nan, D. Yu, S. Agrawal, and R. Zhang: Antisense anti-MDM2 mixed-backbone oligonucleotides enhance therapeutic efficacy of topoisomerase I inhibitor irinotecan in nude mice bearing human cancer xenografts: In vivo activity and mechanisms. Int. J. Oncol. 20, 745-752 (2002)
    • (2002) Int. J. Oncol , vol.20 , pp. 745-752
    • Wang, H.1    Wang, S.2    Nan, L.3    Yu, D.4    Agrawal, S.5    Zhang, R.6
  • 86
    • 0033600759 scopus 로고    scopus 로고
    • Cytoplasmically "sequestered" wild type p53 protein is resistant to Mdm2-mediated degradation
    • A. Zaika, N. Marchenko, and U. M. Moll: Cytoplasmically "sequestered" wild type p53 protein is resistant to Mdm2-mediated degradation. J. Biol. Chem. 274, 27474-27480 (1999)
    • (1999) J. Biol. Chem , vol.274 , pp. 27474-27480
    • Zaika, A.1    Marchenko, N.2    Moll, U.M.3
  • 87
    • 0344925540 scopus 로고    scopus 로고
    • Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription
    • DOI 10.1016/S1535-6108(03)00272-1
    • J. E. Chipuk, U. Maurer, D. R. Green, and M. Schuler: Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription. Cancer Cell 4, 371-381 (2003) (Pubitemid 37491098)
    • (2003) Cancer Cell , vol.4 , Issue.5 , pp. 371-381
    • Chipuk, J.E.1    Maurer, U.2    Green, D.R.3    Schuler, M.4
  • 88
    • 21344434834 scopus 로고    scopus 로고
    • 2-kinase pathway
    • DOI 10.1158/1535-7163.MCT-04-0206
    • Y. Li, Y. Mao, P. W. Brandt-Rauf, A. C. Williams, and R. L. Fine: Selective induction of apoptosis in mutant p53 premalignant and malignant cancer cells by PRIMA-1 through the c-Jun-NH2-kinase pathway. Mol. Cancer Ther. 4, 901-909 (2005) (Pubitemid 40909072)
    • (2005) Molecular Cancer Therapeutics , vol.4 , Issue.6 , pp. 901-909
    • Li, Y.1    Mao, Y.2    Brandt-Rauf, P.W.3    Williams, A.C.4    Fine, R.L.5
  • 89
    • 33748587306 scopus 로고    scopus 로고
    • Expression proteomics to p53 mutation reactivation with PRIMA-1 in breast cancer cells
    • DOI 10.1016/j.bbrc.2006.08.152, PII S0006291X0601970X
    • K. Lee, T. Wang, A. J. Paszczynski, and S. S. Daoud: Expression proteomics to p53 mutation reactivation with PRIMA-1 in breast cancer cells. Biochem. Biophys. Res. Commun. 349, 1117-1124 (2006) (Pubitemid 44380211)
    • (2006) Biochemical and Biophysical Research Communications , vol.349 , Issue.3 , pp. 1117-1124
    • Lee, K.1    Wang, T.2    Paszczynski, A.J.3    Daoud, S.S.4
  • 92
    • 0033601370 scopus 로고    scopus 로고
    • Pharmacological rescue of mutant p53 conformation and function
    • B. A. Foster, H. A. Coffey, M. J. Morin, and F. Rastinejad: Pharmacological rescue of mutant p53 conformation and function. Science 286, 2507-2510 (1999)
    • (1999) Science , vol.286 , pp. 2507-2510
    • Foster, B.A.1    Coffey, H.A.2    Morin, M.J.3    Rastinejad, F.4
  • 93
    • 27544493820 scopus 로고    scopus 로고
    • Mutant p53 melanoma cell lines respond differently to CP-31398-induced apoptosis
    • DOI 10.1111/j.1365-2133.2005.06810.x
    • C. K. Ho and G. Li: Mutant p53 melanoma cell lines respond differently to CP-31398-induced apoptosis. Br. J. Dermatol. 153, 900-910 (2005) (Pubitemid 41540753)
    • (2005) British Journal of Dermatology , vol.153 , Issue.5 , pp. 900-910
    • Ho, C.K.1    Li, G.2
  • 94
    • 18744362141 scopus 로고    scopus 로고
    • The p53-stabilizing compound CP-31398 enhances ultraviolet-B-induced apoptosis in a human melanoma cell line MMRU [3]
    • DOI 10.1046/j.1523-1747.2002.19517.x
    • Y. Luu and G. Li: The p53-stabilizing compound CP-31398 enhances ultraviolet-B-induced apoptosis in a human melanoma cell line MMRU. J. Invest Dermatol. 119, 1207-1209 (2002) (Pubitemid 35430502)
    • (2002) Journal of Investigative Dermatology , vol.119 , Issue.5 , pp. 1207-1209
    • Luu, Y.1    Li, G.2
  • 95
    • 85047687410 scopus 로고    scopus 로고
    • The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein
    • R. Takimoto, W. Wang, D. T. Dicker, F. Rastinejad, J. Lyssikatos, and W. S. El-Deiry: The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein. Cancer Biol. Ther. 1, 47-55 (2002)
    • (2002) Cancer Biol. Ther , vol.1 , pp. 47-55
    • Takimoto, R.1    Wang, W.2    Dicker, D.T.3    Rastinejad, F.4    Lyssikatos, J.5    El-Deiry, W.S.6
  • 96
    • 0037370357 scopus 로고    scopus 로고
    • Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding
    • DOI 10.1128/MCB.23.6.2171-2181.2003
    • W. Wang, R. Takimoto, F. Rastinejad, and W. S. El-Deiry: Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding. Mol. Cell Biol. 23, 2171-2181 (2003) (Pubitemid 36278825)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.6 , pp. 2171-2181
    • Wang, W.1    Takimoto, R.2    Rastinejad, F.3    El-Deiry, W.S.4
  • 97
    • 27544493820 scopus 로고    scopus 로고
    • Mutant p53 melanoma cell lines respond differently to CP-31398-induced apoptosis
    • DOI 10.1111/j.1365-2133.2005.06810.x
    • C. K. Ho and G. Li: Mutant p53 melanoma cell lines respond differently to CP-31398-induced apoptosis. Br. J. Dermatol. 153, 900-910 (2005) (Pubitemid 41540753)
    • (2005) British Journal of Dermatology , vol.153 , Issue.5 , pp. 900-910
    • Ho, C.K.1    Li, G.2
  • 98
    • 18744362141 scopus 로고    scopus 로고
    • The p53-stabilizing compound CP-31398 enhances ultraviolet-B-induced apoptosis in a human melanoma cell line MMRU [3]
    • DOI 10.1046/j.1523-1747.2002.19517.x
    • Y. Luu and G. Li: The p53-stabilizing compound CP-31398 enhances ultraviolet-B-induced apoptosis in a human melanoma cell line MMRU. J. Invest Dermatol. 119, 1207-1209 (2002) (Pubitemid 35430502)
    • (2002) Journal of Investigative Dermatology , vol.119 , Issue.5 , pp. 1207-1209
    • Luu, Y.1    Li, G.2
  • 99
    • 85047687410 scopus 로고    scopus 로고
    • The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein
    • R. Takimoto, W. Wang, D. T. Dicker, F. Rastinejad, J. Lyssikatos, and W. S. El-Deiry: The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein. Cancer Biol. Ther. 1, 47-55 (2002)
    • (2002) Cancer Biol. Ther , vol.1 , pp. 47-55
    • Takimoto, R.1    Wang, W.2    Dicker, D.T.3    Rastinejad, F.4    Lyssikatos, J.5    El-Deiry, W.S.6
  • 100
    • 0033601370 scopus 로고    scopus 로고
    • Pharmacological rescue of mutant p53 conformation and function
    • B. A. Foster, H. A. Coffey, M. J. Morin, and F. Rastinejad: Pharmacological rescue of mutant p53 conformation and function. Science 286, 2507-2510 (1999)
    • (1999) Science , vol.286 , pp. 2507-2510
    • Foster, B.A.1    Coffey, H.A.2    Morin, M.J.3    Rastinejad, F.4
  • 104
    • 33845611951 scopus 로고    scopus 로고
    • Modeling the Therapeutic Efficacy of p53 Restoration in Tumors
    • DOI 10.1016/j.cell.2006.12.007, PII S0092867406015972
    • C. P. Martins, L. Brown-Swigart, and G. I. Evan: Modeling the therapeutic efficacy of p53 restoration in tumors. Cell 127, 1323-1334 (2006) (Pubitemid 44960417)
    • (2006) Cell , vol.127 , Issue.7 , pp. 1323-1334
    • Martins, C.P.1    Brown-Swigart, L.2    Evan, G.I.3
  • 106
    • 33846937033 scopus 로고    scopus 로고
    • Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
    • DOI 10.1038/nature05529, PII NATURE05529
    • W. Xue, L. Zender, C. Miething, R. A. Dickins, E. Hernando, V. Krizhanovsky, C. Cordon-Cardo, and S. W. Lowe: Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 445, 656-660 (2007) (Pubitemid 46232886)
    • (2007) Nature , vol.445 , Issue.7128 , pp. 656-660
    • Xue, W.1    Zender, L.2    Miething, C.3    Dickins, R.A.4    Hernando, E.5    Krizhanovsky, V.6    Cordon-Cardo, C.7    Lowe, S.W.8
  • 107
    • 24144441215 scopus 로고    scopus 로고
    • Gene therapy for severe combined immunodeficiencies
    • DOI 10.1517/14712598.5.9.1175
    • H. B. Gaspar and A. J. Thrasher: Gene therapy for severe combined immunodeficiencies. Expert. Opin. Biol. Ther. 5, 1175-1182 (2005) (Pubitemid 41243353)
    • (2005) Expert Opinion on Biological Therapy , vol.5 , Issue.9 , pp. 1175-1182
    • Gaspar, H.B.1    Thrasher, A.J.2
  • 109
    • 0027728735 scopus 로고
    • Stable expression of the wild-type p53 gene in human lung cancer cells after retrovirus-mediated gene transfer
    • D. W. Cai, T. Mukhopadhyay, Y. Liu, T. Fujiwara, and J. A. Roth: Stable expression of the wild-type p53 gene in human lung cancer cells after retrovirus-mediated gene transfer. Hum. Gene Ther. 4, 617-624 (1993) (Pubitemid 24305758)
    • (1993) Human Gene Therapy , vol.4 , Issue.5 , pp. 617-624
    • Cai, D.W.1    Mukhopadhyay, T.2    Liu, Y.3    Fujiwara, T.4    Roth, J.A.5
  • 110
    • 2442672704 scopus 로고    scopus 로고
    • The acetyltransferase p300/CBP-associated factor is a p53 target gene in breast tumor cells
    • G. S. Watts, M. M. Oshiro, D. J. Junk, R. J. Wozniak, S. Watterson, F. E. Domann, and B. W. Futscher: The acetyltransferase p300/CBP-associated factor is a p53 target gene in breast tumor cells. Neoplasia. 6, 187-194 (2004) (Pubitemid 38657074)
    • (2004) Neoplasia , vol.6 , Issue.3 , pp. 187-194
    • Watts, G.S.1    Oshiro, M.M.2    Junk, D.J.3    Wozniak, R.J.4    Watterson, S.J.5    Domann, F.E.6    Futscher, B.W.7
  • 111
    • 33747888987 scopus 로고    scopus 로고
    • Efficient gene transfer into hematopoietic cells by a retargeting adenoviral vector system with a chimeric fiber of adenovirus serotype 5 and 11p
    • Z. Z. Lu, F. Ni, Z. B. Hu, L. Wang, H. Wang, Q. W. Zhang, W. R. Huang, C. T. Wu, and L. S. Wang: Efficient gene transfer into hematopoietic cells by a retargeting adenoviral vector system with a chimeric fiber of adenovirus serotype 5 and 11p. Exp. Hematol. 34, 1171-1182 (2006)
    • (2006) Exp. Hematol , vol.34 , pp. 1171-1182
    • Lu, Z.Z.1    Ni, F.2    Hu, Z.B.3    Wang, L.4    Wang, H.5    Zhang, Q.W.6    Huang, W.R.7    Wu, C.T.8    Wang, L.S.9
  • 112
    • 33646196844 scopus 로고    scopus 로고
    • Current strategies and future directions for eluding adenoviral vector immunity
    • D. S. Bangari and S. K. Mittal: Current strategies and future directions for eluding adenoviral vector immunity. Curr. Gene Ther. 6, 215-226 (2006)
    • (2006) Curr. Gene Ther , vol.6 , pp. 215-226
    • Bangari, D.S.1    Mittal, S.K.2
  • 113
    • 33646806832 scopus 로고    scopus 로고
    • Current developments in adenovirus-based cancer gene therapy
    • D. T. Rein, M. Breidenbach, and D. T. Curiel: Current developments in adenovirus-based cancer gene therapy. Future. Oncol. 2, 137-143 (2006)
    • (2006) Future. Oncol , vol.2 , pp. 137-143
    • Rein, D.T.1    Breidenbach, M.2    Curiel, D.T.3
  • 114
    • 29444445832 scopus 로고    scopus 로고
    • Adenovirus-based cancer gene therapy
    • DOI 10.2174/156652305774964677
    • J. M. Kaplan: Adenovirus-based cancer gene therapy. Curr. Gene Ther. 5, 595-605 (2005) (Pubitemid 43009504)
    • (2005) Current Gene Therapy , vol.5 , Issue.6 , pp. 595-605
    • Kaplan, J.M.1
  • 115
    • 2442672704 scopus 로고    scopus 로고
    • The acetyltransferase p300/CBP-associated factor is a p53 target gene in breast tumor cells
    • G. S. Watts, M. M. Oshiro, D. J. Junk, R. J. Wozniak, S. Watterson, F. E. Domann, and B. W. Futscher: The acetyltransferase p300/CBP-associated factor is a p53 target gene in breast tumor cells. Neoplasia. 6, 187-194 (2004) (Pubitemid 38657074)
    • (2004) Neoplasia , vol.6 , Issue.3 , pp. 187-194
    • Watts, G.S.1    Oshiro, M.M.2    Junk, D.J.3    Wozniak, R.J.4    Watterson, S.J.5    Domann, F.E.6    Futscher, B.W.7
  • 117
    • 0033895499 scopus 로고    scopus 로고
    • Suppression of primary tumor growth and the progression to metastasis with p53 adenovirus in human prostate cancer
    • J. A. Eastham, W. Grafton, C. M. Martin, and B. J. Williams: Suppression of primary tumor growth and the progression to metastasis with p53 adenovirus in human prostate cancer. J. Urol. 164, 814-819 (2000) (Pubitemid 30637639)
    • (2000) Journal of Urology , vol.164 , Issue.3 , pp. 814-819
    • Eastham, J.A.1    Grafton, W.2    Martin, C.M.3    Williams, B.J.4
  • 118
    • 0034203534 scopus 로고    scopus 로고
    • Adenovirus-mediated wildtype p53 overexpression reverts tumourigenicity of human mesothelioma cells
    • M. Giuliano, A. Catalano, L. Strizzi, G. Vianale, M. Capogrossi, and A. Procopio: Adenovirus-mediated wildtype p53 overexpression reverts tumourigenicity of human mesothelioma cells. Int. J. Mol. Med. 5, 591-596 (2000)
    • (2000) Int. J. Mol. Med , vol.5 , pp. 591-596
    • Giuliano, M.1    Catalano, A.2    Strizzi, L.3    Vianale, G.4    Capogrossi, M.5    Procopio, A.6
  • 119
    • 33746809119 scopus 로고    scopus 로고
    • INGN 201 (Advexin): Adenoviral p53 gene therapy for cancer
    • DOI 10.1517/14712598.6.8.823
    • D. I. Gabrilovich: INGN 201 (Advexin): adenoviral p53 gene therapy for cancer. Expert. Opin. Biol. Ther. 6, 823-832 (2006) (Pubitemid 44174214)
    • (2006) Expert Opinion on Biological Therapy , vol.6 , Issue.8 , pp. 823-832
    • Gabrilovich, D.I.1
  • 122
    • 33751562430 scopus 로고    scopus 로고
    • Splicing out the west?
    • DOI 10.1126/science.314.5803.1232
    • J. Guo and H. Xin: Chinese gene therapy. Splicing out the West? Science 314, 1232-1235 (2006) (Pubitemid 44846373)
    • (2006) Science , vol.314 , Issue.5803 , pp. 1232-1235
    • Guo, J.1    Xin, H.2
  • 123
    • 0031451158 scopus 로고    scopus 로고
    • Viral transactivating proteins
    • DOI 10.1146/annurev.genet.31.1.177
    • J. Flint and T. Shenk: Viral transactivating proteins. Annu. Rev. Genet. 31, 177-212 (1997) (Pubitemid 28023706)
    • (1997) Annual Review of Genetics , vol.31 , pp. 177-212
    • Flint, J.1    Shenk, T.2
  • 126
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • T. Miyashita and J. C. Reed: Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80, 293-299 (1995)
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 127
    • 0025251915 scopus 로고
    • Domains required for in vitro association between the cellular p53 and the adenovirus 2 E1B 55K proteins
    • C. C. Kao, P. R. Yew, and A. J. Berk: Domains required for in vitro association between the cellular p53 and the adenovirus 2 E1B 55K proteins. Virology 179, 806-814 (1990)
    • (1990) Virology , vol.179 , pp. 806-814
    • Kao, C.C.1    Yew, P.R.2    Berk, A.J.3
  • 128
    • 0026560315 scopus 로고
    • Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein
    • P. R. Yew and A. J. Berk: Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein. Nature 357, 82-85 (1992)
    • (1992) Nature , vol.357 , pp. 82-85
    • Yew, P.R.1    Berk, A.J.2
  • 129
    • 0028089283 scopus 로고
    • Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53
    • P. R. Yew, X. Liu, and A. J. Berk: Adenovirus E1B oncoprotein tethers a transcriptional repression domain to p53. Genes Dev. 8, 190-202 (1994)
    • (1994) Genes Dev , vol.8 , pp. 190-202
    • Yew, P.R.1    Liu, X.2    Berk, A.J.3
  • 130
    • 0030753963 scopus 로고    scopus 로고
    • Nuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a rev-like signal sequence
    • DOI 10.1093/emboj/16.14.4276
    • M. Dobbelstein, J. Roth, W. T. Kimberly, A. J. Levine, and T. Shenk: Nuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a revlike signal sequence. EMBO J. 16, 4276-4284 (1997) (Pubitemid 27298180)
    • (1997) EMBO Journal , vol.16 , Issue.14 , pp. 4276-4284
    • Dobbelstein, M.1    Roth, J.2    Kimberly, W.T.3    Levine, A.J.4    Shenk, T.5
  • 131
    • 0032556920 scopus 로고    scopus 로고
    • The large E1B protein together with the E4orf6 protein target p53 for active degradation in adenovirus infected cells
    • W. T. Steegenga, N. Riteco, A. G. Jochemsen, F. J. Fallaux, and J. L. Bos: The large E1B protein together with the E4orf6 protein target p53 for active degradation in adenovirus infected cells. Oncogene 16, 349-357 (1998) (Pubitemid 28052289)
    • (1998) Oncogene , vol.16 , Issue.3 , pp. 349-357
    • Steegenga, W.T.1    Riteco, N.2    Jochemsen, A.G.3    Fallaux, F.J.4    Bos, J.L.5
  • 132
    • 0023099280 scopus 로고
    • Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection
    • DOI 10.1016/0042-6822(87)90441-7
    • D. D. Barker and A. J. Berk: Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection. Virology 156, 107-121 (1987) (Pubitemid 17013653)
    • (1987) Virology , vol.156 , Issue.1 , pp. 107-121
    • Barker, D.D.1    Berk, A.J.2
  • 135
    • 0030917202 scopus 로고    scopus 로고
    • ONYX-015, an E1b gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents
    • DOI 10.1038/nm0697-639
    • C. Heise, A. Sampson-Johannes, A. Williams, F. McCormick, D. D. Von Hoff, and D. H. Kirn: ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nat. Med. 3, 639-645 (1997) (Pubitemid 27264973)
    • (1997) Nature Medicine , vol.3 , Issue.6 , pp. 639-645
    • Heise, C.1    Sampson-Johannes, A.2    Williams, A.3    McCormick, F.4    Von Hoff, D.D.5    Kirn, D.H.6
  • 136
    • 0034115372 scopus 로고    scopus 로고
    • Adenovirus-mediated p53 gene therapy inhibits human sarcoma tumorigenicity
    • M. Milas, D. Yu, A. Lang, T. Ge, B. Feig, A. K. El-Naggar, and R. E. Pollock: Adenovirus-mediated p53 gene therapy inhibits human sarcoma tumorigenicity. Cancer Gene Ther. 7, 422-429 (2000) (Pubitemid 30210409)
    • (2000) Cancer Gene Therapy , vol.7 , Issue.3 , pp. 422-429
    • Milas, M.1    Yu, D.2    Lang, A.3    Ge, T.4    Feig, B.5    El-Naggar, A.K.6    Pollock, R.E.7
  • 137
    • 0033944718 scopus 로고    scopus 로고
    • Synergistic chemosensitization and inhibition of tumor growth and metastasis by adenovirus-mediated P53 gene transfer in human bladder cancer model
    • DOI 10.1016/S0090-4295(00)00567-7, PII S0090429500005677
    • H. Miyake, I. Hara, S. Hara, S. Arakawa, and S. Kamidono: Synergistic chemosensitization and inhibition of tumor growth and metastasis by adenovirus-mediated P53 gene transfer in human bladder cancer model. Urology 56, 332-336 (2000) (Pubitemid 30495606)
    • (2000) Urology , vol.56 , Issue.2 , pp. 332-336
    • Miyake, H.1    Hara, I.2    Hara, S.3    Arakawa, S.4    Kamidono, S.5
  • 138
    • 33748761961 scopus 로고    scopus 로고
    • Adenoviral gene therapy in head and neck cancer
    • DOI 10.1358/dnp.2006.19.6.1015352
    • E. Vattemi and P. P. Claudio: Adenoviral gene therapy in head and neck cancer. Drug News Perspect. 19, 329-337 (2006) (Pubitemid 44409884)
    • (2006) Drug News and Perspectives , vol.19 , Issue.6 , pp. 329-337
    • Vattemi, E.1    Claudio, P.P.2
  • 139
    • 22944476168 scopus 로고    scopus 로고
    • Effects of Onyx-015 among metastatic colorectal cancer patients that have failed prior treatment with 5-FU/leucovorin
    • DOI 10.1038/sj.cgt.7700819
    • T. R. Reid, S. Freeman, L. Post, F. McCormick, and D. Y. Sze: Effects of Onyx-015 among metastatic colorectal cancer patients that have failed prior treatment with 5-FU/leucovorin. Cancer Gene Ther. 12, 673-681 (2005) (Pubitemid 41045565)
    • (2005) Cancer Gene Therapy , vol.12 , Issue.8 , pp. 673-681
    • Reid, T.R.1    Freeman, S.2    Post, L.3    McCormick, F.4    Sze, D.Y.5
  • 140
    • 33751074140 scopus 로고    scopus 로고
    • Targeting Gene-Virotherapy of Cancer and its prosperity
    • DOI 10.1038/sj.cr.7310108, PII 7310108
    • X. Y. Liu: Targeting gene-virotherapy of cancer and its prosperity. Cell Res. 16, 879-886 (2006) (Pubitemid 44764197)
    • (2006) Cell Research , vol.16 , Issue.11 , pp. 879-886
    • Liu, X.Y.1
  • 141
    • 33845611951 scopus 로고    scopus 로고
    • Modeling the Therapeutic Efficacy of p53 Restoration in Tumors
    • DOI 10.1016/j.cell.2006.12.007, PII S0092867406015972
    • C. P. Martins, L. Brown-Swigart, and G. I. Evan: Modeling the therapeutic efficacy of p53 restoration in tumors. Cell 127, 1323-1334 (2006) (Pubitemid 44960417)
    • (2006) Cell , vol.127 , Issue.7 , pp. 1323-1334
    • Martins, C.P.1    Brown-Swigart, L.2    Evan, G.I.3
  • 144
    • 33845185824 scopus 로고    scopus 로고
    • Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo
    • DOI 10.1016/j.ccr.2006.10.010, PII S1535610806003163
    • I. Ringshausen, C. C. O'Shea, A. J. Finch, L. B. Swigart, and G. I. Evan: Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo. Cancer Cell 10, 501-514 (2006) (Pubitemid 44854749)
    • (2006) Cancer Cell , vol.10 , Issue.6 , pp. 501-514
    • Ringshausen, I.1    O'Shea, C.C.2    Finch, A.J.3    Swigart, L.B.4    Evan, G.I.5
  • 145
    • 33748670457 scopus 로고    scopus 로고
    • The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
    • DOI 10.1038/nature05077, PII NATURE05077
    • M. A. Christophorou, I. Ringshausen, A. J. Finch, L. B. Swigart, and G. I. Evan: The pathological response to DNA damage does not contribute to p53-mediated tumour suppression. Nature 443, 214-217 (2006) (Pubitemid 44387609)
    • (2006) Nature , vol.443 , Issue.7108 , pp. 214-217
    • Christophorou, M.A.1    Ringshausen, I.2    Finch, A.J.3    Swigart, L.B.4    Evan, G.I.5
  • 146
    • 33646798450 scopus 로고    scopus 로고
    • P53/p63/p73 isoforms: An orchestra of isoforms to harmonise cell differentiation and response to stress
    • F. Murray-Zmijewski, D. P. Lane, and J. C. Bourdon: p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress. Cell Death. Differ. 13, 962-972 (2006)
    • (2006) Cell Death. Differ , vol.13 , pp. 962-972
    • Murray-Zmijewski, F.1    Lane, D.P.2    Bourdon, J.C.3
  • 149
    • 0037427570 scopus 로고    scopus 로고
    • Waf1/Cip1
    • DOI 10.1016/S0304-3835(02)00495-0, PII S0304383502004950
    • R. H. Weiss, D. Marshall, L. Howard, A. M. Corbacho, A. T. Cheung, and E. T. Sawai: Suppression of breast cancer growth and angiogenesis by an antisense oligodeoxynucleotide to p21 (Waf1/Cip1). Cancer Lett. 189, 39-48 (2003) (Pubitemid 35351518)
    • (2003) Cancer Letters , vol.189 , Issue.1 , pp. 39-48
    • Weiss, R.H.1    Marshall, D.2    Howard, L.3    Corbacho, A.M.4    Cheung, A.T.5    Sawai, E.T.6
  • 150
    • 18144428775 scopus 로고    scopus 로고
    • Prospective therapeutic applications of p53 inhibitors
    • DOI 10.1016/j.bbrc.2005.03.153, Apoptosis Control
    • A. V. Gudkov and E. A. Komarova: Prospective therapeutic applications of p53 inhibitors. Biochem. Biophys. Res. Commun. 331, 726-736 (2005) (Pubitemid 40615504)
    • (2005) Biochemical and Biophysical Research Communications , vol.331 , Issue.3 , pp. 726-736
    • Gudkov, A.V.1    Komarova, E.A.2


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