p53 transcriptional activation domain: A molecular chameleon?

Cell Cycle

Volumn 5, Issue 5, 2006, Pages 489-494

  Kaustov, Lilia ^a   Yi, Gwan Su ^a   Ayed, Ayeda ^a   Bochkareva, Elena ^a   Bochkarev, Alexey ^a   Arrowsmith, Cheryl H ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

NMR; p53; Protein protein interaction; RPA; Transactivation domain; X ray

Indexed keywords

OLIGONUCLEOTIDE; OLIGOSACCHARIDE; PROTEIN P53; REPLICATION PROTEIN A; SINGLE STRANDED DNA;

AMINO TERMINAL SEQUENCE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DISSOCIATION; DNA DAMAGE; DNA METABOLISM; DNA REPAIR; GENE CONTROL; GENETIC LINKAGE; HUMAN; MODULATION; MOLECULAR DYNAMICS; MOLECULAR MIMICRY; NONHUMAN; OXIDATIVE STRESS; POSITIVE FEEDBACK; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

EID: 33644749307     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.5.5.2489     Document Type: Review

References (57)

1. Ko LJ, Prives C. p53: Puzzle and paradigm. Genes Dev 1996; 10:1054-72.
2. Levine AJ. P53, the cellular gatekeeper for growth and division. Cell 1997; 88:323-31.
3. Kastan MB, Zhan Q, El-Deiry WS, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelstein B, Fornace AJ. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 1992; 71:587-97.
4. Lane DP. P53, guardian of the genome. Nature 1992; 358:15-6.
5. Vassilev LT. P53 activation by small molecules: Application in oncology. J Med Chem 2005; 48:4491-9.
6. Midgley CA, Lane DP. P53 protein stability in tumor cells is not determined by mutation but is dependent on mdm2 binding. Oncogene 1997; 15:1179-89.
7. Roth J, Dobblestein M, Freedman DA, Shenk T, Levine AJ. Nucleo-cytoplasmic shuttling of the mdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein. EMBOJ 1998; 17:554-64.
8. Honda R, Tanaka H, Yasuda H. Oncoprotein mdm2 is a ubiquitin ligase for tumor suppressor p53. Science 1998; 281:1677-9.
9. Dutta A, Ruppert JM, Aster JC, Winchester E. Inhibition of DNA replication factor RPA by p53. Nature 1993; 365:79-82.
10. He Z, Brinton BT, Greenblatt J, Hassell JA, Ingles CJ. The transactivator proteins VP16 and GAL4 bind replication factor A. Cell 1993; 73:1223-32.
11. Li R, Botchan MR. The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in vitro BPV-1 DNA replication. Cell 1993; 73:1207-21.
12. Romanova LY, Willers H, Blagosklonny MV, Powell SN. The interaction of p53 with replication protein A mediates suppression of homologous recombination. Oncogene 2004; 23:9025-33.
13. Abramova NA, Russell J, Botchan M, Li R. Interaction between replication protein A and p53 is disrupted after UV damage in a DNA repair-dependent manner. Proc Natl Acad Sci USA 1997; 94:7186-91.
14. Miller SD, Moses K, Jayaraman L, Prives C. Complex formation between p53 and replication protein A inhibits the sequence-specific DNA binding of p53 and is regulated by single-stranded DNA. Mol Cell Biol 1997; 17:2194-2201.
15. Wold MS. Replication protein A: A heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. Annu Rev Biochem 1997; 66:61-92.
16. Bochkarev A, Bochkareva E. From RPA to BRCA2: Lessons from single-stranded DNA binding by the OB-fold. Curr Opin Struct Biol 2004; 14:36-42.
17. Murzin AG. OB(oligonucleotide/oligosaccharide binding)-fold: Common structural and functional solution for nonhomologous sequences. EMBO J 1993; 12:861-7.
18. Bochkarev A, Pfuetzner RA, Edwards AM, Frappier L. Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA. Nature 1997; 385:176-81.
19. Daughdrill GW, Ackerman J, Isern NG, Botuyan MV, Arrowsmith C, Wold MS, Lowry DF. The weak interdomain coupling observed in the 70 kDa subunit of human replication protein A is unaffected by ssDNA binding. Nucleic Acids Res 2001; 29:3270-6.
20. Block WD, Yu Y, Lees-Miller SP. Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21. Nucleic Acids Res 2004; 32:997-1005.
21. Binz SK, Sheehan AM, Wold MS. Replication protein A phosphorylation and the cellular response to DNA damage. DNA Repair (Amst) 2004; 3:1015-24.
22. Leiter LM, Chen J, Marathe T, Tanaka M, Dutta A. Loss of transactivation and transrepression function, and not RPA binding, alters growth suppression by p53. Oncogene 1996; 12:2661-68.
23. Lin YL, Chen C, Keshav KF, Winchester E, Dutta A. Dissection of functional domains of the human DNA replication protein complex replication protein A. J Biol Chem 1996; 271:17190-8.
24. Jacobs DM, Lipton AS, Isern NG, Daughdrill GW, Lowry DF, Gomes X, Wold MS. Human replication protein A: Global fold of the N-terminal RPA-70 domain reveals a basic cleft and flexible C-terminal linker. J Biomol NMR 1999; 14:321-31.
25. Vise PD, Baral B, Latos AJ, Daughrill GW. NMR chemical shift and relxation measurements provide evidence for the coupled folding and binding of the p53 transactivation domain. Nuc Acid Res 2005; 33:2061-77.
26. Bochkareva E, Kaustov L, Ayed A, Yi GW, Lu Y, Pineda-Lucena A, Liao JCC, Okorokov AL, Milner J, Arrowsmith CH, Bochkarev A. Single-stranded DNA mimicry in the p53 transactivation domain interaction with replication protein A. Proc Natl Acad Sci USA 2005; 102:15412-7.
27. Kussie PH, Gorina S, Marechal V, Elenbaas B, Moreau J, Levine AJ, Pavletich NP. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science 1996; 274:948-53.
28. Chi SW, Lee SH, Kim DH, Ahn MJ, Kim JS, Woo JY, Torizawa T, Kainosho M, Han KH. Structural details on mdm2-p53 interaction. J Biol Chem 2005; 280:38795-802.
29. Yang H, Jeffrey PD, Miller J, Kinnucan E, Sun Y, Thoma NH, Zheng N, Chen PL, Lee WH, Pavletich NP. BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure. Science 2002; 297:1837-48.
30. Binz SK, Lao Y, Lowry DF, Wold MS. The phosphorylation domain of the 32-kDa subunit of replication protein A (RPA) modulates RPA-DNA interactions. Evidence for an inter-subunit interaction. J Biol Chem 2003; 278:35584-91.
31. Zernik-Kobak M, Vasunia K, Connelly M, Anderson CW, Dixon K. Sites of UV-induced phosphorylation of the p34 subunit of replication protein A from HeLa cells. J Biol Chem 1997; 272:23896-904.
32. Lee H, Mok KH, Muhandiram R, Park KH, Suk JE, Kim DH, Chang J, Sung YC, Choi KY, Han KH. Local structural elements in the mostly unstructured transcriptional activation domain of human p53. J Biol Chem 2000; 275:29426-32.
33. Botuyan MV, Momand J, Chen Y. Solution conformation of an essential region of the p53 transactivation domain. Fold Des 1997; 2:331-42.
34. Dyson HJ, Wright PE. Coupling of folding and binding for unstructured proteins. Curr Opin Struct Biol 2002; 12:54-60.
35. Wright PE, Dyson HJ. Intrinsically unstructured proteins: Reassessing the protein structurefunction paradigm. J Mol Biol 1999; 293:321-31.
36. Regier JL, Shen F, Triezenberg SJ. Pattern of aromatic and hydrophobic amino acids critical for one of two subdomains of the VP16 transcriptional activator. Proc Natl Acad Sci USA 1993; 90:883-7.
37. Metivier R, Penot G, Flouriot G, Pakdel F. Synergism between ERalpha transactivation function 1 (AF-1) and AF-2 mediated by steroid receptor coactivator protein-1: Requirement for the AF-1 alpha-helical core and for a direct interaction between the N- and C-terminal domains. Mol Endocrinol 2001; 15:1953-70.
38. Semenza GL. HIF-1 and mechanisms of hypoxia sensing Current Opin Cell Biol 2001; 13:167-71.
39. Bode AM, Dong Z. Post-translational modification of p53 in tumorigenesis. Nat Rev Cancer 2004; 4:793-805.
40. Pise-Masison CA, Radonovich M, Sakaguchi K, Appella E, Brady JN. Phosphorylation of p53: A novel pathway for p53 inactivation in human T-cell lymphotropic virus type 1-transformed cells. J Virol 1998;72:6348-55.
41. Brooks CL, Gu W. Ubiquitinqtion, phosphorylation and acetylation: The molecular basis for p53 regulation. Curr Opin Cell Biol 2003; 15:164-71.
42. Iakoucheva LM, Radivojac P, Brown CJ, O'Connor TR, Sikes JG, Obradovic Z, Dunker AK. The importance of intrinsic disorder for protein phosphorylation. Nucleic Acid Res 2004; 32:1037-49.
43. Vetter SW, Leclerc E. Phosphorylation of serine residues affects the conformation of the calmodulin binding domain of human protein 4.1. Eur J Biochem 2001; 268:4292-99.
44. Ojala PM, Yamamoto K, Castanos-Velez E, Biberfeld P, Korsmeyer SJ, Makela TP. The apoptotic v-cyclin-CDK6 complex phosphorylates and inactivates Bcl-2. Nature Cell Biol 2000; 2:819-25.
45. Prives C, Hall PA. The p53 pathway. J Pathol 1999; 187:112-26.
46. Bulavin DV, Saito S, Hollander MC, Sakaguchi K, Anderson CW, Appella E, Fornace AJ. Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation. EMBO J 1999; 18:6845-54.
47. Dohoney KM, Guillerm C, Whiteford C, Elbi C, Lambert PF, Hager GL, Brady JN. Phosphorylation of p53 at serine 37 is important for transcriptional activity and regulation in response to DNA damage. Oncogene 2004; 23:49-57.
48. Oda K, Arakawa H, Tanaka T, Matsuda K, Tanikawa C, Mori T, Nishimori H, Tamai K, Tokino T, Nakamura Y, Taya Y. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell 2000; 102:849-62.
49. Di Stefano V, Blandino G, Sacchi A, Soddu S, D'Orazi G. HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function. Oncogene 2004; 23:5185-92.
50. Bochkareva E, Belegu V, Korolev S, Bochkarev A. Structure of the major single-stranded DNA-binding domain of replication protein A suggests a dynamic mechanism for DNA binding. EMBO J 2001; 20:612-8.
51. Liu VF, Weaver DT. The ionizing radiation-induced replication protein A phosphorylation response differs between ataxia telangiectasia and normal human cells. Mol Cell Biol 1993; 13:7222-31.
52. Brush GS, Anderson CW, Kelly TJ. The DNA-activated protein kinase is required for the phosphorylation of replication protein A during simian virus 40 DNA replication. Proc Natl Acad Sci USA 1994; 91:12520-4.
53. Brush GS, Morrow DM, Hieter P, Kelly TJ. The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast. Proc Natl Acad Sci USA 1996; 93:15075-80.
54. Stauffer ME, Chazin WJ. Physical interaction between replication protein A and Rad51 promotes exchange on single-stranded DNA. J Biol Chem 2004; 279:25638-45.
55. Liu Y, Kvaratskhelia M, Hess S, Qu Y, Zou Y. Modulation of replication protein A function by its hyperphosphorylation-induced conformational change involving DNA binding domain B. J Biol Chem 2005; 280:32775-83.
56. Wong JM, Ionescu D, Ingles CJ. Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2. Oncogene 2003; 22:28-33.
57. Henricksen LA, Carter T, Dutta A, Wold MS. Phosphorylation of human replication protein A by the DNA-dependent protein kinase is involved in the modulation of DNA replication. Nucleic Acids Res 1996; 24:3107-12.