Study of the cytotoxic effect of a peptidic inhibitor of the p53-hdm2 interaction in tumor cells

FEBS Letters

Volumn 529, Issue 2-3, 2002, Pages 293-297

  Chène, Patrick ^a   Fuchs, Jean ^a   Carena, Ilaria ^a   Furet, Pascal ^a   García Echeverría, Carlos ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Apoptosis; mdm2; p53; Protein protein interaction

Indexed keywords

ACETYLPHENYLALANYLMETHIONYL ALPHA AMINOISOBUTYRIC ACID PHOSPHONOMETHYLPHENYLALANYL 6 CHLOROTRYPTOPHYLGLUTAMYL 1 AMINOCYCLOPROPANECARBOXYLIC ACID LEUCINAMIDE; ACETYLPHENYLALANYLMETHIONYL ALPHA AMINOISOBUTYRIC ACID PHOSPHONOMETHYLPHENYLALANYLALANYLGLUTAMYL 1 AMINOCYCLOPROPANECARBOXYLIC ACID LEUCINAMIDE; BETA TUBULIN; CASPASE 9; PEPTIDE DERIVATIVE; PROTEIN; PROTEIN MDM2; PROTEIN P14; PROTEIN P21; PROTEIN P53; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; TUMOR CELL;

APOPTOSIS; BLOTTING, WESTERN; CELL DIVISION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; NUCLEAR PROTEINS; PEPTIDES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0037048646     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(02)03362-8     Document Type: Article

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