Specific targeting of cytosine deaminase to solid tumors by engineered Clostridium acetobutylicum

Cancer Gene Therapy

Volumn 8, Issue 4, 2001, Pages 294-297

  Theys, Jan ^a,b   Landuyt, Willy ^a,b   Nuyts, Sandra ^a,b   Van Mellaert, Lieve ^a   Van Oosterom, Allan ^b   Lambin, Philippe ^b,c   Anné, Jozef ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b Laboratory of Experimental Oncology   (Belgium)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Clostridium; Cytosine deaminase; Gene transfer; Hypoxia

Indexed keywords

COMBRETASTATIN A4; CYTOSINE DEAMINASE;

ANAEROBIC BACTERIUM; ARTICLE; CANCER PATIENT; CLOSTRIDIUM ACETOBUTYLICUM; ENZYME ACTIVITY; GENE TARGETING; GENE THERAPY; GENETIC ENGINEERING; HYPOXIA; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RECOMBINANT DNA TECHNOLOGY; SOLID TUMOR; STRAIN DIFFERENCE; SURVIVAL RATE;

ANIMALS; ANTIFUNGAL AGENTS; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CLOSTRIDIUM; CYTOSINE DEAMINASE; DNA PRIMERS; DRUG DELIVERY SYSTEMS; ESCHERICHIA COLI; FLUCYTOSINE; FLUOROURACIL; GENE THERAPY; GENETIC VECTORS; NEOPLASM TRANSPLANTATION; NUCLEOSIDE DEAMINASES; PLASMIDS; RATS; RECOMBINANT PROTEINS; RHABDOMYOSARCOMA; SKIN NEOPLASMS; STILBENES;

BACTERIA (MICROORGANISMS); CLOSTRIDIUM; CLOSTRIDIUM ACETOBUTYLICUM;

EID: 0035023209     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700303     Document Type: Article

References (5)

1. Brown JM, Giaccia AJ. The unique physiology of solid tumors: opportunities and problems for cancer therapy. Cancer Res. 1998;58:1408-1416.
2. Theys J, Nuyts S, Landuyt W, et al. Stable Escherichia coli-Clostridium acetobutylicum shuttle vector for secretion of murine tumor necrosis factor alpha. Appl Environ Microbiol. 1999;65:4295-4300.
3. Haack K, Moebius U, Knebel Doeberitz MV, et al. Detection of cytosine deaminase in genetically modified tumor cells by specific antibodies. Hum Gene Ther. 1997;8:1395-1401.
4. Landuyt W, Verdoes O, Darius DO, et al. Vascular targeting of solid tumors: a major "inverse" volume-response relationship following combretastatin A-4 phosphate treatment of rat rhabdomyosarcomas. Eur J Cancer. 2000;36:1833-1843.
5. Lambin P, Nuyts S, Landuyt W, et al. The potential therapeutic gain of radiation-associated gene therapy with the suicide gene cytosine deaminase. Int J Radiat Biol. 2000; 76:285-293.