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Volumn 115, Issue 1, 2007, Pages 70-83

A novel therapeutic target in various lung diseases: Airway proteases and protease-activated receptors

Author keywords

Inflammation; Prostaglandin E2; Protease activated receptor; Pulmonary fibrosis; Serine protease

Indexed keywords

CYTOKINE; ENMD 1068; GROWTH FACTOR; HIMBACINE; PROSTAGLANDIN E2; PROSTANOID; PROTEINASE; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 2; PROTEINASE ACTIVATED RECEPTOR 3; PROTEINASE ACTIVATED RECEPTOR 4; PROTEINASE ACTIVATED RECEPTOR ANTAGONIST; RECEPTOR BLOCKING AGENT; RWJ 56110; RWJ 58259; SCH 79797; UNCLASSIFIED DRUG;

EID: 34250878934     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2007.04.002     Document Type: Review
Times cited : (68)

References (113)
  • 1
    • 33646368158 scopus 로고    scopus 로고
    • The house dust mite allergen Der p 1, unlike Der p 3, stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated receptor-2-independent mechanism
    • Adam E., Hansen K.K., Astudillo O.F., Coulon L., Bex F., Duhant X., et al. The house dust mite allergen Der p 1, unlike Der p 3, stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated receptor-2-independent mechanism. J Biol Chem 281 (2006) 6910-6923
    • (2006) J Biol Chem , vol.281 , pp. 6910-6923
    • Adam, E.1    Hansen, K.K.2    Astudillo, O.F.3    Coulon, L.4    Bex, F.5    Duhant, X.6
  • 2
    • 0033584185 scopus 로고    scopus 로고
    • Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists
    • Ahn H.S., Arik L., Boykow G., Burnett D.A., Caplen M.A., Czarniecki M., et al. Structure-activity relationships of pyrroloquinazolines as thrombin receptor antagonists. Bioorg Med Chem Lett 9 (1999) 2073-2078
    • (1999) Bioorg Med Chem Lett , vol.9 , pp. 2073-2078
    • Ahn, H.S.1    Arik, L.2    Boykow, G.3    Burnett, D.A.4    Caplen, M.A.5    Czarniecki, M.6
  • 3
    • 0034670162 scopus 로고    scopus 로고
    • Inhibition of cellular action of thrombin by N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3, 2-f]quinazoline-1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist
    • Ahn H.S., Foster C., Boykow G., Stamford A., Manna M., and Graziano M. Inhibition of cellular action of thrombin by N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3, 2-f]quinazoline-1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist. Biochem Pharmacol 60 (2000) 1425-1434
    • (2000) Biochem Pharmacol , vol.60 , pp. 1425-1434
    • Ahn, H.S.1    Foster, C.2    Boykow, G.3    Stamford, A.4    Manna, M.5    Graziano, M.6
  • 5
    • 0036151657 scopus 로고    scopus 로고
    • Modified proteinase-activated receptor-1 and -2 derived peptides inhibit proteinase-activated receptor-2 activation by trypsin
    • Al-Ani B., Saifeddine M., Wijesuriya S.J., and Hollenberg M.D. Modified proteinase-activated receptor-1 and -2 derived peptides inhibit proteinase-activated receptor-2 activation by trypsin. J Pharmacol Exp Ther 300 (2002) 702-708
    • (2002) J Pharmacol Exp Ther , vol.300 , pp. 702-708
    • Al-Ani, B.1    Saifeddine, M.2    Wijesuriya, S.J.3    Hollenberg, M.D.4
  • 6
    • 0034967927 scopus 로고    scopus 로고
    • Administration of a potent antagonist of protease-activated receptor-1 (PAR-1) attenuates vascular restenosis following balloon angioplasty in rats
    • Andrade-Gordon P., Derian C.K., Maryanoff B.E., Zhang H.C., Addo M.F., Cheung W., et al. Administration of a potent antagonist of protease-activated receptor-1 (PAR-1) attenuates vascular restenosis following balloon angioplasty in rats. J Pharmacol Exp Ther 298 (2001) 34-42
    • (2001) J Pharmacol Exp Ther , vol.298 , pp. 34-42
    • Andrade-Gordon, P.1    Derian, C.K.2    Maryanoff, B.E.3    Zhang, H.C.4    Addo, M.F.5    Cheung, W.6
  • 7
    • 0036533649 scopus 로고    scopus 로고
    • Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells
    • Asokananthan N., Graham P.T., Fink J., Knight D.A., Bakker A.J., McWilliam A.S., et al. Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells. J Immunol 168 (2002) 3577-3585
    • (2002) J Immunol , vol.168 , pp. 3577-3585
    • Asokananthan, N.1    Graham, P.T.2    Fink, J.3    Knight, D.A.4    Bakker, A.J.5    McWilliam, A.S.6
  • 8
    • 0037108373 scopus 로고    scopus 로고
    • House dust mite allergens induce proinflammatory cytokines from respiratory epithelial cells: the cysteine protease allergen, Der p 1, activates protease-activated receptor (PAR)-2 and inactivates PAR-1
    • Asokananthan N., Graham P.T., Stewart D.J., Bakker A.J., Eidne K.A., Thompson P.J., et al. House dust mite allergens induce proinflammatory cytokines from respiratory epithelial cells: the cysteine protease allergen, Der p 1, activates protease-activated receptor (PAR)-2 and inactivates PAR-1. J Immunol 169 (2002) 4572-4578
    • (2002) J Immunol , vol.169 , pp. 4572-4578
    • Asokananthan, N.1    Graham, P.T.2    Stewart, D.J.3    Bakker, A.J.4    Eidne, K.A.5    Thompson, P.J.6
  • 9
    • 0042196170 scopus 로고    scopus 로고
    • Proteinase-activated receptor-2 mediates hyperresponsiveness in isolated guinea pig bronchi
    • Barrios V.E., Jarosinski M.A., and Wright C.D. Proteinase-activated receptor-2 mediates hyperresponsiveness in isolated guinea pig bronchi. Biochem Pharmacol 66 (2003) 519-525
    • (2003) Biochem Pharmacol , vol.66 , pp. 519-525
    • Barrios, V.E.1    Jarosinski, M.A.2    Wright, C.D.3
  • 10
    • 33746457002 scopus 로고    scopus 로고
    • PAR-type thrombin receptors in renal carcinoma cells: PAR1-mediated EGFR activation promotes cell migration
    • Bergmann S., Junker K., Henklein P., Hollenberg M.D., Settmacher U., and Kaufmann R. PAR-type thrombin receptors in renal carcinoma cells: PAR1-mediated EGFR activation promotes cell migration. Oncol Rep 15 (2006) 889-893
    • (2006) Oncol Rep , vol.15 , pp. 889-893
    • Bergmann, S.1    Junker, K.2    Henklein, P.3    Hollenberg, M.D.4    Settmacher, U.5    Kaufmann, R.6
  • 11
    • 0034880428 scopus 로고    scopus 로고
    • Factor Xa is a fibroblast mitogen via binding to effector-cell protease receptor-1 and autocrine release of PDGF
    • Blanc-Brude O.P., Chambers R.C., Leoni P., Dik W.A., and Laurent G.J. Factor Xa is a fibroblast mitogen via binding to effector-cell protease receptor-1 and autocrine release of PDGF. Am J Physiol Cell Physiol 281 (2001) C681-C689
    • (2001) Am J Physiol Cell Physiol , vol.281
    • Blanc-Brude, O.P.1    Chambers, R.C.2    Leoni, P.3    Dik, W.A.4    Laurent, G.J.5
  • 12
    • 13544274283 scopus 로고    scopus 로고
    • Factor Xa stimulates fibroblast procollagen production, proliferation, and calcium signaling via PAR1 activation
    • Blanc-Brude O.P., Archer F., Leoni P., Derian C., Bolsover S., Laurent G.J., et al. Factor Xa stimulates fibroblast procollagen production, proliferation, and calcium signaling via PAR1 activation. Exp Cell Res 304 (2005) 16-27
    • (2005) Exp Cell Res , vol.304 , pp. 16-27
    • Blanc-Brude, O.P.1    Archer, F.2    Leoni, P.3    Derian, C.4    Bolsover, S.5    Laurent, G.J.6
  • 13
    • 0035976915 scopus 로고    scopus 로고
    • Thrombin differentiates normal lung fibroblasts to a myofibroblast phenotype via the proteolytically activated receptor-1 and a protein kinase C-dependent pathway
    • Bogatkevich G.S., Tourkina E., Silver R.M., and Ludwicka-Bradley A. Thrombin differentiates normal lung fibroblasts to a myofibroblast phenotype via the proteolytically activated receptor-1 and a protein kinase C-dependent pathway. J Biol Chem 276 (2001) 45184-45192
    • (2001) J Biol Chem , vol.276 , pp. 45184-45192
    • Bogatkevich, G.S.1    Tourkina, E.2    Silver, R.M.3    Ludwicka-Bradley, A.4
  • 15
    • 13544255506 scopus 로고    scopus 로고
    • PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells
    • Boire A., Covic L., Agarwal A., Jacques S., Sherifi S., and Kuliopulos A. PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells. Cell 120 (2005) 303-313
    • (2005) Cell , vol.120 , pp. 303-313
    • Boire, A.1    Covic, L.2    Agarwal, A.3    Jacques, S.4    Sherifi, S.5    Kuliopulos, A.6
  • 16
    • 0042069969 scopus 로고    scopus 로고
    • Expression of and functional responses to protease-activated receptors on human eosinophils
    • Bolton S.J., McNulty C.A., Thomas R.J., Hewitt C.R., and Wardlaw A.J. Expression of and functional responses to protease-activated receptors on human eosinophils. J Leukoc Biol 74 (2003) 60-68
    • (2003) J Leukoc Biol , vol.74 , pp. 60-68
    • Bolton, S.J.1    McNulty, C.A.2    Thomas, R.J.3    Hewitt, C.R.4    Wardlaw, A.J.5
  • 17
    • 0033395306 scopus 로고    scopus 로고
    • Proteases from Aspergillus fumigatus induce interleukin (IL)-6 and IL-8 production in airway epithelial cell lines by transcriptional mechanisms
    • Borger P., Koeter G.H., Timmerman J.A., Vellenga E., Tomee J.F., and Kauffman H.F. Proteases from Aspergillus fumigatus induce interleukin (IL)-6 and IL-8 production in airway epithelial cell lines by transcriptional mechanisms. J Infect Dis 180 (1999) 1267-1274
    • (1999) J Infect Dis , vol.180 , pp. 1267-1274
    • Borger, P.1    Koeter, G.H.2    Timmerman, J.A.3    Vellenga, E.4    Tomee, J.F.5    Kauffman, H.F.6
  • 19
    • 0344923324 scopus 로고    scopus 로고
    • Up-regulation of proteinase-activated receptor 1 expression in astrocytes during HIV encephalitis
    • Boven L.A., Vergnolle N., Henry S.D., Silva C., Imai Y., Holden J., et al. Up-regulation of proteinase-activated receptor 1 expression in astrocytes during HIV encephalitis. J Immunol 170 (2003) 2638-2646
    • (2003) J Immunol , vol.170 , pp. 2638-2646
    • Boven, L.A.1    Vergnolle, N.2    Henry, S.D.3    Silva, C.4    Imai, Y.5    Holden, J.6
  • 21
    • 0037013268 scopus 로고    scopus 로고
    • Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells
    • Camerer E., Kataoka H., Kahn M., Lease K., and Coughlin S.R. Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells. J Biol Chem 277 (2002) 16081-16087
    • (2002) J Biol Chem , vol.277 , pp. 16081-16087
    • Camerer, E.1    Kataoka, H.2    Kahn, M.3    Lease, K.4    Coughlin, S.R.5
  • 22
    • 33745714777 scopus 로고    scopus 로고
    • Protease-activated receptor-2 activation in gastric cancer cells promotes epidermal growth factor receptor trans-activation and proliferation
    • Caruso R., Pallone F., Fina D., Gioia V., Peluso I., Caprioli F., et al. Protease-activated receptor-2 activation in gastric cancer cells promotes epidermal growth factor receptor trans-activation and proliferation. Am J Pathol 169 (2006) 268-278
    • (2006) Am J Pathol , vol.169 , pp. 268-278
    • Caruso, R.1    Pallone, F.2    Fina, D.3    Gioia, V.4    Peluso, I.5    Caprioli, F.6
  • 23
    • 19444366236 scopus 로고    scopus 로고
    • High expression of pulmonary proteinase-activated receptor 2 in acute and chronic lung injury in preterm infants
    • Cederqvist K., Haglund C., Heikkila P., Hollenberg M.D., Karikoski R., and Andersson S. High expression of pulmonary proteinase-activated receptor 2 in acute and chronic lung injury in preterm infants. Pediatr Res 57 (2005) 831-836
    • (2005) Pediatr Res , vol.57 , pp. 831-836
    • Cederqvist, K.1    Haglund, C.2    Heikkila, P.3    Hollenberg, M.D.4    Karikoski, R.5    Andersson, S.6
  • 24
    • 0036840275 scopus 로고    scopus 로고
    • Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2
    • Cenac N., Coelho A.M., Nguyen C., Compton S., Andrade-Gordon P., MacNaughton W.K., et al. Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2. Am J Pathol 161 (2002) 1903-1915
    • (2002) Am J Pathol , vol.161 , pp. 1903-1915
    • Cenac, N.1    Coelho, A.M.2    Nguyen, C.3    Compton, S.4    Andrade-Gordon, P.5    MacNaughton, W.K.6
  • 26
    • 24944580749 scopus 로고    scopus 로고
    • Discovery of potent orally active thrombin receptor (protease activated receptor 1) antagonists as novel antithrombotic agents
    • Chackalamannil S., Xia Y., Greenlee W.J., Clasby M., Doller D., Tsai H., et al. Discovery of potent orally active thrombin receptor (protease activated receptor 1) antagonists as novel antithrombotic agents. J Med Chem 48 (2005) 5884-5887
    • (2005) J Med Chem , vol.48 , pp. 5884-5887
    • Chackalamannil, S.1    Xia, Y.2    Greenlee, W.J.3    Clasby, M.4    Doller, D.5    Tsai, H.6
  • 27
    • 0042819773 scopus 로고    scopus 로고
    • Proteinase-activated receptors and the pathophysiology in pulmonary fibrosis
    • Chambers R.C. Proteinase-activated receptors and the pathophysiology in pulmonary fibrosis. Drug Dev Res 60 (2003) 29-35
    • (2003) Drug Dev Res , vol.60 , pp. 29-35
    • Chambers, R.C.1
  • 28
  • 29
    • 1842556263 scopus 로고    scopus 로고
    • Human airway trypsin-like protease increases mucin gene expression in airway epithelial cells
    • Chokki M., Yamamura S., Eguchi H., Masegi T., Horiuchi H., Tanabe H., et al. Human airway trypsin-like protease increases mucin gene expression in airway epithelial cells. Am J Respir Cell Mol Biol 30 (2004) 470-478
    • (2004) Am J Respir Cell Mol Biol , vol.30 , pp. 470-478
    • Chokki, M.1    Yamamura, S.2    Eguchi, H.3    Masegi, T.4    Horiuchi, H.5    Tanabe, H.6
  • 30
    • 29144525916 scopus 로고    scopus 로고
    • Human airway trypsin-like protease induces amphiregulin release through a mechanism involving protease-activated receptor-2-mediated ERK activation and TNF alpha-converting enzyme activity in airway epithelial cells
    • Chokki M., Eguchi H., Hamamura I., Mitsuhashi H., and Kamimura T. Human airway trypsin-like protease induces amphiregulin release through a mechanism involving protease-activated receptor-2-mediated ERK activation and TNF alpha-converting enzyme activity in airway epithelial cells. FEBS J 272 (2005) 6387-6399
    • (2005) FEBS J , vol.272 , pp. 6387-6399
    • Chokki, M.1    Eguchi, H.2    Hamamura, I.3    Mitsuhashi, H.4    Kamimura, T.5
  • 32
    • 0141816690 scopus 로고    scopus 로고
    • Differential expression and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells
    • Colognato R., Slupsky J.R., Jendrach M., Burysek L., Syrovets T., and Simmet T. Differential expression and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells. Blood 102 (2003) 2645-2652
    • (2003) Blood , vol.102 , pp. 2645-2652
    • Colognato, R.1    Slupsky, J.R.2    Jendrach, M.3    Burysek, L.4    Syrovets, T.5    Simmet, T.6
  • 33
  • 34
    • 2442692682 scopus 로고    scopus 로고
    • Protease-activated receptor 2 in colon cancer: trypsin-induced MAPK phosphorylation and cell proliferation are mediated by epidermal growth factor receptor transactivation
    • Darmoul D., Gratio V., Devaud H., and Laburthe M. Protease-activated receptor 2 in colon cancer: trypsin-induced MAPK phosphorylation and cell proliferation are mediated by epidermal growth factor receptor transactivation. J Biol Chem 279 (2004) 20927-20934
    • (2004) J Biol Chem , vol.279 , pp. 20927-20934
    • Darmoul, D.1    Gratio, V.2    Devaud, H.3    Laburthe, M.4
  • 35
    • 4644340883 scopus 로고    scopus 로고
    • Activation of proteinase-activated receptor 1 promotes human colon cancer cell proliferation through epidermal growth factor receptor transactivation
    • Darmoul D., Gratio V., Devaud H., Peiretti F., and Laburthe M. Activation of proteinase-activated receptor 1 promotes human colon cancer cell proliferation through epidermal growth factor receptor transactivation. Mol Cancer Res 2 (2004) 514-522
    • (2004) Mol Cancer Res , vol.2 , pp. 514-522
    • Darmoul, D.1    Gratio, V.2    Devaud, H.3    Peiretti, F.4    Laburthe, M.5
  • 36
    • 17844382426 scopus 로고    scopus 로고
    • Stimulation of protease-activated receptor-2 inhibits airway eosinophilia, hyperresponsiveness and bronchoconstriction in a murine model of allergic inflammation
    • De Campo B.A., and Henry P.J. Stimulation of protease-activated receptor-2 inhibits airway eosinophilia, hyperresponsiveness and bronchoconstriction in a murine model of allergic inflammation. Br J Pharmacol 144 (2005) 1100-1108
    • (2005) Br J Pharmacol , vol.144 , pp. 1100-1108
    • De Campo, B.A.1    Henry, P.J.2
  • 37
    • 0037372534 scopus 로고    scopus 로고
    • Proteinase-activated receptor-2 and human lung epithelial cells: disarming by neutrophil serine proteinases
    • Dulon S., Cande C., Bunnett N.W., Hollenberg M.D., Chignard D., and Pidard D. Proteinase-activated receptor-2 and human lung epithelial cells: disarming by neutrophil serine proteinases. Am J Respir Cell Mol Biol 28 (2003) 339-346
    • (2003) Am J Respir Cell Mol Biol , vol.28 , pp. 339-346
    • Dulon, S.1    Cande, C.2    Bunnett, N.W.3    Hollenberg, M.D.4    Chignard, D.5    Pidard, D.6
  • 38
    • 18244404006 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa elastase disables proteinase-activated receptor 2 in respiratory epithelial cells
    • Dulon S., Leduc D., Cottrell G.S., D'Alayer J., Hansen K.K., Bunnett N.W., et al. Pseudomonas aeruginosa elastase disables proteinase-activated receptor 2 in respiratory epithelial cells. Am J Respir Cell Mol Biol 32 (2005) 411-419
    • (2005) Am J Respir Cell Mol Biol , vol.32 , pp. 411-419
    • Dulon, S.1    Leduc, D.2    Cottrell, G.S.3    D'Alayer, J.4    Hansen, K.K.5    Bunnett, N.W.6
  • 39
    • 14844290334 scopus 로고    scopus 로고
    • Proteinase-activated receptor 2 activation in the airways enhances antigen-mediated airway inflammation and airway hyperresponsiveness through different pathways
    • Ebeling C., Forsythe P., Ng J., Gordon J.R., Hollenberg M., and Vliagoftis H. Proteinase-activated receptor 2 activation in the airways enhances antigen-mediated airway inflammation and airway hyperresponsiveness through different pathways. J Allergy Clin Immunol 115 (2005) 623-630
    • (2005) J Allergy Clin Immunol , vol.115 , pp. 623-630
    • Ebeling, C.1    Forsythe, P.2    Ng, J.3    Gordon, J.R.4    Hollenberg, M.5    Vliagoftis, H.6
  • 40
    • 29244436695 scopus 로고    scopus 로고
    • Protease-activated receptors-1 and -2 can mediate endothelial barrier protection: role in factor Xa signaling
    • Feistritzer C., Lenta R., and Riewald M. Protease-activated receptors-1 and -2 can mediate endothelial barrier protection: role in factor Xa signaling. J Thromb Haemost 3 (2005) 2798-2805
    • (2005) J Thromb Haemost , vol.3 , pp. 2798-2805
    • Feistritzer, C.1    Lenta, R.2    Riewald, M.3
  • 41
    • 1242314392 scopus 로고    scopus 로고
    • PAR1 antagonism protects against experimental liver fibrosis. Role of proteinase receptors in stellate cell activation
    • Fiorucci S., Antonelli E., Distrutti E., Severino B., Fiorentina R., Baldoni M., et al. PAR1 antagonism protects against experimental liver fibrosis. Role of proteinase receptors in stellate cell activation. Hepatology 39 (2004) 365-375
    • (2004) Hepatology , vol.39 , pp. 365-375
    • Fiorucci, S.1    Antonelli, E.2    Distrutti, E.3    Severino, B.4    Fiorentina, R.5    Baldoni, M.6
  • 42
    • 33745837481 scopus 로고    scopus 로고
    • Inflammatory conditions increase expression of protease-activated receptor-2 by human airway smooth muscle cells in culture
    • Freund-Michel V., and Frossard N. Inflammatory conditions increase expression of protease-activated receptor-2 by human airway smooth muscle cells in culture. Fundam Clin Pharmacol 20 (2006) 351-357
    • (2006) Fundam Clin Pharmacol , vol.20 , pp. 351-357
    • Freund-Michel, V.1    Frossard, N.2
  • 43
    • 0141958611 scopus 로고    scopus 로고
    • Differential expression of protease-activated receptors 1, 2, and 4 on human endothelial cells from different vascular sites
    • Fujiwara M., Jin E., Ghazizadeh M., and Kawanami O. Differential expression of protease-activated receptors 1, 2, and 4 on human endothelial cells from different vascular sites. Pathobiology 71 (2004) 52-58
    • (2004) Pathobiology , vol.71 , pp. 52-58
    • Fujiwara, M.1    Jin, E.2    Ghazizadeh, M.3    Kawanami, O.4
  • 44
    • 24344475612 scopus 로고    scopus 로고
    • Activation of PAR4 induces a distinct actin fiber formation via p38 MAPK in human lung endothelial cells
    • Fujiwara M., Jin E., Ghazizadeh M., and Kawanami O. Activation of PAR4 induces a distinct actin fiber formation via p38 MAPK in human lung endothelial cells. J Histochem Cytochem 53 (2005) 1121-1129
    • (2005) J Histochem Cytochem , vol.53 , pp. 1121-1129
    • Fujiwara, M.1    Jin, E.2    Ghazizadeh, M.3    Kawanami, O.4
  • 46
    • 0042326597 scopus 로고    scopus 로고
    • ADAM metalloproteases and EGFR signalling
    • Gee J.M., and Knowlden J.M. ADAM metalloproteases and EGFR signalling. Breast Cancer Res 5 (2003) 223-224
    • (2003) Breast Cancer Res , vol.5 , pp. 223-224
    • Gee, J.M.1    Knowlden, J.M.2
  • 47
    • 33747871452 scopus 로고    scopus 로고
    • Tumor-derived matrix metalloproteinase-1 targets endothelial proteinase-activated receptor 1 promoting endothelial cell activation
    • Goerge T., Barg A., Schnaeker E.M., Poppelmann B., Shpacovitch V., Rattenholl A., et al. Tumor-derived matrix metalloproteinase-1 targets endothelial proteinase-activated receptor 1 promoting endothelial cell activation. Cancer Res 66 (2006) 7766-7774
    • (2006) Cancer Res , vol.66 , pp. 7766-7774
    • Goerge, T.1    Barg, A.2    Schnaeker, E.M.3    Poppelmann, B.4    Shpacovitch, V.5    Rattenholl, A.6
  • 48
    • 28444451152 scopus 로고    scopus 로고
    • Activity of recombinant trypsin isoforms on human proteinase-activated receptors (PAR): mesotrypsin cannot activate epithelial PAR-1,-2, but weakly activates brain PAR-1
    • Grishina Z., Ostrowska E., Halangk W., Sahin-Tóth M., and Reiser G. Activity of recombinant trypsin isoforms on human proteinase-activated receptors (PAR): mesotrypsin cannot activate epithelial PAR-1,-2, but weakly activates brain PAR-1. Br J Pharmacol 146 (2005) 990-999
    • (2005) Br J Pharmacol , vol.146 , pp. 990-999
    • Grishina, Z.1    Ostrowska, E.2    Halangk, W.3    Sahin-Tóth, M.4    Reiser, G.5
  • 49
    • 6344269192 scopus 로고    scopus 로고
    • Protease-activated receptor-2 (PAR-2) expression in human fibroblasts is regulated by growth factors and extracellular matrix
    • Gruber B.L., Marchese M.J., Santiago-Schwarz F., Martin C.A., Zhang J., and Kew R.R. Protease-activated receptor-2 (PAR-2) expression in human fibroblasts is regulated by growth factors and extracellular matrix. J Invest Dermatol 123 (2004) 832-839
    • (2004) J Invest Dermatol , vol.123 , pp. 832-839
    • Gruber, B.L.1    Marchese, M.J.2    Santiago-Schwarz, F.3    Martin, C.A.4    Zhang, J.5    Kew, R.R.6
  • 50
    • 0034936715 scopus 로고    scopus 로고
    • Protease-activated receptor (PAR) 1 but not PAR2 or PAR4 mediates endothelium-dependent relaxation to thrombin and trypsin in human pulmonary arteries
    • Hamilton J.R., Moffatt J.D., Frauman A.G., and Cocks T.M. Protease-activated receptor (PAR) 1 but not PAR2 or PAR4 mediates endothelium-dependent relaxation to thrombin and trypsin in human pulmonary arteries. J Cardiovasc Pharmacol 38 (2001) 108-119
    • (2001) J Cardiovasc Pharmacol , vol.38 , pp. 108-119
    • Hamilton, J.R.1    Moffatt, J.D.2    Frauman, A.G.3    Cocks, T.M.4
  • 51
    • 0033848798 scopus 로고    scopus 로고
    • Prostaglandin E2 decreases allergen-stimulated release of prostaglandin D2 in airways of subjects with asthma
    • Hartert T.V., Dworski R.T., Mellen B.G., Oates J.A., Murray J.J., and Sheller J.R. Prostaglandin E2 decreases allergen-stimulated release of prostaglandin D2 in airways of subjects with asthma. Am J Respir Crit Care Med 162 (2000) 637-640
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 637-640
    • Hartert, T.V.1    Dworski, R.T.2    Mellen, B.G.3    Oates, J.A.4    Murray, J.J.5    Sheller, J.R.6
  • 53
    • 1642370953 scopus 로고    scopus 로고
    • Inhibitors of tryptase as mast cell-stabilizing agents in the human airways: effects of tryptase and other agonists of proteinase-activated receptor 2 on histamine release
    • He S., Aslam A., Gaca M.D., He Y., Buckley M.G., Hollenberg M.D., et al. Inhibitors of tryptase as mast cell-stabilizing agents in the human airways: effects of tryptase and other agonists of proteinase-activated receptor 2 on histamine release. J Pharmacol Exp Ther 309 (2004) 119-126
    • (2004) J Pharmacol Exp Ther , vol.309 , pp. 119-126
    • He, S.1    Aslam, A.2    Gaca, M.D.3    He, Y.4    Buckley, M.G.5    Hollenberg, M.D.6
  • 55
    • 1142285213 scopus 로고    scopus 로고
    • German cockroach extract activates protease-activated receptor 2 in human airway epithelial cells
    • Hong J.H., Lee S.I., Kim K.E., Yong T.S., Seo J.T., Sohn M.H., et al. German cockroach extract activates protease-activated receptor 2 in human airway epithelial cells. J Allergy Clin Immunol 113 (2004) 315-319
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 315-319
    • Hong, J.H.1    Lee, S.I.2    Kim, K.E.3    Yong, T.S.4    Seo, J.T.5    Sohn, M.H.6
  • 56
    • 0034795622 scopus 로고    scopus 로고
    • Direct thrombin inhibition reduces lung collagen, accumulation, and connective tissue growth factor mRNA levels in bleomycin-induced pulmonary fibrosis
    • Howell D.C., Goldsack N.R., Marshall R.P., McAnulty R.J., Starke R., Purdy G., et al. Direct thrombin inhibition reduces lung collagen, accumulation, and connective tissue growth factor mRNA levels in bleomycin-induced pulmonary fibrosis. Am J Pathol 159 (2001) 1383-1395
    • (2001) Am J Pathol , vol.159 , pp. 1383-1395
    • Howell, D.C.1    Goldsack, N.R.2    Marshall, R.P.3    McAnulty, R.J.4    Starke, R.5    Purdy, G.6
  • 57
    • 17844399243 scopus 로고    scopus 로고
    • Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis
    • Howell D.C., Johns R.H., Lasky J.A., Shan B., Scotton C.J., Laurent G.J., et al. Absence of proteinase-activated receptor-1 signaling affords protection from bleomycin-induced lung inflammation and fibrosis. Am J Pathol 166 (2005) 1353-1365
    • (2005) Am J Pathol , vol.166 , pp. 1353-1365
    • Howell, D.C.1    Johns, R.H.2    Lasky, J.A.3    Shan, B.4    Scotton, C.J.5    Laurent, G.J.6
  • 58
    • 0037394513 scopus 로고    scopus 로고
    • Coagulation, fibrinolysis, and fibrin deposition in acute lung injury
    • Idell S. Coagulation, fibrinolysis, and fibrin deposition in acute lung injury. Crit Care Med 31 (2003) S213-S220
    • (2003) Crit Care Med , vol.31
    • Idell, S.1
  • 59
    • 33644898880 scopus 로고    scopus 로고
    • Upregulation of protease-activated receptor-1 in astrocytes in Parkinson disease: astrocyte-mediated neuroprotection through increased levels of glutathione peroxidase
    • Ishida Y., Nagai A., Kobayashi S., and Kim S.U. Upregulation of protease-activated receptor-1 in astrocytes in Parkinson disease: astrocyte-mediated neuroprotection through increased levels of glutathione peroxidase. J Neuropathol Exp Neurol 65 (2006) 66-77
    • (2006) J Neuropathol Exp Neurol , vol.65 , pp. 66-77
    • Ishida, Y.1    Nagai, A.2    Kobayashi, S.3    Kim, S.U.4
  • 60
    • 0037303494 scopus 로고    scopus 로고
    • Protease-activated receptor (PAR)-1 and PAR-2 participate in the cell growth of alveolar capillary endothelium in primary lung adenocarcinomas
    • Jin E., Fujiwara M., Pan X., Ghazizadeh M., Arai S., Ohaki Y., et al. Protease-activated receptor (PAR)-1 and PAR-2 participate in the cell growth of alveolar capillary endothelium in primary lung adenocarcinomas. Cancer 97 (2003) 703-713
    • (2003) Cancer , vol.97 , pp. 703-713
    • Jin, E.1    Fujiwara, M.2    Pan, X.3    Ghazizadeh, M.4    Arai, S.5    Ohaki, Y.6
  • 62
    • 0034698062 scopus 로고    scopus 로고
    • Heparin blockade of thrombin-induced smooth muscle cell migration involves inhibition of epidermal growth factor (EGF) receptor transactivation by heparin-binding EGF-like growth factor
    • Kalmes A., Vesti B.R., Daum G., Abraham J.A., and Clowes A.W. Heparin blockade of thrombin-induced smooth muscle cell migration involves inhibition of epidermal growth factor (EGF) receptor transactivation by heparin-binding EGF-like growth factor. Circ Res 87 (2000) 92-98
    • (2000) Circ Res , vol.87 , pp. 92-98
    • Kalmes, A.1    Vesti, B.R.2    Daum, G.3    Abraham, J.A.4    Clowes, A.W.5
  • 63
    • 3142738892 scopus 로고    scopus 로고
    • Immunopathogenesis of allergic bronchopulmonary aspergillosis and airway remodeling
    • Kauffman H.F. Immunopathogenesis of allergic bronchopulmonary aspergillosis and airway remodeling. Front Biosci 8 (2003) e190-e196
    • (2003) Front Biosci , vol.8
    • Kauffman, H.F.1
  • 64
    • 0037529442 scopus 로고    scopus 로고
    • Interaction of environmental allergens with airway epithelium as a key component of asthma
    • Kauffman H.F. Interaction of environmental allergens with airway epithelium as a key component of asthma. Curr Allergy Asthma Rep 3 (2003) 101-108
    • (2003) Curr Allergy Asthma Rep , vol.3 , pp. 101-108
    • Kauffman, H.F.1
  • 65
    • 0033933005 scopus 로고    scopus 로고
    • Protease-dependent activation of epithelial cells by fungal allergens leads to morphologic changes and cytokine production
    • Kauffman H.F., Tomee J.F., van de Riet M.A., Timmerman A.J., and Borger P. Protease-dependent activation of epithelial cells by fungal allergens leads to morphologic changes and cytokine production. J Allergy Clin Immunol 105 (2000) 1185-1193
    • (2000) J Allergy Clin Immunol , vol.105 , pp. 1185-1193
    • Kauffman, H.F.1    Tomee, J.F.2    van de Riet, M.A.3    Timmerman, A.J.4    Borger, P.5
  • 66
    • 14644417853 scopus 로고    scopus 로고
    • Physiology and pathophysiology of proteinase-activated receptors (PARs): PARs in the respiratory system: cellular signaling and physiological/pathological roles
    • Kawabata A., and Kawao N. Physiology and pathophysiology of proteinase-activated receptors (PARs): PARs in the respiratory system: cellular signaling and physiological/pathological roles. J Pharmacol Sci 97 (2005) 20-24
    • (2005) J Pharmacol Sci , vol.97 , pp. 20-24
    • Kawabata, A.1    Kawao, N.2
  • 68
    • 0035184146 scopus 로고    scopus 로고
    • Protease-activated receptors in human airways: upregulation of PAR-2 in respiratory epithelium from patients with asthma
    • Knight D.A., Lim S., Scaffidi A.K., Roche N., Chung K.F., Stewart G.A., et al. Protease-activated receptors in human airways: upregulation of PAR-2 in respiratory epithelium from patients with asthma. J Allergy Clin Immunol 108 (2001) 797-803
    • (2001) J Allergy Clin Immunol , vol.108 , pp. 797-803
    • Knight, D.A.1    Lim, S.2    Scaffidi, A.K.3    Roche, N.4    Chung, K.F.5    Stewart, G.A.6
  • 69
    • 0036710168 scopus 로고    scopus 로고
    • Role of protease-activated receptors in airway function: a target for therapeutic intervention?
    • Lan R.S., Stewart G.A., and Henry P.J. Role of protease-activated receptors in airway function: a target for therapeutic intervention?. Pharmacol Ther 95 (2002) 239-257
    • (2002) Pharmacol Ther , vol.95 , pp. 239-257
    • Lan, R.S.1    Stewart, G.A.2    Henry, P.J.3
  • 71
    • 0034609557 scopus 로고    scopus 로고
    • Proteolysis of the exodomain of recombinant protease-activated receptors: prediction of receptor activation or inactivation by MALDI mass spectrometry
    • Loew D., Perrault C., Morales M., Moog S., Ravanat C., Schuhler S., et al. Proteolysis of the exodomain of recombinant protease-activated receptors: prediction of receptor activation or inactivation by MALDI mass spectrometry. Biochemistry 39 (2000) 10812-10822
    • (2000) Biochemistry , vol.39 , pp. 10812-10822
    • Loew, D.1    Perrault, C.2    Morales, M.3    Moog, S.4    Ravanat, C.5    Schuhler, S.6
  • 73
    • 20444497340 scopus 로고    scopus 로고
    • A novel mechanism of plasmin-induced mitogenesis in fibroblasts
    • Mandal S.K., Rao L.V., Tran T.T., and Pendurthi U.R. A novel mechanism of plasmin-induced mitogenesis in fibroblasts. J Thromb Haemost 3 (2005) 163-169
    • (2005) J Thromb Haemost , vol.3 , pp. 163-169
    • Mandal, S.K.1    Rao, L.V.2    Tran, T.T.3    Pendurthi, U.R.4
  • 74
    • 0037995630 scopus 로고    scopus 로고
    • Discovery of potent peptide-mimetic antagonists for the human thrombin receptor, protease-activated receptor-1 (PAR-1)
    • Maryanoff B.E., Zhang H.C., Andrade-Gordon P., and Derian C.K. Discovery of potent peptide-mimetic antagonists for the human thrombin receptor, protease-activated receptor-1 (PAR-1). Curr Med Chem Cardiovasc Hematol Agents 1 (2003) 13-36
    • (2003) Curr Med Chem Cardiovasc Hematol Agents , vol.1 , pp. 13-36
    • Maryanoff, B.E.1    Zhang, H.C.2    Andrade-Gordon, P.3    Derian, C.K.4
  • 75
    • 33644833762 scopus 로고    scopus 로고
    • Human airway trypsin-like protease stimulates human bronchial fibroblast proliferation in a protease-activated receptor-2-dependent pathway
    • Matsushima R., Takahashi A., Nakaya Y., Maezawa H., Miki M., Nakamura Y., et al. Human airway trypsin-like protease stimulates human bronchial fibroblast proliferation in a protease-activated receptor-2-dependent pathway. Am J Physiol Lung Cell Mol Physiol 290 (2006) L385-L395
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.290
    • Matsushima, R.1    Takahashi, A.2    Nakaya, Y.3    Maezawa, H.4    Miki, M.5    Nakamura, Y.6
  • 76
    • 0036159183 scopus 로고    scopus 로고
    • Expression of protease activated receptor-2 (PAR-2) in central airways of smokers and non-smokers
    • Miotto D., Hollenberg M.D., Bunnett N.W., Papi A., Braccioni F., Boschetto P., et al. Expression of protease activated receptor-2 (PAR-2) in central airways of smokers and non-smokers. Thorax 57 (2002) 146-151
    • (2002) Thorax , vol.57 , pp. 146-151
    • Miotto, D.1    Hollenberg, M.D.2    Bunnett, N.W.3    Papi, A.4    Braccioni, F.5    Boschetto, P.6
  • 77
    • 0036014824 scopus 로고    scopus 로고
    • Protease-activated receptor-2 activating peptide SLIGRL inhibits bacterial lipopolysaccharide-induced recruitment of polymorphonuclear leukocytes into the airways of mice
    • Moffatt J.D., Jeffrey K.L., and Cocks T.M. Protease-activated receptor-2 activating peptide SLIGRL inhibits bacterial lipopolysaccharide-induced recruitment of polymorphonuclear leukocytes into the airways of mice. Am J Respir Cell Mol Biol 26 (2002) 680-684
    • (2002) Am J Respir Cell Mol Biol , vol.26 , pp. 680-684
    • Moffatt, J.D.1    Jeffrey, K.L.2    Cocks, T.M.3
  • 78
    • 28244493665 scopus 로고    scopus 로고
    • A protective role for proteinase activated receptor 2 in airways of lipopolysaccharide-treated rats
    • Morello S., Vellecco V., Roviezzo F., Maffia P., Cuzzocrea S., Cirino G., et al. A protective role for proteinase activated receptor 2 in airways of lipopolysaccharide-treated rats. Biochem Pharmacol 71 (2005) 223-230
    • (2005) Biochem Pharmacol , vol.71 , pp. 223-230
    • Morello, S.1    Vellecco, V.2    Roviezzo, F.3    Maffia, P.4    Cuzzocrea, S.5    Cirino, G.6
  • 79
    • 1242272101 scopus 로고    scopus 로고
    • Thrombin up-regulates tissue factor pathway inhibitor-2 synthesis through a cyclooxygenase-2-dependent, epidermal growth factor receptor-independent mechanism
    • Neaud V., Duplantier J.G., Mazzocco C., Kisiel W., and Rosenbaum J. Thrombin up-regulates tissue factor pathway inhibitor-2 synthesis through a cyclooxygenase-2-dependent, epidermal growth factor receptor-independent mechanism. J Biol Chem 279 (2004) 5200-5206
    • (2004) J Biol Chem , vol.279 , pp. 5200-5206
    • Neaud, V.1    Duplantier, J.G.2    Mazzocco, C.3    Kisiel, W.4    Rosenbaum, J.5
  • 80
    • 18244394288 scopus 로고    scopus 로고
    • Activation of protease-activated receptor-1 triggers astrogliosis after brain injury
    • Nicole O., Goldshmidt A., Hamill C.E., Sorensen S., Sastre D., Lyuboslavsky P., et al. Activation of protease-activated receptor-1 triggers astrogliosis after brain injury. J Neurosci 25 (2005) 4319-4329
    • (2005) J Neurosci , vol.25 , pp. 4319-4329
    • Nicole, O.1    Goldshmidt, A.2    Hamill, C.E.3    Sorensen, S.4    Sastre, D.5    Lyuboslavsky, P.6
  • 81
    • 4544359022 scopus 로고    scopus 로고
    • PAR-1 deficiency protects against neuronal damage and neurologic deficits after unilateral cerebral hypoxia/ischemia
    • Olson E.E., Lyuboslavsky P., Traynelis S.F., and McKeon R.J. PAR-1 deficiency protects against neuronal damage and neurologic deficits after unilateral cerebral hypoxia/ischemia. J Cereb Blood Flow Metab 24 (2004) 964-971
    • (2004) J Cereb Blood Flow Metab , vol.24 , pp. 964-971
    • Olson, E.E.1    Lyuboslavsky, P.2    Traynelis, S.F.3    McKeon, R.J.4
  • 82
    • 15044340298 scopus 로고    scopus 로고
    • German cockroach proteases regulate interleukin-8 expression via nuclear factor for interleukin-6 in human bronchial epithelial cells
    • Page K., Hughes V.S., Odoms K.K., Dunsmore K.E., and Hershenson M.B. German cockroach proteases regulate interleukin-8 expression via nuclear factor for interleukin-6 in human bronchial epithelial cells. Am J Respir Cell Mol Biol 32 (2005) 225-231
    • (2005) Am J Respir Cell Mol Biol , vol.32 , pp. 225-231
    • Page, K.1    Hughes, V.S.2    Odoms, K.K.3    Dunsmore, K.E.4    Hershenson, M.B.5
  • 83
    • 33847725445 scopus 로고    scopus 로고
    • Inflammatory mediators modulate thrombin and cathepsin-G signaling in human bronchial fibroblasts by inducing expression of proteinase-activated receptor-4
    • Ramachandran R., Sadofsky L.R., Xiao Y., Botham A., Cowen M., Morice A.H., et al. Inflammatory mediators modulate thrombin and cathepsin-G signaling in human bronchial fibroblasts by inducing expression of proteinase-activated receptor-4. Am J Physiol Lung Cell Mol Physiol 292 (2007) L788-L798
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.292
    • Ramachandran, R.1    Sadofsky, L.R.2    Xiao, Y.3    Botham, A.4    Cowen, M.5    Morice, A.H.6
  • 84
    • 1242297568 scopus 로고    scopus 로고
    • Thrombin- and factor Xa-induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells
    • Rauch B.H., Millette E., Kenagy R.D., Daum G., and Clowes A.W. Thrombin- and factor Xa-induced DNA synthesis is mediated by transactivation of fibroblast growth factor receptor-1 in human vascular smooth muscle cells. Circ Res 94 (2004) 340-345
    • (2004) Circ Res , vol.94 , pp. 340-345
    • Rauch, B.H.1    Millette, E.2    Kenagy, R.D.3    Daum, G.4    Clowes, A.W.5
  • 85
    • 7944224566 scopus 로고    scopus 로고
    • The role of protease activation of inflammation in allergic respiratory diseases
    • (quiz 1009)
    • Reed C.E., and Kita H. The role of protease activation of inflammation in allergic respiratory diseases. J Allergy Clin Immunol 114 (2004) 997-1008 (quiz 1009)
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 997-1008
    • Reed, C.E.1    Kita, H.2
  • 86
    • 0030968521 scopus 로고    scopus 로고
    • Specific inhibition of thrombin-induced cell activation by the neutrophil proteinases elastase, cathepsin G, and proteinase 3: evidence for distinct cleavage sites within the aminoterminal domain of the thrombin receptor
    • Renesto P., Si-Tahar M., Moniatte M., Balloy V., Van Dorsselaer A., Pidard D., et al. Specific inhibition of thrombin-induced cell activation by the neutrophil proteinases elastase, cathepsin G, and proteinase 3: evidence for distinct cleavage sites within the aminoterminal domain of the thrombin receptor. Blood 89 (1997) 1944-1953
    • (1997) Blood , vol.89 , pp. 1944-1953
    • Renesto, P.1    Si-Tahar, M.2    Moniatte, M.3    Balloy, V.4    Van Dorsselaer, A.5    Pidard, D.6
  • 87
    • 21244502159 scopus 로고    scopus 로고
    • Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling
    • Riewald M., and Ruf W. Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling. J Biol Chem 280 (2005) 19808-19814
    • (2005) J Biol Chem , vol.280 , pp. 19808-19814
    • Riewald, M.1    Ruf, W.2
  • 88
    • 0037373484 scopus 로고    scopus 로고
    • Regulation of protease-activated receptor-1 in mononuclear cells by neutrophil proteases
    • Roche N., Stirling R.G., Lim S., Oliver B.G., and Chung K.F. Regulation of protease-activated receptor-1 in mononuclear cells by neutrophil proteases. Respir Med 97 (2003) 228-233
    • (2003) Respir Med , vol.97 , pp. 228-233
    • Roche, N.1    Stirling, R.G.2    Lim, S.3    Oliver, B.G.4    Chung, K.F.5
  • 89
    • 0037327047 scopus 로고    scopus 로고
    • Effect of acute and chronic inflammatory stimuli on expression of protease-activated receptors 1 and 2 in alveolar macrophages
    • Roche N., Stirling R.G., Lim S., Oliver B.G., Oates T., Jazrawi E., et al. Effect of acute and chronic inflammatory stimuli on expression of protease-activated receptors 1 and 2 in alveolar macrophages. J Allergy Clin Immunol 111 (2003) 367-373
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 367-373
    • Roche, N.1    Stirling, R.G.2    Lim, S.3    Oliver, B.G.4    Oates, T.5    Jazrawi, E.6
  • 90
    • 0141498162 scopus 로고    scopus 로고
    • Specificity of coagulation factor signaling
    • Ruf W., Dorfleutner A., and Riewald M. Specificity of coagulation factor signaling. J Thromb Haemost 1 (2003) 1495-1503
    • (2003) J Thromb Haemost , vol.1 , pp. 1495-1503
    • Ruf, W.1    Dorfleutner, A.2    Riewald, M.3
  • 91
    • 0037144657 scopus 로고    scopus 로고
    • Protease-activated receptor-1-mediated DNA synthesis in cardiac fibroblast is via epidermal growth factor receptor transactivation: distinct PAR-1 signaling pathways in cardiac fibroblasts and cardiomyocytes
    • Sabri A., Short J., Guo J., and Steinberg S.F. Protease-activated receptor-1-mediated DNA synthesis in cardiac fibroblast is via epidermal growth factor receptor transactivation: distinct PAR-1 signaling pathways in cardiac fibroblasts and cardiomyocytes. Circ Res 91 (2002) 532-539
    • (2002) Circ Res , vol.91 , pp. 532-539
    • Sabri, A.1    Short, J.2    Guo, J.3    Steinberg, S.F.4
  • 92
    • 0242405834 scopus 로고    scopus 로고
    • Potential action of IL-4 and IL-13 as fibrogenic factors on lung fibroblasts in vitro
    • Saito A., Okazaki H., Sugawara I., Yamamoto K., and Takizawa H. Potential action of IL-4 and IL-13 as fibrogenic factors on lung fibroblasts in vitro. Int Arch Allergy Immunol 132 (2003) 168-176
    • (2003) Int Arch Allergy Immunol , vol.132 , pp. 168-176
    • Saito, A.1    Okazaki, H.2    Sugawara, I.3    Yamamoto, K.4    Takizawa, H.5
  • 95
    • 1842791473 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor is induced by thrombin and factor Xa in endothelial cells
    • Shimizu T., Nishihira J., Watanabe H., Abe R., Honda A., Ishibashi T., et al. Macrophage migration inhibitory factor is induced by thrombin and factor Xa in endothelial cells. J Biol Chem 279 (2004) 13729-13737
    • (2004) J Biol Chem , vol.279 , pp. 13729-13737
    • Shimizu, T.1    Nishihira, J.2    Watanabe, H.3    Abe, R.4    Honda, A.5    Ishibashi, T.6
  • 96
    • 17444425677 scopus 로고    scopus 로고
    • Protease-activated receptor-1 in human lung fibroblasts mediates a negative feedback downregulation via prostaglandin E2
    • Sokolova E., Grishina Z., Bühling F., Welte T., and Reiser G. Protease-activated receptor-1 in human lung fibroblasts mediates a negative feedback downregulation via prostaglandin E2. Am J Physiol Lung Cell Mol Physiol 288 (2005) L793-L802
    • (2005) Am J Physiol Lung Cell Mol Physiol , vol.288
    • Sokolova, E.1    Grishina, Z.2    Bühling, F.3    Welte, T.4    Reiser, G.5
  • 97
    • 11244297746 scopus 로고    scopus 로고
    • The cardiovascular actions of protease-activated receptors
    • Steinberg S.F. The cardiovascular actions of protease-activated receptors. Mol Pharmacol 67 (2005) 2-11
    • (2005) Mol Pharmacol , vol.67 , pp. 2-11
    • Steinberg, S.F.1
  • 98
    • 0038720558 scopus 로고    scopus 로고
    • Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin
    • Steinhoff M., Neisius U., Ikoma A., Fartasch M., Heyer G., Skov P.S., et al. Proteinase-activated receptor-2 mediates itch: a novel pathway for pruritus in human skin. J Neurosci 23 (2003) 6176-6180
    • (2003) J Neurosci , vol.23 , pp. 6176-6180
    • Steinhoff, M.1    Neisius, U.2    Ikoma, A.3    Fartasch, M.4    Heyer, G.5    Skov, P.S.6
  • 99
    • 13444249470 scopus 로고    scopus 로고
    • Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response
    • Steinhoff M., Buddenkotte J., Shpacovitch V., Rattenholl A., Moormann C., Vergnolle N., et al. Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response. Endocr Rev 26 (2005) 1-43
    • (2005) Endocr Rev , vol.26 , pp. 1-43
    • Steinhoff, M.1    Buddenkotte, J.2    Shpacovitch, V.3    Rattenholl, A.4    Moormann, C.5    Vergnolle, N.6
  • 100
    • 0034053127 scopus 로고    scopus 로고
    • The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations
    • Striggow F., Riek M., Breder J., Henrich Noack P., Reymann K.G., and Reiser G. The protease thrombin is an endogenous mediator of hippocampal neuroprotection against ischemia at low concentrations but causes degeneration at high concentrations. Proc Natl Acad Sci U S A 97 (2000) 2264-2269
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 2264-2269
    • Striggow, F.1    Riek, M.2    Breder, J.3    Henrich Noack, P.4    Reymann, K.G.5    Reiser, G.6
  • 101
    • 23444455036 scopus 로고    scopus 로고
    • Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms
    • Su X., Camerer E., Hamilton J.R., Coughlin S.R., and Matthay M.A. Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms. J Immunol 175 (2005) 2598-2605
    • (2005) J Immunol , vol.175 , pp. 2598-2605
    • Su, X.1    Camerer, E.2    Hamilton, J.R.3    Coughlin, S.R.4    Matthay, M.A.5
  • 102
    • 0035879347 scopus 로고    scopus 로고
    • Interaction of mite allergens Der p3 and Der p9 with protease-activated receptor-2 expressed by lung epithelial cells
    • Sun G., Stacey M.A., Schmidt M., Mori L., and Mattoli S. Interaction of mite allergens Der p3 and Der p9 with protease-activated receptor-2 expressed by lung epithelial cells. J Immunol 167 (2001) 1014-1021
    • (2001) J Immunol , vol.167 , pp. 1014-1021
    • Sun, G.1    Stacey, M.A.2    Schmidt, M.3    Mori, L.4    Mattoli, S.5
  • 104
    • 0035087724 scopus 로고    scopus 로고
    • Localization of human airway trypsin-like protease in the airway: an immunohistochemical study
    • Takahashi M., Sano T., Yamaoka K., Kamimura T., Umemoto N., Nishitani H., et al. Localization of human airway trypsin-like protease in the airway: an immunohistochemical study. Histochem Cell Biol 115 (2001) 181-187
    • (2001) Histochem Cell Biol , vol.115 , pp. 181-187
    • Takahashi, M.1    Sano, T.2    Yamaoka, K.3    Kamimura, T.4    Umemoto, N.5    Nishitani, H.6
  • 105
    • 20444383923 scopus 로고    scopus 로고
    • Abrogation of bronchial eosinophilic inflammation and attenuated eotaxin content in protease-activated receptor 2-deficient mice
    • Takizawa T., Tamiya M., Hara T., Matsumoto J., Saito N., Kanke T., et al. Abrogation of bronchial eosinophilic inflammation and attenuated eotaxin content in protease-activated receptor 2-deficient mice. J Pharmacol Sci 98 (2005) 99-102
    • (2005) J Pharmacol Sci , vol.98 , pp. 99-102
    • Takizawa, T.1    Tamiya, M.2    Hara, T.3    Matsumoto, J.4    Saito, N.5    Kanke, T.6
  • 106
    • 0037349117 scopus 로고    scopus 로고
    • Protease-activated receptor (PAR)-independent growth and pro-inflammatory actions of thrombin on human cultured airway smooth muscle
    • Tran T., and Stewart A.G. Protease-activated receptor (PAR)-independent growth and pro-inflammatory actions of thrombin on human cultured airway smooth muscle. Br J Pharmacol 138 (2003) 865-875
    • (2003) Br J Pharmacol , vol.138 , pp. 865-875
    • Tran, T.1    Stewart, A.G.2
  • 108
    • 0036006726 scopus 로고    scopus 로고
    • Four subtypes of protease-activated receptors, co-expressed in rat astrocytes, evoke different physiological signaling
    • Wang H., Ubl J.J., and Reiser G. Four subtypes of protease-activated receptors, co-expressed in rat astrocytes, evoke different physiological signaling. Glia 37 (2002) 53-63
    • (2002) Glia , vol.37 , pp. 53-63
    • Wang, H.1    Ubl, J.J.2    Reiser, G.3
  • 109
    • 0036838021 scopus 로고    scopus 로고
    • Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways
    • Wang H., Ubl J.J., Stricker R., and Reiser G. Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways. Am J Physiol Cell Physiol 283 (2002) C1351-C1364
    • (2002) Am J Physiol Cell Physiol , vol.283
    • Wang, H.1    Ubl, J.J.2    Stricker, R.3    Reiser, G.4
  • 110
    • 33750077249 scopus 로고    scopus 로고
    • Mesotrypsin, a brain trypsin, activates selectively proteinase-activated receptor-1, but not proteinase-activated receptor-2, in rat astrocytes
    • Wang Y., Luo W., Wartmann T., Halangk W., Sahin-Toth M., and Reiser G. Mesotrypsin, a brain trypsin, activates selectively proteinase-activated receptor-1, but not proteinase-activated receptor-2, in rat astrocytes. J Neurochem 99 (2006) 759-769
    • (2006) J Neurochem , vol.99 , pp. 759-769
    • Wang, Y.1    Luo, W.2    Wartmann, T.3    Halangk, W.4    Sahin-Toth, M.5    Reiser, G.6
  • 111
    • 0028924146 scopus 로고
    • Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2
    • Wilborn J., Crofford L.J., Burdick M.D., Kunkel S.L., Strieter R.M., and Peters-Golden M. Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2. J Clin Invest 95 (1995) 1861-1868
    • (1995) J Clin Invest , vol.95 , pp. 1861-1868
    • Wilborn, J.1    Crofford, L.J.2    Burdick, M.D.3    Kunkel, S.L.4    Strieter, R.M.5    Peters-Golden, M.6
  • 112
    • 33745231782 scopus 로고    scopus 로고
    • Blockade of angiogenesis by small molecule antagonists to protease-activated receptor-1: association with endothelial cell growth suppression and induction of apoptosis
    • Zania P., Kritikou S., Flordellis C.S., Maragoudakis M.E., and Tsopanoglou N.E. Blockade of angiogenesis by small molecule antagonists to protease-activated receptor-1: association with endothelial cell growth suppression and induction of apoptosis. J Pharmacol Exp Ther 318 (2006) 246-254
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 246-254
    • Zania, P.1    Kritikou, S.2    Flordellis, C.S.3    Maragoudakis, M.E.4    Tsopanoglou, N.E.5
  • 113
    • 0035966876 scopus 로고    scopus 로고
    • Discovery and optimization of a novel series of thrombin receptor (par-1) antagonists: potent, selective peptide mimetics based on indole and indazole templates
    • Zhang H.C., Derian C.K., Andrade-Gordon P., Hoekstra W.J., McComsey D.F., White K.B., et al. Discovery and optimization of a novel series of thrombin receptor (par-1) antagonists: potent, selective peptide mimetics based on indole and indazole templates. J Med Chem 44 (2001) 1021-1024
    • (2001) J Med Chem , vol.44 , pp. 1021-1024
    • Zhang, H.C.1    Derian, C.K.2    Andrade-Gordon, P.3    Hoekstra, W.J.4    McComsey, D.F.5    White, K.B.6


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