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Volumn 60, Issue 1, 2003, Pages 29-35

Proteinase-activated receptors and the pathophysiology of pulmonary fibrosis

Author keywords

Bleomycin; PARs; Pulmonary fibrosis

Indexed keywords

BLEOMYCIN; COLLAGEN; HIRUDIN; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 1 ANTAGONIST; RECEPTOR BLOCKING AGENT; THROMBIN; THROMBIN INHIBITOR; UNCLASSIFIED DRUG;

EID: 0042819773     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.10317     Document Type: Review
Times cited : (14)

References (52)
  • 1
    • 0036051343 scopus 로고    scopus 로고
    • Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta
    • Abreu JG, Ketpura NI, Reversade B, De Robertis EM. 2002. Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta. Nat Cell Biol 4:599-604.
    • (2002) Nat Cell Biol , vol.4 , pp. 599-604
    • Abreu, J.G.1    Ketpura, N.I.2    Reversade, B.3    De Robertis, E.M.4
  • 3
    • 0033258181 scopus 로고    scopus 로고
    • Enhanced insulin-like growth factor binding protein-related protein 2 (connective tissue growth factor) expression in patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis
    • Allen JT, Knight RA, Bloor CA, Spiteri MA. 1999. Enhanced insulin-like growth factor binding protein-related protein 2 (connective tissue growth factor) expression in patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis. Am J Respir Cell Mol Biol 21:693-700.
    • (1999) Am J Respir Cell Mol Biol , vol.21 , pp. 693-700
    • Allen, J.T.1    Knight, R.A.2    Bloor, C.A.3    Spiteri, M.A.4
  • 4
    • 0036533649 scopus 로고    scopus 로고
    • Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells
    • Asokananthan N, Graham PT, Fink J, Knight DA, Bakker AJ, McWilliam AS, Thompson PJ, Stewart GA. 2002. Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells. J Immunol 168:3577-3585.
    • (2002) J Immunol , vol.168 , pp. 3577-3585
    • Asokananthan, N.1    Graham, P.T.2    Fink, J.3    Knight, D.A.4    Bakker, A.J.5    McWilliam, A.S.6    Thompson, P.J.7    Stewart, G.A.8
  • 5
    • 0030470167 scopus 로고    scopus 로고
    • Trypsin stimulates proteinase-activated receptor-2-dependent and -independent activation of mitogen-activated protein kinases
    • Belham CM, Tate RJ, Scott PH, Pemberton AD, Miller HR, Wadsworth RM, Gould GW, Plevin R. 1996. Trypsin stimulates proteinase-activated receptor-2-dependent and -independent activation of mitogen-activated protein kinases. Biochem J 320:939-946.
    • (1996) Biochem J , vol.320 , pp. 939-946
    • Belham, C.M.1    Tate, R.J.2    Scott, P.H.3    Pemberton, A.D.4    Miller, H.R.5    Wadsworth, R.M.6    Gould, G.W.7    Plevin, R.8
  • 6
    • 0035976915 scopus 로고    scopus 로고
    • Thrombin differentiates normal lung fibroblasts to a myofibroblast phenotype via the proteolytically activated receptor-1 and a protein kinase C-dependent pathway
    • Bogatkevich GS, Tourkina E, Silver RM, Ludwicka-Bradley A. 2001. Thrombin differentiates normal lung fibroblasts to a myofibroblast phenotype via the proteolytically activated receptor-1 and a protein kinase C-dependent pathway. J Biol Chem 276:45184-45192.
    • (2001) J Biol Chem , vol.276 , pp. 45184-45192
    • Bogatkevich, G.S.1    Tourkina, E.2    Silver, R.M.3    Ludwicka-Bradley, A.4
  • 8
    • 0030952324 scopus 로고    scopus 로고
    • Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts
    • Cairns JA, Walls AF. 1997. Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts. J Clin Invest 99:1313-1321.
    • (1997) J Clin Invest , vol.99 , pp. 1313-1321
    • Cairns, J.A.1    Walls, A.F.2
  • 9
    • 0037013268 scopus 로고    scopus 로고
    • Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells
    • Camerer E, Kataoka H, Kahn M, Lease K, Coughlin SR. 2002. Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells. J Biol Chem 277:16081-16087.
    • (2002) J Biol Chem , vol.277 , pp. 16081-16087
    • Camerer, E.1    Kataoka, H.2    Kahn, M.3    Lease, K.4    Coughlin, S.R.5
  • 10
    • 0032126368 scopus 로고    scopus 로고
    • Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1
    • Chambers RC, Dabbagh K, McAnulty RJ, Gray AJ, Blanc Brude OP, Laurent GJ. 1998. Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1. Biochem J 333:121-127.
    • (1998) Biochem J , vol.333 , pp. 121-127
    • Chambers, R.C.1    Dabbagh, K.2    McAnulty, R.J.3    Gray, A.J.4    Blanc Brude, O.P.5    Laurent, G.J.6
  • 12
    • 0034634622 scopus 로고    scopus 로고
    • Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1
    • Chambers RC, Leoni P, Blanc-Brude OP, Wembridge DE, Laurent GJ. 2000. Thrombin is a potent inducer of connective tissue growth factor production via proteolytic activation of protease-activated receptor-1. J Biol Chem 275:35584-35591.
    • (2000) J Biol Chem , vol.275 , pp. 35584-35591
    • Chambers, R.C.1    Leoni, P.2    Blanc-Brude, O.P.3    Wembridge, D.E.4    Laurent, G.J.5
  • 13
    • 0028222277 scopus 로고
    • Expression of monocyte chemotactic protein-1 by monocytes and endothelial cells exposed to thrombin
    • Colotta F, Sciacca FL, Sironi M, Luini W, Rabiet MJ, Mantovani A. 1994. Expression of monocyte chemotactic protein-1 by monocytes and endothelial cells exposed to thrombin. Am J Pathol 144:975-985.
    • (1994) Am J Pathol , vol.144 , pp. 975-985
    • Colotta, F.1    Sciacca, F.L.2    Sironi, M.3    Luini, W.4    Rabiet, M.J.5    Mantovani, A.6
  • 14
    • 0034614895 scopus 로고    scopus 로고
    • Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis
    • Cunningham MA, Rondeau E, Chen X, Coughlin R, Holdsworth SR, Tipping PG. 2000. Protease-activated receptor 1 mediates thrombin-dependent, cell-mediated renal inflammation in crescentic glomerulonephritis. J Exp Med 191:455-462.
    • (2000) J Exp Med , vol.191 , pp. 455-462
    • Cunningham, M.A.1    Rondeau, E.2    Chen, X.3    Coughlin, R.4    Holdsworth, S.R.5    Tipping, P.G.6
  • 15
    • 0027240440 scopus 로고
    • Thrombin stimulates fibroblast chemotaxis and replication
    • Dawes KE, Gray AJ, Laurent GJ. 1993. Thrombin stimulates fibroblast chemotaxis and replication. Eur J Cell Biol 61:126-130.
    • (1993) Eur J Cell Biol , vol.61 , pp. 126-130
    • Dawes, K.E.1    Gray, A.J.2    Laurent, G.J.3
  • 17
    • 0030054203 scopus 로고    scopus 로고
    • Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene
    • Eitzman DT, McCoy RD, Zheng X, Fay WP, Shen T, Ginsburg D, Simon RH. 1996. Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene. J Clin Invest 97:232-237.
    • (1996) J Clin Invest , vol.97 , pp. 232-237
    • Eitzman, D.T.1    McCoy, R.D.2    Zheng, X.3    Fay, W.P.4    Shen, T.5    Ginsburg, D.6    Simon, R.H.7
  • 18
    • 0034912330 scopus 로고    scopus 로고
    • Role of coagulation inhibitors in inflammation
    • Esmon CT. 2001. Role of coagulation inhibitors in inflammation. Thromb Haemost 86:51-56.
    • (2001) Thromb Haemost , vol.86 , pp. 51-56
    • Esmon, C.T.1
  • 19
    • 0031225015 scopus 로고    scopus 로고
    • Connective tissue growth factor: A mediator of TGF-beta action on fibroblasts
    • Grotendorst GR. 1997. Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts. Cytokine Growth Factor Rev 8:171-179.
    • (1997) Cytokine Growth Factor Rev , vol.8 , pp. 171-179
    • Grotendorst, G.R.1
  • 23
    • 0034795622 scopus 로고    scopus 로고
    • Direct thrombin inhibition reduces lung collagen, accumulation, and connective tissue growth factor mRNA levels in bleomycin-induced pulmonary fibrosis
    • Howell DC, Goldsack NR, Marshall RP, McAnulty RJ, Starke R, Purdy G, Laurent GJ, Chambers RC. 2001. Direct thrombin inhibition reduces lung collagen, accumulation, and connective tissue growth factor mRNA levels in bleomycin-induced pulmonary fibrosis. Am J Pathol 159:1383-1395.
    • (2001) Am J Pathol , vol.159 , pp. 1383-1395
    • Howell, D.C.1    Goldsack, N.R.2    Marshall, R.P.3    McAnulty, R.J.4    Starke, R.5    Purdy, G.6    Laurent, G.J.7    Chambers, R.C.8
  • 24
    • 0036549805 scopus 로고    scopus 로고
    • Role of thrombin and its major cellular receptor, protease-activated receptor-1, in pulmonary fibrosis
    • Howell DC, Laurent GJ, Chambers RC. 2002. Role of thrombin and its major cellular receptor, protease-activated receptor-1, in pulmonary fibrosis. Biochem Soc Trans 30:211-216.
    • (2002) Biochem Soc Trans , vol.30 , pp. 211-216
    • Howell, D.C.1    Laurent, G.J.2    Chambers, R.C.3
  • 25
    • 0029899775 scopus 로고    scopus 로고
    • Mortality rates from cryptogenic fibrosing alveolitis in seven countries
    • Hubbard R, Johnston I, Coultas DB, Britton J. 1996. Mortality rates from cryptogenic fibrosing alveolitis in seven countries, Thorax 51:711-716.
    • (1996) Thorax , vol.51 , pp. 711-716
    • Hubbard, R.1    Johnston, I.2    Coultas, D.B.3    Britton, J.4
  • 26
    • 0037394513 scopus 로고    scopus 로고
    • Coagulation, fibrinolysis, and fibrin deposition in acute lung injury
    • Idell S. 2003. Coagulation, fibrinolysis, and fibrin deposition in acute lung injury. Crit Care Med 31:S213-S220.
    • (2003) Crit Care Med , vol.31
    • Idell, S.1
  • 27
    • 0030791559 scopus 로고    scopus 로고
    • Tissue factor expression and fibrin deposition in the lungs of patients with idiopathic pulmonary fibrosis and systemic sclerosis
    • Imokawa S, Sato A, Hayakawa H, Kotani M, Urano T, Takada A. 1997. Tissue factor expression and fibrin deposition in the lungs of patients with idiopathic pulmonary fibrosis and systemic sclerosis. Am J Respir Crit Care Med 156:631-636.
    • (1997) Am J Respir Crit Care Med , vol.156 , pp. 631-636
    • Imokawa, S.1    Sato, A.2    Hayakawa, H.3    Kotani, M.4    Urano, T.5    Takada, A.6
  • 29
  • 31
    • 0042867247 scopus 로고    scopus 로고
    • Thrombin enhancement of interleukin-1 expression in mononuclear cells: Involvement of proteinase-activated receptor-1
    • Naldini A, Pucci A, Carney DH, Fanetti G, Carraro F. 2002. Thrombin enhancement of interleukin-1 expression in mononuclear cells: involvement of proteinase-activated receptor-1. Cytokine 20:191-199.
    • (2002) Cytokine , vol.20 , pp. 191-199
    • Naldini, A.1    Pucci, A.2    Carney, D.H.3    Fanetti, G.4    Carraro, F.5
  • 32
    • 0028418608 scopus 로고
    • Scleroderma bronchoalveolar lavage fluid contains thrombin, a mediator of human lung fibroblast proliferation via induction of platelet-derived growth factor alpha-receptor
    • Ohba T, McDonald JK, Silver RM, Strange C, LeRoy EC, Ludwicka A. 1994. Scleroderma bronchoalveolar lavage fluid contains thrombin, a mediator of human lung fibroblast proliferation via induction of platelet-derived growth factor alpha-receptor. Am J Respir Cell Mol Biol 10:405-412.
    • (1994) Am J Respir Cell Mol Biol , vol.10 , pp. 405-412
    • Ohba, T.1    McDonald, J.K.2    Silver, R.M.3    Strange, C.4    LeRoy, E.C.5    Ludwicka, A.6
  • 33
    • 0029118192 scopus 로고
    • Changes in procoagulant and fibrinolytic gene expression during bleomycin-induced lung injury in the mouse
    • Olman MA, Mackman N, Gladson CL, Moser KM, Loskutoff DJ, 1995. Changes in procoagulant and fibrinolytic gene expression during bleomycin-induced lung injury in the mouse. J Clin Invest 96:1621-1630.
    • (1995) J Clin Invest , vol.96 , pp. 1621-1630
    • Olman, M.A.1    Mackman, N.2    Gladson, C.L.3    Moser, K.M.4    Loskutoff, D.J.5
  • 34
    • 0034640499 scopus 로고    scopus 로고
    • Factor VIIa and thrombin induce the expression of cyr61 and connective tissue growth factor, extracellular matrix signalling proteins that could act as possible downstream mediators in factor VIIa-tissue factor-induced signal transduction
    • Pendurthi UR, Allen KE, Ezban M, Rao LV. 2000. Factor VIIa and thrombin induce the expression of cyr61 and connective tissue growth factor, extracellular matrix signalling proteins that could act as possible downstream mediators in factor VIIa-tissue factor-induced signal transduction. J Biol Chem 275:14632-14641.
    • (2000) J Biol Chem , vol.275 , pp. 14632-14641
    • Pendurthi, U.R.1    Allen, K.E.2    Ezban, M.3    Rao, L.V.4
  • 35
    • 0025370725 scopus 로고
    • Intra-alveolar fibrosis of idiopathic bronchiolitis obliterans-organizing pneumonia. Cell-matrix patterns
    • Peyrol S, Cordier JF, Grimaud JA. 1990. Intra-alveolar fibrosis of idiopathic bronchiolitis obliterans-organizing pneumonia. Cell-matrix patterns. Am J Pathol 137:155-170.
    • (1990) Am J Pathol , vol.137 , pp. 155-170
    • Peyrol, S.1    Cordier, J.F.2    Grimaud, J.A.3
  • 36
    • 10244243727 scopus 로고    scopus 로고
    • Heparin attenuates bleomycin but not silica-induced pulmonary fibrosis in mice: Possible relationship with involvement of myofibroblasts in bleomycin, and fibroblasts in silica-induced fibrosis
    • Piguet PF, Van GY, Guo J. 1996. Heparin attenuates bleomycin but not silica-induced pulmonary fibrosis in mice: possible relationship with involvement of myofibroblasts in bleomycin, and fibroblasts in silica-induced fibrosis. Int J Exp Pathol 77:155-161.
    • (1996) Int J Exp Pathol , vol.77 , pp. 155-161
    • Piguet, P.F.1    Van, G.Y.2    Guo, J.3
  • 38
    • 0034933683 scopus 로고    scopus 로고
    • Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor
    • Riewald M, Ruf W. 2001. Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor. Proc Natl Acad Sci U S A 98:7742-7747.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 7742-7747
    • Riewald, M.1    Ruf, W.2
  • 39
    • 0037036069 scopus 로고    scopus 로고
    • Activation of endothelial cell protease activated receptor 1 by the protein C pathway
    • Riewald M, Petrovan RJ, Donner A, Mueller BM, Ruf W. 2002. Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science 296:1880-1882.
    • (2002) Science , vol.296 , pp. 1880-1882
    • Riewald, M.1    Petrovan, R.J.2    Donner, A.3    Mueller, B.M.4    Ruf, W.5
  • 41
    • 0030065943 scopus 로고    scopus 로고
    • Identification of a thrombin response element in the human platelet-derived growth factor B-chain (c-sis) promoter
    • Scarpati EM, DiCorleto PE. 1996. Identification of a thrombin response element in the human platelet-derived growth factor B-chain (c-sis) promoter. J Biol Chem 271:3025-3032.
    • (1996) J Biol Chem , vol.271 , pp. 3025-3032
    • Scarpati, E.M.1    DiCorleto, P.E.2
  • 42
    • 0037372379 scopus 로고    scopus 로고
    • Protein kinase C modulates pulmonary endothelial permeability: A paradigm for acute lung injury
    • Siflinger-Birnboim A, Johnson A. 2003. Protein kinase C modulates pulmonary endothelial permeability: a paradigm for acute lung injury. Am J Physiol Lung Cell Mol Physiol 284:LA38-LA51.
    • (2003) Am J Physiol Lung Cell Mol Physiol , vol.284
    • Siflinger-Birnboim, A.1    Johnson, A.2
  • 43
    • 0029011957 scopus 로고
    • Thrombin induces IL-6 production in fibroblasts and epithelial cells. Evidence for the involvement of the seven-transmembrane domain (STD) receptor for alpha-thrombin
    • Sower LE, Froelich CJ, Carney DH, Fenton JW, Klimpel GR. 1995. Thrombin induces IL-6 production in fibroblasts and epithelial cells. Evidence for the involvement of the seven-transmembrane domain (STD) receptor for alpha-thrombin. J Immunol 155:895-901.
    • (1995) J Immunol , vol.155 , pp. 895-901
    • Sower, L.E.1    Froelich, C.J.2    Carney, D.H.3    Fenton, J.W.4    Klimpel, G.R.5
  • 44
    • 0026486191 scopus 로고
    • Thrombin-induced expression of endothelial P-selectin and intercellular adhesion molecule-1: A mechanism for stabilizing neutrophil adhesion
    • Sugama Y, Tiruppathi C, Offakidevi K, Andersen TT, Fenton JW II, Malik AB. 1992. Thrombin-induced expression of endothelial P-selectin and intercellular adhesion molecule-1: a mechanism for stabilizing neutrophil adhesion. J Cell Biol 119:935-944.
    • (1992) J Cell Biol , vol.119 , pp. 935-944
    • Sugama, Y.1    Tiruppathi, C.2    Offakidevi, K.3    Andersen, T.T.4    Fenton J.W. II5    Malik, A.B.6
  • 45
    • 0034714379 scopus 로고    scopus 로고
    • Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates
    • Takeuchi T, Harris JL, Huang W, Yan KW, Coughlin SR, Craik CS. 2000. Cellular localization of membrane-type serine protease 1 and identification of protease-activated receptor-2 and single-chain urokinase-type plasminogen activator as substrates. J Biol Chem 275:26333-26342.
    • (2000) J Biol Chem , vol.275 , pp. 26333-26342
    • Takeuchi, T.1    Harris, J.L.2    Huang, W.3    Yan, K.W.4    Coughlin, S.R.5    Craik, C.S.6
  • 46
    • 0031196958 scopus 로고    scopus 로고
    • Thrombin stimulates platelet-derived growth factor release by alveolar macrophages in rats-significance in bleomycin-induced pulmonary fibrosis
    • Tani K, Ogushi F, Takahashi H, Kawano T, Endo T, Sone S. 1997. Thrombin stimulates platelet-derived growth factor release by alveolar macrophages in rats-significance in bleomycin-induced pulmonary fibrosis. J Med Invest 44:59-65.
    • (1997) J Med Invest , vol.44 , pp. 59-65
    • Tani, K.1    Ogushi, F.2    Takahashi, H.3    Kawano, T.4    Endo, T.5    Sone, S.6
  • 47
    • 0029812590 scopus 로고    scopus 로고
    • The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice
    • Trejo J, Connolly AJ, Coughlin SR. 1996. The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice. J Biol Chem 271:21536-21541.
    • (1996) J Biol Chem , vol.271 , pp. 21536-21541
    • Trejo, J.1    Connolly, A.J.2    Coughlin, S.R.3
  • 48
    • 0037108503 scopus 로고    scopus 로고
    • Activation of human oral epithelial cells by neutrophil proteinase 3 through protease-activated receptor-2
    • Uehara A, Sugawara S, Muramoto K, Takada H. 2002. Activation of human oral epithelial cells by neutrophil proteinase 3 through protease-activated receptor-2. J Immunol 169:4594-4603.
    • (2002) J Immunol , vol.169 , pp. 4594-4603
    • Uehara, A.1    Sugawara, S.2    Muramoto, K.3    Takada, H.4
  • 49
    • 0030004297 scopus 로고    scopus 로고
    • Thrombin stimulates production of interleukin-8 in human umbilical vein endothelial cells
    • Ueno A, Murakami K, Yamanouchi K, Watanabe M, Kondo T. 1996. Thrombin stimulates production of interleukin-8 in human umbilical vein endothelial cells. Immunology 88:76-81.
    • (1996) Immunology , vol.88 , pp. 76-81
    • Ueno, A.1    Murakami, K.2    Yamanouchi, K.3    Watanabe, M.4    Kondo, T.5
  • 51
    • 0026035523 scopus 로고
    • Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation
    • Vu TK, Hung DT, Wheaton VI, Coughlin SR. 1991. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 64:1057-1068.
    • (1991) Cell , vol.64 , pp. 1057-1068
    • Vu, T.K.1    Hung, D.T.2    Wheaton, V.I.3    Coughlin, S.R.4


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