Factor Xa is a fibroblast mitogen via binding to effector-cell protease receptor-1 and autocrine release of PDGF

American Journal of Physiology - Cell Physiology

Volumn 281, Issue 2 50-2, 2001, Pages

  Blanc Brude, Olivier P ^a,c   Chambers, Rachel C ^a   Leoni, Patricia ^a   Dik, Willem A ^b   Laurent, Geoffrey J ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Human fibroblasts; Platelet derived growth factor; Proliferation

Indexed keywords

BLOOD CLOTTING FACTOR 10A; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR A; PLATELET DERIVED GROWTH FACTOR B; PROTEINASE; THROMBIN;

ARTICLE; AUTOCRINE EFFECT; CELL COUNT; COLORIMETRY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS; EFFECTOR CELL; FETUS; FETUS LUNG; HEART; HUMAN; HUMAN CELL; KIDNEY; LIVER; LUNG FIBROBLAST; MITOGENESIS; NORTHERN BLOTTING; PRIORITY JOURNAL; SKIN FIBROBLAST; WESTERN BLOTTING;

EID: 0034880428     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.2001.281.2.c681     Document Type: Article

References (37)

1. Molecular cloning of effector cell protease receptor-1, a novel cell surface receptor for the protease factor Xa
2. Splicing of effector cell protease receptor-1 mRNA is modulated by an unusual retained intron
3. Identification of effector cell protease receptor-1. A leukocyte-distributed receptor for the serine protease factor Xa
4. Protease-dependent T cell activation: Ligation of effector cell protease receptor-1 (EPR-1) stimulates lymphocyte proliferation
5. Molecular dissection of effector cell protease receptor- 1 recognition of factor Xa. Assignment of critical residues involved in antibody reactivity and ligand binding
6. 88 in factor Xa mediates ligand binding to effector cell protease receptor-1
7. Human umbilical vein endothelial cells express high affinity receptors for factor Xa
8. Effector cell receptor-1, a platelet activation-dependent membrane protein, regulates prothrombinase-catalyzed thrombin generation
9. The activation of human blood coagulation factor X on the surface of endothelial cells: A comparison with various vascular cells, platelets and monocytes
10. Enhancement of incisional wound healing and neovascularization in normal rats by thrombin and synthetic thrombin receptor-activating peptides
11. Thrombin stimulates fibroblast procollagen production via proteolytic activation of protease-activated receptor 1
12. Biochemical and molecular aspects of the coagulation cascade
13. Coagulation factors X, Xa and protein S as potent mitogens of cultured aortic smooth muscle cells
14. The functional expression of tissue factor by fibroblasts and endothelial cells under flow conditions
15. Inhibition of cellular proliferation after experimental balloon angioplasty by low-molecular-weight heparin
16. Effector protease receptor-1 mediates the mitogenic activity of factor Xa for vascular smooth muscle cells in vitro and in vivo
17. Role of thrombin in pulmonary fibrosis
18. Procoagulant activity in bronchoalveolar lavage in the adult respiratory distress syndrome. Contribution of tissue factor associated with factor VII
19. Reaction pathway for inhibition of blood coagulation factor Xa by tick anticoagulant peptide
20. Coagulation factor Xa stimulates platelet-derived growth factor release and mitogenesis in cultured vascular smooth muscle cells
21. Protein C anticoagulant system in patients with interstitial lung disease
22. Inhibition of factor Xa-mediated procoagulant activity of human lung fibroblasts and pleural mesothelial cells
23. Chrysotile asbestos stimulates gene expression and secretion of PDGF-AA by rat lung fibroblasts: Evidence for an autocrine loop
24. The biology of haemostasis and thrombosis
25. Effector cell protease receptor-1 is a vascular receptor for coagulation factor Xa
26. Time course of smooth muscle cell proliferation after local drug delivery of low-molecular-weight heparin using a porous balloon catheter
27. Scleroderma bronchoalveolar lavage fluid contains thrombin, a mediator of human lung fibroblast proliferation via induction of platelet-derived growth factor α-receptor
28. Thrombin in the synovial fluid of patients with rheumatoid arthritis mediates proliferation of synovial fibroblast-like cells by induction of platelet derived growth factor
29. Interaction of antistasin-related peptides with factor Xa: Identification of a core inhibitory sequence
30. A rapid and convenient assay for counting cells cultured in microwell plates: Application for assessment of growth factors
31. Specific factor Xa inhibition reduces restenosis after balloon angioplasty of atherosclerotic femoral arteries in rabbits
32. Enhanced expression of monocyte tissue factor in patients with liver cirrhosis
33. Neointimal thickening after severe coronary artery injury is limited by a short-term administration of a factor Xa inhibitor. Results in a porcine model
34. Glomerular procoagulant activity in human proliferative glomerulonephritis
35. The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice
36. Interleukin-1β and interferon-γ differentially regulate release of monocyte chemotactic protein-1 and interleukin-8 by human bronchial epithelial cells
37. Cellular localization of activated factor X by Xa-specific probes