Heparin blockade of thrombin-induced smooth muscle cell migration involves inhibition of epidermal growth factor (EGF) receptor transactivation by heparin-binding EGF-like growth factor

Circulation Research

Volumn 87, Issue 2, 2000, Pages 92-98

  Kalmes, Andreas ^a   Vesti, Beatrice R ^a   Daum, Günter ^a   Abraham, Judith A ^b   Clowes, Alexander W ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b SCIOS INC   (United States)

Author keywords

Growth factors; Heparin; Migration; Muscle, smooth

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; HEPARIN; MITOGEN ACTIVATED PROTEIN KINASE; THROMBIN;

ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CELL MIGRATION; DRUG MECHANISM; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

EID: 0034698062     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.87.2.92     Document Type: Article

References (46)

1. The pathogenesis of atherosclerosis: A perspective for the 1990s
2. The intima; soil for atherosclerosis and restenosis
3. Suppression by heparin of smooth muscle cell proliferation in injured arteries
4. Suppression by heparin of injury-induced myointimal thickening
5. Inhibition of rat arterial smooth muscle cell proliferation by heparin: In vivo studies with anticoagulant and nonanticoagulant heparin
6. Inhibition of vascular smooth muscle cell migration by heparin-like glycosaminoglycans
7. Regulation of smooth muscle proliferation by heparin in vitro and in vivo
8. Heparin inhibits c-fos and c-myc mRNA expression in vascular smooth muscle cells
9. Mechanisms of inhibition by heparin of vascular smooth muscle cell proliferation and migration
10. Heparin inhibits the induction of three matrix metalloproteinases (stromelysin, 92-kD gelatinase, and collagenase) in primate arterial smooth muscle cells
11. Regulation of baboon arterial smooth muscle cell plasminogen activators by heparin and growth factors
12. Smooth muscle cell expression of extracellular matrix genes after arterial injury
13. Heparin modulates the composition of the extracellular matrix domain surrounding arterial smooth muscle cells
14. Heparin inhibits thrombin-induced mitogen-activated protein kinase signaling in arterial smooth muscle cells
15. The EGF receptor as central transducer of heterologous signalling systems
16. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors
17. Signal characteristics of G protein-transactivated EGF receptor
18. Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells
19. 2+/calmodulin-dependent transactivation of epidermal growth factor receptor
20. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
21. Heparin-binding EGF-like growth factor
22. A monoclonal antibody which inhibits epidermal growth factor binding has opposite effects on the biological action of epidermal growth factor in different cells
23. Growth inhibition of human tumor cells in athymic mice by anti-epidermal growth factor receptor monoclonal antibodies
24. Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes
25. Heparin-binding EGF-like growth factor is a mitogen for rat alveolar type II cells
26. Intercellular communication between vascular smooth muscle and endothelial cells mediated by heparin-binding epidermal growth factor-like growth factor and vascular endothelial growth factor
27. Long-term biological response of injured rat carotid artery seeded with smooth muscle cells expressing retrovirally introduced human genes
28. Diverse effects of heparin on mitogen-activated protein kinase-dependent signal transduction in vascular smooth muscle cells
29. Cell cycle-dependent activation of Ras
30. Different functions of the platelet-derived growth factor-α and -β receptors for the migration and proliferation of cultured baboon smooth muscle cells
31. Cellular consequences of thrombin-receptor activation
32. Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity
33. Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: Conversion from juxtacrine to paracrine growth factor activity
34. Matrix metalloproteinase-3 releases active heparin-binding EGF-like growth factor by cleavage at a specific juxtamembrane site
35. Extracellular calcium influx stimulates metalloproteinase cleavage and secretion of heparin-binding EGF-like growth factor independently of protein kinase C
36. Failure of heparin to inhibit intimal hyperplasia in injured baboon arteries: The role of heparin-sensitive and -insensitive pathways in the stimulation of smooth muscle cell migration and proliferation
37. Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor: A scaffold for G protein-coupled receptor-mediated Ras activation
38. Role of tyrosine kinase activity of epidermal growth factor receptor in the lysophosphatidic acid-stimulated mitogen-activated protein kinase pathway
39. Localization of heparin-binding EGF-like growth factor in the smooth muscle cells and macrophages of human atherosclerotic plaques
40. Localization of heparin-binding epidermal growth factor-like growth factor in human coronary arteries: Possible roles of HB-EGF in the formation of coronary atherosclerosis
41. Detection and cellular localization of heparin-binding epidermal growth factor-like growth factor mRNA and protein in human atherosclerotic tissue
42. Expression of heparin-binding epidermal growth factor-like growth factor in neointimal cells induced by balloon injury in rat carotid arteries
43. Interaction of heparin-binding EGF-like growth factor (HB-EGF) with the epidermal growth factor receptor: Modulation by heparin, heparinase, or synthetic heparin-binding HB-EGF fragments
44. Protease-activated receptor 3 is a second thrombin receptor in humans
45. Cloning and characterization of human protease-activated receptor 4
46. Proteinase-activated receptor 4 (PAR4): Action of PAR4-activating peptides in vascular and gastric tissue and lack of cross-reactivity with PAR1 and PAR2