Discovery and optimization of a novel series of thrombin receptor (PAR-1) antagonists: Potent, selective peptide mimetics based on indole and indazole templates [2]

Journal of Medicinal Chemistry

Volumn 44, Issue 7, 2001, Pages 1021-1024

  Zhang, H C ^a   Derian, C K ^a   Andrade Gordon, P ^a   Hoekstra, W J ^a   McComsey, D F ^a   White, K B ^a   Poulter, B L ^a   Addo, M F ^a   Cheung, W M ^a   Damiano, B P ^a   Oksenberg, D ^a   Reynolds, E E ^a   Pandey, A ^a   Scarborough, R M ^a   Maryanoff, B E ^a  

^a R W JOHNSON PHARMACEUTICAL RES I   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INDAZOLE DERIVATIVE; INDOLE DERIVATIVE; PROTEINASE ACTIVATED RECEPTOR 1 ANTAGONIST; RECEPTOR BLOCKING AGENT; ROSE BENGAL; RWJ 58259; THROMBIN; THROMBIN RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIOVENOUS SHUNT; ASSAY; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; GUINEA PIG; HEMODYNAMICS; HUMAN; HUMAN CELL; IC 50; IN VIVO STUDY; LETTER; NONHUMAN; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PHOTOACTIVATION; RAT; RESTENOSIS; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION; THROMBOSIS; VASCULAR SMOOTH MUSCLE;

ANGIOPLASTY, BALLOON; ANIMALS; CONSTRICTION, PATHOLOGIC; FIBRINOLYTIC AGENTS; GUINEA PIGS; INDAZOLES; INDOLES; MOLECULAR MIMICRY; MUSCLE, SMOOTH; RATS; RECEPTOR, PAR-1; RECEPTORS, THROMBIN; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 0035966876     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000506s     Document Type: Letter

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