Intramuscular triglyceride content is increased in IDDM

Diabetologia

Volumn 41, Issue 1, 1998, Pages 111-115

  Ebeling, P ^a,c   Essen Gustavsson B ^b   Tuominen, J A ^a   Koivisto, V A ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Insulin sensitivity; Lipid oxidation; Muscle; Triglycerides; Type 1 diabetes

Indexed keywords

FATTY ACID; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL PROTOCOL; CONTROLLED STUDY; GLUCOSE OXIDATION; HUMAN; HUMAN TISSUE; HYPERINSULINEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID OXIDATION; MALE; MUSCLE BIOPSY; MUSCLE LEVEL; PRIORITY JOURNAL; VASTUS LATERALIS MUSCLE;

ADULT; BLOOD GLUCOSE; BODY MASS INDEX; CHOLESTEROL; CHOLESTEROL, HDL; DIABETES MELLITUS, TYPE 1; GLUCOSE CLAMP TECHNIQUE; HUMAN GROWTH HORMONE; HUMANS; HYDROCORTISONE; HYPERINSULINISM; INFUSIONS, INTRAVENOUS; INSULIN; MALE; MUSCLE, SKELETAL; OXIDATION-REDUCTION; OXYGEN CONSUMPTION; REFERENCE VALUES; TRIGLYCERIDES;

EID: 0031930724     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050875     Document Type: Article

References (32)

1. Groop LC, Bonadonna RC, Simonson DC, Petrides AS, Shank M, DeFronzo RA (1992) Effect of insulin on oxidative and nonoxidative pathways of free fatty acid metabolism in human obesity. Am J Physiol 263:E79-E84
2. Dagenais GR, Tancredi RG, Zierler KL (1976) Free fatty acid oxidation by forearm muscle at rest, and evidence for an intramuscular lipid pool in the human forearm. J Clin Invest 58: 421-431
3. Oscai LB, Essig DA, Palmer WK (1990) Lipase regulation of muscle triglyceride hydrolysis. J Appl Physiol 69: 1571-1577
4. Schonfeld G, Kipnis DM (1966) Studies of extracellular and tissue fatty acid pools and glucose metabolism in striated muscle. J Clin Invest 45: 1071
5. Yki-Järvinen H, Puhakainen I, Koivisto VA (1991) Effect of free fatty acids on glucose uptake and nonoxidative glycolysis across human forearm tissues in the basal state and during insulin stimulation. J Clin Endocrinol Metab 72: 1268-1277
6. Falholt K, Jensen I, Lindkaer Jensen S et al. (1987) Carbohydrate and lipid metabolism of skeletal muscle in type 2 diabetic patients. Diabet Med 5: 27-31
7. Falholt K, Hjelms E, Jensen I, Voelund A, Heding LG, Falholt W (1987) Intracellular metabolism in biopsies from the aorta in patients undergoing coronary bypass surgery. Diabete Metab 13: 312-317
8. Falholt K, Cutfield R, Alejandro R, Heding L, Mintz D (1985) The effects of hyperinsulinemia on arterial wall and peripheral muscle metabolism in dogs. Metabolism 34: 1146-1149
9. Standl E, Lotz N, Dexel T, Janka H-U, Kolb HJ (1980) Muscle triglycerides in diabetic subjects. Effect of insulin deficiency and exercise. Diabetologia 18: 463-469
10. Pan DA, Lillioja S, Kriketos AD et al. (1997) Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes 46: 983-988
11. Storlien LH, Jenkins AB, Chisholm DJ, Pascoe WS, Khouri S, Kraegen EW (1991) Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and w-3 fatty acids in muscle phospholipid. Diabetes 40: 280-289
12. Yki-Järvinen H, Koivisto VA (1986) Natural course of insulin resistance in type I diabetes. N Engl J Med 315: 224-230
13. DeFronzo RA, Tobin JD, Andres R (1979) Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237:E214-E223
14. Ebeling P, Bourey R, Koranyi L et al. (1993) Mechanism of enhanced insulin sensitivity in athletes: Increased blood flow, muscle glucose transport protein (GLUT-4) concentration and glycogen synthase activity. J Clin Invest 92: 1623-1631
15. Ferrannini E (1988) The theoretical bases of indirect calorimetry: a review. Metabolism 37: 287-301
16. Laron Z, Mannheimer S (1966) Measurement of human growth hormone. Isr J Med Sci 2: 115-119
17. Rolleri E, Zannino M, Orlandini S, Malvano R (1976) Direct radioimmunoassay of plasma cortisol. Clin Chim Acta 66: 319-330
18. Bergmeier HU (1974) Metoden der enzymatischen Analyse. 3. Auflage, Bd II, Verlag Chemie Weinheim: 1878
19. Siedel J, Hägele EO, Ziegenhorn J, Wahlefeld AW (1983) Reagent for the enzymatic determination of serum total cholesterol with improved lipolytic efficiency. Clin Chem 29: 1075-1080
20. Finley PR, Schifman RB, Williams RJ, Lichti DA (1978) Cholesterol in high-density lipoprotein: use of Mg2 + /dextran sulfate in its enzymic measurement. Clin Chem 26: 931-933
21. Miles J, Glasscock R, Aikens J, Gerich J, Haymond M (1983) Microfluorometric method for the determination of free fatty acids in plasma. J Lipid Res 24: 96-99
22. Desbuquois B, Aurhach GD (1971) Use of polyethylene glycol to separate free and antibody-bound peptide hormones in radioimmunoassays. J Clin Endocr 33: 732-738
23. Kiens B, Essén-Gustavsson B, Gad P, Lithell H (1987) Lipoprotein lipase activity and intramuscular triglyceride stores after long-term high-fat and high-carbohydrate diets in physically trained men. Clin Physiol 7: 1-9
24. Anyan WRJ (1978) Adolescent medicine in primary care. Wiley, New York, p. 137
25. Nikkilä EA, Hormila P (1978) Serum lipids and lipoproteins in insulin-treated diabetes. Demonstration of increased high density lipoprotein concentrations. Diabetes 27: 1078-1086
26. Randle PJ, Priestman DA, Mistry S, Halsall A (1994) Mechanisms modifying glucose oxidation in diabetes mellitus. Diabetologia 37[Suppl 2]:S155-S161
27. Groop LC, Bonadonna RC, Shank M, Petrides AS, DeFronzo RA (1991) Role of free fatty acids and insulin in determining free fatty acid and lipid oxidation in man. J Clin Invest 87: 83-89
28. Jansson E, Kaijser L (1982) Effect of diet on the utilization of blood-borne and intramuscular substrates during exercise in man. Acta Physiol Scand 115: 19-30
29. Essén-Gustavsson B, Tesch PA (1990) Glycogen and triglyceride utilization in relation to muscle metabolic characteristics in men performing heavy-resistance exercise. Eur J Appl Physiol 61: 5-10
30. Carlson LA, Ekelund L-G, Fröberg SO (1971) Concentrations of triglycerides, phospholipids and glycogen in skeletal muscle and of free fatty acids and B-hydroxybutyric acid in blood in man in response to exercise. Eur J Clin Invest 1: 248-254
31. Falholt K, Alberti KGMM, Heding LG (1985) Aorta and muscle metabolism in pigs with peripheral hyperinsulinaemia. Diabetologia 28: 32-37
32. Mandarino LJ, Consoli G, Jain A, Kelley DE (1996) Interaction of carbohydrate and fat fuels in human skeletal muscle: impact of obesity and NIDDM. Am J Physiol 270:E463-E470