Early growth responce proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression

Nucleic Acids Research

Volumn 31, Issue 3, 2003, Pages 911-921

  Decker, Eva L ^b,c   Nehmann, Nina ^a   Kampen, Eva ^c   Eibel, Herman ^b   Zipfel, Peter F ^a   Skerka, Christine ^a  

^a HANS KNÖLL INSTITUTE   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; DIMER; EARLY GROWTH RESPONSE FACTOR 1; EARLY GROWTH RESPONSE FACTOR 4; GLUTATHIONE TRANSFERASE; INTERLEUKIN 2; LUCIFERASE; RECOMBINANT PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NFAT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; DNA BINDING PROTEIN; EARLY GROWTH RESPONSE FACTOR; EGR1 PROTEIN, HUMAN; EGR4 PROTEIN, HUMAN; IMMEDIATE EARLY PROTEIN; NUCLEAR PROTEIN;

BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; GENE CONSTRUCT; GENE DELETION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION INITIATION; WESTERN BLOTTING; ARTICLE; CELL LINE; DIMERIZATION; DNA RESPONSIVE ELEMENT; GENETICS; IMMUNOLOGY; INFLAMMATION; LEUKEMIA CELL LINE; METABOLISM; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; TRANSACTIVATION;

EUKARYOTA;

BASE SEQUENCE; BINDING SITES; CELL LINE; CONSERVED SEQUENCE; CYTOKINES; DIMERIZATION; DNA-BINDING PROTEINS; EARLY GROWTH RESPONSE PROTEIN 1; EARLY GROWTH RESPONSE TRANSCRIPTION FACTORS; HUMANS; IMMEDIATE-EARLY PROTEINS; INFLAMMATION; INTERLEUKIN-2; JURKAT CELLS; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); RESPONSE ELEMENTS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037315381     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkg186     Document Type: Review

References (56)

1. Müller,H.-J., Skerka,C., Bialonski,A. and Zipfel,P.F. (1991) Clone pAT 133 identifies a gene that encodes another human member of a class of growth factor induced genes with almost identical zinc-finger domains. Proc. Natl Acad. Sci. USA, 88, 10079-10083.
2. Perez-Castillo,A., Pipaon,C., Garcia,I. and Alemany,S. (1993) NGFI-A gene expression is necessary for T lymphocyte proliferation. J. Biol. Chem., 268, 19445-19450.
3. Gashler,A. and Sukhatme,V.P. (1995) Early growth response protein 1 (Egr-1): prototype of a zinc-finger family of transcription factors. Prog. Nucleic Acid Res. Mol. Biol., 50, 191-224.
4. Beckmann,M.A. and Wilce,P.A. (1997) Egr transcription factors in the nervous system. Neurochem. Int., 31, 477-510.
5. Milbrandt,J. (1987) A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. Science, 238, 797-799.
6. Suggs,S.V., Katzowitz,J.L., Tsai-Morris,C. and Sukhaktme,V.P. (1990) cDNA sequence of the human cellular early growth response gene Egr-1. Nucleic Acids Res., 18, 4283.
7. Wright,J.J., Gunter,K.C., Mitsuya,H., Irving,S.G., Kelly,K. and Siebenlist,U. (1990) Expression of a zinc finger gene in HTLV-I and HTLV-II transformed cells. Science, 248, 588-591.
8. Chavrier,P., Zerial,M., Lemaire,P., Almendral,J., Bravo,R. and Charney,P. (1988) A gene encoding a protein with zinc fingers is activated during G0/G1 transition in cultured cells. EMBO J., 7, 29-35.
9. Joseph,L.J., Le Beau,M.M., Jamieson,G.A.,Jr, Acharya,S., Shows,T.B., Rowley,J.D. and Sukhatme,V.P. (1988) Molecular colning, sequencing and mapping of EGR2, a human early growth response gene encoding a protein with 'zinc-binding finger' structure. Proc. Natl Acad. Sci. USA, 85, 7164-7168.
10. Mages,H.W., Stamminger,T., Rilke,O., Bravo,R. and Kroczek,R.A. (1993) Expression of Pilot, a putative transcription factor, requires two signals and is cyclosporin A sensitive in T cells. Int. Immunol., 5, 63-70.
11. Patwardhan,S., Gashler,A., Siegel,M.G., Chang,L.C., Joseph,L., Shows,T.B., Le Beau,M.M. and Sukhatme,V.P. (1991) EGR-3, a novel member of the Egr family of genes encoding immediate-early transcription factors. Oncogene, 6, 917-928.
12. Crosby,S.D., Puetz,J.J., Simburger,K.S., Fahrner,T.J. and Milbrandt,J. (1991) The early response gene NGFI-C encodes a zinc finger transcriptional activator and is a member of the GCGGGGGCG (GSG) element-binding protein family. Mol. Cell. Biol., 11, 3835-3841.
13. Cao,X., Guy,G.R., Sukhatme,V.P. and Tan,Y.H. (1993) Regulation of the EGR-1 gene by tumor necrosis factor and interferons in primary human fibroblasts. J. Biol. Chem., 267, 1345-1349.
14. Skerka,C., Decker,E.L. and Zipfel,P.F. (1995) A regulatory element in the human interleukin 2 gene promoter is a binding site for zinc finger proteins Sp1 and EGR-1. J. Biol. Chem., 270, 22500-22506.
15. Krämer,B., Meichle,A., Hensel,G., Charnay,P. and Krönke,M. (1994) Characterization of an Krox-24/Egr-1 responsive element in the human tumor necrosis factor promoter. Biochim. Biophys. Acta, 1219, 413-421.
16. Lin,J.-X. and Leonard,W.J. (1997) The immediate-early gene product Egr-1 regulates the human interleukin-2 receptor b-chain promoter through noncanonical Egr and Sp1 binding sites. Mol. Cell. Biol., 17, 3714-3722.
17. Dinkel,A., Aicher,W.K., Haas,C., Zipfel,P.F., Peter,H.H. and Eibel,H. (1997) Transcription factor Egr-1 activity down-regulates Fas and CD23 expression in B cells. J. Immunol., 159, 2678-2684.
18. Maltzman,J.S., Carmen,J.A. and Monroe,J.G. (1996) Transcriptional regulation of the Icam-1 gene in antigen receptor- and phorbol ester-stimulated B lymphocytes: role for transcription factor EGR-1. J. Exp. Med., 183, 1747-1759.
19. Li-Weber,M., Laur,O. and Krammer,P.H. (1999) Novel Egr/NFAT composite sites mediate activation of the CD95 (APO/Fas) ligand promoter in response to T cell stimulation, Eur. J. Immunol., 29, 3017-3027.
20. Christy,B. and Nathans,D. (1989) DNA binding site of the growth factor-inducible protein Zif268. Proc. Natl Acad. Sci. USA, 86, 8737-8745.
21. Wang,Z.Y. and Duel,T.F. (1992) An S1 nuclease-sensitive homopurine/homopyrimidine domain in the PDGF A-chain promoter contains a novel binding site for the growth factor-inducible protein EGR-1. Biochem. Biophys. Res. Commun., 188, 433-439.
22. Zipfel,P.F., Decker,E.L., Holst,C. and Skerka,C. (1997) The human zinc finger protein EGR-4 acts as autoregulatory transcriptional repressor. Biochim. Biophys. Acta, 1354, 134-144.
23. Biesiada,E., Razandi,M. and Levin,E.R. (1996) Egr-1 activates basic fibroblast growth factor transcription. J. Biol. Chem., 271, 18576-18581.
24. Hu,R.M. and Levin,E.R. (1994) Astrocyte growth is regulated by neuropeptides through Tis 8 and basic fibroblast growth factor. J. Clin. Invest., 193, 1820-1827.
25. Khachigian,L.M., Lindner,V., Williams,A.J. and Collins,T. (1996) Egr-1-induced endothelial gene expression: a common theme in vascular injury. Science, 271, 1427-1430.
26. Liu,J., Grogan,L., Nau,M.M., Allegra,C.J., Chu,E. and Wright,J.J. (2001) Physical interaction between p53 and primary response gene Egr-1. Int. J. Oncol., 18, 863-870.
27. Cui,M.-Z., Party,G.C.N., Oeth,P., Larson,H., Smith,M., Huang,R.-P., Adamson,E.D. and Mackman,N. (1996) Transcriptional regulation of the tissue factor gene in human epithelial cells is mediated by Sp1 and EGR-1. J. Biol. Chem., 271, 2731-2739.
28. Lui,C., Adamson,E. and Mercola,D. (1996) Transcription factor EGR-1 suppresses the growth and transformation of human HAT-1080 fibrosarcoma cells by induction of transforming growth factor b1. Proc. Natl Acad. Sci. USA, 93, 11831-11836.
29. Day,M.L., Wu,S. and Basler,J.W. (1993) Prostatic nerve growth factor inducible A gene binds a novel element in the retinoblastoma gene promoter. Cancer Res., 53, 5597-5599.
30. Philipp,A., Schneider,A., Vasrick,I., Finke,K., Xiong,Y., Besch,D., Alitalo,K. and Eilers,E. (1994) Repression of cyclin D1: a novel function of MYC. Mol. Cell. Biol., 14, 4032-4043.
31. Tremblay,J.J. and Drouin,J. (1999) Egr-1 is a downstream effector of GnRH and synergizes by direct interaction with Ptx1 and SF-1 to enhance luteinizing hormone β gene transcription. Mol. Cell. Biol., 19, 2567-2576.
32. Lee,S.L., Sadovsky,Y., Swirnoff,H., Polish,J.A., Goda,P., Gavrilina,G. and Milbrandt,J. (1996) Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1). Science, 273, 1219-1221.
33. Schneider-Maunoury,S., Topilka,P., Seitandou,T., Levi,G., Cohen-Tannoudji,M., Pournin,S., Babinet,C. and Charnay,P. (1993) Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain. Cell, 75, 1199-1214.
34. Tourtellotte,W.G. and Milbrandt,J. (1998) Sensory ataxis and muscle spindle agenesis in mice lacking the transcription factor Egr3. Nature Genet., 20, 87-91.
35. Tourtellotte,W.G., Nagarajan,R., Auyeung,A., Mueller,C. and Milbrandt,J. (1999) Infertility associated with incomplete spermatogenic arrest and oligospermia in Egr-4 deficient mice. Development, 126, 5061-5071.
36. Cogswell,P.C., Mayo,M.W. and Baldwin,A.S.,Jr (1997) Involvement of Egr-1/RelA synergy in distinguishing T cell activation from tumor necrosis factor-α-induced NF-kB1 transcription. J. Exp. Med., 185, 491-497.
37. Silverman,E.S., Du,J., Williams,A.J., Wadgaonkar,R., Drazen,J.M. and Collins T. (1998) cAMP-response-element-binding-protein-binding-protein (CBP) and p300 are transcriptional co-activators of early growth response factor-1 (Egr-1). Biochem. J., 336, 183-189.
38. Srivastava,S., Weitzmann,M.N., Kimble,R.B., Rizzo,M., Zahner,M., Milbrandt,J., Ross,F.P. and Pacifici,R. (1998) Estrogen blocks M-CSF gene expression and osteoclast formation by regulating phosphorylation of Egr-1 and its interaction with Sp1. J. Clin. Invest., 102, 1850-1859.
39. Yang,Y., Dong,B., Mittelstadt,P.R., Xiao,H. and Ashwell,J.D. (2002) HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promotor. J. Biol. Chem., 277, 19482-19487.
40. Trejo,S.R., Fahl,W.E. and Ratner,L. (1997) The Tax protein of human T-cell leukemia virus type 1 mediates the transactivation of the c-sis/platelet-derived growth factor-B promoter through interactions with the zinc finger transcription factors Sp1 and NGFI-A/Egr-1. J. Biol. Chem., 272, 27411-27421.
41. Yoo,Y.D., Ueda,H., Park,K., Flanders,K.C., Lee,Y.I., Jay,G. and Kim,S.-J. (1996) Regulation of transforming growth factor-β1 expression by Hepatitis B virus (HBV) X transactivator. J. Clin. Invest., 97, 388-395.
42. Yoo,Y.D., Chiou,C.-J., Choi,K.S., Yi,Y., Michelson,S., Kim,S., Hayward,G.S. and Kim,S.-J. (1996) The IE2 regulatory protein of human cytomegalovirus induces expression of the human transforming growth factor β1 gene through an Egr-1 binding site. J. Virol., 70, 7062-7070.
43. Russo,M., Sevetson,B.R. and Milbrandt,J. (1995) Identification of Nab1, a repressor of NGFI-A- and Krox20-mediated transcription. Proc. Natl Acad. Sci. USA, 92, 6873-6877.
44. Svaren,J., Sevetson,B.R., Apel,E.D., Zimonjic,D.B., Popescu,N.C. and Milbrandt,J. (1996) NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and diferentiative stimuli. Mol. Cell. Biol., 16, 3545-3553.
45. Locksley,R.M., Killeen,N. and Lenardo,M.J. (2001) The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell, 104, 487-501.
46. Decker,E.L., Skerka,C. and Zipfel,P.F. (1998) The early growth response protein (EGR-1) regulates interleukine-2 transcription by synergistic interaction with the nuclear factor of activated T cells. J. Biol. Chem., 273, 26923-26930.
47. Rao,A., Luo,C. and Hogan,P.G. (1997) Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol., 15, 707-747.
48. Kuklina,E.M. and Shirshev,S.V. (2001) Role of transcription factor NFAT in the immune response. Biochemistry, 66, 467-475.
49. Lopez-Rodriguez,C., Aramburu,J., Rakeman,A.S. and Rao,A. (1999) NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun. Proc. Natl Acad. Sci. USA, 96, 7214-7219.
50. Skerka,C., Decker,E.L. and Zipfel,P.F. (1997) Coordinate expression and distinct DNA-binding characteristics of the four EGR-zinc finger proteins in Jurkat T lymphocytes. Immunobiology, 198, 179-191.
51. Durand,D.B., Busch,M.R., Morgan,J.G., Wess,A. and Crabtree,G.R. (1988) Characterization of antigen receptor response elements within the interleukin-2 enhancer. Mol. Cell. Biol., 8, 1715-1724.
52. Jain,J., McCaffrey,P.G., Valge-Archer,V.E. and Rao,A. (1992) Analysis of the AP-1 sites in the IL-2 promoter. Nature, 356, 801-804.
53. Tsai,E.Y., Jain,J., Pesavento,P.A., Rao,A. and Goldfeld,A.E. (1996) Tumor necrosis factor alpha gene regulation in activated T cells involves ATF-2/Jun and NFATp. Mol. Cell. Biol., 16, 459-467.
54. Goldfield,A.E., McCaffrey,P.G., Stromonger,J.K. and Rao,A. (1993) Identification of a novel cyclosporin-sensitive element in the human tumor necrosis factor α gene promoter. J. Exp. Med., 178, 1365-1379.
55. Russo,M.W., Sevetson,B.R. and Milbrandt,J. (1995) Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription. Proc. Natl Acad. Sci. USA, 92, 6873-6877.
56. Svaren,J., Sevetson,B.R., Apel,E.D., Zimonjic,D.B., Popescu,N.C. and Milbrandt,J. (1996) Nab2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. Mol. Cell. Biol., 16, 3545-3553.