Calcineurin-GATA-6 pathway is involved in smooth muscle-specific transcription

Journal of Cell Biology

Volumn 156, Issue 6, 2002, Pages 983-991

  Wada, Hiromichi ^a   Hasegawa, Koji ^a   Morimoto, Tatsuya ^a   Kakita, Tsuyoshi ^a   Yanazume, Tetsuhiko ^a   Abe, Mitsuru ^a   Sasayama, Shigetake ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Calcineurin; GATA 6; Myosin; Smooth muscle; Transcription

Indexed keywords

CALCINEURIN; MYOSIN HEAVY CHAIN; TRANSCRIPTION FACTOR GATA 6; TRANSCRIPTION FACTOR NFAT;

ARTICLE; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CELL DIFFERENTIATION; DNA BINDING; DOWN REGULATION; GENE; GENE EXPRESSION; GENE INDUCTION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SM MHC GENE; SMOOTH MUSCLE; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING; ZINC FINGER MOTIF;

ACTINS; ANIMALS; CALCINEURIN; CALCIUM SIGNALING; CELL DIFFERENTIATION; CELL DIVISION; CELL NUCLEUS; COMMON VARIABLE IMMUNODEFICIENCY; COS CELLS; DNA; DNA-BINDING PROTEINS; GATA6 TRANSCRIPTION FACTOR; HUMANS; IMMUNOHISTOCHEMISTRY; MUSCLE, SMOOTH, VASCULAR; MYOSIN HEAVY CHAINS; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; PHENOTYPE; PROMOTER REGIONS (GENETICS); PROTEIN TRANSPORT; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0037128922     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200106057     Document Type: Article

References (34)

1. The downstream consequences of calcineurin inhibition
2. The cyclosporin A-sensitive nuclear factor of activated T cells (NFAT) proteins are expressed in vascular smooth muscle cells
3. Calcineurin activity is required for the initiation of skeletal muscle differentiation
4. Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300/CREB-binding protein (CBP)
5. 2+/calcineurin and NFATc3/4 pattern the developing vasculature
6. Ventricular expression of brain natriuretic peptide in hypertrophic cardiomyopathy
7. Transcriptional coactivator p300 stimulates cell type-specific gene expression in cardiac myocytes
8. NFATc3, a lymphoid specific NF-AT3 family member that is calcium-regulated and exhibits distinct DNA binding specificity
9. Isolation of two new members of the NF-AT gene family and functional characterization of NF-AT proteins
10. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
11. cDNA cloning of a myosin heavy chain isoform in embryonic smooth muscle and its expression during vascular development and in arteriosclerosis
12. Calcineurin binds the transcription factor NFAT-1 and reversibly regulates its activity
13. Expression of the smooth muscle myosin heavy chain gene is regulated by a negative-acting GC-rich element located between two positive-acting serum response factor binding elements
14. NF-ATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus
15. Isolation of the cyclosporin-sensitive T cell transcription factor NFATp
16. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy
17. Phosphorylation of GATA-4 is involved in alpha 1-adrenergic agonist-responsive transcription of the endothelin-1 gene in cardiac myocytes
18. GATA-6: A zinc finger transcription factor that is expressed in multiple cell lineages derived from lateral mesoderm
19. GATA-5: A transcriptional activator expressed in a novel temporally and spatially-restricted pattern during embryonic development
20. Identification of two types of smooth muscle myosin heavy chain isoforms by cDNA cloning and immunoblot analysis
21. The gene for transcription factor GATA-6 residues on mouse chromosome 18 and is expressed in myocardium and vascular smooth muscle
22. NFAT components define a family of transcription factors targeted in T-cell activation
23. Regulation of differentiation of vascular smooth muscle cells
24. Molecular cloning and functional characterization of murine cDNA encoding transcription factor NFATc
25. Characterization of a new isoform of the NFAT (nuclear family of activated T cells) gene family member NFATc
26. GATA-6 induces p21cip1 expression and GI cell cycle arrest
27. Calcium regulation of skeletal myogenesis. I. Cell content critical to myotube formation
28. A common factor regulates both Th1- and The-specific cytokine gene expression
29. Interruption of myogenesis by transforming growth factor beta 1 or EGTA inhibits expression and activity of the myogenic-associated (2′-5′) oligoadenylate synthetase and PKR
30. Involvement of the dihydropyridine receptor and internal Ca2+ stores in myoblast fusion
31. Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT-1 in stimulated immune cells
32. The human GATA-6 gene: Structure, chromosomal location and regulation of expression by tissue-specific and mitogen-responsive signals
33. A p300 proteins as a coactivator of GATA-6 in the transcription of smooth muscle myosin heavy chain gene
34. Identification of a novel smooth muscle myosin heavy chain cDNA: Isoform diversity in the S1 head region