메뉴 건너뛰기




Volumn 68, Issue 3, 1997, Pages 1142-1149

Cyclosporin A, an immunosuppressive drug, induces programmed cell death in rat C6 glioma cells by a mechanism that involves the AP-1 transcription factor

Author keywords

Apoptosis; c Jun protein; Cyclosporin A; DNA fragmentation; Glioma; Transcription factors

Indexed keywords

ACRIDINE ORANGE; CYCLOHEXIMIDE; CYCLOSPORIN A; DNA FRAGMENT; IMMUNOSUPPRESSIVE AGENT; ONCOPROTEIN; TRANSCRIPTION FACTOR AP 1;

EID: 0031028816     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.68031142.x     Document Type: Article
Times cited : (62)

References (37)
  • 1
    • 0029976253 scopus 로고    scopus 로고
    • DNA damage and apoptosis in Alzheimer's disease: Colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay
    • Anderson A. J., Su J. H., and Cotman C. W. (1996) DNA damage and apoptosis in Alzheimer's disease: colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay. J. Neurosci. 16, 1710-1719.
    • (1996) J. Neurosci. , vol.16 , pp. 1710-1719
    • Anderson, A.J.1    Su, J.H.2    Cotman, C.W.3
  • 2
    • 0021287833 scopus 로고
    • Cyclosporine-associated central nervous system toxicity after allogeneic bone marrow transplantation
    • Atkinson K., Biggs J., Darveniza P., Boland J., Concannon A., and Dodds A. (1984) Cyclosporine-associated central nervous system toxicity after allogeneic bone marrow transplantation. Transplantation 38, 34-37.
    • (1984) Transplantation , vol.38 , pp. 34-37
    • Atkinson, K.1    Biggs, J.2    Darveniza, P.3    Boland, J.4    Concannon, A.5    Dodds, A.6
  • 3
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 4
    • 0026664289 scopus 로고
    • Emulsifier for intravenous cyclosporin inhibits neurite outgrowth, causes deficits in rapid axonal transport and leads to structural abnormalities in differentiating N1E.115 neuroblastoma
    • Brat D. J., Windebank A. J., and Brimijoin S. (1992) Emulsifier for intravenous cyclosporin inhibits neurite outgrowth, causes deficits in rapid axonal transport and leads to structural abnormalities in differentiating N1E.115 neuroblastoma. J. Pharmacol. Exp. Ther. 261, 803-810.
    • (1992) J. Pharmacol. Exp. Ther. , vol.261 , pp. 803-810
    • Brat, D.J.1    Windebank, A.J.2    Brimijoin, S.3
  • 5
    • 0026643141 scopus 로고
    • Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
    • Clipstone N. A. and Crabtree G. R. (1992) Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 357, 695-697.
    • (1992) Nature , vol.357 , pp. 695-697
    • Clipstone, N.A.1    Crabtree, G.R.2
  • 6
    • 0026645859 scopus 로고
    • Expression and involvement of c-fos and c-jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines
    • Colotta F., Polentarutti N., Sironi M., and Mantovani A. (1992) Expression and involvement of c-fos and c-jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines. J. Biol. Chem. 267, 18278-18283.
    • (1992) J. Biol. Chem. , vol.267 , pp. 18278-18283
    • Colotta, F.1    Polentarutti, N.2    Sironi, M.3    Mantovani, A.4
  • 7
    • 0028342952 scopus 로고
    • Signal transmission between the plasma membrane and nucleus of T lymphocytes
    • Crabtree G. R. and Clipstone N. A. (1994) Signal transmission between the plasma membrane and nucleus of T lymphocytes. Annu. Rev. Biochem. 63, 1045-1083.
    • (1994) Annu. Rev. Biochem. , vol.63 , pp. 1045-1083
    • Crabtree, G.R.1    Clipstone, N.A.2
  • 8
    • 0025619106 scopus 로고
    • Differential staining of DNA and RNA in intact cells and isolated cell nuclei with acridine orange
    • Darzynkiewicz Z. (1990) Differential staining of DNA and RNA in intact cells and isolated cell nuclei with acridine orange. Methods Cell Biol. 33, 285-298.
    • (1990) Methods Cell Biol. , vol.33 , pp. 285-298
    • Darzynkiewicz, Z.1
  • 9
    • 0021822464 scopus 로고
    • Cyclosporine as prophylaxis for graft-versus-host disease: A randomized study in patients undergoing marrow transplantation for acute non-lymphoblastic leukemia
    • Deeg M. J., Strob R., and Thomas E. D. (1985) Cyclosporine as prophylaxis for graft-versus-host disease: a randomized study in patients undergoing marrow transplantation for acute non-lymphoblastic leukemia. Blood 65, 1325-1328.
    • (1985) Blood , vol.65 , pp. 1325-1328
    • Deeg, M.J.1    Strob, R.2    Thomas, E.D.3
  • 10
    • 0023630918 scopus 로고
    • Central nervous system toxicity after liver transplantation
    • DeGroen P. C., Aksamit A. J., and Rekela J. (1987) Central nervous system toxicity after liver transplantation. N. Engl. J. Med. 317, 861-886.
    • (1987) N. Engl. J. Med. , vol.317 , pp. 861-886
    • DeGroen, P.C.1    Aksamit, A.J.2    Rekela, J.3
  • 11
    • 0028866102 scopus 로고
    • The role of inducible transcription factors in apoptotic nerve cell death
    • Dragunow M. and Preston K. (1995) The role of inducible transcription factors in apoptotic nerve cell death. Brain Res. Brain Res. Rev. 21, 1-28.
    • (1995) Brain Res. Brain Res. Rev. , vol.21 , pp. 1-28
    • Dragunow, M.1    Preston, K.2
  • 13
    • 0027946686 scopus 로고
    • Altered gene expression in neurons during programmed cell death: Identification of c-jun as necessary for neuronal apoptosis
    • Estus S., Zaks W. J., Freeman R. S., Gruda M., Bravo R., and Johnston E. M. (1994) Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis. J. Cell Biol. 127, 1717-1727.
    • (1994) J. Cell Biol. , vol.127 , pp. 1717-1727
    • Estus, S.1    Zaks, W.J.2    Freeman, R.S.3    Gruda, M.4    Bravo, R.5    Johnston, E.M.6
  • 14
    • 0027931560 scopus 로고
    • DNA fragmentation in rat brain after intraperitoneal administration of kainate
    • Filipkowski R. K., Hetman M., Kaminska B., and Kaczmarek L. (1994) DNA fragmentation in rat brain after intraperitoneal administration of kainate. Neuroreport 5, 1538-1540.
    • (1994) Neuroreport , vol.5 , pp. 1538-1540
    • Filipkowski, R.K.1    Hetman, M.2    Kaminska, B.3    Kaczmarek, L.4
  • 15
    • 0026503434 scopus 로고
    • Calcineurin phosphatase activity in T lymphocytes is inhibited by FK506 and cyclosporin A
    • Furman D. A., Klee C. B., Bierer B. E., and Burakoff S. J. (1992) Calcineurin phosphatase activity in T lymphocytes is inhibited by FK506 and cyclosporin A. Proc. Natl. Acad. Sci. USA 89, 3686-3690.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 3686-3690
    • Furman, D.A.1    Klee, C.B.2    Bierer, B.E.3    Burakoff, S.J.4
  • 16
    • 0025917430 scopus 로고
    • Cyclosporine-associated seizures in bone marrow transplant recipients given busulfan and cyclophosphamide preparative therapy
    • Ghany A. M., Tutschka P. J., McGhee R. B., Avalos B. R., Cunningham I., Kapoor N., and Copelan E. A. (1991) Cyclosporine-associated seizures in bone marrow transplant recipients given busulfan and cyclophosphamide preparative therapy. Transplantation 52, 310-315.
    • (1991) Transplantation , vol.52 , pp. 310-315
    • Ghany, A.M.1    Tutschka, P.J.2    McGhee, R.B.3    Avalos, B.R.4    Cunningham, I.5    Kapoor, N.6    Copelan, E.A.7
  • 17
    • 0029012476 scopus 로고
    • A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death
    • Ham J., Babij C., Whitefield J., Pfarr C. M., Lallemand D., Yaniv M., and Rubin L. L. (1995) A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron 14, 927-939.
    • (1995) Neuron , vol.14 , pp. 927-939
    • Ham, J.1    Babij, C.2    Whitefield, J.3    Pfarr, C.M.4    Lallemand, D.5    Yaniv, M.6    Rubin, L.L.7
  • 19
    • 0028075436 scopus 로고
    • Dynamic changes in composition of the AP-1 transcription factor DNA-binding activity in rat brain following kainate-induced seizures and cell death
    • Kaminska B., Filipkowski R. K., Mosieniak G., Lason W., Przewlocki R., and Kaczmarek L. (1994) Dynamic changes in composition of the AP-1 transcription factor DNA-binding activity in rat brain following kainate-induced seizures and cell death. Eur. J. Neurosci. 6, 1558-1566.
    • (1994) Eur. J. Neurosci. , vol.6 , pp. 1558-1566
    • Kaminska, B.1    Filipkowski, R.K.2    Mosieniak, G.3    Lason, W.4    Przewlocki, R.5    Kaczmarek, L.6
  • 20
    • 0029087372 scopus 로고
    • Elevated AP-1 transcription factor DNA-binding activity at the onset of functional plasticity during development of rat sensory cortical areas
    • Kaminska B., Mosieniak G., Gierdalski M., Kossut M., and Kaczmarek L. (1995) Elevated AP-1 transcription factor DNA-binding activity at the onset of functional plasticity during development of rat sensory cortical areas. Mol. Brain Res. 33, 295-304.
    • (1995) Mol. Brain Res. , vol.33 , pp. 295-304
    • Kaminska, B.1    Mosieniak, G.2    Gierdalski, M.3    Kossut, M.4    Kaczmarek, L.5
  • 21
    • 0029993163 scopus 로고    scopus 로고
    • Visual stimulation regulates the expression of transcription factors and modulates the composition of AP-1 in rat visual cortex
    • Kaminska B., Kaczmarek L., and Chaudhuri A. (1996) Visual stimulation regulates the expression of transcription factors and modulates the composition of AP-1 in rat visual cortex. J. Neurosci. 15, 3968-3978.
    • (1996) J. Neurosci. , vol.15 , pp. 3968-3978
    • Kaminska, B.1    Kaczmarek, L.2    Chaudhuri, A.3
  • 22
    • 0029025008 scopus 로고
    • Kainic acid-induced neuronal death is associated with DNa damage and a unique immediate-early gene response in c-fos-lacZ transgenic rats
    • Kasof G. M., Mandelzys A., Maika S. D., Hammer R. E., Curran T., and Morgan J. I. (1995) Kainic acid-induced neuronal death is associated with DNA damage and a unique immediate-early gene response in c-fos-lacZ transgenic rats. J. Neurosci. 15, 4238-4249.
    • (1995) J. Neurosci. , vol.15 , pp. 4238-4249
    • Kasof, G.M.1    Mandelzys, A.2    Maika, S.D.3    Hammer, R.E.4    Curran, T.5    Morgan, J.I.6
  • 23
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr J. F., Wyllie A. H., and Currie A. R. (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26, 239-257.
    • (1972) Br. J. Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 25
    • 0025893168 scopus 로고
    • Calcineurin is a common target of cyclophilin-cyclosporin a and FKBP-FK506 complexes
    • Liu J., Farmer J. D., Lane W. S., Friedman J., Weissman I., and Schreiber S. L. (1991) Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66, 807-815.
    • (1991) Cell , vol.66 , pp. 807-815
    • Liu, J.1    Farmer, J.D.2    Lane, W.S.3    Friedman, J.4    Weissman, I.5    Schreiber, S.L.6
  • 26
    • 0028266976 scopus 로고
    • AP-1 and CRE DNA binding activities in rat brain following pentylenetetrazole induced seizures
    • Lukasiuk K. and Kaczmarek L. (1994) AP-1 and CRE DNA binding activities in rat brain following pentylenetetrazole induced seizures. Brain Res. 643, 227-233.
    • (1994) Brain Res. , vol.643 , pp. 227-233
    • Lukasiuk, K.1    Kaczmarek, L.2
  • 27
    • 1842281659 scopus 로고
    • Cyclosporin-A and okadaic acid induced apoptosis of cultured cortical neurons
    • McDonald J. W., Goldberg M. P., Gwag B. J., and Choi D. W. (1995) Cyclosporin-A and okadaic acid induced apoptosis of cultured cortical neurons. Soc. Neurosci. Abstr. 21, 751.
    • (1995) Soc. Neurosci. Abstr. , vol.21 , pp. 751
    • McDonald, J.W.1    Goldberg, M.P.2    Gwag, B.J.3    Choi, D.W.4
  • 30
    • 0028097246 scopus 로고
    • Induction of apoptosis in mouse thymocytes by cyclosporin A: An in vitro study
    • Saiagh S., Auger C., Fabien N., and Monier J. C. (1994) Induction of apoptosis in mouse thymocytes by cyclosporin A: an in vitro study. Immunopharmacol. Immunotoxicol. 16, 553-576.
    • (1994) Immunopharmacol. Immunotoxicol. , vol.16 , pp. 553-576
    • Saiagh, S.1    Auger, C.2    Fabien, N.3    Monier, J.C.4
  • 31
    • 0026575932 scopus 로고
    • The mechanism of action of cyclosporin A and FK506
    • Schreiber L. S. and Crabtree G. R. (1992) The mechanism of action of cyclosporin A and FK506. Immunol. Today 13, 136-142.
    • (1992) Immunol. Today , vol.13 , pp. 136-142
    • Schreiber, L.S.1    Crabtree, G.R.2
  • 32
    • 0026748870 scopus 로고
    • Cyclosporin A, FK506, and rapamycin: Pharmacologic probes of lymphocyte signal transduction
    • Sigal N. H. and Dumont F. J. (1992) Cyclosporin A, FK506, and rapamycin: pharmacologic probes of lymphocyte signal transduction. Annu. Rev. Immunol. 10, 519-560.
    • (1992) Annu. Rev. Immunol. , vol.10 , pp. 519-560
    • Sigal, N.H.1    Dumont, F.J.2
  • 33
    • 0029918952 scopus 로고    scopus 로고
    • Apoptosis and c-Jun in the thalamus of the rat following cortical infraction
    • Soriano M. A., Ferrer I., Rodriguez-Farre E., and Planas A. M. (1996) Apoptosis and c-Jun in the thalamus of the rat following cortical infraction. Neuroreport 7, 425-428.
    • (1996) Neuroreport , vol.7 , pp. 425-428
    • Soriano, M.A.1    Ferrer, I.2    Rodriguez-Farre, E.3    Planas, A.M.4
  • 35
    • 0021918470 scopus 로고
    • Cyclosporin-associated fatal convulsion
    • Velu T., Debusscher L., and Stryckmans P. A. (1985) Cyclosporin-associated fatal convulsion. Lancet 1, 219.
    • (1985) Lancet , vol.1 , pp. 219
    • Velu, T.1    Debusscher, L.2    Stryckmans, P.A.3
  • 36
    • 0023730639 scopus 로고
    • Neurologic complications of immunosuppressive agents
    • Walker R. W. and Brochstein J. A. (1988) Neurologic complications of immunosuppressive agents. Neurol. Clin. 6, 261-278.
    • (1988) Neurol. Clin. , vol.6 , pp. 261-278
    • Walker, R.W.1    Brochstein, J.A.2
  • 37
    • 0019225636 scopus 로고
    • Cell death: The significance of apoptosis
    • Wyllie A. H., Kerr J. F., and Currie A. R. (1980) Cell death: the significance of apoptosis. Int. Rev. Cytol. 68, 251-306.
    • (1980) Int. Rev. Cytol. , vol.68 , pp. 251-306
    • Wyllie, A.H.1    Kerr, J.F.2    Currie, A.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.