Inhibition of amyloid β-peptide production by blockage of β-secretase cleavage site of amyloid precursor protein

Journal of Neurochemistry

Volumn 101, Issue 6, 2007, Pages 1583-1595

  Na, Chan Hyun ^a,b   Jeon, Sang Hee ^a   Zhang, Guangtao ^c   Olson, Gary L ^c   Chae, Chi Bom ^a,b  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

^b Konkuk University   (South Korea)

^c Provid Pharmaceuticals Inc   (United States)

Author keywords

amyloid; Alzheimer's disease; Amyloid precursor protein; APP specific inhibitor; BACE1; Hydropathic complementarity

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ARGINYLLEUCYLHISTIDYLLEUCYLASPARTYLARGINYLLEUCYLLYSYLALANINE; ARGINYLLEUCYLHISTIDYLPHENYLALANYLTYROSYLLEUCYLARGINYLLEUCYLLYSYLALANINE; ASPARTYLALANYLGLUTAMYLPHENYLALANYLARGININE; BETA SECRETASE; COMPLEMENT INHIBITOR; CYSTEINYLISOLEUCYLGLUTAMINYLISOLEUCYLHISTIDYLPHENYLALANINE; PROTEIN INHIBITOR; PV 557; PV 698; PV 699; PV 700; PV 723; PV 731; RECOMBINANT ENZYME; SERYLGLUTAMYLPHENYLALANYLCYSTEINYLISOLEUCYLGLUTAMINYLISOLEUCYL HISTIDYLPHENYLALANYLARGININE; SERYLGLUTAMYLPHENYLALANYLCYSTEINYLISOLEUCYLHISTIDYLLEUCYLHISTIDYL PHENYLALANYLARGININE; SERYLGLUTAMYLVALYLASPARAGINYLLEUCINE; SERYLGLUTAMYLVALYLLYSYLMETHIONINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CHEMICAL MODIFICATION; DRUG BINDING; DRUG DESIGN; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; EMBRYO; ENZYME DEGRADATION; HUMAN; HUMAN CELL; IC 50; INHIBITION KINETICS; LIPOPHILICITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BINDING SITES; HUMANS; MALE; PEPTIDES; RATS;

EID: 34249796079     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.04441.x     Document Type: Article

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