Accelerated ageing changes in the choroid plexus of a case with multiple mitochondrial DNA deletions

Neuropathology and Applied Neurobiology

Volumn 27, Issue 3, 2001, Pages 206-214

  Cottrell, D A ^a   Ince, P G ^b,c   Wardell, T M ^a   Turnbull, D M ^a   Johnson, M A ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c NEWCASTLE GENERAL HOSPITAL   (United Kingdom)

Author keywords

Accelerated; Ageing; Biondi; Choroid; Cytochrome c oxidase; DNA; Mitochondrial; Plexus

Indexed keywords

CYTOCHROME C OXIDASE; MITOCHONDRIAL DNA;

ADULT; AGED; AGING; ARTICLE; CASE REPORT; CHOROID PLEXUS; CONTROLLED STUDY; DEGENERATIVE DISEASE; DELETION MUTANT; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME DEFICIENCY; FEMALE; GENE MUTATION; HISTOCHEMISTRY; HUMAN; HUMAN TISSUE; MALE; MALIGNANT TRANSFORMATION; OXIDATIVE PHOSPHORYLATION; POINT MUTATION; PRIORITY JOURNAL;

ADULT; AGING; CHOROID PLEXUS; DNA, MITOCHONDRIAL; FEMALE; GENE DELETION; HUMANS; MALE; MIDDLE AGED; MITOCHONDRIAL MYOPATHIES; POINT MUTATION; TIME FACTORS;

EID: 0034915760     PISSN: 03051846     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2990.2001.00315.x     Document Type: Article

References (32)

1. Ein neuer histologischer befund am epithel des plexus chorioideus
2. Multiple mitochondrial DNA deletions associated with autosomal recessive ophthalmoplegia and severe cardiomyopathy
3. Mitochondrial enzyme activity in amyotrophic lateral sclerosis: Implications for the role of mitochondria in neuronal cell death
4. Role of mitochondrial DNA mutations in human aging: Implications for the central nervous system and muscle
5. The inheritance of MELAS and MERRF, the relationship between maternal mutation load and the frequency of affected offspring
6. Mitochondrial content of choroid plexus epithelium
7. Role of mitochondrial DNA mutations in disease and aging
8. Cytochrome c oxidase deficient cells accumulate in the hippocampus and choroid plexus with age
9. Cytochrome c oxidase deficient hippocampal neurons and choroid epithelial cells are increased in Alzheimer's disease
10. Detection of cytochrome oxidase deficient neurons in a patient with multiple mitochondrial DNA deletions
11. Human choroid plexus: A light and electron microscopic study
12. Amyloid inclusions in choroid plexus epithelial cells. A simple autopsy method to rapidly obtain information of the age of an unknown dead person
13. Characterisation of intracellular amyloid fibrils in the human choroid plexus epithelial cells
14. The biologic clock: The mitochondria?
15. Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): Clinical, biochemical, and genetic features of an autosomal recessive mitochondrial disorder
16. Oncocytic transformation of choroid plexus epithelium
17. Curly fiber and tangle-like inclusions in the ependyma and choroid plexus-a pathogenetic relationship with the cortical Alzheimer-type changes?
18. Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder
19. Involvement of choroid plexus in mitochondrial encephalomyopathy (MELAS)
20. Mitochondrial abnormalities in choroid plexus of Leigh disease
21. Methods of microphotometric assay of succinate dehyrogenase and cytochrome c oxidase activities for use on human skeletal muscle
22. Distribution of wild-type and common deletion forms of mtDNA in normal and respiration-deficient muscle fibers from patients with mitochondrial myopathy
23. Non-droplet ultrastructural demonstration of cytochrome oxidase activity with a polymerising osmiophilic reagent, diaminobenzidine (DAB)
24. Volume and number of neurons of the human hippocampal formation in normal aging and Alzheimer's disease
25. Neuropathology of mitochondrial encephalomyopathies due to mitochondrial DNA defects
26. Choroid plexus in the central nervous system: Biology and physiopathology
27. An autosomal locus predisposing to deletions of mitochondrial DNA
28. Biondi ring tangles in the choroid plexus of Alzheimer's disease and normal aging brains: A quantitative study
29. Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
30. Regionally specific loss of neurons in the aging human hippocampus
31. An autosomal dominant disorder with multiple deletions of mitochondrial DNA starting at the D-loop region