-
1
-
-
0027017232
-
Mitochondrial DNA deletions in human brain: Regional variability and increase with advanced age
-
Corral-Debrinski, M., Horton, T., Lott, M. T., Shoffner, J. M., Beal, M. F., and Wallace, D. C. (1992) Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. Nature Genet. 2, 324-329.
-
(1992)
Nature Genet
, vol.2
, pp. 324-329
-
-
Corral-Debrinski, M.1
Horton, T.2
Lott, M.T.3
Shoffner, J.M.4
Beal, M.F.5
Wallace, D.C.6
-
2
-
-
0025674177
-
Detection of a specific mitochondrial DNA deletion in tissues of older humans
-
Cortopassi, G. A., and Arnheim, N. (1990) Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucleic Acids Res. 18, 6927-6933.
-
(1990)
Nucleic Acids Res.
, vol.18
, pp. 6927-6933
-
-
Cortopassi, G.A.1
Arnheim, N.2
-
3
-
-
0026732706
-
A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues
-
Cortopassi, G. A., Shibata, D., Soong, N. W., and Arnheim, N. (1992) A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc. Natl. Acad. Sci. USA 89, 7370-7374.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 7370-7374
-
-
Cortopassi, G.A.1
Shibata, D.2
Soong, N.W.3
Arnheim, N.4
-
4
-
-
0027971105
-
Detection and quantitation by competitive PCR of an age-associated increase in a 4.8-kb deletion in rat mitochondrial DNA
-
Edris, W., Burgett, B., Stine, O. C., and Filburn, C. R. (1994) Detection and quantitation by competitive PCR of an age-associated increase in a 4.8-kb deletion in rat mitochondrial DNA. Mutat. Res. 316, 69-78.
-
(1994)
Mutat. Res.
, vol.316
, pp. 69-78
-
-
Edris, W.1
Burgett, B.2
Stine, O.C.3
Filburn, C.R.4
-
5
-
-
0031557655
-
Quantification of wild-type mitochondrial DNA and its 4.8-kb deletion in rat organs
-
Filser, N., Margue, C., and Richter, C. (1997) Quantification of wild-type mitochondrial DNA and its 4.8-kb deletion in rat organs. Biochem. Biophys. Res. Commun. 233, 102-107.
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.233
, pp. 102-107
-
-
Filser, N.1
Margue, C.2
Richter, C.3
-
6
-
-
77049308856
-
Aging: A theory based on free radical and radiation chemistry
-
Harman, D. (1956) Aging: a theory based on free radical and radiation chemistry. J. Gerontl. 11, 298-300.
-
(1956)
J. Gerontl.
, vol.11
, pp. 298-300
-
-
Harman, D.1
-
7
-
-
0027055332
-
Age-associated oxygen damage and mutations in mitochondrial DNA in human hearts
-
Hayakawa, M., Hattori, K., Sugiyama, S., and Ozawa, T. (1992) Age-associated oxygen damage and mutations in mitochondrial DNA in human hearts. Biochem. Biophys. Res. Commun. 189, 979-985.
-
(1992)
Biochem. Biophys. Res. Commun.
, vol.189
, pp. 979-985
-
-
Hayakawa, M.1
Hattori, K.2
Sugiyama, S.3
Ozawa, T.4
-
8
-
-
0029971563
-
The expression of a reporter protein, β-galactosidase, is preserved during maturation and aging in some cells of the adult Drosophila melanogaster
-
Helfand, S. L., and Naprta, B. (1996) The expression of a reporter protein, β-galactosidase, is preserved during maturation and aging in some cells of the adult Drosophila melanogaster. Mech. Dev. 55, 45-51.
-
(1996)
Mech. Dev.
, vol.55
, pp. 45-51
-
-
Helfand, S.L.1
Naprta, B.2
-
9
-
-
0037167855
-
Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans
-
Herndon, L. A., Schmeissner, P. J., Dudaronek, J. M., Brown, P. A., Listner, K. M., Sakano, Y., Paupard, M. C., Hall, D. H., and Driscoll, M. (2002) Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature 419, 808-814.
-
(2002)
Nature
, vol.419
, pp. 808-814
-
-
Herndon, L.A.1
Schmeissner, P.J.2
Dudaronek, J.M.3
Brown, P.A.4
Listner, K.M.5
Sakano, Y.6
Paupard, M.C.7
Hall, D.H.8
Driscoll, M.9
-
10
-
-
0027366179
-
Multiple mitochondrial DNA deletions associated with age in skeletal muscle of rhesus monkeys
-
Lee, C. M., Chung, S. S., Kaczkowski, J. M., Weindruch, R., and Aiken, J. M. (1993) Multiple mitochondrial DNA deletions associated with age in skeletal muscle of rhesus monkeys. J. Gerontol. 48, B201-B205.
-
(1993)
J. Gerontol.
, vol.48
-
-
Lee, C.M.1
Chung, S.S.2
Kaczkowski, J.M.3
Weindruch, R.4
Aiken, J.M.5
-
11
-
-
0026778182
-
Degeneration of photoreceptors in rhodopsin mutants of Drosophila
-
Leonard, D. S., Bowman, V. D., Ready, D. F., and Pak, W. L. (1992) Degeneration of photoreceptors in rhodopsin mutants of Drosophila. J. Neurobiol. 23, 605-626.
-
(1992)
J. Neurobiol.
, vol.23
, pp. 605-626
-
-
Leonard, D.S.1
Bowman, V.D.2
Ready, D.F.3
Pak, W.L.4
-
12
-
-
0032030309
-
Mutations in mitochondrial DNA accumulate differentially in three different human tissues during ageing
-
Liu, V. W. S., Zhang, C., and Nagley, P. (1998) Mutations in mitochondrial DNA accumulate differentially in three different human tissues during ageing. Nucleic Acids Res. 26, 1268-1275.
-
(1998)
Nucleic Acids Res.
, vol.26
, pp. 1268-1275
-
-
Liu, V.W.S.1
Zhang, C.2
Nagley, P.3
-
13
-
-
0028285538
-
Detection of deletions in the mitochondrial genome of Caenorhabditis elegans
-
Melov, S., Hertz, G. Z., Stormo, G. D., and Johnson, T. E. (1994) Detection of deletions in the mitochondrial genome of Caenorhabditis elegans. Nucleic Acids Res. 22, 1075-1078.
-
(1994)
Nucleic Acids Res.
, vol.22
, pp. 1075-1078
-
-
Melov, S.1
Hertz, G.Z.2
Stormo, G.D.3
Johnson, T.E.4
-
14
-
-
0029019546
-
Increased frequency of deletions in the mitochondrial genome with age of Caenorhabditis elegans
-
Melov, S., Lithgow, G. J., Fischer, D. R., Tedesco, P. M., and Johnson, T. E. (1995a) Increased frequency of deletions in the mitochondrial genome with age of Caenorhabditis elegans. Nucleic Acids Res. 23, 1419-1425.
-
(1995)
Nucleic Acids Res.
, vol.23
, pp. 1419-1425
-
-
Melov, S.1
Lithgow, G.J.2
Fischer, D.R.3
Tedesco, P.M.4
Johnson, T.E.5
-
15
-
-
0033457963
-
Mitochondrial DNA rearrangements in aging human brain and in situ PCR of mtDNA
-
Melov, S., Schneider, J. A., Coskun, P. E., Bennett, D. A., and Wallace, D. C. (1999) Mitochondrial DNA rearrangements in aging human brain and in situ PCR of mtDNA. Neurobiol. Aging 20, 565-571.
-
(1999)
Neurobiol. Aging
, vol.20
, pp. 565-571
-
-
Melov, S.1
Schneider, J.A.2
Coskun, P.E.3
Bennett, D.A.4
Wallace, D.C.5
-
16
-
-
0028787717
-
Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle
-
Melov, S., Shoffner, J. M., Kaufman, A., and Wallace, D. C. (1995b) Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle. Nucleic Acids Res. 23, 4122-4126.
-
(1995)
Nucleic Acids Res.
, vol.23
, pp. 4122-4126
-
-
Melov, S.1
Shoffner, J.M.2
Kaufman, A.3
Wallace, D.C.4
-
17
-
-
0033595684
-
Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication
-
Michikawa, Y., Mazzucchelli, F., Bresolin, N., Scarlato, G., and Attardi, G. (1999) Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. Science 286, 774-779.
-
(1999)
Science
, vol.286
, pp. 774-779
-
-
Michikawa, Y.1
Mazzucchelli, F.2
Bresolin, N.3
Scarlato, G.4
Attardi, G.5
-
18
-
-
0028220114
-
Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster
-
Orr, W. C., and Sohal, R. S. (1994) Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science 263, 1128-1130.
-
(1994)
Science
, vol.263
, pp. 1128-1130
-
-
Orr, W.C.1
Sohal, R.S.2
-
19
-
-
0023444196
-
Analysis of nucleotide substitutions of mitochondrial DNAs in Drosophila melanogaster and its sibling species
-
Satta, Y., Ishiwa, H., and Chigusa, S. I. (1987) Analysis of nucleotide substitutions of mitochondrial DNAs in Drosophila melanogaster and its sibling species. Mol. Biol. Evol. 4, 638-650.
-
(1987)
Mol. Biol. Evol.
, vol.4
, pp. 638-650
-
-
Satta, Y.1
Ishiwa, H.2
Chigusa, S.I.3
-
20
-
-
0032078622
-
Decreased mitochondrial RNA levels without accumulation of mitochondrial DNA deletions in aging Drosophila melanogaster
-
Schwarze, S. R., Weindruch, R., and Aiken, J. M. (1998a) Decreased mitochondrial RNA levels without accumulation of mitochondrial DNA deletions in aging Drosophila melanogaster. Mutat. Res. 382, 99-107.
-
(1998)
Mutat. Res.
, vol.382
, pp. 99-107
-
-
Schwarze, S.R.1
Weindruch, R.2
Aiken, J.M.3
-
21
-
-
0032189120
-
Oxidative stress and aging reduce COX I RNA and cytochrome oxidase activity in Drosophila
-
Schwarze, S. R., Weindruch, R., and Aiken, J. M. (1998b) Oxidative stress and aging reduce COX I RNA and cytochrome oxidase activity in Drosophila. Free Radic. Biol. Med. 25, 740-747.
-
(1998)
Free Radic. Biol. Med.
, vol.25
, pp. 740-747
-
-
Schwarze, S.R.1
Weindruch, R.2
Aiken, J.M.3
-
22
-
-
0024317560
-
Spontaneous Kearns-Sayre/chronic external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: A slip-replication model and metabolic therapy
-
Shoffner, J. M., Lott, M. T., Voljavec, A. S., Soueidan, S. A., Costigan, D. A., and Wallace, D. C. (1989) Spontaneous Kearns-Sayre/chronic external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: a slip-replication model and metabolic therapy. Proc. Natl. Acad. Sci. USA 86, 7952-7956.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 7952-7956
-
-
Shoffner, J.M.1
Lott, M.T.2
Voljavec, A.S.3
Soueidan, S.A.4
Costigan, D.A.5
Wallace, D.C.6
-
23
-
-
0027021442
-
Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain
-
Soong, N. W., Hinton, D. R., Cortopassi, G., and Arnheim, N. (1992) Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. Nature Genet. 2, 318-323.
-
(1992)
Nature Genet.
, vol.2
, pp. 318-323
-
-
Soong, N.W.1
Hinton, D.R.2
Cortopassi, G.3
Arnheim, N.4
-
24
-
-
0028879644
-
Multiple deletions are detectable in mitochondrial DNA of aging mice
-
Tanhauser, S. M., and Laipis, P. J. (1995) Multiple deletions are detectable in mitochondrial DNA of aging mice. J. Biol. Chem. 270, 24769-24775.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 24769-24775
-
-
Tanhauser, S.M.1
Laipis, P.J.2
-
25
-
-
0026437588
-
Stable heteroplasmy for a large-scale deletion in the coding region of Drosophila subobscura mitochondrial DNA
-
Volz-Lingenhöhl, A., Solignac, M., and Sperlich, D. (1992) Stable heteroplasmy for a large-scale deletion in the coding region of Drosophila subobscura mitochondrial DNA. Proc. Natl. Acad. Sci. USA 89, 11528-11532.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 11528-11532
-
-
Volz-Lingenhöhl, A.1
Solignac, M.2
Sperlich, D.3
-
26
-
-
0026587335
-
Mitochondrial genetics: A paradigm for aging and degenerative diseases?
-
Wallace, D. C. (1992) Mitochondrial genetics: a paradigm for aging and degenerative diseases? Science 256, 628-632.
-
(1992)
Science
, vol.256
, pp. 628-632
-
-
Wallace, D.C.1
-
27
-
-
0030747292
-
The rate of mitochondrial mutagenesis is faster in mice than humans
-
Wang, E., Wong, A., and Cortopassi, G. (1997) The rate of mitochondrial mutagenesis is faster in mice than humans. Mutat. Res. 377, 157-166.
-
(1997)
Mutat. Res.
, vol.377
, pp. 157-166
-
-
Wang, E.1
Wong, A.2
Cortopassi, G.3
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