Combined simulation and mutagenesis analyses reveal the involvement of key residues for peroxisome proliferator-activated receptor α helix 12 dynamic behavior

Journal of Biological Chemistry

Volumn 282, Issue 13, 2007, Pages 9666-9677

  Michalik, Liliane ^a   Zoete, Vincent ^a   Krey, Grigorios ^b   Grosdidier, Auré Lien ^a,c   Gelman, Laurent ^a,e   Chodanowski, Pierre ^a   Feige, Jérôme N ^a   Desvergne, Béatrice ^a   Wahli, Walter ^a   Michielin, Olivier ^a,c,d  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b INSTITUTE OF TECHNOLOGY OF AGRICULTURAL PRODUCTS   (Greece)

^c LUDWIG INSTITUTE FOR CANCER RESEARCH   (Switzerland)

^d LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^e FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; COMPUTER SIMULATION; CONFORMATIONS; MOLECULAR DYNAMICS; MOLECULAR STRUCTURE; TRANSCRIPTION;

DYNAMIC PROPERTIES; FREE ENERGY MOLECULAR DYNAMICS SIMULATIONS; FUNCTIONAL ASSAYS;

MUTAGENESIS;

LIGAND; MUTANT PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; AF 2 PROTEIN, HUMAN; AF-2 PROTEIN, HUMAN; NUCLEAR PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CHEMICAL MODEL; CONTROLLED STUDY; ENERGY; FEMALE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; MUTAGENESIS; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; SIMULATION; STRUCTURE ANALYSIS; AMINO ACID SEQUENCE; ANIMAL; BIOLOGICAL MODEL; BIOLOGY; CHEMISTRY; COMPUTER SIMULATION; GENETICS; HELA CELL; MOLECULAR GENETICS; PHYSIOLOGY; POINT MUTATION; PROTEIN SECONDARY STRUCTURE; SITE DIRECTED MUTAGENESIS; THERMODYNAMICS; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANIMALS; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; HELA CELLS; HUMANS; LIGANDS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NUCLEAR PROTEINS; POINT MUTATION; PPAR ALPHA; PROTEIN STRUCTURE, SECONDARY; THERMODYNAMICS; TRANSCRIPTION, GENETIC; XENOPUS LAEVIS;

EID: 34248137526     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M610523200     Document Type: Article

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