PPARα structure-function relationships derived from species-specific differences in responsiveness to hypolipidemic agents

Biological Chemistry

Volumn 378, Issue 7, 1997, Pages 651-655

  Keller, Hansjörg ^a,b   Devchand, Pallavi R ^a   Perroud, Mai ^a   Wahli, Walter ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Ligand binding determinants; Nuclear hormone receptor

Indexed keywords

5,8,11,14 ICOSATETRAYNOIC ACID; ANTILIPEMIC AGENT; CELL NUCLEUS RECEPTOR; PEROXISOME PROLIFERATOR; PIRINIXIC ACID; TRANSCRIPTION FACTOR;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION; XENOPUS;

EID: 0030854677     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/bchm.1997.378.7.651     Document Type: Article

References (15)

1. Devchand, P.R., Keller, H., Peters, J.M., Vazquez, M., Gonzalez, F.J., and Wahli, W. (1996). The PPARα-leukotriene B4 pathway to inflammation control. Nature 384, 39-43.
2. Devchand, P.R., and Wahli, W. PPARα: Tempting fate with fat. In: Hormones and Signalling. B. O'Malley, ed. (San Diego: Academic Press), in press.
3. Dreyer, C., Krey, G., Keller, H., Givel, F., Helftenbein, G., and Wahli, W. (1992). Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors. Cell 68, 879-887.
4. Dreyer, C., Keller, H., Mahfoudi, A., Laudet, V., Krey, G., and Wahli, W. (1993). Positive regulation of the peroxisomal beta-oxidation pathway by fatty acids through activation of peroxisome proliferator-activated receptors (PPAR). Biol. Cell 77, 67-76.
5. Ho, S.N., Hunt, H.D., Norton, R.M., Pullen, J.K., and Pease, L.R. (1989). Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension. Gene 77, 51-59.
6. Issemann, I., and Green, S. (1990). Cloning of novel members of the steroid hormone receptor superfamily. Nature 347, 645-650.
7. Keller, H., Dreyer, C., Medin, J., Mahfoudi, A., Ozato, K., and Wahli, W. (1993). Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers. Proc. Natl. Acad. Sci. USA 90, 2160-2164.
8. Keller, H., Givel, F., Perroud, M., and Wahli, W. (1995). Signaling cross-talk between peroxisome proliferator-activated receptor/retinoid X receptor and estrogen receptor through estrogen response elements. Mol. Endocrinol. 14, 2561-2569.
9. Lee, S.S.T., Pineau, T., Drago, J., Lee, E.J., Owens, J.W., Kroetz, D.L., Fernandez-Salguero, P.M., Westphal, H., and Gonzalez, F. (1995). Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol. Cell. Biol. 15, 3012-3022.
10. Lemberger, T., Desvergne, B., and Wahli, W. (1996). Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology. Annu. Rev. Cell Dev. Biol. 12, 335-363.
11. Mukherjee, R., Jow, L., Noonan, D., and McDonnell, D.P. (1994). Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. J. Steroid Biochemistry and Molecular Biology 51, 157-166.
12. Renaud, J.-P., Rochel, N., Ruff, M., Vivat, V., Chambon, P., Gronemeyer, H., and Moras, D. (1995). Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid. Nature 378, 681-689.
13. Serhan, C. (1996). Inflammation. Signalling the fat controller. Nature 384, 23-24.
14. Sher, T., Yi, H.F., McBride, O.W., and Gonzalez, F.J. (1993). cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor. Biochem. 32, 5598-5604.
15. Wagner, R.L., Apriletti, J.W., McGrath, M.E., West, B.L., Baxter, J.D., and Fletterick, R.J. (1995). A structural role for hormone in the thyroid hormone receptor. Nature 378, 690-697.