Elastin-Elastases and Inflamm-Aging

Current Topics in Developmental Biology

Volumn 79, Issue , 2007, Pages 99-155

  Antonicelli, Frank ^a   Bellon, Georges ^a   Debelle, Laurent ^a   Hornebeck, William ^a  

^a UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; ELASTIN; ELASTIN BINDING PROTEINS; ELASTIN-BINDING PROTEINS; MATRIX METALLOPROTEINASE; PANCREATIC ELASTASE; PEPTIDE; UNCLASSIFIED DRUG;

AGING; ANGIOGENESIS; ANIMAL; ARTERY; DISEASE COURSE; ELASTIC TISSUE; GENETICS; HUMAN; INFLAMMATION; MELANOMA; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROTEIN MOTIF; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; VASCULAR DISEASE;

AGING; AMINO ACID MOTIFS; ANIMALS; ARTERIES; DISEASE PROGRESSION; ELASTIC TISSUE; ELASTIN; HUMANS; INFLAMMATION; MATRIX METALLOPROTEINASES; MELANOMA; NEOVASCULARIZATION, PHYSIOLOGIC; PANCREATIC ELASTASE; PEPTIDES; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; VASCULAR DISEASES;

EID: 34247882000     PISSN: 00702153     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0070-2153(06)79005-6     Document Type: Review

References (327)

1. Ailawadi G., Eliason J.L., and Upchurch Jr. G.R. Current concepts in the pathogenesis of abdominal aortic aneurysm. J. Vasc. Surg. 38 (2003) 584-588
2. Ala-aho R., and Kahari V.M. Collagenases in cancer. Biochimie 87 (2005) 273-286
3. Alberti S., Cevenini E., Ostan R., Capri M., Salvioli S., Bucci L., Ginaldi L., De Martinis M., Franceschi C., and Monti D. Age-dependent modifications of Type 1 and Type 2 cytokines within virgin and memory CD4+ T cells in humans. Mech. Ageing Dev. 127 (2006) 560-566
4. Amiri K.I., and Richmond A. Role of nuclear factor-kappa B in melanoma. Cancer Metastasis Rev. 24 (2005) 301-313
5. Arikan M.C., Shapiro S.D., and Mariani T.J. Induction of macrophage elastase (MMP-12) gene expression by statins. J. Cell. Physiol. 204 (2005) 139-145
6. Arthur W.T., Vernon R.B., Sage E.H., and Reed M.J. Growth factors reverse the impaired sprouting of microvessels from aged mice. Microvasc. Res. 55 (1998) 260-270
7. Auge F., Hornebeck W., and Laronze J.Y. A novel strategy for designing specific gelatinase A inhibitors: Potential use to control tumor progression. Crit. Rev. Oncol. Hematol. 49 (2004) 277-282
8. Augustin-Voss H.G., Voss A.K., and Pauli B.U. Senescence of aortic endothelial cells in culture: Effects of basic fibroblast growth factor expression on cell phenotype, migration, and proliferation. J. Cell. Physiol. 157 (1993) 279-288
9. Bach M.H., Sadoun E., and Reed M.J. Defects in activation of nitric oxide synthases occur during delayed angiogenesis in aging. Mech. Ageing Dev. 126 (2005) 467-473
10. Balkwill F., and Mantovani A. Inflammation and cancer: Back to Virchow?. Lancet 357 (2001) 539-545
11. Balo J., and Banga I. The elastolytic activity of pancreatic extracts. Biochem. J. 46 (1950) 384-387
12. Bangalore N., Travis J., Onunka V.C., Pohl J., and Shafer W.M. Identification of the primary antimicrobial domains in human neutrophil cathepsin G. J. Biol. Chem. 265 (1990) 13584-13588
13. Bannikov G.A., Karelina T.V., Collier I.E., Marmer B.L., and Goldberg G.I. Substrate binding of gelatinase B induces its enzymatic activity in the presence of intact propeptide. J. Biol. Chem. 277 (2002) 16022-16027
14. Barroso B., Abello N., and Bischoff R. Study of human lung elastin degradation by different elastases using high-performance liquid chromatography/mass spectrometry. Anal. Biochem. 358 (2006) 216-224
15. Baydanoff S., Nicoloff G., and Alexiev C. Age-related changes in anti-elastin antibodies in serum from normal and atherosclerotic subjects. Atherosclerosis 63 (1987) 267-271
16. Belaaouaj A., Shipley J.M., Kobayashi D.K., Zimonjic D.B., Popescu N., Silverman G.A., and Shapiro S.D. Human macrophage metalloelastase. Genomic organization, chromosomal location, gene linkage, and tissue-specific expression. J. Biol. Chem. 270 (1995) 14568-14575
17. Bellon G., Martiny L., and Robinet A. Matrix metalloproteinases and matrikines in angiogenesis. Crit. Rev. Oncol. Hematol. 49 (2004) 203-220
18. Berger S.P., Seelen M.A., Hiemstra P.S., Gerritsma J.S., Heemskerk E., van der Woude F.J., and Daha M.R. Proteinase 3, the major autoantigen of Wegener's granulomatosis, enhances IL-8 production by endothelial cells in vitro. J. Am. Soc. Nephrol. 7 (1996) 694-701
19. Berton A., Godeau G., Emonard H., Baba K., Bellon P., Hornebeck W., and Bellon G. Analysis of the ex vivo specificity of human gelatinases A and B towards skin collagen and elastic fibers by computerized morphometry. Matrix Biol. 19 (2000) 139-148
20. Berton A., Rigot V., Huet E., Decarme M., Eeckhout Y., Patthy L., Godeau G., Hornebeck W., Bellon G., and Emonard H. Involvement of fibronectin type II repeats in the efficient inhibition of gelatinases A and B by long-chain unsaturated fatty acids. J. Biol. Chem. 276 (2001) 20458-20465
21. Bieth J.G. Elastases: Catalytic and biological properties. "Biology of Extra-Cellular Matrix, Vol. 1: Regulation of Matrix Accumulation," (1986), Academic Press, New York 217-320
22. Bisaccia F., Castiglione-Morelli M.A., Spisani S., Ostuni A., Serafini-Fracassini A., Bavoso A., and Tamburro A.M. The amino acid sequence coded by the rarely expressed exon 26A of human elastin contains a stable beta-turn with chemotactic activity for monocytes. Biochemistry 37 (1998) 11128-11135
23. Bizbiz L., Alperovitch A., and Robert L. Aging of the vascular wall: Serum concentration of elastin peptides and elastase inhibitors in relation to cardiovascular risk factors. The EVA study. Atherosclerosis 131 (1997) 73-78
24. Bizot-Foulon V., Bouchard B., Hornebeck W., Dubertret L., and Bertaux B. Uncoordinate expressions of type I and III collagens, collagenase and tissue inhibitor of matrix metalloproteinase 1 along in vitro proliferative life span of human skin fibroblasts. Regulation by all-trans retinoic acid. Cell Biol. Int. 19 (1995) 129-135
25. Blood C.H., and Zetter B.R. Membrane-bound protein kinase C modulates receptor affinity and chemotactic responsiveness of Lewis lung carcinoma sublines to an elastin-derived peptide. J. Biol. Chem. 264 (1989) 10614-10620
26. Boire A., Covic L., Agarwal A., Jacques S., Sherifi S., and Kuliopulos A. PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells. Cell 120 (2005) 303-313
27. Booms P., Ney A., Barthel F., Moroy G., Counsell D., Gille C., Guo G., Pregla R., Mundlos S., Alix A.J., and Robinson P.N. A fibrillin-1-fragment containing the elastin-binding-protein GxxPG consensus sequence upregulates matrix metalloproteinase-1: Biochemical and computational analysis. J. Mol. Cell. Cardiol. 40 (2006) 234-246
28. Boudghene F., Anidjar S., Allaire E., Osborne-Pellegrin M., Bigot J.M., and Michel J.B. Endovascular grafting in elastase-induced experimental aortic aneurysms in dogs: Feasibility and preliminary results. J. Vasc. Interv. Radiol. 4 (1993) 497-504
29. Boudier C., Godeau G., Hornebeck W., Robert L., and Bieth J.G. The elastolytic activity of cathepsin G: An ex vivo study with dermal elastin. Am. J. Respir. Cell Mol. Biol. 4 (1991) 497-503
30. Brassart B., Fuchs P., Huet E., Alix A.J., Wallach J., Tamburro A.M., Delacoux F., Haye B., Emonard H., Hornebeck W., and Debelle L. Conformational dependence of collagenase (matrix metalloproteinase-1) up-regulation by elastin peptides in cultured fibroblasts. J. Biol. Chem. 276 (2001) 5222-5227
31. Breitschopf K., Zeiher A.M., and Dimmeler S. Pro-atherogenic factors induce telomerase inactivation in endothelial cells through an Akt-dependent mechanism. FEBS Lett. 493 (2001) 21-25
32. Bromme D., Rinne R., and Kirschke H. Tight-binding inhibition of cathepsin S by cystatins. Biomed. Biochim. Acta 50 (1991) 631-635
33. Busuttil R.W., Rinderbriecht H., Flesher A., and Carmack C. Elastase activity: The role of elastase in aortic aneurysm formation. J. Surg. Res. 32 (1982) 214-217
34. Campbell E.J., Campbell M.A., Boukedes S.S., and Owen C.A. Quantum proteolysis by neutrophils: Implications for pulmonary emphysema in alpha(1)-antitrypsin deficiency. Chest 117 (2000) 303S
35. Cannon D.J., and Read R.C. Blood elastolytic activity in patients with aortic aneurysm. Ann. Thorac. Surg. 34 (1982) 10-15
36. Carmeliet P., and Jain R.K. Angiogenesis in cancer and other diseases. Nature 407 (2000) 249-257
37. Cernadas M.R., Sanchez de Miguel L., Garcia-Duran M., Gonzalez-Fernandez F., Millas I., Monton M., Rodrigo J., Rico L., Fernandez P., de Frutos T., Rodriguez-Feo J.A., Guerra J., et al. Expression of constitutive and inducible nitric oxide synthases in the vascular wall of young and aging rats. Circ. Res. 83 (1998) 279-286
38. Chan W.L., Pejnovic N., Liew T.V., Lee C.A., Groves R., and Hamilton H. NKT cell subsets in infection and inflammation. Immunol. Lett. 85 (2003) 159-163
39. Chan W.L., Pejnovic N., Hamilton H., Liew T.V., Popadic D., Poggi A., and Khan S.M. Atherosclerotic abdominal aortic aneurysm and the interaction between autologous human plaque-derived vascular smooth muscle cells, type 1, N. K. T., and helper T cells. Circ. Res. 96 (2005) 675-683
40. Chan W.L., Pejnovic N., Liew T.V., and Hamilton H. Predominance of Th2 response in human abdominal aortic aneurysm: Mistaken identity for IL-4-producing NK and NKT cells?. Cell. Immunol. 233 (2005) 109-114
41. Chang E., Yang J., Nagavarapu U., and Herron G.S. Aging and survival of cutaneous microvasculature. J. Invest. Dermatol. 118 (2002) 752-758
42. Chavakis E., and Dimmeler S. Regulation of endothelial cell survival and apoptosis during angiogenesis. Arterioscler. Thromb. Vasc. Biol. 22 (2002) 887-893
43. Chen X.P., Enioutina E.Y., and Daynes R.A. The control of IL-4 gene expression in activated murine T lymphocytes: A novel role for neu-1 sialidase. J. Immunol. 158 (1997) 3070-3080
44. Clamp A.R., and Jayson G.C. The clinical potential of antiangiogenic fragments of extracellular matrix proteins. Br. J. Cancer 93 (2005) 967-972
45. Clarke A.W., Arnspang E.C., Mithieux S.M., Korkmaz E., Braet F., and Weiss A.S. Tropoelastin massively associates during coacervation to form quantized protein spheres. Biochemistry 45 (2006) 9989-9996
46. Clemente C.G., Mihm Jr. M.C., Bufalino R., Zurrida S., Collini P., and Cascinelli N. Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma. Cancer 77 (1996) 1303-1310
47. Cohen J.R., Sarfati I., Danna D., and Wise L. Smooth muscle cell elastase, atherosclerosis, and abdominal aortic aneurysms. Ann. Surg. 216 (1992) 327-330 discussion, 330-332
48. Collier I.E., Bruns G.A., Goldberg G.I., and Gerhard D.S. On the structure and chromosome location of the 72- and 92-kDa human type IV collagenase genes. Genomics 9 (1991) 429-434
49. Coussens L.M., and Werb Z. Inflammation and cancer. Nature 420 (2002) 860-867
50. Cowan K.N., Leung W.C., Mar C., Bhattacharjee R., Zhu Y., and Rabinovitch M. Caspases from apoptotic myocytes degrade extracellular matrix: A novel remodeling paradigm. FASEB J. 19 (2005) 1848-1850
51. Dadras S.S., and Detmar M. Angiogenesis and lymphangiogenesis of skin cancers. Hematol. Oncol. Clin. North Am. 18 (2004) 1059-1070 viii.
52. De Petro G., Barlati S., Vartio T., and Vaheri A. Transformation-enhancing activity of gelatin-binding fragments of fibronectin. Proc. Natl. Acad. Sci. USA 78 (1981) 4965-4969
53. Debret R., Antonicelli F., Theill A., Hornebeck W., Bernard P., Guenounou M., and Le Naour R. Elastin-derived peptides induce a T-helper type 1 polarization of human blood lymphocytes. Arterioscler. Thromb. Vasc. Biol. 25 (2005) 1353-1358
54. Debret R., Le Naour R.R., Sallenave J.M., Deshorgue A., Hornebeck W.G., Guenounou M., Bernard P., and Antonicelli F.D. Elastin fragments induce IL-1beta upregulation via NF-kappaB pathway in melanoma cells. J. Invest. Dermatol. 126 (2006) 1860-1868
55. Desai A., Krathen R., Orengo I., and Medrano E.E. The age of skin cancers. Sci. Aging Knowl. Environ. 2006 (2006) pe13
56. Deschamps A.M., and Spinale F.G. Pathways of matrix metalloproteinase induction in heart failure: Bioactive molecules and transcriptional regulation. Cardiovasc. Res. 69 (2006) 666-676
57. Di Iorio A., Ferrucci L., Sparvieri E., Cherubini A., Volpato S., Corsi A., Bonafe M., Franceschi C., Abate G., and Paganelli R. Serum IL-1beta levels in health and disease: A population-based study. 'The InCHIANTI study.'. Cytokine 22 (2003) 198-205
58. Dome B., Raso E., Dobos J., Meszaros L., Varga N., Puskas L.G., Feher L.Z., Lorincz T., Ladanyi A., Trikha M., Honn K.V., and Timar J. Parallel expression of alphaIIbbeta3 and alphavbeta3 integrins in human melanoma cells upregulates bFGF expression and promotes their angiogenic phenotype. Int. J. Cancer 116 (2005) 27-35
59. Duca L., Debelle L., Debret R., Antonicelli F., Hornebeck W., and Haye B. The elastin peptides-mediated induction of pro-collagenase-1 production by human fibroblasts involves activation of MEK/ERK pathway via PKA- and PI(3)K-dependent signaling. FEBS Lett. 524 (2002) 193-198
60. Duca L., Lambert E., Debret R., Rothhut B., Blanchevoye C., Delacoux F., Hornebeck W., Martiny L., and Debelle L. Elastin peptides activate extracellular signal-regulated kinase 1/2 via a Ras-independent mechanism requiring both p110gamma/Raf-1 and protein kinase A/B-Raf signaling in human skin fibroblasts. Mol. Pharmacol. 67 (2005) 1315-1324
61. Edelberg J.M., and Reed M.J. Aging and angiogenesis. Front. Biosci. 8 (2003) s1199-s1209
62. Edelberg J.M., Tang L., Hattori K., Lyden D., and Rafii S. Young adult bone marrow-derived endothelial precursor cells restore aging-impaired cardiac angiogenic function. Circ. Res. 90 (2002) E89-E93
63. Ekmekcioglu S., Tang C.H., and Grimm E.A. NO news is not necessarily good news in cancer. Curr. Cancer Drug Targets 5 (2005) 103-115
64. Emonard H., and Hornebeck W. Binding of 92 kDa and 72 kDa progelatinases to insoluble elastin modulates their proteolytic activation. Biol. Chem. 378 (1997) 265-271
65. Faury G. Role of the elastin-laminin receptor in the cardiovascular system. Pathol. Biol. (Paris) 46 (1998) 517-526
66. Faury G., Ristori M.T., Verdetti J., Jacob M.P., and Robert L. Effect of elastin peptides on vascular tone. J. Vasc. Res. 32 (1995) 112-119
67. Faury G., Garnier S., Weiss A.S., Wallach J., Fulop Jr. T., Jacob M.P., Mecham R.P., Robert L., and Verdetti J. Action of tropoelastin and synthetic elastin sequences on vascular tone and on free Ca2+ level in human vascular endothelial cells. Circ. Res. 82 (1998) 328-336
68. Faury G., Usson Y., Robert-Nicoud M., Robert L., and Verdetti J. Nuclear and cytoplasmic free calcium level changes induced by elastin peptides in human endothelial cells. Proc. Natl. Acad. Sci. USA 95 (1998) 2967-2972
69. Fazio M.J., Mattei M.G., Passage E., Chu M.L., Black D., Solomon E., Davidson J.M., and Uitto J. Human elastin gene: New evidence for localization to the long arm of chromosome 7. Am. J. Hum. Genet. 48 (1991) 696-703
70. Ferrara N., and Gerber H.P. The role of vascular endothelial growth factor in angiogenesis. Acta Haematol. 106 (2001) 148-156
71. Filippov S., Caras I., Murray R., Matrisian L.M., Chapman Jr. H.A., Shapiro S., and Weiss S.J. Matrilysin-dependent elastolysis by human macrophages. J. Exp. Med. 198 (2003) 925-935
72. Finkel T., and Holbrook N.J. Oxidants, oxidative stress and the biology of ageing. Nature 408 (2000) 239-247
73. Fisher G.J., and Voorhees J.J. Molecular mechanisms of photoaging and its prevention by retinoic acid: Ultraviolet irradiation induces MAP kinase signal transduction cascades that induce Ap-1-regulated matrix metalloproteinases that degrade human skin in vivo. J. Investig. Dermatol. Symp. Proc. 3 (1998) 61-68
74. Folkman J. Tumor angiogenesis in women with node-positive breast cancer. Cancer J. Sci. Am. 1 (1995) 106-108
75. Frances C., and Robert L. Elastin and elastic fibers in normal and pathologic skin. Int. J. Dermatol. 23 (1984) 166-179
76. Fridman R., Toth M., Pena D., and Mobashery S. Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2). Cancer Res. 55 (1995) 2548-2555
77. Frostegard J., Ulfgren A.K., Nyberg P., Hedin U., Swedenborg J., Andersson U., and Hansson G.K. Cytokine expression in advanced human atherosclerotic plaques: Dominance of pro-inflammatory (Th1) and macrophage-stimulating cytokines. Atherosclerosis 145 (1999) 33-43
78. Fulop Jr. T., Jacob M.P., Varga Z., Foris G., Leovey A., and Robert L. Effect of elastin peptides on human monocytes: Ca2+ mobilization, stimulation of respiratory burst and enzyme secretion. Biochem. Biophys. Res. Commun. 141 (1986) 92-98
79. Fulop Jr. T., Wei S.M., Robert L., and Jacob M.P. Determination of elastin peptides in normal and arteriosclerotic human sera by ELISA. Clin. Physiol. Biochem. 8 (1990) 273-282
80. Fulop Jr. T., Varga Z., Jacob M.P., and Robert L. Effect of lithium on superoxide production and intracellular free calcium mobilization in elastin peptide (kappa-elastin) and FMLP stimulated human PMNS. Effect of age. Life Sci. 60 (1997) PL325-PL332
81. Fulop Jr. T., Douziech N., Jacob M.P., Hauck M., Wallach J., and Robert L. Age-related alterations in the signal transduction pathways of the elastin-laminin receptor. Pathol. Biol. (Paris) 49 (2001) 339-348
82. Fulop T., Dupuis G., Fortin C., Douziech N., and Larbi A. T cell response in aging: Influence of cellular cholesterol modulation. Adv. Exp. Med. Biol. 584 (2006) 157-169
83. Gaire M., Magbanua Z., McDonnell S., McNeil L., Lovett D.H., and Matrisian L.M. Structure and expression of the human gene for the matrix metalloproteinase matrilysin. J. Biol. Chem. 269 (1994) 2032-2040
84. Galis Z.S., Sukhova G.K., Lark M.W., and Libby P. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J. Clin. Invest. 94 (1994) 2493-2503
85. Gardner E.M., and Murasko D.M. Age-related changes in Type 1 and Type 2 cytokine production in humans. Biogerontology 3 (2002) 271-290
86. Gelb B.D., Edelson J.G., and Desnick R.J. Linkage of pycnodysostosis to chromosome 1q21 by homozygosity mapping. Nat. Genet. 10 (1995) 235-237
87. Ghajar C.M., Blevins K.S., Hughes C.C., George S.C., and Putnam A.J. Mesenchymal stem cells enhance angiogenesis in mechanically viable prevascularized tissues via early matrix metalloproteinase upregulation. Tissue Eng. 12 (2006) 2875-2882
88. Ghuysen-Itard A.F., Robert L., and Jacob M.P. Effect of elastin peptides on cell proliferation. C. R. Acad. Sci. III 315 (1992) 473-478
89. Goon P.K., Lip G.Y., Boos C.J., Stonelake P.S., and Blann A.D. Circulating endothelial cells, endothelial progenitor cells, and endothelial microparticles in cancer. Neoplasia 8 (2006) 79-88
90. Gronski Jr. T.J., Martin R.L., Kobayashi D.K., Walsh B.C., Holman M.C., Huber M., Van Wart H.E., and Shapiro S.D. Hydrolysis of a broad spectrum of extracellular matrix proteins by human macrophage elastase. J. Biol. Chem. 272 (1997) 12189-12194
91. Grosso L.E., and Scott M. PGAIPG, a repeated hexapeptide of bovine and human tropoelastin, is chemotactic for neutrophils and Lewis lung carcinoma cells. Arch. Biochem. Biophys. 305 (1993) 401-404
92. Grosso L.E., and Scott M. PGAIPG, a repeated hexapeptide of bovine tropoelastin, is a ligand for the 67-kDa bovine elastin receptor. Matrix 13 (1993) 157-164
93. Haendeler J. Nitric oxide and endothelial cell aging. Eur. J. Clin. Pharmacol. 62 Suppl. 13 (2006) 137-140
94. Halpert I., Sires U.I., Roby J.D., Potter-Perigo S., Wight T.N., Shapiro S.D., Welgus H.G., Wickline S.A., and Parks W.C. Matrilysin is expressed by lipid-laden macrophages at sites of potential rupture in atherosclerotic lesions and localizes to areas of versican deposition, a proteoglycan substrate for the enzyme. Proc. Natl. Acad. Sci. USA 93 (1996) 9748-9753
95. Hanahan D., and Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86 (1996) 353-364
96. Hance K.A., Tataria M., Ziporin S.J., Lee J.K., and Thompson R.W. Monocyte chemotactic activity in human abdominal aortic aneurysms: Role of elastin degradation peptides and the 67-kD cell surface elastin receptor. J. Vasc. Surg. 35 (2002) 254-261
97. Hansson G.K., Jonasson L., Seifert P.S., and Stemme S. Immune mechanisms in atherosclerosis. Arteriosclerosis 9 (1989) 567-578
98. Hendrix M.J., Seftor E.A., Hess A.R., and Seftor R.E. Vasculogenic mimicry and tumour-cell plasticity: Lessons from melanoma. Nat. Rev. Cancer 3 (2003) 411-421
99. Hernberg M., Turunen J.P., Muhonen T., and Pyrhonen S. Tumor-infiltrating lymphocytes in patients with metastatic melanoma receiving chemoimmunotherapy. J. Immunother. 20 (1997) 488-495
100. Herron G.S., Unemori E., Wong M., Rapp J.H., Hibbs M.H., and Stoney R.J. Connective tissue proteinases and inhibitors in abdominal aortic aneurysms. Involvement of the vasa vasorum in the pathogenesis of aortic aneurysms. Arterioscler. Thromb. 11 (1991) 1667-1677
101. Hinek A. Biological roles of the non-integrin elastin/laminin receptor. Biol. Chem. 377 (1996) 471-480
102. Hinek A., and Rabinovitch M. 67-kD elastin-binding protein is a protective "companion" of extracellular insoluble elastin and intracellular tropoelastin. J. Cell Biol. 126 (1994) 563-574
103. Hinek A., Wrenn D.S., Mecham R.P., and Barondes S.H. The elastin receptor: A galactoside-binding protein. Science 239 (1988) 1539-1541
104. Hinek A., Pshezhetsky A.V., von Itzstein M., and Starcher B. Lysosomal sialidase (neuraminidase-1) is targeted to the cell surface in a multiprotein complex that facilitates elastic fiber assembly. J. Biol. Chem. 281 (2006) 3698-3710
105. Hiraiwa M. Cathepsin A/protective protein: An unusual lysosomal multifunctional protein. Cell. Mol. Life Sci. 56 (1999) 894-907
106. Hirano E., Okamoto K., Matsubara Y., Takehana M., Kobayashi S., and Tajima S. Elastin expression in cultured human keratinocytes: Exon 26A of elastin primary transcript is always included in terminally differentiated keratinocytes. Arch. Dermatol. Res. 293 (2001) 430-433
107. Hoffmann J., Haendeler J., Aicher A., Rossig L., Vasa M., Zeiher A.M., and Dimmeler S. Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli: Important role of nitric oxide. Circ. Res. 89 (2001) 709-715
108. Hofmann U.B., Westphal J.R., Van Muijen G.N., and Ruiter D.J. Matrix metalloproteinases in human melanoma. J. Invest. Dermatol. 115 (2000) 337-344
109. Hohn P.A., Popescu N.C., Hanson R.D., Salvesen G., and Ley T.J. Genomic organization and chromosomal localization of the human cathepsin G gene. J. Biol. Chem. 264 (1989) 13412-13419
110. Hoidal J.R., Rao N.V., and Gray B. Myeloblastin: Leukocyte proteinase 3. Methods Enzymol. 244 (1994) 61-67
111. Holmes D.R., Liao S., Parks W.C., and Thompson R.W. Medial neovascularization in abdominal aortic aneurysms: A histopathologic marker of aneurysmal degeneration with pathophysiologic implications. J. Vasc. Surg. 21 (1995) 761-771 discussion, 771-772
112. Homsy R., Pelletier-Lebon P., Tixier J.M., Godeau G., Robert L., and Hornebeck W. Characterization of human skin fibroblasts elastase activity. J. Invest. Dermatol. 91 (1988) 472-477
113. Hornebeck W., and Maquart F.X. Proteolyzed matrix as a template for the regulation of tumor progression. Biomed. Pharmacother. 57 (2003) 223-230
114. Hornebeck W., and Partridge S.M. Conformational changes in fibrous elastin due to calcium ions. Eur. J. Biochem. 51 (1975) 73-78
115. Hornebeck W., and Robert L. Elastase-like enzymes in aortas and human breast carcinomas: Quantitative variations with age and pathology. Adv. Exp. Med. Biol. 79 (1977) 145-164
116. Hornebeck W., and Schnebli H.P. Effect of different elastase inhibitors on leukocyte elastase pre-adsorbed to elastin. Hoppe Seylers Z. Physiol. Chem. 363 (1982) 455-458
117. Hornebeck W., Robert B., and Robert L. Kinetic and thermodynamic study of the alkaline dispersion of elastin. C. R. Acad. Sci. Hebd. Seances Acad. Sci. D 275 (1972) 2981-2984
118. Hornebeck W., Derouette J.C., and Robert L. Isolation, purification and properties of aortic elastase. FEBS Lett. 58 (1975) 66-70
119. Hornebeck W., Derouette J.C., Roland J., Chatelet F., Bouissou H., and Robert L. Correlation between age, arteriosclerosis and elastinolytic activity of human aorta wall. C. R. Acad. Sci. Hebd. Seances Acad. Sci. D 282 (1976) 2003-2006
120. Hornebeck W., Brechemier D., Jacob M.P., Frances C., and Robert L. On the multiplicity of cellular elastases and their inefficient control by natural inhibitors. Adv. Exp. Med. Biol. 167 (1984) 111-119
121. Hornebeck W., Tixier J.M., and Robert L. Inducible adhesion of mesenchymal cells to elastic fibers: Elastonectin. Proc. Natl. Acad. Sci. USA 83 (1986) 5517-5520
122. Hornebeck W., Emonard H., Monboisse J.C., and Bellon G. Matrix-directed regulation of pericellular proteolysis and tumor progression. Semin. Cancer Biol. 12 (2002) 231-241
123. Hornebeck W., Robinet A., Duca L., Antonicelli F., Wallach J., and Bellon G. The elastin connection and melanoma progression. Anticancer Res. 25 (2005) 2617-2625
124. Hussein M.R. Tumour-associated macrophages and melanoma tumourigenesis: Integrating the complexity. Int. J. Exp. Pathol. 87 (2006) 163-176
125. Ilmonen S., Kariniemi A.L., Vlaykova T., Muhonen T., Pyrhonen S., and Asko-Seljavaara S. Prognostic value of tumour vascularity in primary melanoma. Melanoma Res. 9 (1999) 273-278
126. Indik Z., Yeh H., Ornstein-Goldstein N., Sheppard P., Anderson N., Rosenbloom J.C., Peltonen L., and Rosenbloom J. Alternative splicing of human elastin mRNA indicated by sequence analysis of cloned genomic and complementary DNA. Proc. Natl. Acad. Sci. USA 84 (1987) 5680-5684
127. Ishii Y., Ogura T., Tatemichi M., Fujisawa H., Otsuka F., and Esumi H. Induction of matrix metalloproteinase gene transcription by nitric oxide and mechanisms of MMP-1 gene induction in human melanoma cell lines. Int. J. Cancer 103 (2003) 161-168
128. Ito Y., Betsuyaku T., Nagai K., Nasuhara Y., and Nishimura M. Expression of pulmonary VEGF family declines with age and is further down-regulated in lipopolysaccharide (LPS)-induced lung injury. Exp. Gerontol. 40 (2005) 315-323
129. Itoh R., Kawamoto S., Adachi W., Kinoshita S., and Okubo K. Genomic organization and chromosomal localization of the human cathepsin L2 gene. DNA Res. 6 (1999) 137-140
130. Jacob M.P., Fulop Jr. T., Foris G., and Robert L. Effect of elastin peptides on ion fluxes in mononuclear cells, fibroblasts, and smooth muscle cells. Proc. Natl. Acad. Sci. USA 84 (1987) 995-999
131. Johnson D.A., Barrett A.J., and Mason R.W. Cathepsin L inactivates alpha 1-proteinase inhibitor by cleavage in the reactive site region. J. Biol. Chem. 261 (1986) 14748-14751
132. Jung S., Rutka J.T., and Hinek A. Tropoelastin and elastin degradation products promote proliferation of human astrocytoma cell lines. J. Neuropathol. Exp. Neurol. 57 (1998) 439-448
133. Juvonen T., Parkkila S., Lepojarvi M., and Niemela O. Demonstration of a bioactive elastin-derived peptide (Val-Gly-Val-Ala-Pro-Gly) in vascular lesions characterised by the segmental destruction of media. Ann. Chir. Gynaecol. 83 (1994) 296-302
134. Kahari V.M., Fazio M.J., Chen Y.Q., Bashir M.M., Rosenbloom J., and Uitto J. Deletion analyses of 5′-flanking region of the human elastin gene. Delineation of functional promoter and regulatory cis-elements. J. Biol. Chem. 265 (1990) 9485-9490
135. Kahari V.M., Chen Y.Q., Bashir M.M., Rosenbloom J., and Uitto J. Tumor necrosis factor-alpha down-regulates human elastin gene expression. Evidence for the role of AP-1 in the suppression of promoter activity. J. Biol. Chem. 267 (1992) 26134-26141
136. Kahari V.M., Olsen D.R., Rhudy R.W., Carrillo P., Chen Y.Q., and Uitto J. Transforming growth factor-beta up-regulates elastin gene expression in human skin fibroblasts. Evidence for post-transcriptional modulation. Lab. Invest. 66 (1992) 580-588
137. Kalluri R., and Zeisberg M. Fibroblasts in cancer. Nat. Rev. Cancer 6 (2006) 392-401
138. Kamisato S., Uemura Y., Takami N., and Okamoto K. Involvement of intracellular cyclic GMP and cyclic GMP-dependent protein kinase in alpha-elastin-induced macrophage chemotaxis. J. Biochem. (Tokyo) 121 (1997) 862-867
139. Kamoun A., Landeau J.M., Godeau G., Wallach J., Duchesnay A., Pellat B., and Hornebeck W. Growth stimulation of human skin fibroblasts by elastin-derived peptides. Cell Adhes. Commun. 3 (1995) 273-281
140. Karnik S.K., Brooke B.S., Bayes-Genis A., Sorensen L., Wythe J.D., Schwartz R.S., Keating M.T., and Li D.Y. A critical role for elastin signaling in vascular morphogenesis and disease. Development 130 (2003) 411-423
141. Kashani-Sabet M., Sagebiel R.W., Ferreira C.M., Nosrati M., and Miller III J.R. Tumor vascularity in the prognostic assessment of primary cutaneous melanoma. J. Clin. Oncol. 20 (2002) 1826-1831
142. Kielty C.M., Sherratt M.J., and Shuttleworth C.A. Elastic fibres. J. Cell Sci. 115 (2002) 2817-2828
143. Kim D., and Chung J. Akt: Versatile mediator of cell survival and beyond. J. Biochem. Mol. Biol. 35 (2002) 106-115
144. Kirschke H., and Wiederanders B. Cathepsin S and related lysosomal endopeptidases. Methods Enzymol. 244 (1994) 500-511
145. Kirschke H., Barrett A.J., and Rawlings N.D. Proteinases 1: Lysosomal cysteine proteinases. Protein Profile 2 (1995) 1581-1643
146. Koch A.E., Haines G.K., Rizzo R.J., Radosevich J.A., Pope R.M., Robinson P.G., and Pearce W.H. Human abdominal aortic aneurysms. Immunophenotypic analysis suggesting an immune-mediated response. Am. J. Pathol. 137 (1990) 1199-1213
147. Koike T., Vernon R.B., Gooden M.D., Sadoun E., and Reed M.J. Inhibited angiogenesis in aging: A role for TIMP-2. J. Gerontol. A Biol. Sci. Med. Sci. 58 (2003) B798-B805
148. Konovalova N.P., Goncharova S.A., Volkova L.M., Raevskaia T.A., Eremenko L.T., and Korolev A.M. Nitric oxide donor increases the effectiveness of cytostatic therapy and inhibits the development of drug resistance. Vopr. Onkol. 49 (2003) 71-75
149. Kozel B.A., Wachi H., Davis E.C., and Mecham R.P. Domains in tropoelastin that mediate elastin deposition in vitro and in vivo. J. Biol. Chem. 278 (2003) 18491-18498
150. Kozel B.A., Rongish B.J., Czirok A., Zach J., Little C.D., Davis E.C., Knutsen R.H., Wagenseil J.E., Levy M.A., and Mecham R.P. Elastic fiber formation: A dynamic view of extracellular matrix assembly using timer reporters. J. Cell. Physiol. 207 (2006) 87-96
151. Krettek A., Sukhova G.K., and Libby P. Elastogenesis in human arterial disease: A role for macrophages in disordered elastin synthesis. Arterioscler. Thromb. Vasc. Biol. 23 (2003) 582-587
152. Krtolica A., and Campisi J. Cancer and aging: A model for the cancer promoting effects of the aging stroma. Int. J. Biochem. Cell Biol. 34 (2002) 1401-1414
153. Labrousse A.L., Ntayi C., Hornebeck W., and Bernard P. Stromal reaction in cutaneous melanoma. Crit. Rev. Oncol. Hematol. 49 (2004) 269-275
154. Larbi A., Dupuis G., Khalil A., Douziech N., Fortin C., and Fulop Jr. T. Differential role of lipid rafts in the functions of CD4+ and CD8+ human T lymphocytes with aging. Cell. Signal. 18 (2006) 1017-1030
155. Larsen G.L., and Henson P.M. Mediators of inflammation. Annu. Rev. Immunol. 1 (1983) 335-359
156. Lee J.S., Basalyga D.M., Simionescu A., Isenburg J.C., Simionescu D.T., and Vyavahare N.R. Elastin calcification in the rat subdermal model is accompanied by up-regulation of degradative and osteogenic cellular responses. Am. J. Pathol. 168 (2006) 490-498
157. Leppert D., Hauser S.L., Kishiyama J.L., An S., Zeng L., and Goetzl E.J. Stimulation of matrix metalloproteinase-dependent migration of T cells by eicosanoids. FASEB J. 9 (1995) 1473-1481
158. Leppert D., Waubant E., Galardy R., Bunnett N.W., and Hauser S.L. T cell gelatinases mediate basement membrane transmigration in vitro. J. Immunol. 154 (1995) 4379-4389
159. Li Y.P., Alexander M., Wucherpfennig A.L., Yelick P., Chen W., and Stashenko P. Cloning and complete coding sequence of a novel human cathepsin expressed in giant cells of osteoclastomas. J. Bone Miner. Res. 10 (1995) 1197-1202
160. Libby P. Inflammation in atherosclerosis. Nature 420 (2002) 868-874
161. Limb G.A., Matter K., Murphy G., Cambrey A.D., Bishop P.N., Morris G.E., and Khaw P.T. Matrix metalloproteinase-1 associates with intracellular organelles and confers resistance to lamin A/C degradation during apoptosis. Am. J. Pathol. 166 (2005) 1555-1563
162. Lindholt J.S., Ashton H.A., Heickendorff L., and Scott R.A. Serum elastin peptides in the preoperative evaluation of abdominal aortic aneurysms. Eur. J. Vasc. Endovasc. Surg. 22 (2001) 546-550
163. Liu Z., Zhou X., Shapiro S.D., Shipley J.M., Twining S.S., Diaz L.A., Senior R.M., and Werb Z. The serpin alpha1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo. Cell 102 (2000) 647-655
164. Lombard C., Bouchu D., Wallach J., and Saulnier J. Proteinase 3 hydrolysis of peptides derived from human elastin exon 24. Amino Acids 28 (2005) 403-408
165. Lombard C., Arzel L., Bouchu D., Wallach J., and Saulnier J. Human leukocyte elastase hydrolysis of peptides derived from human elastin exon 24. Biochimie 88 12 (2006) 1915-1921
166. Long M.M., King V.J., Prasad K.U., and Urry D.W. Chemotaxis of fibroblasts toward nonapeptide of elastin. Biochim. Biophys. Acta 968 (1988) 300-311
167. Long M.M., King V.J., Prasad K.U., Freeman B.A., and Urry D.W. Elastin repeat peptides as chemoattractants for bovine aortic endothelial cells. J. Cell. Physiol. 140 (1989) 512-518
168. Longo G.M., Xiong W., Greiner T.C., Zhao Y., Fiotti N., and Baxter B.T. Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms. J. Clin. Invest. 110 (2002) 625-632
169. Lopez-Candales A., Holmes D.R., Liao S., Scott M.J., Wickline S.A., and Thompson R.W. Decreased vascular smooth muscle cell density in medial degeneration of human abdominal aortic aneurysms. Am. J. Pathol. 150 (1997) 993-1007
170. Luca M., Huang S., Gershenwald J.E., Singh R.K., Reich R., and Bar-Eli M. Expression of interleukin-8 by human melanoma cells up-regulates MMP-2 activity and increases tumor growth and metastasis. Am. J. Pathol. 151 (1997) 1105-1113
171. Lukong K.E., Seyrantepe V., Landry K., Trudel S., Ahmad A., Gahl W.A., Lefrancois S., Morales C.R., and Pshezhetsky A.V. Intracellular distribution of lysosomal sialidase is controlled by the internalization signal in its cytoplasmic tail. J. Biol. Chem. 276 (2001) 46172-46181
172. Maniotis A.J., Folberg R., Hess A., Seftor E.A., Gardner L.M., Pe'er J., Trent J.M., Meltzer P.S., and Hendrix M.J. Vascular channel formation by human melanoma cells in vivo and in vitro: Vasculogenic mimicry. Am. J. Pathol. 155 (1999) 739-752
173. Marcq V., Mirand C., Decarme M., Emonard H., and Hornebeck W. MMPs inhibitors: New succinylhydroxamates with selective inhibition of MMP-2 over MMP-3. Bioorg. Med. Chem. Lett. 13 (2003) 2843-2846
174. Martens J.W., Sieuwerts A.M., Bolt-deVries J., Bosma P.T., Swiggers S.J., Klijn J.G., and Foekens J.A. Aging of stromal-derived human breast fibroblasts might contribute to breast cancer progression. Thromb. Haemost. 89 (2003) 393-404
175. Matsushita H., Chang E., Glassford A.J., Cooke J.P., Chiu C.P., and Tsao P.S. eNOS activity is reduced in senescent human endothelial cells: Preservation by hTERT immortalization. Circ. Res. 89 (2001) 793-798
176. Matthews N.E., Adams M.A., Maxwell L.R., Gofton T.E., and Graham C.H. Nitric oxide-mediated regulation of chemosensitivity in cancer cells. J. Natl. Cancer Inst. 93 (2001) 1879-1885
177. Mauviel A. Cytokine regulation of metalloproteinase gene expression. J. Cell. Biochem. 53 (1993) 288-295
178. Mauviel A., Chen Y.Q., Kahari V.M., Ledo I., Wu M., Rudnicka L., and Uitto J. Human recombinant interleukin-1 beta up-regulates elastin gene expression in dermal fibroblasts. Evidence for transcriptional regulation in vitro and in vivo. J. Biol. Chem. 268 (1993) 6520-6524
179. McCaffrey T.A., and Falcone D.J. Evidence for an age-related dysfunction in the antiproliferative response to transforming growth factor-beta in vascular smooth muscle cells. Mol. Biol. Cell 4 (1993) 315-322
180. McCawley L.J., and Matrisian L.M. Matrix metalloproteinases: They're not just for matrix anymore!. Curr. Opin. Cell Biol. 13 (2001) 534-540
181. McGeer P.L., and McGeer E.G. Inflammation and the degenerative diseases of aging. Ann. N. Y. Acad. Sci. 1035 (2004) 104-116
182. McNulty M., Spiers P., McGovern E., and Feely J. Aging is associated with increased matrix metalloproteinase-2 activity in the human aorta. Am. J. Hypertens. 18 (2005) 504-509
183. McQuibban G.A., Gong J.H., Tam E.M., McCulloch C.A., Clark-Lewis I., and Overall C.M. Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3. Science 289 (2000) 1202-1206
184. McQuibban G.A., Gong J.H., Wong J.P., Wallace J.L., Clark-Lewis I., and Overall C.M. Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo. Blood 100 (2002) 1160-1167
185. Mecham R.P., Hinek A., Griffin G.L., Senior R.M., and Liotta L.A. The elastin receptor shows structural and functional similarities to the 67-kDa tumor cell laminin receptor. J. Biol. Chem. 264 (1989) 16652-16657
186. Mecham R.P., Broekelmann T.J., Fliszar C.J., Shapiro S.D., Welgus H.G., and Senior R.M. Elastin degradation by matrix metalloproteinases. Cleavage site specificity and mechanisms of elastolysis. J. Biol. Chem. 272 (1997) 18071-18076
187. Miao M., Bellingham C.M., Stahl R.J., Sitarz E.E., Lane C.J., and Keeley F.W. Sequence and structure determinants for the self-aggregation of recombinant polypeptides modeled after human elastin. J. Biol. Chem. 278 (2003) 48553-48562
188. Miller A.J., and Mihm Jr. M.C. Melanoma. N. Engl. J. Med. 355 (2006) 51-65
189. Minamino T., Miyauchi H., Tateno K., Kunieda T., and Komuro I. Akt-induced cellular senescence: Implication for human disease. Cell Cycle 3 (2004) 449-451
190. Mochizuki S., Brassart B., and Hinek A. Signaling pathways transduced through the elastin receptor facilitate proliferation of arterial smooth muscle cells. J. Biol. Chem. 277 (2002) 44854-44863
191. Mogford J.E., Tawil N., Chen A., Gies D., Xia Y., and Mustoe T.A. Effect of age and hypoxia on TGFbeta1 receptor expression and signal transduction in human dermal fibroblasts: Impact on cell migration. J. Cell. Physiol. 190 (2002) 259-265
192. Monboisse J.C., Garnotel R., Bellon G., Ohno N., Perreau C., Borel J.P., and Kefalides N.A. The alpha 3 chain of type IV collagen prevents activation of human polymorphonuclear leukocytes. J. Biol. Chem. 269 (1994) 25475-25482
193. Mott J.D., and Werb Z. Regulation of matrix biology by matrix metalloproteinases. Curr. Opin. Cell Biol. 16 (2004) 558-564
194. Nackman G.B., Karkowski F.J., Halpern V.J., Gaetz H.P., and Tilson M.D. Elastin degradation products induce adventitial angiogenesis in the Anidjar/Dobrin rat aneurysm model. Surgery 122 (1997) 39-44
195. Nagase H., and Woessner Jr. J.F. Matrix metalloproteinases. J. Biol. Chem. 274 (1999) 21491-21494
196. Nagase H., Visse R., and Murphy G. Structure and function of matrix metalloproteinases and TIMPs. Cardiovasc. Res. 69 (2006) 562-573
197. Nelson K.K., and Melendez J.A. Mitochondrial redox control of matrix metalloproteinases. Free Radic. Biol. Med. 37 (2004) 768-784
198. Nissen N.N., Polverini P.J., Koch A.E., Volin M.V., Gamelli R.L., and DiPietro L.A. Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing. Am. J. Pathol. 152 (1998) 1445-1452
199. Ntayi C., Labrousse A.L., Debret R., Birembaut P., Bellon G., Antonicelli F., Hornebeck W., and Bernard P. Elastin-derived peptides upregulate matrix metalloproteinase-2-mediated melanoma cell invasion through elastin-binding protein. J. Invest. Dermatol. 122 (2004) 256-265
200. Nurnberg W., Tobias D., Otto F., Henz B.M., and Schadendorf D. Expression of interleukin-8 detected by in situ hybridization correlates with worse prognosis in primary cutaneous melanoma. J. Pathol. 189 (1999) 546-551
201. Nyberg P., Xie L., and Kalluri R. Endogenous inhibitors of angiogenesis. Cancer Res. 65 (2005) 3967-3979
202. Okada Y., Watanabe S., Nakanishi I., Kishi J., Hayakawa T., Watorek W., Travis J., and Nagase H. Inactivation of tissue inhibitor of metalloproteinases by neutrophil elastase and other serine proteinases. FEBS Lett. 229 (1988) 157-160
203. Ooyama T., Fukuda K., Oda H., Nakamura H., and Hikita Y. Substratum-bound elastin peptide inhibits aortic smooth muscle cell migration in vitro. Arteriosclerosis 7 (1987) 593-598
204. Opdenakker G., Van den Steen P.E., Dubois B., Nelissen I., Van Coillie E., Masure S., Proost P., and Van Damme J. Gelatinase B functions as regulator and effector in leukocyte biology. J. Leukoc. Biol. 69 (2001) 851-859
205. Overall C.M., and Dean R.A. Degradomics: Systems biology of the protease web. Pleiotropic roles of MMPs in cancer. Cancer Metastasis Rev. 25 (2006) 69-75
206. Overall C.M., and Kleifeld O. Tumour microenvironment-opinion: Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy. Nat. Rev. Cancer 6 (2006) 227-239
207. Paik D.C., Fu C., Bhattacharya J., and Tilson M.D. Ongoing angiogenesis in blood vessels of the abdominal aortic aneurysm. Exp. Mol. Med. 36 (2004) 524-533
208. Parks W.C., Kolodziej M.E., and Pierce R.A. Phorbol ester-mediated downregulation of tropoelastin expression is controlled by a posttranscriptional mechanism. Biochemistry 31 (1992) 6639-6645
209. Pasquali-Ronchetti I., and Baccarani-Contri M. Elastic fiber during development and aging. Microsc. Res. Tech. 38 (1997) 428-435
210. Peppin G.J., and Weiss S.J. Activation of the endogenous metalloproteinase, gelatinase, by triggered human neutrophils. Proc. Natl. Acad. Sci. USA 83 (1986) 4322-4326
211. Pereira L., Andrikopoulos K., Tian J., Lee S.Y., Keene D.R., Ono R., Reinhardt D.P., Sakai L.Y., Biery N.J., Bunton T., Dietz H.C., and Ramirez F. Targeting of the gene encoding fibrillin-1 recapitulates the vascular aspect of Marfan syndrome. Nat. Genet. 17 (1997) 218-222
212. Petersen E., Wagberg F., and Angquist K.A. Serum concentrations of elastin-derived peptides in patients with specific manifestations of atherosclerotic disease. Eur. J. Vasc. Endovasc. Surg. 24 (2002) 440-444
213. Peterszegi G., and Robert L. Cell death induced in lymphocytes expressing the elastin-laminin receptor by excess agonists: Necrosis and apoptosis. Biomed. Pharmacother. 52 (1998) 369-377
214. Peterszegi G., Robert A.M., and Robert L. Presence of the elastin-laminin receptor on human activated lymphocytes. C. R. Acad. Sci. III 319 (1996) 799-803
215. Peterszegi G., Mandet C., Texier S., Robert L., and Bruneval P. Lymphocytes in human atherosclerotic plaque exhibit the elastin-laminin receptor: Potential role in atherogenesis. Atherosclerosis 135 (1997) 103-107
216. Peterszegi G., Texier S., and Robert L. Human helper and memory lymphocytes exhibit an inducible elastin-laminin receptor. Int. Arch. Allergy Immunol. 114 (1997) 218-223
217. Peterszegi G., Texier S., and Robert L. Cell death by overload of the elastin-laminin receptor on human activated lymphocytes: Protection by lactose and melibiose. Eur. J. Clin. Invest. 29 (1999) 166-172
218. Pham C.T. Neutrophil serine proteases: Specific regulators of inflammation. Nat. Rev. Immunol. 6 (2006) 541-550
219. Pierce R.A., Moore C.H., and Arikan M.C. Positive transcriptional regulatory element located within exon 1 of elastin gene. Am. J. Physiol. Lung Cell. Mol. Physiol. 291 (2006) L391-L399
220. Plackett T.P., Boehmer E.D., Faunce D.E., and Kovacs E.J. Aging and innate immune cells. J. Leukoc. Biol. 76 (2004) 291-299
221. Poggi A., and Mingari M.C. Development of human NK cells from the immature cell precursors. Semin. Immunol. 7 (1995) 61-66
222. Privitera S., Prody C.A., Callahan J.W., and Hinek A. The 67-kDa enzymatically inactive alternatively spliced variant of beta-galactosidase is identical to the elastin/laminin-binding protein. J. Biol. Chem. 273 (1998) 6319-6326
223. Proctor R.A. Fibronectin: An enhancer of phagocyte function. Rev. Infect. Dis. 9 Suppl. 4 (1987) S412-S419
224. Punturieri A., Filippov S., Allen E., Caras I., Murray R., Reddy V., and Weiss S.J. Regulation of elastinolytic cysteine proteinase activity in normal and cathepsin K-deficient human macrophages. J. Exp. Med. 192 (2000) 789-799
225. Pyo R., Lee J.K., Shipley J.M., Curci J.A., Mao D., Ziporin S.J., Ennis T.L., Shapiro S.D., Senior R.M., and Thompson R.W. Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms. J. Clin. Invest. 105 (2000) 1641-1649
226. Qin X., Corriere M.A., Matrisian L.M., and Guzman R.J. Matrix metalloproteinase inhibition attenuates aortic calcification. Arterioscler. Thromb. Vasc. Biol. 26 (2006) 1510-1516
227. Qiu H., Orr F.W., Jensen D., Wang H.H., McIntosh A.R., Hasinoff B.B., Nance D.M., Pylypas S., Qi K., Song C., Muschel R.J., and Al-Mehdi A.B. Arrest of B16 melanoma cells in the mouse pulmonary microcirculation induces endothelial nitric oxide synthase-dependent nitric oxide release that is cytotoxic to the tumor cells. Am. J. Pathol. 162 (2003) 403-412
228. Quaranta V. Motility cues in the tumor microenvironment. Differentiation 70 (2002) 590-598
229. Radisky D.C., Levy D.D., Littlepage L.E., Liu H., Nelson C.M., Fata J.E., Leake D., Godden E.L., Albertson D.G., Nieto M.A., Werb Z., and Bissell M.J. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature 436 (2005) 123-127
230. Ramjeesingh R., Leung R., and Siu C.H. Interleukin-8 secreted by endothelial cells induces chemotaxis of melanoma cells through the chemokine receptor CXCR1. FASEB J. 17 (2003) 1292-1294
231. Reddy V.Y., Zhang Q.Y., and Weiss S.J. Pericellular mobilization of the tissue-destructive cysteine proteinases, cathepsins B, L, and S, by human monocyte-derived macrophages. Proc. Natl. Acad. Sci. USA 92 (1995) 3849-3853
232. Reed M.J., and Edelberg J.M. Impaired angiogenesis in the aged. Sci. Aging Knowledge Environ. (2004) pe7
233. Reed M.J., Corsa A., Pendergrass W., Penn P., Sage E.H., and Abrass I.B. Neovascularization in aged mice: Delayed angiogenesis is coincident with decreased levels of transforming growth factor beta1 and type I collagen. Am. J. Pathol. 152 (1998) 113-123
234. Reed M.J., Corsa A.C., Kudravi S.A., McCormick R.S., and Arthur W.T. A deficit in collagenase activity contributes to impaired migration of aged microvascular endothelial cells. J. Cell. Biochem. 77 (2000) 116-126
235. Reed M.J., Ferara N.S., and Vernon R.B. Impaired migration, integrin function, and actin cytoskeletal organization in dermal fibroblasts from a subset of aged human donors. Mech. Ageing Dev. 122 (2001) 1203-1220
236. Rink L., Cakman I., and Kirchner H. Altered cytokine production in the elderly. Mech. Ageing Dev. 102 (1998) 199-209
237. Risau W. Mechanisms of angiogenesis. Nature 386 (1997) 671-674
238. Rivard A., Fabre J.E., Silver M., Chen D., Murohara T., Kearney M., Magner M., Asahara T., and Isner J.M. Age-dependent impairment of angiogenesis. Circulation 99 (1999) 111-120
239. Robache-Gallea S., Morand V., Bruneau J.M., Schoot B., Tagat E., Realo E., Chouaib S., and Roman-Roman S. In vitro processing of human tumor necrosis factor-alpha. J. Biol. Chem. 270 (1995) 23688-23692
240. Robert A.M., Grosgogeat Y., Reverdy V., Robert B., and Robert L. Arterial lesions produced in rabbits by immunisation with elastin and structural glycoproteins of aorta. Biochemical and morphological studies. Atherosclerosis 13 (1971) 427-449
241. Robert L. Aging of the vascular-wall and atherosclerosis. Exp. Gerontol. 34 (1999) 491-501
242. Robert L., Jacob M.P., Frances C., Godeau G., and Hornebeck W. Interaction between elastin and elastases and its role in the aging of the arterial wall, skin and other connective tissues. A review. Mech. Ageing Dev. 28 (1984) 155-166
243. Robinet A., Fahem A., Cauchard J.H., Huet E., Vincent L., Lorimier S., Antonicelli F., Soria C., Crepin M., Hornebeck W., and Bellon G. Elastin-derived peptides enhance angiogenesis by promoting endothelial cell migration and tubulogenesis through upregulation of MT1-MMP. J. Cell Sci. 118 (2005) 343-356
244. Robinet A., Millart H., Dszust F., Hornebeck W., and Bellon G. Binding of elastin peptides to S-Gal protects the heart against ischemia/reperfusion injury by triggering the risk pathway. FASEB J. (2007) (in press)
245. Rock M.J., Cain S.A., Freeman L.J., Morgan A., Mellody K., Marson A., Shuttleworth C.A., Weiss A.S., and Kielty C.M. Molecular basis of elastic fiber formation. Critical interactions and a tropoelastin-fibrillin-1 cross-link. J. Biol. Chem. 279 (2004) 23748-23758
246. Rodgers U.R., and Weiss A.S. Integrin alpha v beta 3 binds a unique non-RGD site near the C-terminus of human tropoelastin. Biochimie 86 (2004) 173-178
247. Rose S.D., and MacDonald R.J. Evolutionary silencing of the human elastase I gene (ELA1). Hum. Mol. Genet. 6 (1997) 897-903
248. Rosenbloom J., Abrams W.R., and Mecham R. Extracellular matrix 4: The elastic fiber. FASEB J. 7 (1993) 1208-1218
249. Rossignol P., Fontaine V., Meilhac O., Angles-Cano E., Jacob M.P., and Michel J.B. Physiopathology of aortic aneurysm. Rev. Prat. 52 (2002) 1061-1065
250. Sadoun E., and Reed M.J. Impaired angiogenesis in aging is associated with alterations in vessel density, matrix composition, inflammatory response, and growth factor expression. J. Histochem. Cytochem. 51 (2003) 1119-1130
251. Saito S., Zempo N., Yamashita A., Takenaka H., Fujioka K., and Esato K. Matrix metalloproteinase expressions in arteriosclerotic aneurysmal disease. Vasc. Endovascular Surg. 36 (2002) 1-7
252. Sarkar D., and Fisher P.B. Molecular mechanisms of aging-associated inflammation. Cancer Lett. 236 (2006) 13-23
253. Sartippour M.R., Heber D., Zhang L., Beatty P., Elashoff D., Elashoff R., Go V.L., and Brooks M.N. Inhibition of fibroblast growth factors by green tea. Int. J. Oncol. 21 (2002) 487-491
254. Sata M. Role of circulating vascular progenitors in angiogenesis, vascular healing, and pulmonary hypertension: Lessons from animal models. Arterioscler. Thromb. Vasc. Biol. 26 (2006) 1008-1014
255. Satta J., Soini Y., Mosorin M., and Juvonen T. Angiogenesis is associated with mononuclear inflammatory cells in abdominal aortic aneurysms. Ann. Chir. Gynaecol. 87 (1998) 40-42
256. Schafer P.H., Gandhi A.K., Loveland M.A., Chen R.S., Man H.W., Schnetkamp P.P., Wolbring G., Govinda S., Corral L.G., Payvandi F., Muller G.W., and Stirling D.I. Enhancement of cytokine production and AP-1 transcriptional activity in T cells by thalidomide-related immunomodulatory drugs. J. Pharmacol. Exp. Ther. 305 (2003) 1222-1232
257. Schenk S., and Quaranta V. Tales from the crypt(ic) sites of the extracellular matrix. Trends Cell Biol. 13 (2003) 366-375
258. Schonbeck U., Sukhova G.K., Gerdes N., and Libby P. T(H)2 predominant immune responses prevail in human abdominal aortic aneurysm. Am. J. Pathol. 161 (2002) 499-506
259. Senior R.M., Griffin G.L., and Mecham R.P. Chemotactic activity of elastin-derived peptides. J. Clin. Invest. 66 (1980) 859-862
260. Senior R.M., Griffin G.L., Mecham R.P., Wrenn D.S., Prasad K.U., and Urry D.W. Val-Gly-Val-Ala-Pro-Gly, a repeating peptide in elastin, is chemotactic for fibroblasts and monocytes. J. Cell Biol. 99 (1984) 870-874
261. Sephel G.C., and Davidson J.M. Elastin production in human skin fibroblast cultures and its decline with age. J. Invest. Dermatol. 86 (1986) 279-285
262. Serrano M., Lin A.W., McCurrach M.E., Beach D., and Lowe S.W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88 (1997) 593-602
263. Sewing A., Wiseman B., Lloyd A.C., and Land H. High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1. Mol. Cell. Biol. 17 (1997) 5588-5597
264. Shapiro S.D., Endicott S.K., Province M.A., Pierce J.A., and Campbell E.J. Marked longevity of human lung parenchymal elastic fibers deduced from prevalence of D-aspartate and nuclear weapons-related radiocarbon. J. Clin. Invest. 87 (1991) 1828-1834
265. Shapiro S.D., Kobayashi D.K., and Ley T.J. Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages. J. Biol. Chem. 268 (1993) 23824-23829
266. Shearer G.M. Th1/Th2 changes in aging. Mech. Ageing Dev. 94 (1997) 1-5
267. Shelton D.N., Chang E., Whittier P.S., Choi D., and Funk W.D. Microarray analysis of replicative senescence. Curr. Biol. 9 (1999) 939-945
268. Sheu B.C., Hsu S.M., Ho H.N., Lin R.H., Torng P.L., and Huang S.C. Reversed CD4/CD8 ratios of tumor-infiltrating lymphocytes are correlated with the progression of human cervical carcinoma. Cancer 86 (1999) 1537-1543
269. Sheu B.C., Hsu S.M., Ho H.N., Lien H.C., Huang S.C., and Lin R.H. A novel role of metalloproteinase in cancer-mediated immunosuppression. Cancer Res. 61 (2001) 237-242
270. Shimizu K., Shichiri M., Libby P., Lee R.T., and Mitchell R.N. Th2-predominant inflammation and blockade of IFN-gamma signaling induce aneurysms in allografted aortas. J. Clin. Invest. 114 (2004) 300-308
271. Shimizu K., Libby P., and Mitchell R.N. Local cytokine environments drive aneurysm formation in allografted aortas. Trends Cardiovasc. Med. 15 (2005) 142-148
272. Shimizu K., Mitchell R.N., and Libby P. Inflammation and cellular immune responses in abdominal aortic aneurysms. Arterioscler. Thromb. Vasc. Biol. 26 (2006) 987-994
273. Shinohara T., Suzuki K., Okada M., Shiigai M., Shimizu M., Maehara T., and Ohsuzu F. Soluble elastin fragments in serum are elevated in acute aortic dissection. Arterioscler. Thromb. Vasc. Biol. 23 (2003) 1839-1844
274. Si-Tayeb K., Monvoisin A., Mazzocco C., Lepreux S., Decossas M., Cubel G., Taras D., Blanc J.F., Robinson D.R., and Rosenbaum J. Matrix metalloproteinase 3 is present in the cell nucleus and is involved in apoptosis. Am. J. Pathol. 169 (2006) 1390-1401
275. Simionescu A., Philips K., and Vyavahare N. Elastin-derived peptides and TGF-beta1 induce osteogenic responses in smooth muscle cells. Biochem. Biophys. Res. Commun. 334 (2005) 524-532
276. Sires U.I., Murphy G., Baragi V.M., Fliszar C.J., Welgus H.G., and Senior R.M. Matrilysin is much more efficient than other matrix metalloproteinases in the proteolytic inactivation of alpha 1-antitrypsin. Biochem. Biophys. Res. Commun. 204 (1994) 613-620
277. Sivaprasad S., Chong N.V., and Bailey T.A. Serum elastin-derived peptides in age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 46 (2005) 3046-3051
278. Smith A.R., and Hagen T.M. Vascular endothelial dysfunction in aging: Loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-alpha-lipoic acid. Biochem. Soc. Trans. 31 (2003) 1447-1449
279. Smith A.R., Visioli F., and Hagen T.M. Plasma membrane-associated endothelial nitric oxide synthase and activity in aging rat aortic vascular endothelia markedly decline with age. Arch. Biochem. Biophys. 454 (2006) 100-105
280. Somerville R.P., Oblander S.A., and Apte S.S. Matrix metalloproteinases: Old dogs with new tricks. Genome Biol. 4 (2003) 216
281. Sosman J.A., and Puzanov I. Molecular targets in melanoma from angiogenesis to apoptosis. Clin. Cancer Res. 12 (2006) 2376s-2383s
282. Srivastava A., Ralhan R., and Kaur J. Angiogenesis in cutaneous melanoma: Pathogenesis and clinical implications. Microsc. Res. Tech. 60 (2003) 208-224
283. Streit M., and Detmar M. Angiogenesis, lymphangiogenesis, and melanoma metastasis. Oncogene 22 (2003) 3172-3179
284. Sturrock A.B., Franklin K.F., Rao G., Marshall B.C., Rebentisch M.B., Lemons R.S., and Hoidal J.R. Structure, chromosomal assignment, and expression of the gene for proteinase-3. The Wegener's granulomatosis autoantigen. J. Biol. Chem. 267 (1992) 21193-21199
285. Swee M.H., Parks W.C., and Pierce R.A. Developmental regulation of elastin production. Expression of tropoelastin pre-mRNA persists after down-regulation of steady-state mRNA levels. J. Biol. Chem. 270 (1995) 14899-14906
286. Swetter S.M., Geller A.C., and Kirkwood J.M. Melanoma in the older person. Oncology (Williston Park) 18 (2004) 1187-1196 discussion, 1196-1197.
287. Swift M.E., Kleinman H.K., and DiPietro L.A. Impaired wound repair and delayed angiogenesis in aged mice. Lab. Invest. 79 (1999) 1479-1487
288. Syrigos K.N., Tzannou I., Katirtzoglou N., and Georgiou E. Skin cancer in the elderly. In Vivo 19 (2005) 643-652
289. Tajima S., Wachi H., Uemura Y., and Okamoto K. Modulation by elastin peptide VGVAPG of cell proliferation and elastin expression in human skin fibroblasts. Arch. Dermatol. Res. 289 (1997) 489-492
290. Takahashi H., Nukiwa T., Yoshimura K., Quick C.D., States D.J., Holmes M.D., Whang-Peng J., Knutsen T., and Crystal R.G. Structure of the human neutrophil elastase gene. J. Biol. Chem. 263 (1988) 14739-14747
291. Talas U., Dunlop J., Khalaf S., Leigh I.M., and Kelsell D.P. Human elastase 1: Evidence for expression in the skin and the identification of a frequent frameshift polymorphism. J. Invest. Dermatol. 114 (2000) 165-170
292. Timar J., Lapis K., Fulop T., Varga Z.S., Tixier J.M., Robert L., and Hornebeck W. Interaction between elastin and tumor cell lines with different metastatic potential; in vitro and in vivo studies. J. Cancer Res. Clin. Oncol. 117 (1991) 232-238
293. Toonkool P., Jensen S.A., Maxwell A.L., and Weiss A.S. Hydrophobic domains of human tropoelastin interact in a context-dependent manner. J. Biol. Chem. 276 (2001) 44575-44580
294. Toussaint O., Medrano E.E., and von Zglinicki T. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp. Gerontol. 35 (2000) 927-945
295. Toussaint O., Remacle J., Dierick J.F., Pascal T., Frippiat C., Royer V., and Chainiaux F. Approach of evolutionary theories of ageing, stress, senescence-like phenotypes, calorie restriction and hormesis from the view point of far-from-equilibrium thermodynamics. Mech. Ageing Dev. 123 (2002) 937-946
296. Tran K.T., Lamb P., and Deng J.S. Matrikines and matricryptins: Implications for cutaneous cancers and skin repair. J. Dermatol. Sci. 40 (2005) 11-20
297. Trejo J.L., Carro E., Lopez-Lopez C., and Torres-Aleman I. Role of serum insulin-like growth factor I in mammalian brain aging. Growth Horm. IGF Res. 14 Suppl. A (2004) S39-S43
298. Tschudi M.R., Barton M., Bersinger N.A., Moreau P., Cosentino F., Noll G., Malinski T., and Luscher T.F. Effect of age on kinetics of nitric oxide release in rat aorta and pulmonary artery. J. Clin. Invest. 98 (1996) 899-905
299. Uemura Y., and Okamoto K. Elastin-derived peptide induces monocyte chemotaxis by increasing intracellular cyclic GMP level and activating cyclic GMP dependent protein kinase. Biochem. Mol. Biol. Int. 41 (1997) 1085-1092
300. Uitto J., and Bernstein E.F. Molecular mechanisms of cutaneous aging: Connective tissue alterations in the dermis. J. Investig. Dermatol. Symp. Proc. 3 (1998) 41-44
301. Vaday G.G., and Lider O. Extracellular matrix moieties, cytokines, and enzymes: Dynamic effects on immune cell behavior and inflammation. J. Leukoc. Biol. 67 (2000) 149-159
302. Van den Steen P.E., Proost P., Wuyts A., Van Damme J., and Opdenakker G. Neutrophil gelatinase B potentiates interleukin-8 tenfold by aminoterminal processing, whereas it degrades CTAP-III, PF-4, and GRO-alpha and leaves RANTES and MCP-2 intact. Blood 96 (2000) 2673-2681
303. van der Loo B., Labugger R., Skepper J.N., Bachschmid M., Kilo J., Powell J.M., Palacios-Callender M., Erusalimsky J.D., Quaschning T., Malinski T., Gygi D., Ullrich V., et al. Enhanced peroxynitrite formation is associated with vascular aging. J. Exp. Med. 192 (2000) 1731-1744
304. Varga Z., Jacob M.P., Robert L., Csongor J., and Fulop Jr. T. Age-dependent changes of K-elastin stimulated effector functions of human phagocytic cells: Relevance for atherogenesis. Exp. Gerontol. 32 (1997) 653-662
305. Varga Z., Kovacs E.M., Paragh G., Jacob M.P., Robert L., and Fulop Jr. T. Effect of elastin peptides and N-formyl-methionyl-leucyl phenylalanine on cytosolic free calcium in polymorphonuclear leukocytes of healthy middle-aged and elderly subjects. Clin. Biochem. 21 (1988) 127-130
306. Varney M.L., Li A., Dave B.J., Bucana C.D., Johansson S.L., and Singh R.K. Expression of CXCR1 and CXCR2 receptors in malignant melanoma with different metastatic potential and their role in interleukin-8 (CXCL-8)-mediated modulation of metastatic phenotype. Clin. Exp. Metastasis 20 (2003) 723-731
307. Varney M.L., Johansson S.L., and Singh R.K. Distinct expression of CXCL8 and its receptors CXCR1 and CXCR2 and their association with vessel density and aggressiveness in malignant melanoma. Am. J. Clin. Pathol. 125 (2006) 209-216
308. Vasa M., Breitschopf K., Zeiher A.M., and Dimmeler S. Nitric oxide activates telomerase and delays endothelial cell senescence. Circ. Res. 87 (2000) 540-542
309. Wachi H., Seyama Y., Yamashita S., Suganami H., Uemura Y., Okamoto K., Yamada H., and Tajima S. Stimulation of cell proliferation and autoregulation of elastin expression by elastin peptide VPGVG in cultured chick vascular smooth muscle cells. FEBS Lett. 368 (1995) 215-219
310. Wang H., Keiser J.A., Olszewski B., Rosebury W., Robertson A., Kovesdi I., and Gordon D. Delayed angiogenesis in aging rats and therapeutic effect of adenoviral gene transfer of VEGF. Int. J. Mol. Med. 13 (2004) 581-587
311. Wang Z., Zheng T., Zhu Z., Homer R.J., Riese R.J., Chapman Jr. H.A., Shapiro S.D., and Elias J.A. Interferon gamma induction of pulmonary emphysema in the adult murine lung. J. Exp. Med. 192 (2000) 1587-1600
312. Wassef M., Baxter B.T., Chisholm R.L., Dalman R.L., Fillinger M.F., Heinecke J., Humphrey J.D., Kuivaniemi H., Parks W.C., Pearce W.H., Platsoucas C.D., Sukhova G.K., et al. Pathogenesis of abdominal aortic aneurysms: A multidisciplinary research program supported by the National Heart, Lung, and Blood Institute. J. Vasc. Surg. 34 (2001) 730-738
313. Watanabe T., Shimokama T., Haraoka S., and Kishikawa H. T lymphocytes in atherosclerotic lesions. Ann. N. Y. Acad. Sci. 748 (1995) 40-55 discussion, 55-56
314. Wei S.M., Erdei J., Fulop Jr. T., Robert L., and Jacob M.P. Elastin peptide concentration in human serum: Variation with antibodies and elastin peptides used for the enzyme-linked immunosorbent assay. J. Immunol. Methods 164 (1993) 175-187
315. Weinberger B., Hanna N., Laskin J.D., Heck D.E., Gardner C.R., Gerecke D.R., and Laskin D.L. Mechanisms mediating the biologic activity of synthetic proline, glycine, and hydroxyproline polypeptides in human neutrophils. Mediators Inflamm. 1 (2005) 31-38
316. Weinsaft J.W., and Edelberg J.M. Aging-associated changes in vascular activity: A potential link to geriatric cardiovascular disease. Am. J. Geriatr. Cardiol. 10 (2001) 348-354
317. Westermarck J., Li S.P., Kallunki T., Han J., and Kahari V.M. p38 mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression. Mol. Cell. Biol. 21 (2001) 2373-2383
318. Wilson C.L., and Matrisian L.M. Matrilysin: An epithelial matrix metalloproteinase with potentially novel functions. Int. J. Biochem. Cell Biol. 28 (1996) 123-136
319. Woessner Jr. J.F. Matrilysin. Methods Enzymol. 248 (1995) 485-495
320. Woessner J.F., and Nagase I. "Matrix Metalloproteinases and TIMPs." (2000), Oxford University Press, London, UK
321. Xiong W., Zhao Y., Prall A., Greiner T.C., and Baxter B.T. Key roles of CD4+ T cells and IFN-gamma in the development of abdominal aortic aneurysms in a murine model. J. Immunol. 172 (2004) 2607-2612
322. Yanagisawa H., Davis E.C., Starcher B.C., Ouchi T., Yanagisawa M., Richardson J.A., and Olson E.N. Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo. Nature 415 (2002) 168-171
323. Yasuda Y., Li Z., Greenbaum D., Bogyo M., Weber E., and Bromme D. Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages. J. Biol. Chem. 279 (2004) 36761-36770
324. Yeh H., Anderson N., Ornstein-Goldstein N., Bashir M.M., Rosenbloom J.C., Abrams W., Indik Z., Yoon K., Parks W., Mecham R., and Rosenbloom J. Structure of the bovine elastin gene and S1 nuclease analysis of alternative splicing of elastin mRNA in the bovine nuchal ligament. Biochemistry 28 (1989) 2365-2370
325. Yoshino I., Yano T., Miyamoto M., Yamada K., Kajii Y., Onodera K., Ishida T., Sugimachi K., Kimura G., and Nomoto K. Characterization of lung squamous cell carcinoma-derived T-cell suppressive factor. Cancer 72 (1993) 2347-2357
326. Zeng G., and Millis A.J. Expression of 72-kDa gelatinase and TIMP-2 in early and late passage human fibroblasts. Exp. Cell Res. 213 (1994) 148-155
327. Zimmer M., Medcalf R.L., Fink T.M., Mattmann C., Lichter P., and Jenne D.E. Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter. Proc. Natl. Acad. Sci. USA 89 (1992) 8215-8219