Pathogenesis of abdominal aortic aneurysms: A multidisciplinary research program supported by the National Heart, Lung, and Blood Institute

Journal of Vascular Surgery

Volumn 34, Issue 4, 2001, Pages 730-738

  Wassef, Momtaz ^a   Baxter, B Timothy ^a   Chisholm, Rex L ^a   Dalman, Ronald L ^a   Fillinger, Mark F ^a   Heinecke, Jay ^a   Humphrey, Jay D ^a   Kuivaniemi, Helena ^a   Parks, William C ^a   Pearce, William H ^a   Platsoucas, Christopher D ^a   Sukhova, Galina K ^a   Thompson, Robert W ^a   Tilson, M David ^a   Zarins, Christopher K ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE; GELATINASE B; PEPTIDE HYDROLASE;

ABDOMINAL AORTA ANEURYSM; BIOMECHANICS; BLOOD RHEOLOGY; CONFERENCE PAPER; CONNECTIVE TISSUE; DISEASE COURSE; DRUG EFFECT; EPIDEMIOLOGY; FINANCIAL MANAGEMENT; HEALTH CARE ORGANIZATION; HUMAN; INFLAMMATION; METABOLISM; MOLECULAR BIOLOGY; NEEDS ASSESSMENT; ORGANIZATION; ORGANIZATION AND MANAGEMENT; PATIENT CARE; PHYSIOLOGY; RESEARCH; UNITED STATES;

AORTIC ANEURYSM, ABDOMINAL; BIOMECHANICS; CAUSALITY; CONNECTIVE TISSUE; DISEASE PROGRESSION; DOXYCYCLINE; HEMORHEOLOGY; HUMANS; INFLAMMATION; MATRIX METALLOPROTEINASE 9; MOLECULAR BIOLOGY; NATIONAL INSTITUTES OF HEALTH (U.S.); NEEDS ASSESSMENT; ORGANIZATIONAL OBJECTIVES; PATIENT CARE TEAM; PEPTIDE HYDROLASES; RESEARCH; RESEARCH SUPPORT; UNITED STATES;

EID: 0035488323     PISSN: 07415214     EISSN: None     Source Type: Journal    
DOI: 10.1067/mva.2001.116966     Document Type: Article

References (55)

1. Johnston KW, Rutherford RB, Tilson MD, Shah DM, Hollier L, Stanley JC. Suggested standards for reporting on arterial aneurysms. Subcommittee on Reporting Standards for Arterial Aneurysms, Ad Hoc Committee on Reporting Standards, Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery. J Vasc Surg 1991;13:452-8.
2. Hollier LH, Taylor LM, Ochsner J. Recommended indications for operative treatment of abdominal aortic aneurysms. J Vasc Surg 1992;15:1046-56.
3. Cole CW, Hill GB, Lindsay J, Mickelson WP, Mills C, Wigle DT. Proceedings of the workshop on the control of abdominal aortic aneurysm. Chronic Dis Can 1994;15(Suppl):S1-64.
4. Thompson RW. Basic science of abdominal aortic aneurysms: emerging therapeutic strategies for an unresolved clinical problem. Curr Opin Cardiol 1996;11:504-18.
5. Boyd CD, Tilson MD. The abdominal aortic aneurysm: etiology, pathophysiology and genetics. New York: New York Academy of Science; 1996.
6. Davies MJ. Aortic aneurysm formation: lessons from human studies and experimental models. Circulation 1998;98:193-5.
7. Dobrin PB, Mrkvicka R. Failure of elastin or collagen as possible critical connective tissue alterations underlying aneurysmal dilatation. Cardiovasc Surg 1994;2:484-8.
8. Thompson RW, Parks WC. Role of matrix metalloproteinases in abdominal aortic aneurysms. Ann N Y Acad Sci 1996;800:157-74.
9. Tamarina NA, McMillan WD, Shively VP, Pearce WH. Expression of matrix metalloproteinases and their inhibitors in aneurysms and normal aorta. Surgery 1997;122:264-71.
10. Shah PK. Inflammation, metalloproteinases, and increased proteolysis: an emerging pathophysiological paradigm in aortic aneurysm. Circulation 1997;96:2115-7.
11. McMillan WD, Tamarina NA, Cipollone M, Johnson DA, Parker MA, Pearce WH. Size matters: the relationship between MMP-9 expression and aortic diameter. Circulation 1997;96:2228-32.
12. McMillan WD, Pearce WH. Increased plasma levels of metalloproteinase-9 are associated with abdominal aortic aneurysms. J Vasc Surg 1999;29:122-7.
13. Chiou AC, Chiu B, Oppat WF, Matsumura JS, Chisholm RL, Pearce WH. Transrectal ultrasound assessment of murine aorta and iliac arteries. J Surg Res 2000;88:193-9.
14. Davis V, Persidskaia R, Baca-Regen L, Itoh Y, Nagase H, Persidsky Y, et al. Matrix metalloproteinase-2 production and its binding to the matrix are increased in abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol 1998;18:1625-33.
15. Thompson RW, Baxter BT. MMP inhibition in abdominal aortic aneurysms: rationale for a prospective randomized clinical trial. Ann N Y Acad Sci 1999;878:159-78.
16. Petrinec D, Liao S, Holmes DR, Reilly JM, Parks WC, Thompson RW. Doxycycline inhibition of aneurysmal degeneration in an elastase-induced rat model of abdominal aortic aneurysm: preservation of aortic elastin associated with suppressed production of 92 kD gelatinase. J Vasc Surg 1996;23:336-46.
17. Curci JA, Mao D, Bohner DG, Allen BT, Rubin BG, Reilly JM, et al. Preoperative treatment with doxycycline reduces aortic wall expression and activation of matrix metalloproteinases in patients with abdominal aortic aneurysms. J Vasc Surg 2000;31:325-42.
18. Pyo R, Lee JK, Shipley JM, Curci JA, Mao D, Ziporin SJ, et al. Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms. J Clin Invest 2000;105:1641-9.
19. Mao D, Lee JK, VanVickle SJ, Thompson RW. Expression of collage-nase-3 (MMP-13) in human abdominal aortic aneurysms and vascular smooth muscle cells in culture. Biochem Biophys Res Commun 1999;261:904-10.
20. Huffman MD, Curci JA, Moore G, Kerns DB, Starcher BC, Thompson RW. Functional importance of connective tissue repair during the development of experimental abdominal aortic aneurysms. Surgery 2000;128:429-38.
21. Liao S, Curci JA, Kelley B, Sicard GA, Thompson RW. Accelerated replicative senescence of medial smooth muscle cells derived from abdominal aortic aneurysms as compared to the adjacent inferior mesenteric artery. J Surg Res 2000;92:85-95.
22. Heinecke JW. Mechanisms of oxidative damage by myeloperoxidase in atherosclerosis and other inflammatory disorders. J Lab Clin Med 1999;133:321-5.
23. Heinecke JW, Hsu FF, Crowley JR, Hazen SL, Leeuwenburgh C, Mueller DM, et al. Detecting oxidative modification of bio molecules with isotope dilution mass spectrometry: sensitive and quantitative assays for oxidized amino acids in proteins and tissues. Methods Enzymol 1999;300:124-44.
24. Heinecke JW. Mass spectrometric quantification of amino acid oxidation products in proteins: insights into pathways that promote LDL oxidation in the human artery wall. FASEB J 1999;13:1113-20.
25. Parks WC, Pierce RA, Lee KA, Mecham RP. Elastin. Advances in Molecular Cell Biology 1993;6:133-82.
26. Pierce RA, Kolodziej ME, Parks WC. 1,25-Dihydroxyvitamin D3 represses tropoelastin expression by a posttranscriptional mechanism. J Biol Chem 1992;267:11593-9.
27. Swee MH, Parks WC, Pierce RA. Developmental regulation of elastin production. Expression of tropoelastin pre-mRNA persists after down-regulation of steady-state mRNA levels. J Biol Chem 1995;270:14899-906.
28. Parks WC. Posttranscriptional regulation of lung elastin production. Am J Respir Cell Mol Biol 1997;17:1-2.
29. Zhang M, Pierce RA, Wachi H, Mecham RP, Parks WC. An open reading frame element mediates posttranscriptional regulation of tropoelastin and responsive ness to transforming growth factor beta1. Mol Cell Biol 1999;19:7314-26.
30. Sukhova GK, Shi GP, Simon DI, Chapman HA, Libby P. Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. J Clin Invest 1998;102:576-83.
31. Shi GP, Sukhova GK, Grubb A, Ducharme A, Rhode LH, Lee RT, et al. Cystatin C deficiency in human atherosclerosis and aortic aneurysms. J Clin Invest 1999;104:1191-7.
32. McMillan WD, Pearce WH. Inflammation and cytokine signaling in aneurysms. Ann Vasc Surg 1997;11:540-5.
33. Koch AE, Haines GK, Rizzo RJ, Radosevich JA, Pope RM, Robinson PG, et al. Human abdominal aortic aneurysms. Immunophenotypic analysis suggesting an immune-mediated response. Am J Pathol 1990;137:1199-213.
34. Gregory AK, Yin NX, Capella J, Xia S, Newman KM, Tilson MD. Features of autoimmunity in the abdominal aortic aneurysm. Arch Surg 1996;131:85-8.
35. Slachta CA, Jeevanandam V, Goldman B, Lin WL, Platsoucas CD. Coronary arteries from human cardiac allografts with chronic rejection contain oligoclonal T cells: persistence of identical clonally expanded TCR transcripts from the early post-transplantation period (endomyocardial biopsies) to chronic rejection (coronary arteries). J Immunol 2000;165:3469-83.
36. Tilson MD. Similarities of an autoantigen in aneurysmal disease of the human abdominal aorta to a 36-kDa microfibril-associated bovine aortic glycoprotein. Biochem Biophys Res Commun 1995;213:40-3.
37. Xia S, Ozsvath K, Hirose H, Tilson MD. Partial amino acid sequence of a novel 40-kDa human aortic protein, with vitronectin-like, fibrinogen-like, and calcium binding domains: aortic aneurysm-associated protein-40 (AAAP-40) [human MAGP-3, proposed]. Biochem Biophys Res Commun 1996;219:36-9.
38. Hirose H, Ozsvath KJ, Xia S, Tilson MD. Molecular cloning of the complementary DNA for an additional member of the family of aortic aneurysm antigenic proteins. J Vasc Surg 1997;26:313-8.
39. Hirose H, Takagi M, Miyagawa N, Hashiyada H, Noguchi M, Tada S, et al. Genetic risk factor for abdominal aortic aneurysm: HLA-DR2(15), a Japanese study. J Vasc Surg 1998;27:500-3.
40. Borromeo JR, Koshy N, Park WM, Xia S, Hardy K, Tilson MD. Regional distribution in the mouse of proteins homologous to artery-specific antigenic proteins (ASAPs). J Surg Res 1999;85:217-24.
41. Chew DK, Knoetgen Jr, Xia S, Gaetz HP, Tilson MD. Regional distribution in human of a novel aortic collagen-associated microfibrillar protein. Exp Mol Pathol 1999;66:59-65.
42. Vorp DA, Trachtenberg JD, Webster MW. Arterial hemodynamics and wall mechanics. Semin Vasc Surg 1998;11:169-80.
43. Masuda H, Zhuang YJ, Singh TM, Kawamura K, Murakami M, Zarins CK, et al. Adaptive remodeling of internal elastic lamina and endothelial lining during flow-induced arterial enlargement. Arterioscler Thromb Vasc Biol 1999;19:2298-307.
44. Tropea BI, Schwarzacher SP, Chang A, Asvar C, Huie P, Sibley RK, et al. Reduction of aortic wall motion inhibits hypertension-mediated experimental atherosclerosis. Arterioscler Thromb Vasc Biol 2000;20:2127-33.
45. Abbruzzese TA, Guzman RJ, Martin RL, Yee C, Zarins CK, Dalman RL. Matrix metalloproteinase inhibition limits arterial enlargements in a rodent arteriovenous fistula model. Surgery 1998;124:328-34.
46. Karwowski JK, Markezich A, Whitson J, Abbruzzese TA, Zarins CK, Dalman RL. Dose-dependent limitation of arterial enlargement by the matrix metalloproteinase inhibitor RS-113,456. J Surg Res 1999;87:122-9.
47. Vorp DA, Raghavan ML, Webster MW. Mechanical wall stress in abdominal aortic aneurysm: influence of diameter and asymmetry. J Vasc Surg 1998;27:632-9.
48. Fillinger MF. New imaging techniques in endovascular surgery. Surg Clin North Am 1999;79:451-75.
49. Kyriacou SK, Humphrey JD. Influence of size, shape and properties on the mechanics of axisymmetric saccular aneurysms. J Biomech 1996;29:1015-22.
50. Shah AD, Humphrey JD. Finite strain elastodynamics of intracranial saccular aneurysms. J Biomech 1999;32:593-9.
51. Shah AD, Naff N, Humphrey JD, Rigamonti D. Mechanical behavior of a vein pouch saccular aneurysm model. Neurol Res 1999;21:569-73.
52. Ryan JM, Humphrey JD. Finite element based predictions of preferred material symmetries in saccular aneurysms. Ann Biomed Eng 1999;27:641-7.
53. Kuivaniemi H, Marshall A, Ganguly A, Chu ML, Abbott WM, Tromp G. Fibulin-2 exhibits high degree of variability, but no structural changes concordant with abdominal aortic aneurysms. Eur J Hum Genet 1998;6:642-6.
54. Wang X, Tromp G, Cole CW, Verloes A, Sakalihasan N, Yoon S, et al. Analysis of coding sequences for tissue inhibitor of metalloproteinases 1 (TIMP1) and 2 (TIMP2) in patients with aneurysms. Matrix Biol 1999;18:121-4.
55. Yoon S, Tromp G, Vongpunsawad S, Ronkainen A, Juvonen T, Kuivaniemi H. Genetic analysis of MMP3, MMP9, and PAI-1 in Finnish patients with abdominal aortic or intracranial aneurysms. Biochem Biophys Res Commun 1999;265:563-8.