Proteinase 3, the major autoantigen of Wegener's granulomatosis, enhances IL-8 production by endothelial cells in vitro

Journal of the American Society of Nephrology

Volumn 7, Issue 5, 1996, Pages 694-701

  Berger, Stefan P ^a   Seelen, Marc A J ^a   Hiemstra, Pieter S ^a   Gerritsma, Jort S J ^a   Heemskerk, Evert ^a   Van Der Woude, Fokko J ^a   Daha, Mohamed R ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Endothelial cells; Interleukin 8; Proteinase 3; Wegener's disease

Indexed keywords

AUTOANTIGEN; CATHEPSIN G; CYCLOHEXIMIDE; INTERLEUKIN 8; LEUKOCYTE ELASTASE; LYSOSOME ENZYME; MESSENGER RNA; MYELOBLASTIN; NEUTROPHIL CYTOPLASMIC ANTIBODY; PROTEINASE;

ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; INFLAMMATION; NEUTROPHIL; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SYSTEMIC VASCULITIS; UMBILICAL VEIN; WEGENER GRANULOMATOSIS;

EID: 0030367937     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Lüdemann J, Utecht B, Gross WL: Anti-neutrophil cytoplasm antibodies in Wegener's granulomatosis recognize an elastinolytic enzyme. J Exp Med 1990;171:357-362.
2. Jenette JC, Falk RJ: The pathology of vasculitis involving the kidney. Am J Kidney Dis 1994;24:130-141.
3. Savage C, Gaskin G, Pusey CD, Pearson JD. Myeloperoxidase binds to vascular endothelial cells, is recognized by ANCA and can enhance complement dependent cytotoxicity. In: Gross WL, ed. ANCA-Associated Vasculitides. London: Plenum Press; 1993:121-123.
4. Brouwer E, Huitema MG, Mulder AHL, et al.: Neutrophil activation in vitro and in vivo in Wegener's granulomatosis. Kidney Int 1994;45:1120-1131.
5. Ballieux BEPB, Hiemstra PS, Klar-Mohamad N, et al.: Detachment and cytolysis of human endothelial cells by proteinase 3. Eur J Immunol 1994;24:3211-3215.
6. Kao R, Wehner NG, Skubitz KM, Gray BH, Hoidal JR: Proteinase 3. A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters. J Clin Invest 1988;82:1963-1973.
7. Renesto P, Halbwachs-Mecarelli L, Nusbaum P, Lesavre P, Chignard M: Proteinase 3. A neutrophil proteinase with activity on platelets. J Immunol 1994;152:4612-4617.
8. Csernok E, Ernst M, Schmitt W, Bainton DF, Gross WL: Activated neutrophils express PR3 on their plasma membrane in vitro and in vivo. Clin Exp Immunol 1994;95: 244-250.
9. Nakamura H, Yoshimura K, McElvaney NG, Crystal RG: Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line. Clin Invest 1992;89:1478-1484.
10. Leid RW, Ballieux BEPB, van der Heyden I, et al. Cleavage and inactivation of human C1 inhibitor by the human leukocyte proteinase, proteinase 3. Eur J Immunol 1993;23:2939-2944.
11. Feinstein G, Janoff A: A rapid method of purification of human granulocyte cationic neutral proteases: Purification ana further characterization of human granulocyte elastase. Biochim Biophys Acta 1975;403:493-505.
12. Kramps JA, van der Falk P, van der Sandt MM, Lindemann J, Meijer CJLM: Elastase as a marker for neutrophic myeloid cells. J Histochem Cytochem 1984;32:389-394.
13. Jaffe EA, Nachman RL, Becker CG, Minick CR: Culture of human endothelial cells from human umbilical veins: Identification by morphologic and immunologie criteria. J Clin Invest 1973;52:2745-2750.
14. Brooimans RA, Hiemstra PS, van der Ark AAJ, Sim RB, van Es LA, Daha MR: Biosynthesis of complement factor H by human umbilical vein endothelial cells. J Immunol 1989;142:2024-2030.
15. Seelen MAJ, Brooimans RA, van der Woude FJ, van Es LA, Daha MR: IFN-γ mediates stimulation of complement C4 biosynthesis in human proximal tubular epithelial cells. Kidney Int 1993;44:50-57.
16. Chomczynski P, Sacchi N: Single step method of RNA isolation by acid quanidium thiocyanate-phenolchloroform extraction. Anal Biochem 1987;162:156-159.
17. Maniatis T, Fisch EF, Sambrook J. Molecular Cloning. A Laboratory Manual. New York: Cold Spring Harbor Laboratory Press; 1989:737-752.
18. Church GM, Gilbert W: Genomic sequencing. Proc Natl Acad Sci USA 1984;81:1991-1995.
19. Feinberg AP, Vogelstein B: A technique for radiolabeling restriction endonuclease fragments to high specific activity. Anal Biochem 1983;132:6-13.
20. Henshaw TJ, Malone CC, Gabay JE, Williams RC: Elevations of neutrophil proteinase 3 in serum of patients with Wegener's granulomatosis and polyarteritis nodosa. Arthritis Rheum 1994;37:104-112.
21. Panyutich AV, Panyutich EA, Krapivin VA, Baturevich EA, Ganz T: Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis. J Lab Clin Med 1993;122:202-207.
22. 1-proteinase inhibitor J Clin Chem Clin Biochem 1984;22:693-697.
23. Keogan MT, Esnault VL, Green AJ, Lockwood CM, Brown DL: Activation of normal neutrophils by antineutrophil cytoplasm antibodies. Clin Exp Immunol 1992; 90:228-234.
24. Perlmutter DH: The SEC receptor: A possible link between neonatal hepatitis in α1-antitrypsin deficiency and Alzheimer's disease. Pediatr Res 1994;36:271-277.
25. Kurdowska A, Travis J: Acute phase protein stimulation by α1-antichymotrypsin-cathepsin G complexes. J Biol Chem 1990;34:21032-21026.
26. Padrines M, Wolf M, Walz A, Baggiolini M: Interleukin-8 processing by neutrophil elastase, cathepsin G and proteinase-3. FEBS (Fed Eur Biochem Soc) Lett 1994;352: 231-235
27. Fauci AS, Haynes BF, Katz P, Wolff SM: Wegener's granulomatosis: Prospective clinical and therapeutic experience with 85 patients over 21 years. Ann Intern Med 1983;98:76-85.
28. Falk RJ, Terrell RS, Charles LA, Jenette JC: Antineutrophil cytoplasmatic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro. Proc Natl Acad Sci USA 1990;87:4115-4119.
29. Dolman KM, van de Wiel BA, Kam CM, et al. Proteinase 3 substrate specifity and possible pathogenetic effect of Wegener's granulomatosis autoanibodies (c-ANCA) by disregulation of the enzyme. In: Gross WL, ed. ANCA-Associated Vasculitides. London: Plenum Press; 1993: 55-60.
30. van de Wiel BA, Dolman KM, van der Meer-Gerritsen CH, Hack CE, von dem Borne AEGK, Goldschmeding R: Interference of Wegener's granulomatosis autoantibodies with neutrophil proteinase 3 activity. Clin Exp Immunol 1992;90:409-414.
31. Daouk GH, Palsson R, Arnaout MA: Inhibitor of proteinase 3 by ANCA and its correlation with disease activity in Wegener's granulomatosis. Kidney Int 1995;47:1528-1536.