메뉴 건너뛰기




Volumn 247, Issue 1, 2007, Pages 77-102

Elucidating the interactions between the adhesive and transcriptional functions of β-catenin in normal and cancerous cells

Author keywords

Adherens junction; APC mutation; Colorectal cancer; Crypt dynamics

Indexed keywords

BETA CATENIN; TRANSCRIPTION FACTOR; WNT PROTEIN;

EID: 34247335443     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2007.01.019     Document Type: Article
Times cited : (54)

References (126)
  • 2
    • 0030978351 scopus 로고    scopus 로고
    • β-catenin is a target for the ubiquitin-proteasome pathway
    • Aberle H., Bauer A., Stappert J., Kispert A., and Kemler R. β-catenin is a target for the ubiquitin-proteasome pathway. EMBO J. 16 (1997) 3797-3804
    • (1997) EMBO J. , vol.16 , pp. 3797-3804
    • Aberle, H.1    Bauer, A.2    Stappert, J.3    Kispert, A.4    Kemler, R.5
  • 4
    • 0037096906 scopus 로고    scopus 로고
    • The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the β-catenin signaling cascade
    • Albuquerque C., Breukel C., Van der Luijt R., Fidalgo P., Lage P., Slors F., Leitão C.N., Fodde R., and Smits R. The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the β-catenin signaling cascade. Human Mol. Gen. 11 (2002) 1549-1560
    • (2002) Human Mol. Gen. , vol.11 , pp. 1549-1560
    • Albuquerque, C.1    Breukel, C.2    Van der Luijt, R.3    Fidalgo, P.4    Lage, P.5    Slors, F.6    Leitão, C.N.7    Fodde, R.8    Smits, R.9
  • 5
    • 7944230668 scopus 로고    scopus 로고
    • An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells
    • Bafico A., Liu G., Goldin L., Harris V., and Aaronson S.A. An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells. Cancer Cell 6 (2004) 497-506
    • (2004) Cancer Cell , vol.6 , pp. 497-506
    • Bafico, A.1    Liu, G.2    Goldin, L.3    Harris, V.4    Aaronson, S.A.5
  • 7
    • 23844507181 scopus 로고    scopus 로고
    • The role of the Wnt signalling pathway in colorectal tumorigenesis
    • Behrens J. The role of the Wnt signalling pathway in colorectal tumorigenesis. Biochem. Soc. Trans. 33 (2005) 672-675
    • (2005) Biochem. Soc. Trans. , vol.33 , pp. 672-675
    • Behrens, J.1
  • 8
    • 0037386102 scopus 로고    scopus 로고
    • Cell fate specification and competence by Coco, a maternal BMP, TGF β and Wnt inhibitor
    • Bell E., Muñoz SanJuán I., Altmann C.R., Vonica A., and Brivanlou A.H. Cell fate specification and competence by Coco, a maternal BMP, TGF β and Wnt inhibitor. Development 130 (2003) 1381-1389
    • (2003) Development , vol.130 , pp. 1381-1389
    • Bell, E.1    Muñoz SanJuán, I.2    Altmann, C.R.3    Vonica, A.4    Brivanlou, A.H.5
  • 9
    • 12544252343 scopus 로고    scopus 로고
    • β-catenin: a pivot between cell adhesion and Wnt signalling
    • Bienz M. β-catenin: a pivot between cell adhesion and Wnt signalling. Curr. Biol. 15 (2005) R64-R67
    • (2005) Curr. Biol. , vol.15
    • Bienz, M.1
  • 10
    • 0027761007 scopus 로고
    • Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion
    • Bradley R.S., Cowin P., and Brown A.M. Expression of Wnt-1 in PC12 cells results in modulation of plakoglobin and E-cadherin and increased cellular adhesion. J. Cell Biol. 123 (1993) 1857-1865
    • (1993) J. Cell Biol. , vol.123 , pp. 1857-1865
    • Bradley, R.S.1    Cowin, P.2    Brown, A.M.3
  • 12
    • 30644458570 scopus 로고    scopus 로고
    • Balancing cell adhesion and Wnt signaling, the key role of β-catenin
    • Brembeck F.H., Rosário M., and Birchmeier W. Balancing cell adhesion and Wnt signaling, the key role of β-catenin. Curr. Opinion Genet. Dev. 16 (2006) 51-59
    • (2006) Curr. Opinion Genet. Dev. , vol.16 , pp. 51-59
    • Brembeck, F.H.1    Rosário, M.2    Birchmeier, W.3
  • 14
    • 33644967242 scopus 로고    scopus 로고
    • Wnt signaling: complexity at the surface
    • Cadigan K.M., and Liu Y.I. Wnt signaling: complexity at the surface. J. Cell Sci. 119 (2006) 395-402
    • (2006) J. Cell Sci. , vol.119 , pp. 395-402
    • Cadigan, K.M.1    Liu, Y.I.2
  • 15
    • 0037169868 scopus 로고    scopus 로고
    • Cadherins and the tumour progression: is it all in a switch?
    • Cavallaro U., Schaffhauser B., and Christofori G. Cadherins and the tumour progression: is it all in a switch?. Cancer Lett. 176 (2002) 123-128
    • (2002) Cancer Lett. , vol.176 , pp. 123-128
    • Cavallaro, U.1    Schaffhauser, B.2    Christofori, G.3
  • 16
    • 0032574319 scopus 로고    scopus 로고
    • Mutagenesis, tumorigenicity, and apoptosis: are the mitochondria involved?
    • Cavalli L.R., and Liang B.C. Mutagenesis, tumorigenicity, and apoptosis: are the mitochondria involved?. Mut. Res. 398 (1998) 19-26
    • (1998) Mut. Res. , vol.398 , pp. 19-26
    • Cavalli, L.R.1    Liang, B.C.2
  • 17
    • 21244476031 scopus 로고    scopus 로고
    • Perturbed neurogenesis in the adult hippocampus associated with preselin-1 A246E mutation
    • Chevallier N.L., Soriano S., Kang D.E., Masliah E., Hu G., and Koo E.H. Perturbed neurogenesis in the adult hippocampus associated with preselin-1 A246E mutation. Am. J. Pathol. 167 (2005) 151-159
    • (2005) Am. J. Pathol. , vol.167 , pp. 151-159
    • Chevallier, N.L.1    Soriano, S.2    Kang, D.E.3    Masliah, E.4    Hu, G.5    Koo, E.H.6
  • 18
    • 33746803311 scopus 로고    scopus 로고
    • Wnt pathway mutations selected by optimal β-catenin signaling for tumorigenesis
    • Cho K.-H., Baek S., and Sung M.-H. Wnt pathway mutations selected by optimal β-catenin signaling for tumorigenesis. FEBS Lett. 580 (2006) 3665-3670
    • (2006) FEBS Lett. , vol.580 , pp. 3665-3670
    • Cho, K.-H.1    Baek, S.2    Sung, M.-H.3
  • 19
    • 33745297408 scopus 로고    scopus 로고
    • New signals from the invase front
    • Christofori G. New signals from the invase front. Nature 441 (2006) 444-450
    • (2006) Nature , vol.441 , pp. 444-450
    • Christofori, G.1
  • 20
    • 0033079605 scopus 로고    scopus 로고
    • The role of the cell-adhesion molecule E-cadherin as a tumor-suppressor gene
    • Christofori G., and Semb H. The role of the cell-adhesion molecule E-cadherin as a tumor-suppressor gene. Trends Biochem. Sci. 24 (1999) 73-76
    • (1999) Trends Biochem. Sci. , vol.24 , pp. 73-76
    • Christofori, G.1    Semb, H.2
  • 21
    • 0032535483 scopus 로고    scopus 로고
    • The ubiquitin-proteosome pathway: on protein death and cell life
    • Ciechanover A. The ubiquitin-proteosome pathway: on protein death and cell life. EMBO J. 17 (1998) 7151-7160
    • (1998) EMBO J. , vol.17 , pp. 7151-7160
    • Ciechanover, A.1
  • 22
    • 5144221019 scopus 로고    scopus 로고
    • β-catenin-mediated signaling: a molecular target for early chemopreventive intervention
    • Clapper M.L., Coudry J., and Chang W.C. β-catenin-mediated signaling: a molecular target for early chemopreventive intervention. Mut. Res. 555 (2004) 97-105
    • (2004) Mut. Res. , vol.555 , pp. 97-105
    • Clapper, M.L.1    Coudry, J.2    Chang, W.C.3
  • 23
    • 0345599013 scopus 로고    scopus 로고
    • Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of β-catenin signaling, Slug, and MAPK
    • Conacci-Sorrell M., Simcha I., Ben-Yedidia T., Blachman J., Savagner P., and Ben-Ze'ev A. Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of β-catenin signaling, Slug, and MAPK. J. Cell Biol. 163 (2003) 847-857
    • (2003) J. Cell Biol. , vol.163 , pp. 847-857
    • Conacci-Sorrell, M.1    Simcha, I.2    Ben-Yedidia, T.3    Blachman, J.4    Savagner, P.5    Ben-Ze'ev, A.6
  • 24
    • 0037415737 scopus 로고    scopus 로고
    • Structural basis for recruitment of glycogen synthase kinase 3 β to the axin-APC scaffold complex
    • Dajani R., Fraser E., Roe S.M., Yeo M., Good V., Thompson V., Dale T.C., and Pearl L.H. Structural basis for recruitment of glycogen synthase kinase 3 β to the axin-APC scaffold complex. EMBO J. 22 (2003) 494-501
    • (2003) EMBO J. , vol.22 , pp. 494-501
    • Dajani, R.1    Fraser, E.2    Roe, S.M.3    Yeo, M.4    Good, V.5    Thompson, V.6    Dale, T.C.7    Pearl, L.H.8
  • 25
    • 18744400798 scopus 로고    scopus 로고
    • β-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation
    • Daniels D.L., and Weis W.I. β-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation. Nat. Struct. Mol. Biol. 12 (2005) 364-371
    • (2005) Nat. Struct. Mol. Biol. , vol.12 , pp. 364-371
    • Daniels, D.L.1    Weis, W.I.2
  • 27
    • 0242708621 scopus 로고    scopus 로고
    • A core function for p120-catenin in cadherin turnover
    • Davis M.A., Ireton R.C., and Reynolds A.B. A core function for p120-catenin in cadherin turnover. J. Cell Biol. 163 (2003) 525-534
    • (2003) J. Cell Biol. , vol.163 , pp. 525-534
    • Davis, M.A.1    Ireton, R.C.2    Reynolds, A.B.3
  • 28
    • 1542649391 scopus 로고    scopus 로고
    • Reduction of β-catenin/T-cell transcription factor signaling by aspirin and indomethacin is caused by an increased stabilization of phosphorylated β-catenin
    • Dihlmann S., Klein S., and Doeberitz M.M.K. Reduction of β-catenin/T-cell transcription factor signaling by aspirin and indomethacin is caused by an increased stabilization of phosphorylated β-catenin. Mol. Cancer Ther. 2 (2003) 509-516
    • (2003) Mol. Cancer Ther. , vol.2 , pp. 509-516
    • Dihlmann, S.1    Klein, S.2    Doeberitz, M.M.K.3
  • 30
    • 0029915306 scopus 로고    scopus 로고
    • Binding to cadherins antagonizes the signaling activity of β-catenin during axis formation in Xenopus
    • Fagotto F., Funayama N., Gluck U., and Gumbiner B.M. Binding to cadherins antagonizes the signaling activity of β-catenin during axis formation in Xenopus. J. Cell Biol. 132 (1996) 1105-1114
    • (1996) J. Cell Biol. , vol.132 , pp. 1105-1114
    • Fagotto, F.1    Funayama, N.2    Gluck, U.3    Gumbiner, B.M.4
  • 31
    • 0025312728 scopus 로고
    • A genetic model for colorectal tumorigenesis
    • Fearon E.R., and Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 61 (1990) 759-767
    • (1990) Cell , vol.61 , pp. 759-767
    • Fearon, E.R.1    Vogelstein, B.2
  • 32
    • 0037031887 scopus 로고    scopus 로고
    • Wnt-3A/β-catenin signaling induces transcription from the LEF-1 promoter
    • Filali M., Cheng N., Abbott D., Leontiev V., and Engelhardt J.F. Wnt-3A/β-catenin signaling induces transcription from the LEF-1 promoter. J. Biol. Chem. 277 (2002) 33398-33410
    • (2002) J. Biol. Chem. , vol.277 , pp. 33398-33410
    • Filali, M.1    Cheng, N.2    Abbott, D.3    Leontiev, V.4    Engelhardt, J.F.5
  • 33
    • 0037340399 scopus 로고    scopus 로고
    • The multiple functions of tumour suppressors: it's all in APC
    • Fodde R. The multiple functions of tumour suppressors: it's all in APC. Nat. Cell Biol. 5 (2003) 190-192
    • (2003) Nat. Cell Biol. , vol.5 , pp. 190-192
    • Fodde, R.1
  • 34
    • 0035496104 scopus 로고    scopus 로고
    • APC, signal transduction and genetic instability in colorectal cancer
    • Fodde R., Smits R., and Clevers H. APC, signal transduction and genetic instability in colorectal cancer. Nat. Rev. Cancer 1 (2001) 55-67
    • (2001) Nat. Rev. Cancer , vol.1 , pp. 55-67
    • Fodde, R.1    Smits, R.2    Clevers, H.3
  • 36
    • 5444233462 scopus 로고    scopus 로고
    • APC dosage effects in tumorigenesis and stem cell differentiation
    • Gaspar C., and Fodde R. APC dosage effects in tumorigenesis and stem cell differentiation. Int. J. Dev. Biol. 48 (2004) 377-386
    • (2004) Int. J. Dev. Biol. , vol.48 , pp. 377-386
    • Gaspar, C.1    Fodde, R.2
  • 39
    • 2442680430 scopus 로고    scopus 로고
    • Wnt proteins induce Dishevelled phosphorylation via an LPR5/6 independent mechanism, irrespective of their ability to stabilize β-catenin
    • Gonzalez-Sancho J.M., Brennan K.R., Castelo-Soccio L.A., and Brown A.M. Wnt proteins induce Dishevelled phosphorylation via an LPR5/6 independent mechanism, irrespective of their ability to stabilize β-catenin. Mol. Cell. Biol. 24 (2004) 4757-4768
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 4757-4768
    • Gonzalez-Sancho, J.M.1    Brennan, K.R.2    Castelo-Soccio, L.A.3    Brown, A.M.4
  • 40
    • 7244229604 scopus 로고    scopus 로고
    • Distinct molecular forms of β-catenin are targeted to adhesive or transcriptional complexes
    • Gottardi C.J., and Gumbiner B.M. Distinct molecular forms of β-catenin are targeted to adhesive or transcriptional complexes. J. Cell Biol. 167 (2004) 339-349
    • (2004) J. Cell Biol. , vol.167 , pp. 339-349
    • Gottardi, C.J.1    Gumbiner, B.M.2
  • 41
    • 0035947772 scopus 로고    scopus 로고
    • E-cadherin suppresses cellular transformation by inhibiting β-catenin signaling in an adhesion-independent manner
    • Gottardi C.J., Wong E., and Gumbiner B.M. E-cadherin suppresses cellular transformation by inhibiting β-catenin signaling in an adhesion-independent manner. J. Cell Biol. 153 (2001) 1049-1059
    • (2001) J. Cell Biol. , vol.153 , pp. 1049-1059
    • Gottardi, C.J.1    Wong, E.2    Gumbiner, B.M.3
  • 42
    • 0033635606 scopus 로고    scopus 로고
    • Crystal structure of the β-catenin/Tcf complex
    • Graham T.A., Weaver C., Mao F., Kimmelman D., and Xu W. Crystal structure of the β-catenin/Tcf complex. Cell 103 (2000) 885-896
    • (2000) Cell , vol.103 , pp. 885-896
    • Graham, T.A.1    Weaver, C.2    Mao, F.3    Kimmelman, D.4    Xu, W.5
  • 43
    • 0035180690 scopus 로고    scopus 로고
    • Tcf4 can specifically recognize β-catenin using alternative conformations
    • Graham T.A., Ferkey D.M., Mao F., Kimmelman D., and Xu W. Tcf4 can specifically recognize β-catenin using alternative conformations. Nat. Str. Biol. 8 (2001) 1048-1052
    • (2001) Nat. Str. Biol. , vol.8 , pp. 1048-1052
    • Graham, T.A.1    Ferkey, D.M.2    Mao, F.3    Kimmelman, D.4    Xu, W.5
  • 44
    • 0034614941 scopus 로고    scopus 로고
    • Regulation of cadherin adhesive activity
    • Gumbiner B.M. Regulation of cadherin adhesive activity. J. Cell Biol. 148 (2000) 399-403
    • (2000) J. Cell Biol. , vol.148 , pp. 399-403
    • Gumbiner, B.M.1
  • 45
    • 4344562126 scopus 로고    scopus 로고
    • Mechanism of phosphorylation-dependent binding of APC to β-catenin and its role in β-catenin degradation
    • Ha N.C., Tonozuka T., Stamos J.L., Choi H.J., and Weis W.I. Mechanism of phosphorylation-dependent binding of APC to β-catenin and its role in β-catenin degradation. Mol. Cell 15 (2004) 511-521
    • (2004) Mol. Cell , vol.15 , pp. 511-521
    • Ha, N.C.1    Tonozuka, T.2    Stamos, J.L.3    Choi, H.J.4    Weis, W.I.5
  • 46
    • 23044511438 scopus 로고    scopus 로고
    • The Wnt signalling pathway in retinal degenerations
    • Hackman A.S. The Wnt signalling pathway in retinal degenerations. IUBMB Life 57 (2005) 381-388
    • (2005) IUBMB Life , vol.57 , pp. 381-388
    • Hackman, A.S.1
  • 47
    • 18044373963 scopus 로고    scopus 로고
    • Decisions, decisions: β-catenin chooses between adhesion and transcription
    • Harris T.J.C., and Peifer M. Decisions, decisions: β-catenin chooses between adhesion and transcription. Trends Cell Biol. 15 (2005) 234-237
    • (2005) Trends Cell Biol. , vol.15 , pp. 234-237
    • Harris, T.J.C.1    Peifer, M.2
  • 50
    • 34248634485 scopus 로고    scopus 로고
    • Herzig, M., Savarese, F., Novatchkova, M., Semb, H., Christofori, G., 2006. Tumor progression induced by the loss of E-cadherin independent of β-catenin/Tcf-mediated Wnt signaling. Oncogene 1-9.
  • 51
    • 0028258445 scopus 로고
    • Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing β-catenin binding to the cell adhesion protein cadherin
    • Hinck L., Nelson W.J., and Papkoff J. Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing β-catenin binding to the cell adhesion protein cadherin. J. Cell Biol. 124 (1994) 729-741
    • (1994) J. Cell Biol. , vol.124 , pp. 729-741
    • Hinck, L.1    Nelson, W.J.2    Papkoff, J.3
  • 52
    • 0036342469 scopus 로고    scopus 로고
    • Expression of Wnt ligands and Frizzled receptors in colonic mucosa and in colon carcinoma
    • Holcombe R.F., Marsh J.L., Waterman M.L., Lin F., Milovanovic T., and Truong T. Expression of Wnt ligands and Frizzled receptors in colonic mucosa and in colon carcinoma. Mol. Pathol. 55 (2002) 220-226
    • (2002) Mol. Pathol. , vol.55 , pp. 220-226
    • Holcombe, R.F.1    Marsh, J.L.2    Waterman, M.L.3    Lin, F.4    Milovanovic, T.5    Truong, T.6
  • 54
    • 0035805117 scopus 로고    scopus 로고
    • The structure of the β-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by β-catenin
    • Huber A.H., and Weis W.I. The structure of the β-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by β-catenin. Cell 105 (2001) 391-402
    • (2001) Cell , vol.105 , pp. 391-402
    • Huber, A.H.1    Weis, W.I.2
  • 55
    • 0035853847 scopus 로고    scopus 로고
    • The cadherin cytoplasmic domain is unstructured in the absence of β-catenin. A possible mechanism for regulating cadherin turnover
    • Huber A.H., Stewart D.B., Laurents D.V., Nelson W.J., and Weis W.I. The cadherin cytoplasmic domain is unstructured in the absence of β-catenin. A possible mechanism for regulating cadherin turnover. J. Biol. Chem. 276 (2001) 12301-12309
    • (2001) J. Biol. Chem. , vol.276 , pp. 12301-12309
    • Huber, A.H.1    Stewart, D.B.2    Laurents, D.V.3    Nelson, W.J.4    Weis, W.I.5
  • 56
    • 0030923587 scopus 로고    scopus 로고
    • β-catenin mutations in cell lines established from human colorectal cancers
    • Ilyas M. β-catenin mutations in cell lines established from human colorectal cancers. Proc. Natl Acad. Sci. USA 94 (1997) 10330-10334
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 10330-10334
    • Ilyas, M.1
  • 57
    • 13644269949 scopus 로고    scopus 로고
    • Wnt signalling and the mechanistic basis of tumour development
    • Ilyas M. Wnt signalling and the mechanistic basis of tumour development. J. Pathol. 205 (2005) 130-144
    • (2005) J. Pathol. , vol.205 , pp. 130-144
    • Ilyas, M.1
  • 58
    • 0036228744 scopus 로고    scopus 로고
    • Intercellular adhesion, signalling and the cytoskeleton
    • Jamora C., and Fuchs E. Intercellular adhesion, signalling and the cytoskeleton. Nat. Cell Biol. 4 (2002) 101-108
    • (2002) Nat. Cell Biol. , vol.4 , pp. 101-108
    • Jamora, C.1    Fuchs, E.2
  • 59
    • 0037456847 scopus 로고    scopus 로고
    • Link between signal transduction, transcription and adhesion in epithelial bud development
    • Jamora C., DasGupta R., Kocieniewski P., and Fuchs E. Link between signal transduction, transcription and adhesion in epithelial bud development. Nature 422 (2003) 317-322
    • (2003) Nature , vol.422 , pp. 317-322
    • Jamora, C.1    DasGupta, R.2    Kocieniewski, P.3    Fuchs, E.4
  • 60
    • 0033834262 scopus 로고    scopus 로고
    • A metabolic control analysis of kinetic controls in ATP free energy metabolism in contracting skeletal muscle
    • Jeneson J.A., Westerhoff H.V., and Kushmerick M.J. A metabolic control analysis of kinetic controls in ATP free energy metabolism in contracting skeletal muscle. Am. J. Phys. 279 (2000) 813
    • (2000) Am. J. Phys. , vol.279 , pp. 813
    • Jeneson, J.A.1    Westerhoff, H.V.2    Kushmerick, M.J.3
  • 61
    • 0036148208 scopus 로고    scopus 로고
    • Wnt/β-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway
    • Jho E., Zhang T., Domon C., Joo C.K., Freund J.N., and Costanti F. Wnt/β-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway. Mol. Cell. Biol. 22 (2002) 1172-1183
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 1172-1183
    • Jho, E.1    Zhang, T.2    Domon, C.3    Joo, C.K.4    Freund, J.N.5    Costanti, F.6
  • 62
    • 0036714307 scopus 로고    scopus 로고
    • Secreted Frizzled-related proteins: searching for relationships and patterns
    • Jones S.E., and Jomary C. Secreted Frizzled-related proteins: searching for relationships and patterns. BioEssays 24 (2002) 811-820
    • (2002) BioEssays , vol.24 , pp. 811-820
    • Jones, S.E.1    Jomary, C.2
  • 65
    • 0033790502 scopus 로고    scopus 로고
    • Overexpression of β-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators
    • Kim K.M., Pang K.M., Evans M., and Hay E.D. Overexpression of β-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators. Mol. Biol. Cell 11 (2000) 3509-3523
    • (2000) Mol. Biol. Cell , vol.11 , pp. 3509-3523
    • Kim, K.M.1    Pang, K.M.2    Evans, M.3    Hay, E.D.4
  • 66
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler K., and Vogelstein B. Lessons from hereditary colorectal cancer. Cell 87 (1996) 159-170
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.1    Vogelstein, B.2
  • 68
    • 14844284570 scopus 로고    scopus 로고
    • Genetic disorders of the LRP5-Wnt signalling pathway affecting the skeleton
    • Koay M.A., and Brown M.A. Genetic disorders of the LRP5-Wnt signalling pathway affecting the skeleton. Trends Mol. Med. 11 (2005) 129-137
    • (2005) Trends Mol. Med. , vol.11 , pp. 129-137
    • Koay, M.A.1    Brown, M.A.2
  • 69
    • 0031848068 scopus 로고    scopus 로고
    • Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
    • Korinek V., Barker N., Moerer P., Donselaar E., Huls G., Peters P.J., and Clevers H. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4. Nat. Gen. 19 (1998) 379-383
    • (1998) Nat. Gen. , vol.19 , pp. 379-383
    • Korinek, V.1    Barker, N.2    Moerer, P.3    Donselaar, E.4    Huls, G.5    Peters, P.J.6    Clevers, H.7
  • 70
    • 0037023584 scopus 로고    scopus 로고
    • Wnt/Wingless signaling requires BCL9/Legless-mediated recruitments of Pygopus to the nuclear β-catenin-TCF complex
    • Kramps T., Peter O., Brunner E., Nellen D., Froesch B., Chatterjee S., Murone M., Zülling S., and Basler K. Wnt/Wingless signaling requires BCL9/Legless-mediated recruitments of Pygopus to the nuclear β-catenin-TCF complex. Cell 109 (2002) 47-60
    • (2002) Cell , vol.109 , pp. 47-60
    • Kramps, T.1    Peter, O.2    Brunner, E.3    Nellen, D.4    Froesch, B.5    Chatterjee, S.6    Murone, M.7    Zülling, S.8    Basler, K.9
  • 72
    • 18244372714 scopus 로고    scopus 로고
    • Model reduction and analysis of robustness for the Wnt/β-catenin signal transduction pathway
    • Krüger R., and Heinrich R. Model reduction and analysis of robustness for the Wnt/β-catenin signal transduction pathway. Genome Inf. 15 (2004) 138-148
    • (2004) Genome Inf. , vol.15 , pp. 138-148
    • Krüger, R.1    Heinrich, R.2
  • 73
    • 29144536745 scopus 로고    scopus 로고
    • E-cadherin modulates Wnt-dependent transcription in colorectal cancer cells but does not alter Wnt-independent gene expression in fibroblasts
    • Kuphal F., and Behrens J. E-cadherin modulates Wnt-dependent transcription in colorectal cancer cells but does not alter Wnt-independent gene expression in fibroblasts. Exp. Cell. Res. 312 (2006) 457-467
    • (2006) Exp. Cell. Res. , vol.312 , pp. 457-467
    • Kuphal, F.1    Behrens, J.2
  • 74
    • 4243067196 scopus 로고    scopus 로고
    • The roles of APC and axin derived from experimental and theoretical analysis of the wnt pathway
    • Lee E., Salic A., Krüger R., Heinrich R., and Kirschner M.W. The roles of APC and axin derived from experimental and theoretical analysis of the wnt pathway. Pub. Lib. Sci. Biol. 1 (2003) 116-132
    • (2003) Pub. Lib. Sci. Biol. , vol.1 , pp. 116-132
    • Lee, E.1    Salic, A.2    Krüger, R.3    Heinrich, R.4    Kirschner, M.W.5
  • 75
    • 33744979495 scopus 로고    scopus 로고
    • Crypt dynamics and colorectal cancer: advances in mathematical modelling
    • Van Leeuwen I.M.M., Byrne H.M., Jensen O.E., and King J.R. Crypt dynamics and colorectal cancer: advances in mathematical modelling. Cell Prolif. 39 (2006) 157-181
    • (2006) Cell Prolif. , vol.39 , pp. 157-181
    • Van Leeuwen, I.M.M.1    Byrne, H.M.2    Jensen, O.E.3    King, J.R.4
  • 76
    • 0037077266 scopus 로고    scopus 로고
    • Activation of AXIN2 expression by β-catenin-T cell factor. A feedback repressor pathway regulating Wnt signalling
    • Leung J.Y., Kolligs F.T., Wu R., Zhai Y., Kuick R., Hanash S., Cho K.R., and Fearon E.R. Activation of AXIN2 expression by β-catenin-T cell factor. A feedback repressor pathway regulating Wnt signalling. J. Biol. Chem. 277 (2002) 21657-21665
    • (2002) J. Biol. Chem. , vol.277 , pp. 21657-21665
    • Leung, J.Y.1    Kolligs, F.T.2    Wu, R.3    Zhai, Y.4    Kuick, R.5    Hanash, S.6    Cho, K.R.7    Fearon, E.R.8
  • 77
    • 25444497707 scopus 로고    scopus 로고
    • The threshold level of adenomatous polyposis coli protein for mouse intestinal tumorigenesis
    • Li Q., Ishikawa T., Oshima M., and Taketo M.M. The threshold level of adenomatous polyposis coli protein for mouse intestinal tumorigenesis. Cancer Res. 65 (2005) 8622-8627
    • (2005) Cancer Res. , vol.65 , pp. 8622-8627
    • Li, Q.1    Ishikawa, T.2    Oshima, M.3    Taketo, M.M.4
  • 78
    • 0037155691 scopus 로고    scopus 로고
    • Control of β-catenin phosphorylation/degradation by a dual-kinase mechanism
    • Liu C., Li Y., Semenov M., Han C., Baeg G.H., Zhang Z., Lin X., and He X. Control of β-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 108 (2002) 837-847
    • (2002) Cell , vol.108 , pp. 837-847
    • Liu, C.1    Li, Y.2    Semenov, M.3    Han, C.4    Baeg, G.H.5    Zhang, Z.6    Lin, X.7    He, X.8
  • 79
    • 0035947083 scopus 로고    scopus 로고
    • Siah-1 mediates a novel β-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein
    • Liu J., Stevens J., and Rote C.A. Siah-1 mediates a novel β-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. Mol. Cell 7 (2001) 837-847
    • (2001) Mol. Cell , vol.7 , pp. 837-847
    • Liu, J.1    Stevens, J.2    Rote, C.A.3
  • 80
    • 18244427021 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor-related protein-5 binds to axin and regulates the canonical Wnt signalling pathway
    • Mao B., Wang J., Liu B., Pan W., Farr G.H., Flynn C., Yuan H., Takada S., Kimelman D., and Li L.D.W. Low-density lipoprotein receptor-related protein-5 binds to axin and regulates the canonical Wnt signalling pathway. Mol. Cell 7 (2001) 801-809
    • (2001) Mol. Cell , vol.7 , pp. 801-809
    • Mao, B.1    Wang, J.2    Liu, B.3    Pan, W.4    Farr, G.H.5    Flynn, C.6    Yuan, H.7    Takada, S.8    Kimelman, D.9    Li, L.D.W.10
  • 81
    • 0035902050 scopus 로고    scopus 로고
    • LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
    • Mao B., Wu W., Li Y., Hoppe D., Stannek P., Glinka A., and Niehrs C. LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 411 (2001) 321-325
    • (2001) Nature , vol.411 , pp. 321-325
    • Mao, B.1    Wu, W.2    Li, Y.3    Hoppe, D.4    Stannek, P.5    Glinka, A.6    Niehrs, C.7
  • 83
    • 16444368642 scopus 로고    scopus 로고
    • E-cadherin suppression accelerates squamous cell carcinoma progression in three-dimensional, human tissue constructs
    • Margulis A., Zhang W., Alt-Holland A., Crawford H.C., Fusenig N.E., and Garlick J.A. E-cadherin suppression accelerates squamous cell carcinoma progression in three-dimensional, human tissue constructs. Cancer Res. 65 (2005) 1783-1791
    • (2005) Cancer Res. , vol.65 , pp. 1783-1791
    • Margulis, A.1    Zhang, W.2    Alt-Holland, A.3    Crawford, H.C.4    Fusenig, N.E.5    Garlick, J.A.6
  • 84
    • 0035947080 scopus 로고    scopus 로고
    • Siah-1, SIP, and Ebi collaborate in a novel pathway for β-catenin degradation linked to p53 responses
    • Matsuzawa S.I., and Reed J.C. Siah-1, SIP, and Ebi collaborate in a novel pathway for β-catenin degradation linked to p53 responses. Mol. Cell 7 (2001) 915-926
    • (2001) Mol. Cell , vol.7 , pp. 915-926
    • Matsuzawa, S.I.1    Reed, J.C.2
  • 86
    • 0037205007 scopus 로고    scopus 로고
    • The promise and perils of Wnt signaling through β-catenin
    • Moon R.T., Bowerman B., Boutros M., and Perrimon N. The promise and perils of Wnt signaling through β-catenin. Science 31 (2002) 1644-1646
    • (2002) Science , vol.31 , pp. 1644-1646
    • Moon, R.T.1    Bowerman, B.2    Boutros, M.3    Perrimon, N.4
  • 87
    • 0030949463 scopus 로고    scopus 로고
    • Activation of β-catenin-TCF signaling in colon cancer by mutations in β-catenin or APC
    • Morin P.J., Sparks A.B., Korinek V., Barker N., Vogelstein B., and Kinzler K.W. Activation of β-catenin-TCF signaling in colon cancer by mutations in β-catenin or APC. Science 275 (1997) 1787-1790
    • (1997) Science , vol.275 , pp. 1787-1790
    • Morin, P.J.1    Sparks, A.B.2    Korinek, V.3    Barker, N.4    Vogelstein, B.5    Kinzler, K.W.6
  • 88
    • 1542347695 scopus 로고    scopus 로고
    • Convergence of Wnt, β-catenin, and cadherin pathways
    • Nelson W.J., and Nusse R. Convergence of Wnt, β-catenin, and cadherin pathways. Science 303 (2004) 1483-1487
    • (2004) Science , vol.303 , pp. 1483-1487
    • Nelson, W.J.1    Nusse, R.2
  • 89
    • 0036499997 scopus 로고    scopus 로고
    • Modeling the heart-from genes to cell to the whole organ
    • Noble D. Modeling the heart-from genes to cell to the whole organ. Science 295 (2002) 1678-1682
    • (2002) Science , vol.295 , pp. 1678-1682
    • Noble, D.1
  • 90
    • 4444349425 scopus 로고    scopus 로고
    • A model for restriction point control of the mammalian cell cycle
    • Novák B., and Tyson J.J. A model for restriction point control of the mammalian cell cycle. J. Theor. Biol. 230 (2004) 563-579
    • (2004) J. Theor. Biol. , vol.230 , pp. 563-579
    • Novák, B.1    Tyson, J.J.2
  • 91
    • 0019133661 scopus 로고
    • Mutations affecting segment number and polarity in Drosophila
    • Nusslein-Volhard C., and Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature 287 (1980) 795-801
    • (1980) Nature , vol.287 , pp. 795-801
    • Nusslein-Volhard, C.1    Wieschaus, E.2
  • 92
    • 0024451982 scopus 로고
    • The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species
    • Ozawa M., Baribault H., and Kemler R. The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J. 8 (1989) 1711-1717
    • (1989) EMBO J. , vol.8 , pp. 1711-1717
    • Ozawa, M.1    Baribault, H.2    Kemler, R.3
  • 93
    • 0037459077 scopus 로고    scopus 로고
    • Sticky business: orchestrating cellular signals at adherens junctions
    • Perez-Moreno M., Jamora C., and Fuchs E. Sticky business: orchestrating cellular signals at adherens junctions. Cell 112 (2003) 535-548
    • (2003) Cell , vol.112 , pp. 535-548
    • Perez-Moreno, M.1    Jamora, C.2    Fuchs, E.3
  • 94
    • 0032510494 scopus 로고    scopus 로고
    • A causal role for E-cadherin in the transition from adenoma to carcinoma
    • Perl A.K., Wilgenbus P., Dahl U., Semb H., and Christofori G. A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature 392 (1998) 190-193
    • (1998) Nature , vol.392 , pp. 190-193
    • Perl, A.K.1    Wilgenbus, P.2    Dahl, U.3    Semb, H.4    Christofori, G.5
  • 96
    • 0033695362 scopus 로고    scopus 로고
    • Structure of the dimerization and β-catenin-binding region of α-catenin
    • Pokutta S., and Weis W.I. Structure of the dimerization and β-catenin-binding region of α-catenin. Mol. Cell 5 (2000) 533-543
    • (2000) Mol. Cell , vol.5 , pp. 533-543
    • Pokutta, S.1    Weis, W.I.2
  • 97
    • 0033054464 scopus 로고    scopus 로고
    • The oncogenic activation of β-catenin
    • Polakis P. The oncogenic activation of β-catenin. Curr. Opinion Gen. Dev. 9 (1999) 15-21
    • (1999) Curr. Opinion Gen. Dev. , vol.9 , pp. 15-21
    • Polakis, P.1
  • 98
    • 15544381570 scopus 로고    scopus 로고
    • Self-renewal and cancer of the gut: two sides of a coin
    • Radtke F., and Clevers H. Self-renewal and cancer of the gut: two sides of a coin. Science 307 (2005) 1904-1909
    • (2005) Science , vol.307 , pp. 1904-1909
    • Radtke, F.1    Clevers, H.2
  • 99
    • 33646249607 scopus 로고    scopus 로고
    • Ribba, B., Colin, T., Schnell, S., 2006. A multiscale mathematical model of cancer, and its use in analyzing irradiation therapies. Theor. Biol. Med. Model. 3, doi:10.1186/1742-4682-3-7.
  • 101
  • 102
    • 2542483551 scopus 로고    scopus 로고
    • Src in human carcinogenesis
    • Russello S.V., and Shore S.K. Src in human carcinogenesis. Front. Biosci. 9 (2004) 139-144
    • (2004) Front. Biosci. , vol.9 , pp. 139-144
    • Russello, S.V.1    Shore, S.K.2
  • 103
    • 0029995674 scopus 로고    scopus 로고
    • Uncoupling cadhering-based adhesion from Wingless signalling in Drosophila
    • Sanson B., White P., and Vincent J.P. Uncoupling cadhering-based adhesion from Wingless signalling in Drosophila. Nature 383 (1996) 627-630
    • (1996) Nature , vol.383 , pp. 627-630
    • Sanson, B.1    White, P.2    Vincent, J.P.3
  • 104
    • 0028141707 scopus 로고
    • Wnt-1-dependent regulation of local E-cadherin and α N-catenin expression in the embryonic mouse brain
    • Shimamura K., Hirano S., McMahon A.P., and Takeichi M. Wnt-1-dependent regulation of local E-cadherin and α N-catenin expression in the embryonic mouse brain. Development 120 (1994) 22225-22234
    • (1994) Development , vol.120 , pp. 22225-22234
    • Shimamura, K.1    Hirano, S.2    McMahon, A.P.3    Takeichi, M.4
  • 107
    • 11244305618 scopus 로고    scopus 로고
    • WNT signalling and haematopoiesis: a WNT-WNT situation
    • Staal F.J., and Clevers H.C. WNT signalling and haematopoiesis: a WNT-WNT situation. Nat. Rev. Immunol. 5 (2005) 21-30
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 21-30
    • Staal, F.J.1    Clevers, H.C.2
  • 111
    • 24344462625 scopus 로고    scopus 로고
    • Analysis of combinatorial effects of Wnts and Frizzled on β-catenin/Armadillo stabilization and Dishevelled phosphorilation
    • Takada R., Hijikata H., Kondoh H., and Takada S. Analysis of combinatorial effects of Wnts and Frizzled on β-catenin/Armadillo stabilization and Dishevelled phosphorilation. Gen. Cell. 10 (2005) 919-928
    • (2005) Gen. Cell. , vol.10 , pp. 919-928
    • Takada, R.1    Hijikata, H.2    Kondoh, H.3    Takada, S.4
  • 112
    • 0242515751 scopus 로고    scopus 로고
    • Chibby, a nuclear β-catenin-associated antagonist of the Wnt/Wingless pathway
    • Takemaru K.I., Yamaguchi S., Lee Y.S., Zhang Y., Carthew R.W., and Moon R.T. Chibby, a nuclear β-catenin-associated antagonist of the Wnt/Wingless pathway. Nature 422 (2002) 905-909
    • (2002) Nature , vol.422 , pp. 905-909
    • Takemaru, K.I.1    Yamaguchi, S.2    Lee, Y.S.3    Zhang, Y.4    Carthew, R.W.5    Moon, R.T.6
  • 113
    • 0035984637 scopus 로고    scopus 로고
    • Adherens junctions: new insight into assembly, modulation and function
    • Tepass U. Adherens junctions: new insight into assembly, modulation and function. BioEssays 24 (2002) 690-695
    • (2002) BioEssays , vol.24 , pp. 690-695
    • Tepass, U.1
  • 114
    • 0033119801 scopus 로고    scopus 로고
    • β-catenin regulates expression of cyclinD1 in colon carcinoma
    • Tetsu O., and McCormick F. β-catenin regulates expression of cyclinD1 in colon carcinoma. Nature 398 (1999) 422-426
    • (1999) Nature , vol.398 , pp. 422-426
    • Tetsu, O.1    McCormick, F.2
  • 116
  • 117
  • 118
    • 3242706980 scopus 로고    scopus 로고
    • Pygopus and Legless target Armadillo/β-catenin to the nucleus to enable its transcriptional co-activator function
    • Townsley F.M., Cliffe A., and Bienz M. Pygopus and Legless target Armadillo/β-catenin to the nucleus to enable its transcriptional co-activator function. Nat. Cell Biol. 6 (2004) 579-580
    • (2004) Nat. Cell Biol. , vol.6 , pp. 579-580
    • Townsley, F.M.1    Cliffe, A.2    Bienz, M.3
  • 120
    • 0025818032 scopus 로고
    • Genetic manipulation of E-cadherin expression by epithelial tumour cells reveals an invasion suppressor role
    • Vleminckx K., Vakaet Jr. L., Mareel M., Fiers W., and Van Roy F. Genetic manipulation of E-cadherin expression by epithelial tumour cells reveals an invasion suppressor role. Cell 66 (1991) 107-119
    • (1991) Cell , vol.66 , pp. 107-119
    • Vleminckx, K.1    Vakaet Jr., L.2    Mareel, M.3    Fiers, W.4    Van Roy, F.5
  • 121
    • 5044228112 scopus 로고    scopus 로고
    • Wnt signaling in osteoblasts and bone disease
    • Westendorf J.J., Kahler R.A., and Schroeder T.M. Wnt signaling in osteoblasts and bone disease. Gene 341 (2004) 19-39
    • (2004) Gene , vol.341 , pp. 19-39
    • Westendorf, J.J.1    Kahler, R.A.2    Schroeder, T.M.3
  • 123
    • 0344413477 scopus 로고    scopus 로고
    • Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled
    • Wong H.C., Bourdelas A., Krauss A., Lee H.J., Shao Y., Wu D., Mlodzik M., Shi D.L., and Zheng J. Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. Mol. Cell 12 (2003) 1251-1260
    • (2003) Mol. Cell , vol.12 , pp. 1251-1260
    • Wong, H.C.1    Bourdelas, A.2    Krauss, A.3    Lee, H.J.4    Shao, Y.5    Wu, D.6    Mlodzik, M.7    Shi, D.L.8    Zheng, J.9
  • 124
    • 0037756787 scopus 로고    scopus 로고
    • Structure of a β-catenin-TrCP1-Skp1-β-catenin complex: destruction motif binding and lysine specificity of the SCF(β-TrCP) ubiquitin ligase
    • Wu G., Xu G., Schulman B.A., Jeffrey P.D., Harper J.W., and Pavletich N.P. Structure of a β-catenin-TrCP1-Skp1-β-catenin complex: destruction motif binding and lysine specificity of the SCF(β-TrCP) ubiquitin ligase. Mol. Cell 11 (2003) 1445-1456
    • (2003) Mol. Cell , vol.11 , pp. 1445-1456
    • Wu, G.1    Xu, G.2    Schulman, B.A.3    Jeffrey, P.D.4    Harper, J.W.5    Pavletich, N.P.6
  • 125
    • 0344442773 scopus 로고    scopus 로고
    • Crystal structure of a β-catenin/axin complex suggests a mechanism for the β-catenin destruction complex
    • Xing Y., Clements W.K., and Kimelman D. Crystal structure of a β-catenin/axin complex suggests a mechanism for the β-catenin destruction complex. Gen. Dev. 17 (2003) 2753-2764
    • (2003) Gen. Dev. , vol.17 , pp. 2753-2764
    • Xing, Y.1    Clements, W.K.2    Kimelman, D.3
  • 126
    • 4344684495 scopus 로고    scopus 로고
    • Crystal structure of a β-catenin/APC complex reveals a critical role of APC phosphorylation in APC function
    • Xing Y., Clements W.K., Le Trong I., Hinds T.R., Stenkamp R., Kimelman D., and Xu W. Crystal structure of a β-catenin/APC complex reveals a critical role of APC phosphorylation in APC function. Mol. Cell 15 (2004) 523-533
    • (2004) Mol. Cell , vol.15 , pp. 523-533
    • Xing, Y.1    Clements, W.K.2    Le Trong, I.3    Hinds, T.R.4    Stenkamp, R.5    Kimelman, D.6    Xu, W.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.