Reduction of β-catenin/T-cell transcription factor signaling by aspirin and indomethacin is caused by an increased stabilization of phosphorylated β-catenin

Molecular Cancer Therapeutics

Volumn 2, Issue 6, 2003, Pages 509-516

  Dihlmann, Susanne ^a   Klein, Simone ^a   Von Knebel Doeberitz, Magnus ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; BETA CATENIN; CTNNB1 PROTEIN, HUMAN; CYTOSKELETON PROTEIN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; INDOMETACIN; LUCIFERASE; NONSTEROID ANTIINFLAMMATORY AGENT; TRANSACTIVATOR PROTEIN;

ARTICLE; BINDING SITE; CELL LINE; DOWN REGULATION; DRUG EFFECT; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; IMMUNOBLOTTING; METABOLISM; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; REPORTER GENE; SIGNAL TRANSDUCTION; TIME; TUMOR CELL LINE;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; BETA CATENIN; BINDING SITES; CELL LINE; CELL LINE, TUMOR; CYTOSKELETAL PROTEINS; DOWN-REGULATION; GENES, REPORTER; GLYCOGEN SYNTHASE KINASE 3; HUMANS; IMMUNOBLOTTING; INDOMETHACIN; LUCIFERASES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; TIME FACTORS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 1542649391     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Polakis, P. Wnt signaling and cancer. Genes Dev., 14: 1837-1851, 2000. (Pubitemid 30639518)
2. Wong, N. A., and Pignatelli, M. β-Catenin: a linchpin in colorectal carcinogenesis? Am. J. Pathol., 160: 389-401, 2002.
3. Peifer, M., Pai, L. M., and Casey, M. Phosphorylation of the Drosophila adherens junction protein Armadillo: roles for wingless signal and zestewhite 3 kinase. Dev. Biol., 166: 543-556, 1994.
4. Liu, C., Li, Y., Semenov, M., Han, C., Baeg, G. H., Tan, Y., Zhang, Z., Lin, X., and He, X. Control of β-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell, 108: 837-847, 2002. (Pubitemid 34327534)
5. van Noort, M., Meeldijk, J., van der, Z. R., Destree, O., and Clevers, H. Wnt signaling controls the phosphorylation status of beta-catenin. J. Biol. Chem., 277: 17901-17905, 2002. (Pubitemid 34967600)
6. Manoukian, A. S., and Woodgett, J. R. Role of glycogen synthase kinase-3 in cancer: regulation by wnts and other signaling pathways. Adv. Cancer Res., 84: 203-229, 2002. (Pubitemid 34188198)
7. Kishida, M., Koyama, S., Kishida, S., Matsubara, K., Nakashima, S., Higano, K., Takada, R., Takada, S., and Kikuchi, A. Axin prevents Wnt-3a-induced accumulation of β-catenin. Oncogene, 18: 979-985, 1999. (Pubitemid 29086274)
8. Hart, M., Concordet, J. P., Lassot, I., Albert, I., del los Santos, R., Durand, H., Perret, C., Rubinfeld, B., Margottin, F., Benarous, R., and Polakis, P. The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell. Curr. Biol., 9: 207-210, 1999. (Pubitemid 29120385)
9. Taketo, M. M. Cyclooxygenase-2 inhibitors in tumorigenesis (part I). J. Natl. Cancer Inst. (Bethesda), 90: 1529-1536, 1998.
10. Taketo, M. M. Cyclooxygenase-2 inhibitors in tumorigenesis (Part II). J. Natl. Cancer Inst. (Bethesda), 90: 1609-1620, 1998. (Pubitemid 28523435)
11. Husain, S. S., Szabo, I. L., and Tamawski, A. S. NSAID inhibition of GI cancer growth: clinical implications and molecular mechanisms of action. Am. J. Gastroenterol., 97: 542-553, 2002. (Pubitemid 34245879)
12. Giercksky, K. E. COX-2 inhibition and prevention of cancer. Best Pract. Res. Clin. Gastroenterol., 15: 821-833, 2001.
13. Marx, J. Cancer research. Anti-inflammatories inhibit cancer growth, but how? Science (Wash. DC), 291: 581-582, 2001. (Pubitemid 32150402)
14. Zhang, X., Morham, S. G., Langenbach, R., and Young, D. A. Malignant transformation and antineoplastic actions of nonsteroidal anti-inflammatory drugs (NSAIDs) on cyclooxygenase-null embryo fibroblasts. J. Exp. Med., 190: 451-459, 1999. (Pubitemid 29395373)
15. Dihlmann, S., Siermann, A., and von Knebel Doeberitz, M. The non-steroidal anti-inflammatory drugs aspirin and indomethacin attenuate β-catenin/TCF-4 signaling. Oncogene, 20: 645-653, 2001. (Pubitemid 32156189)
16. Goodman, L. S., Limbird, L. E., Molinoff, P. B., Ruddon, R. W., Gilman, A. G., and Hardman, J. G. The Pharmacological Basis of Therapeutics, Ed. 9. New York: McGraw-Hill, Health Professions Division, 1996.
17. Stark, L. A., Din, F. V., Zwacka, R. M., and Dunlop, M. G. Aspirin-induced activation of the NF-κB signaling pathway: a novel mechanism for aspirin-mediated apoptosis in colon cancer cells. FASEB J., 15: 1273-1275, 2001.
18. Dihlmann, S., Gebert, J., Siermann, A., Herfarth, C., and von Knebel Doeberitz, M. Dominant negative effect of the APC1309 mutation: a possible explanation for genotype-phenotype correlations in familial adenomatous polyposis. Cancer Res., 59: 1857-1860, 1999. (Pubitemid 29186157)
19. Korinek, V., Barker, N., Morin, P. J., van Wichen, D., de Weger, R., Kinzler, K. W., Vogelstein, B., and Clevers, H. Constitutive transcriptional activation by a β-catenin-Tcf complex in APC-/- colon carcinoma [see comments]. Science (Wash. DC), 275: 1784-1787, 1997. (Pubitemid 27136714)
20. Morin, P. J., Sparks, A. B., Korinek, V., Barker, N., Clevers, H., Vogelstein, B., and Kinzler, K. W. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC [see comments]. Science (Wash. DC), 275: 1787-1790, 1997. (Pubitemid 27136715)
21. Serres, M., Grangeasse, C., Haftek, M., Durocher, Y., Duclos, B., and Schmitt, D. Hyperphosphorylation of β-catenin on serine-threonine residues and loss of cell-cell contacts induced by calyculin A and okadaic acid in human epidermal cells. Exp. Cell Res., 231: 163-172, 1997. (Pubitemid 27187525)
22. Yin, M. J., Yamamoto, Y., and Gaynor, R. B. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(κ)B kinase-β [see comments]. Nature (Lond.), 396: 77-80, 1998. (Pubitemid 28520452)
23. Orford, K., Crockett, C., Jensen, J. P., Weissman, A. M., and Byers, S. W. Serine phosphorylation-regulated ubiquitination and degradation of β-catenin. J. Biol. Chem., 272: 24735-24738, 1997. (Pubitemid 27415637)
24. Chen, F., Castranova, V., and Shi, X. New insights into the role of nuclear factor-κB in cell growth regulation. Am. J. Pathol., 159: 387-397, 2001. (Pubitemid 32751067)
25. Cohen, P., and Frame, S. The renaissance of GSK3. Nat. Rev. Mol. Cell Biol., 2: 769-776, 2001. (Pubitemid 33679839)
26. Monick, M. M., Carter, A. B., Robeff, P. K., Flaherty, D. M., Peterson, M. W., and Hunninghake, G. W. Lipopolysaccharide activates Akt in human alveolar macrophages resulting in nuclear accumulation and transcriptional activity of β-catenin. J. Immunol., 166: 4713-4720, 2001. (Pubitemid 32233759)
27. Rubinfeld, B., Robbins, P., El Gamil, M., Albert, I., Porfiri, E., and Polakis, P. Stabilization of β-catenin by genetic defects in melanoma celllines. Science (Wash. DC), 275: 1790-1792, 1997. (Pubitemid 27136716)
28. Sadot, E., Conacci-Sorrell, M., Zhurinsky, J., Shnizer, D., Lando, Z., Zharhary, D., Kam, Z., Ben Ze'ev, A., and Geiger, B. Regulation of S33/S37 phosphorylated β-catenin in normal and transformed cells. J. Cell Sci., 115: 2771-2780, 2002. (Pubitemid 34846517)
29. Staal, F. J., Noort, M. M., Strous, G. J., and Clevers, H. C. Wnt signals are transmitted through N-terminally dephosphorylated β-catenin. EMBO Rep., 3: 63-68, 2002. (Pubitemid 34144817)
30. Shirane, M., Hatakeyama, S., Hattori, K., Nakayama, K., and Nakayama, K. Common pathway for the ubiquitination of IκBα, IκBβ, and IκBε mediated by the F-box protein FWD1. J. Biol. Chem., 274: 28169-28174, 1999.
31. Kitagawa, M., Hatakeyama, S., Shirane, M., Matsumoto, M., Ishida, N., Hattori, K., Nakamichi, I., Kikuchi, A., Nakayama, K., and Nakayama, K. An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin. EMBO J., 18: 2401-2410, 1999. (Pubitemid 29213274)
32. Aberle, H., Bauer, A., Stappert, J., Kispert, A., and Kemler, R. β-Cateninis a target for the ubiquitin-proteasome pathway. EMBO J., 16: 3797-3804, 1997.
33. Ishihara, H., Martin, B. L., Brautigan, D. L., Karaki, H., Ozaki, H., Kato, Y., Fusetani, N., Watabe, S., Hashimoto, K., Uemura, D., et al. Calyculin A and okadaic acid: inhibitors of protein phosphatase activity. Biochem. Biophys. Res. Commun., 159: 871-877, 1989. (Pubitemid 19101063)
34. Lin, J. H., Cocchetto, D. M., and Duggan, D. E. Protein binding as a primary determinant of the clinical pharmacokinetic properties of non-steroidal anti-inflammatory drugs. Clin. Pharmacokinet., 12: 402-432, 1987.