Wnt pathway mutations selected by optimal β-catenin signaling for tumorigenesis

FEBS Letters

Volumn 580, Issue 15, 2006, Pages 3665-3670

  Cho, Kwang Hyun ^a   Baek, Songjoon ^a   Sung, Myong Hee ^b  

^a Seoul National University   (South Korea)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

APC mutations; Mathematical modeling; Systems biology; Wnt

Indexed keywords

AXIN 2; BETA CATENIN; PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; AXIN PROTEIN; REPRESSOR PROTEIN;

ARTICLE; CARCINOGENESIS; CELL ADHESION; CELL DIVISION; CELL RENEWAL; CELL SURVIVAL; CHROMOSOMAL INSTABILITY; COLON POLYPOSIS; GENE MUTATION; MATHEMATICAL MODEL; NEGATIVE FEEDBACK; PRIORITY JOURNAL; STEM CELL; TISSUE SPECIFICITY; ANIMAL; CELL TRANSFORMATION; GENETICS; METABOLISM; MUTATION; NEOPLASM; OOCYTE; PATHOLOGY; SIGNAL TRANSDUCTION; XENOPUS LAEVIS;

ADENOMATOUS POLYPOSIS COLI; ANIMALS; BETA CATENIN; CELL TRANSFORMATION, NEOPLASTIC; MUTATION; NEOPLASMS; OOCYTES; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; WNT PROTEINS; XENOPUS LAEVIS;

EID: 33746803311     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2006.05.053     Document Type: Article

References (14)

1. Fearnhead N.S., Britton M.P., and Bodmer W.F. The ABC of APC. Hum. Mol. Genet. 10 (2001) 721-733
2. Gaspar C., and Fodde R. APC dosage effects in tumorigenesis and stem cell differentiation. Int. J. Dev. Biol. 48 (2004) 377-386
3. Kikuchi A. Tumor formation by genetic mutations in the components of the Wnt signaling pathway. Cancer Sci. 94 (2003) 225-229
4. Albuquerque C., et al. The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade. Hum. Mol. Genet. 11 (2002) 1549-1560
5. Fodde R., Smits R., and Clevers H. APC, signal transduction and genetic instability in colorectal cancer. Nat. Rev. Cancer 1 (2001) 55-67
6. Rubinfeld B., Albert I., Porfiri E., Munemitsu S., and Polakis P. Loss of beta-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene. Cancer Res. 57 (1997) 4624-4630
7. Lee E., Salic A., Kruger R., Heinrich R., and Kirschner M.W. The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. PLoS Biol. 1 (2003) E10
8. Leung J.Y., Kolligs F.T., Wu R., Zhai Y., Kuick R., Hanash S., Cho K.R., and Fearon E.R. Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling. J. Biol. Chem. 277 (2002) 21657-21665
9. Lustig B., et al. Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol. Cell Biol. 22 (2002) 1184-1193
10. Yan D., et al. Elevated expression of axin2 and hnkd mRNA provides evidence that Wnt/beta-catenin signaling is activated in human colon tumors. Proc. Natl. Acad. Sci. USA 98 (2001) 14973-14978
11. Salic A., Lee E., Mayer L., and Kirschner M.W. Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts. Mol. Cell 5 (2000) 523-532
12. Fodde R., et al. Mutations in the APC tumour suppressor gene cause chromosomal instability. Nat. Cell Biol. 3 (2001) 433-438
13. Yamashita Y.M., Jones D.L., and Fuller M.T. Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome. Science 301 (2003) 1547-1550
14. Reya T., and Clevers H. Wnt signalling in stem cells and cancer. Nature 434 (2005) 843-850