Phytosterols and cardiovascular risk;Phytostérols et risque cardiovasculaire

Nutrition Clinique et Metabolisme

Volumn 21, Issue 1, 2007, Pages 17-27

  Lecerf, Jean Michel ^a  

^a INSTITUT PASTEUR DE LILLE   (France)

Author keywords

Cardiovascular risk; Carotenoids; Dietary cholesterol; LDL cholesterol; Phytostanols; Plant sterols; Sitosterolemia

Indexed keywords

CHOLESTEROL; PHYTOSTEROL;

ABSORPTION; ARTICLE; ATHEROMA; CARDIOVASCULAR RISK; CHOLESTEROL INTAKE; DOSE RESPONSE; HUMAN; HYDROGENATION; ISCHEMIC HEART DISEASE; METABOLISM; NONHUMAN;

ANIMALIA;

EID: 34047188609     PISSN: 09850562     EISSN: 17683092     Source Type: Journal    
DOI: 10.1016/j.nupar.2007.01.004     Document Type: Article

References (103)

1. Dawson P.A., and Rudel L.L. Intestinal cholesterol absorption. Curr. Opin. Lipidol. 10 (1999) 315-320
2. Turley S.D. Dietary cholesterol and the mechanisms of cholesterol absorption. Eur. Heart J. Suppl. 1 (1999) S29-S35
3. Ostlund R.E., Bosner M.S., and Stenson N.F. Cholesterol absorption officiency declines et moderate dietary doses in normal human subjects. J Lip Res 40 (1999) 1453-1458
4. Sachs F.M., Miller L., Sutherland M., Albers J.J., Salazar J., Foster J.M., et al. Ingestion of egg raises plasma low density lipoproteins in free-living subjects. Lancet 8378 (1984) 647-649
5. Vorster H.H., Benade A.J., Barnard H.C., Locke M.N., Silvis N., Venter C.S., et al. Egg does not change plasma lipoprotein and coagulation profiles. Am. J. Clin. Nutr. 55 (1992) 400-410
6. Weggemans P.M., Zock P.L., and Katan M.B. Dietary cholesterol from eggs increases the ration of total cholestrol to high density lipoprotein cholesterol in humans : a metaanalysis. Am. J. Clin. Nutr. 73 (2001) 885-891
7. Kern F. Normal plasma cholesterol or an 88 year old man who eats 25 eggs a day. Mechanisms of adaptation. N. Engl. J. Med. 324 (1991) 896-897
8. Simons L.A., Von Konigsmark M., Simons J., Friedlander Y., and Balasubramanian S. Effect of on egg per day on plasma cholesterol levels in moderate hypercholesterolemia. Nutr. Metab. Cardiovasc. Dis. 3 (1993) 78-82
9. Lee A. Dietary cholesterol, eggs and coronary heart disease in prespective. Nutr. Bull. 31 (2006) 21-27
10. Shekelle R.B., and Stamler J. Dietary cholesterol and ischemic heart disease. Lancet 1 8648 (1989) 1177-1179
11. Dawber T.R., Nickerson R.J., Brand F.N., and Pool J. Eggs, serum cholesterol and coronary heart disease. Am. J. Clin. Nutr. 36 (1982) 617-625
12. Hu F.B., Stampfer M.J., Rimm E.B., Manson J.E., Ascherio A., et al. A prospective study of egg consumption and risk of cardiovascular disease in men and women. JAMA 281 (1999) 1387-1394
13. Sutherland W.H.F., Ball M.J., and Walker H. The effect of increases egg consumption in plasma cholesteryl ester transfer activity in healthy subjects. Eur. J. Clin. Nutr. 51 (1997) 172-176
14. Nakamura Y., Okamura T., Tamaki S., Kadowaki T., Hayakawa T., Kita Y., et al. Egg consumption, serum cholesterol and cause specific and all cause mortality the National Integrated Project for Prospective Observation of Non Communicable Disease and its trends in the aged, 1980. Am. J. Clin. Nutr. 80 (2004) 58-63
15. Plat J., and Mensink R.P. Plant stanol and sterol esters in the control of blood cholesterol levels : mechanism and safety aspects. Am J Cardiol 96 Suppl (2005) 15D-22D
16. Ling W.H., and Jones P.J.H. Minireview. Dietary phytosterols. A review of metabolism, benefits and side effects. Life Sci. 57 (1995) 195-206
17. Mendy A. Synergie et acides gras. Une révolution. Une ère nouvelle. Diététique et Médecine (2005-2006) 75-80
18. Korpela R., Tuomiletto J., Hogstrom P., Seppo L., Piironen V., Salo-Vaananew P., et al. Safety aspects and cholesterol-lowering efficacy of low fat dairy products containing plant sterols. Eur J Clin Nutr 60 (2006) 633-649
19. Nissinen M.J., Gylling H., and Miettinen T.A. Effects of plant starol esters supplied in a fat-free milieu by pastilles on cholesterol metabolism in colectomized human subjects. Nutr Metab Cardivasc Dis 16 (2006) 426-439
20. Andersson S.W., Skinner J., Ellegard L., Welch A.A., et al. Intake of dietary plant sterols is inversely related to serum cholesterol concentration in men and women in the EPIC Norfolk population: a cross sectional study. Eur. J. Clin. Nutr. 58 (2004) 1378-1385
21. Mac Dougall J.P.J.H., Ntanios F., and Vanstone C.A. Dietary phytosterols as cholesterol-lowering agents in humans. Can. J. Physiol. Pharmacol. 75 (1997) 217-227
22. Ostlund R.E., Racette S.B., and Stenson W.F. Phytosterols that are naturally present in commercial corn oil significantly reduce cholesterol absorption in humans. Am. J. Clin. Nutr. 75 (2002) 1000-1004
23. Phillips K.M., Ruggio D.M., and Ashraf-Khorassani M. Phytosterols composition of nuts and seeds in the United States. J. Agric. Food Chem. 53 (2005) 9436-9445
24. Ikeda I., and Sugano M. Inhibition on cholesterol absorption by plants sterols for mass intervention. Curr. Opin. Lipidol. 9 (1998) 527-531
25. Hendriks H.F., Westrate J.A., Van Viet T., and Meijer G.W. Spreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in nomocholesterolemic and mildly hypercholesterolemic subjects. Eur. J. Clin. Nutr. 53 (1999) 319-327
26. Weststrate J.A., and Meijer G.N. Plant sterol enriched margarines and reduction of plasma total cholesterol and LDL cholesterol concentrations in normocholesterolemic and mildly hypercholesterolemic subjects. Eur. J. Clin. Nutr. 52 (1998) 334-343
27. O'Neill F.H., Sanders T.A., and Thompson G.R. Comparison of efficacy of plant stanol ester and sterol ester : short term and longer-term studies. Am. J. Cardiol. 96 Suppl (2005) 29D-36D
28. O'Neill F.H., Brynes A., Mandeno R., Rendell N., Taylor G., Seed M., et al. Comparison of the effects of dietary plant and sterol esters on lipid metabolism. Nutr. Metab. Cardiovasc. Dis. 14 (2004) 133-142
29. Jublanc C., Farmier M., Lecerf J.M., Gambert P., Chantre P., and Bruckert E. Reduction of serum cholesterol with low doses of a capsule form of phytosterols in hypercholesterolemic subjects. Nutr. Metab. Cardiovasc. Dis. (2007) (in press)
30. Chen J.L., Wesley R., Shamburek R.D., Pucino F., and Csako G. Meta-analysis of natural therapies for hyperlipidemia : plants sterols and stanols versus policosanol. Pharmacotherapy 25 (2005) 171-183
31. Katan M.B., Grundy S.M., Jones P., Law M., Miettinen T., and Paoletti R. Efficacity safety of plants stanols and sterols in the management of blood cholesterol levels. Mayo Clin. Proc. 78 (2003) 965-978
32. Devaraj S.J., Alal I., and Vega S. Plant sterol fortified orange juice effectively lowers cholesterol levels in mildly hypercholesterolemic healthy individuals. Arterioscler. Thromb. Vasc. Biol. 241 (2004) 25-28
33. Mensink R.P., Ebbing S., Lindhout M., Plat J., and Heugten Marjoline M.A. Effects of plant stanol esters supplied in low fat yoghurt on serum lipids and lipoproteins, non cholesterol sterols and fat soluble antioxydant concentrations. Atherosclerosis 160 (2002) 205-213
34. Nestel P., Cehun M., Pomeroy S., Abbey M., and Weldon G. Cholesterol lowering effects of plant sterol esters and non esterified stanols in margarine, butter and low-fat foods. Eur. J. Clin. Nutr. 55 (2001) 1084-1090
35. Doornbos A.M.E., Meynen E.M., Duchateau G.S.M.J.E., Van Der Knaap H.C.M., and Trautwein E.A. Intake occasion effects the serum cholestrol lowering of a plant sterol enriched single-dose yoghurt drink in middly hypercholesterolemic subjects. Eur. J. Clin. Nutr. 59 (2005) 1-9
36. Plat J., Van Onselen E.N., Van Heugten M.M., and Mensink R.P. Effects on serum lipids, lipoproteins and fat soluble antioxydant concentrations of consumption frequency of magarines and shortenings enriched with plant stanol esters. Eur. J. Clin. Nutr. 54 (2000) 671-677
37. Lau U.N.Y., Journoud M., and Jones P.J.H. Plant sterols are efficious in lowering plasma LDL and non HDL cholesterol in hypercholesterolemic type 2 diabetic and non diabetic persons. Am. J. Clin. Nutr. 81 (2005) 1351-1358
38. Skeaff C.H., Thoma C., Mann J., Chisolm A., Williams S., and Richmond K. Isocaloric substitution of plant sterol-enriched fat spread for carbo-hydrate rich foods in a low-fat, fiber-rich diet decreases plasma low-density lipoprotein cholesterol and increases high density lipoprotein concentrations. Nutr. Metab. Cardiovasc. Dis. 15 (2005) 337-344
39. Ostlund R.E., Racette S.B., and Stenson W.F. Effects of trace components of dietary fat on cholesterol metabolism: phytosterols, oxysterols and squalene. Nutr. Rev. 60 (2002) 349-359
40. Ellegard L., Andersson H., and Bosaeus I. Rapeseed oil, olive oil, plant sterols and cholesterol metabolism : an ileostomy study. Eur. J. Clin. Nutr. 59 (2005) 1374-1378
41. Howell J.J., Mac Dougall D.E., and Jones P.H.J. Phytosterols partially explain differences in cholesterol metabolism caused by corn or olive feeding. J. Lipid Res. 39 (1998) 892-900
42. Pelletier X., Belbraouet S., Mirabel D., Mordret F., et al. A diet moderately enriched in phytosterols lowers plasma cholesterol concentrations in normocholesterolemic humans. Ann. Nutr. Metab. 39 (1995) 291-295
43. Andersson A., Karlstrom B., Mohsen, and Vessby B. Cholesterol-lowering effects of a stanol ester-containing low-fat margarine used in conjunction with a strict lipid-lowering diet. Eur. Heart J. 1 Suppl S (1999) S80-S90
44. Hallikainen M.A., and Uusitupa M.I. Effects of 2 low-fat stanol ester-containing margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic subjects. Am. J. Clin. Nutr. 69 (1999) 403-410
45. Gylling H., and Miettinen T.A. The effects on inhibiting cholesterol synthesis and absorption and lipoprotein metabolism in hypercholesterolemic non insulin dependant diabetic men. J. Lipid Res. 31 (1996) 1776-1785
46. Miettinen T.A., Uvoristo M., Nissinen H., Jarvinen H.T., and Gylling H. Serum, biliary and fecal cholesterol and plant sterols in colectomized patients before and during consumption of stanol ester margarine. Am. J. Clin. Nutr. 71 (2000) 1095-1102
47. Chan Y.M., Varady K.A., Lin Y.L., Trantweine E., Mensink R.P., Plat J., et al. Plasma concentrations of plant sterols: physiology and relationship with coronary heart disease. Nutr. Rev. 64 (2006) 385-402
48. Miettinen T.A., Railo M., Le Pantalo M., and Gylling H. Plant sterols in serum and in atherosclerotic plaques of patients undergoing carotid endarteriectomy. Am. J. Coll. Cardiol. 45 (2005) 1794-1801
49. Hallikainen M.A., Sarkkinew E.S., and Vusitupa M.I.J. Effects of low fat sterol ester enriched margarines on concentrations of serum carotenoids in subjects with elevated serum cholesterol concentration. Eur. J. Clin. Nutr. 53 (1999) 966-969
50. Hendricks H.F.J., Brink E.J., Meijer G.W., Princen H.M.G., and Ntanios F.Y. Safety of long term consumption of plant sterol-esters enriched spread. Eur. J. Clin. Nutr. 57 (2003) 681-692
51. Richelle M., Enslen M., Hager C., Groux M., et al. Both free and esterified plant sterols reduce cholesterol absorption and the bioavailability of β-carotene and α-tocopherol in normocholesterolemic humans. Am J. Clin. Nutr. 80 (2004) 171-177
52. Tammi A. Plant stanol ester margarine lowers serum total and low density cholesterol concentrations of healthy children. J. Pediatr. 136 (2000) 303-310
53. Amundsen A.L., Ntanius F., Van Derput N., and OSE L. Long term compliance and changes in plasmatic lipids, plant sterols and carotenoids in children and parents with FH consuming plant sterol-ester enriched spread. Eur. J. Clin. Nutr. 58 (2004) 1612-1620
54. Wolfs M., De Jong N., Ocke M.C., Verhagen H., and Verschuren N.M.M. Effectivness of customary use of phytosterol/stanol enriched maragrines on blood cholestrol lowering. Food Chem. Toxicol. 44 (2006) 1682-1688
55. Windler F., Zyriax B., Kuipers F., Linseisen J., and Boeing H. Lack of association of plasma phytosterols with risk of coronary heart disease in the CORA Study. Atherosclerosis 7 (2006) 177
56. Visser M.N., Pinedo S., Boekholdt S.M., Vonbergmann K., Elharchaoui K., Bingham S.A., et al. Plasma levels of plant sterols and the risk of future coronary heart disease in healthy men and women: the prospective EPIC-NORFOLK population study. Atherosclerosis 7 (2006) 318
57. Pinedo S., Visser M.N., Von Bergmann K., Elharchaoui K., Lutjohann D., Luben R., et al. Plasma levels of plant sterols and the risk of future coronary artery disease in apparently healthy men and women; the prospective EPIC-NORFOLK population study. J. Lipid. Res. 48 1 (2006) 139-144
58. Wilund K.R., Yu L., Vega L.G., Grundy S.M., Cohen J.C., and Hobbs H.H. No association between plasma levels of plant sterols and atherosclerosis in mice and men. Arterioscl. Thromb Vasc. Biol 24 (2004) 2326-2332
59. Zhang X., Shu X.O., Gao Y.T., Yang G., Li Q., Li H., et al. Soy food consumption is associated with lower risk of coronary heart disease in Chinese women. J. Nutr. 133 (2003) 2874-2878
60. Phillips C., Belsey J., and Shindler J. Flora pro.activ: a clinical and financial impact analysis. J of Med Eco 3 (2000) 61-76
61. Glueck C.J., Speirs J., Tracy T., Streicher P., Illig E., and Vandegrift J. Relationships of serum plant sterols (phytosterols) and cholesterol in 595 hypercholesterolemic subjects and familial aggregation of phytosterols, cholesterol and premature coronary heart disease in hypercholesterolemic probands and their first degree relatives. Metabolism 40 (1991) 842-848
62. Rajaratnam R.A., Gylling H., and Miettinen T.A. Independent association of serum squalene and non cholesterol sterols with coronary artery disease in postmenopausal women. Am. J. Coll. Cardiol. 35 (2000) 1185-1191
63. Gylling H. Miettinen. Cholesterol absorption and lipoprotein metabolism in type II diabetes mellitus with and without coronary artery disease. Atherosclerosis 126 (1996) 325-332
64. Sutherland W.H.F., Williams M.J.A., Nye E.R., Restieaux N.J., et al. Associations of plasma non cholesterol sterol levels with severity of coronary artery disease. Nutr. Metab. Cardiovasc. Dis. 8 (1998) 386-391
65. Matthan N.R., La Rocque J.M., Pencina M., D'Agostino R.B., Schaeffer E.J., and Lichtenstein A.H. Increased cholesterol absorption and decreased cholesterol synthesis characterize Framingham offspring study participants with coronary heart disease. Circulation 112 (2005) II816-II817
66. Miettinen T.A., and Gylling H. Synthesis and absorption markers of cholesterol in serum and lipoproteins during a large dose of statin treatment. Eur. J. Clin. Invest. 33 (2003) 976-982
67. Miettinen T.A., and Gylling H. Cholesterol synthesis and absorption in coronary patients with lipid trial and isolated high LDL cholesterol in a 4S sungroup. Atherosclerosis 168 (2003) 343-349
68. Watts G.F., Chan D.C., Barrett P.H.R., O'Neill F.A., and Thompson G.R. Effect of a statin on hepatic apolipoprotein B-100 secretion and plasma campesterol levels in the metabolic syndrome. Int. J. Obes. 27 (2003) 862-865
69. Miettinen T.A., Gylling H., Strandberg T., and Sarna S. Baseline serum cholestanol as predictor of recurrent coronary events in subgroup of Scandinavian simvastatin survey study. BMJ 316 (1998) 1127-1130
70. Miettinen T.A., Strandberg H., and Gylling H. For the Finish investigators of the Scandinavian simvastatin survival study group. Non cholesterol sterols and cholesterol lowering by long-term simvastatin treatment in coronary patients. Relation to basal cholestanol. Arterioscler. Thromb. Vasc. Biol. 20 (2000) 1340-1346
71. Patel M.D., and Thompson P.D. Phytosterols and vascular disease. Atherosclerosis 186 (2006) 12-19
72. Gylling H., Puska P., Vartiainen E., and Miettinen T.A. Serum sterols during stanol ester feeding in a mildly hypercholesterolemic population. J Lip Res 40 (1999) 593-600
73. Assemann G., Cullen P., Erbey J.R., Ramey D.R., Kannenberg F., and Schulte H. Plasma sistosterol elevations are associated with an increased incidence of coronary events in men: results of a nested case-control analysis of the prospective cardiovascular Münster (PROCAM) study. Nutr. Metab. Cardiovasc. Dis. 16 (2006) 13-21
74. Sudhop T., Gottwald B.M., and Von Bergmann K. Serum plant sterols as a potential risk factor for coronary heart disease. Metabolism 51 (2002) 1519-1521
75. Thiery J., Ceglarec U., Fiedler G.M., Leichte A., Baumann S., and Teupser D. Elevated campesterol serum levels - a significant predictor of incident myocardial infection (2006), Circulation
76. Plat J., and Menstink R.P. Effect of plant sterols ans stanols on lipid metabolism and cardiovascular risk. Nutr. Metab. Cardiovasc. Dis. 11 (2001) 31-40
77. Salen G., Horak I., Rothkopf M., Cphan J.L., et al. Lethal atherosclerosis associated with abnormal plasma and tissue sterol composition in sitosterolemia with xanthomatosis. J. Lipid Res. 25 (1985) 1126-1133
78. Bhattacharyya A.K., and Connor W.E. Beta-sitosterolemia and xanthomatosis. A newly described lipid storage disease in two sisters. J. Clin. Invest. 53 (1974) 1033-1043
79. Bhattacharyya A.K., Connor W.E., Lin D.S., Mac Murry M.M., and Shulman R.S. Sluggish sitosterol turnover and hepatic failure to excrete sitosterol into bile cause expansion of body pool of sitosterol in patients with sitosterolemia and xanthomatosis. Arterioscler. Thromb. 11 (1991) 1287-1296
80. Berge K.F., Tian H., Graf G.A., Yu L., Grishin N.V., Schultz J., et al. Acccumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science 290 (2000) 1771-1775
81. Sehayek E., and Breslow W. Plasma plant sterol levels. Another coronary heart disease risk factor?. Arterioscler. Thromb. Vasc. Biol. 25 (2005) 5-6
82. Homma Y., Ikeda I., Ishikawa T., Tateno M., Sugano M., and Nakamura H. Decrease in plasma low-density lipoprotein cholesterol apolipoprotein B, cholesterol ester Transfer Protein and oxidized low-density lipoprotein by plant stanol ester-containing spread : a randomized, placebo-controlled trial. Nutrition 19 (2003) 369-374
83. Varady K.A., St. Pierre A.C., Lamarche B., and Jones P.J.H. Effect of plant sterols and endurance training on LDL particle size and distribution in previously sedentary hypercholesterolemic adults. Eur. J. Clin. Nutr. 59 (2005) 518-525
84. Charest A., Vanstone C., St. Onge M.P., Warson W., Jones P.J.H., and Lamarche B. Phytosterols in non fat and low-fat beverages have no impact on the LDL size phenotype. Eur. J. Clin. Nutr. 59 (2005) 801-804
85. Blomqyist S.M., Jauhiainen M., Van Tol A., Hyvonen M., Torstila I., Vanhanen H.T., et al. Effect of sitosterol ester on composition and size distribution of low and high-density lipoprotein. Nutr. Metab. Cardiovasc. Dis. 3 (1993) 158-164
86. Verges B. Place de l'Ézétimibe et des stérols. Actualités en diététique et nutrition 47 (2006) 51-58
87. Moghadasian M.H., Manus B.M., Pritchard P.H., and Frohlich J.J. "Tail oil" derived phytosterols reduce atherosclerosis in apoE-deficient mice. Arterioscler. Thromb. Vasc. Biol. 17 (1997) 119-126
88. Volger O.L., Vander Boom D.E., Wite C.M., Duyvenvoorde Van W., et al. Dietary vegetables -wood- or vegetable/wood derived stanol esters reduce atherosclerosis lesion size and severity in ApoE3-Leiden transgenic mice. Atherosclerosis 151 (2000) 151-177
89. Ntanios F.Y., Jones P.H.J., and Frohlich J.J. Dietary sitostanol reduces plaque formation but not lecithin cholesterol acyl transferase activity in rabbits. Atherosclerosis 138 (1998) 101-110
90. Ikeda I., Kawasaki A., Samezima K., and Sugano M. Antihypercholesterolemic activity of β-sistanol in rabbits. J. Nutr. Sci. Vitaminol. (Tokyo) 27 (1981) 243-251
91. Moghadasian M.H., Godin D.V., Macmanus B.M., and Frohlich J.J. Lack of regression of atherosclerosis lesions in phytosterols-treated apo E-deficient mice. Life Sci. 64 (1999) 1029-1036
92. e Congrès de la Société Française de Nutrition - Marseille 17-19/11/05.
93. Ratnayake W.M.N., L'Abbe M.R., Mueller R., Hayward S., et al. Vegetables oils high in phytosterols make erythrocytes less deformable and shorten the life span of stroke-prone spontaneously hypertensive rats. J. Nutr. 130 (2000) 166-178
94. Ratnayake W.M.N., Plouffe L., L'Abbe M.R., Trick K., et al. Comparative health effects of margarines fortified with plant sterols and stanols on a rat model for hemorrahagic stroke. Lipids 38 (2003) 1237-1247
95. Ikeda I., Nakagiri H., Michihiro S., Ohara S., et al. Mechanisms of phytosterolemia in stroke-prone spontaneously hypertensive and WKY rats. Metabolism 50 (2001) 1361-1368
96. Raicht R.F., Cohen B.I., Fazzini E.P., Sarwal A.N., and Takahashi M. Prospective effect of plant sterols against chemically induced colon tumors in rats. Cancer Res. 40 (1980) 908-913
97. Normen A.L., Brants H.A.M., Voorrips L.E., Anderssonn H.A., et al. Plant sterol intakes and colorectal cancer risk in the netherlands cohort study on diet and cancer. Am J Clin Nutr 74 (2001) 141-148
98. Ebine N., Demonty I., Jiax X., and Jones P.H.B. Plant sterol ascorbate esters reduce body weight gain through decreased energy absorption in hamsters. Int. J. Obes. 30 (2006) 751-757
99. Neil H.A.W., Meiter G.W., and Rue L.S. Randomized controlled trial of use by hypercholesterolemic patients of a vegetable oil sterol-enriched fat spread. Atherosclerosis 156 (2001) 329-337
100. Sudhop T., Lutjohann D., Kodal A., Igel M., et al. Inhibition of intestinal cholesterol absorption by Ézétimibe in humans. Circulation 106 (2002) 1943-1948
101. De Jong N., Pijpers L., Bleeker J.K., and Ocke M.C. Potential intake of phytosterols/-stanols: results of a stimulation study. Eur. J. Clin. Nutr. 58 (2004) 907-919
102. Devaraj S., and Jialal I. The role of dietary supplementation with plant sterols and stanols in the prevention of cardiovascular disease. Nutr. Rev. 64 (2006) 348-354
103. Grundy S.M. Stanols esters as a component of maximal dietary therapy in the National Cholesterol Education Program Adult Treatment Panel III report. Am. J. Cardiol. 96 (2005) 47D-50D