Phytosterols in nonfat and low-fat beverages have no impact on the LDL size phenotype

European Journal of Clinical Nutrition

Volumn 59, Issue 6, 2005, Pages 801-804

  Charest, A ^a   Vanstone, C ^b   St Onge, M P ^b   Parson, W ^b   Jones, P J H ^a,b   Lamarche, Benoit ^a  

^a LAVAL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Beverage; Coronary heart disease; Dense LDL; Phytosterols; Small

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHYTOSTEROL; PLACEBO; POLYACRYLAMIDE; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; BEVERAGE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIETARY INTAKE; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG RESPONSE; ELECTROPHORESIS; FEMALE; FOOD COMPOSITION; HUMAN; HYPERCHOLESTEROLEMIA; ISCHEMIC HEART DISEASE; LOW FAT DIET; MALE; NUTRITIONAL REQUIREMENT; OUTCOMES RESEARCH; PHENOTYPE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN ANALYSIS; RANDOMIZED CONTROLLED TRIAL; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; AGED; BEVERAGES; CHOLESTEROL, HDL; CHOLESTEROL, LDL; CROSS-OVER STUDIES; DIETARY FATS; DOUBLE-BLIND METHOD; FEMALE; HEALTH FOOD; HUMANS; HYPERCHOLESTEROLEMIA; MALE; MIDDLE AGED; PARTICLE SIZE; PHENOTYPE; PHYTOSTEROLS; TRIGLYCERIDES;

EID: 21244451972     PISSN: 09543007     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ejcn.1602142     Document Type: Article

References (20)

1. Armstrong MJ & Carey MC (1987): Thermodynamic and molecular determinants of sterol solubilities in bile salt micelles. J. Lipid Res. 28, 1144-1155.
2. Austin MA (2000): Triglyceride, small, dense low-density lipoprotein, and the atherogenic lipoprotein phenotype. Curr. Atheroscler. Rep. 2, 200-207.
3. Charest A, Desroches S, Vanstone CA, Jones PJH & Lamarche B (2004): Unesterified plant sterols and stanols do not effect LDL electrophoretic characteristics in hypercholesterolemic subjects. J. Nutr. 134, 592-595.
4. Desroches S, Mauger JF, Ausman LM, Lichtenstein AH & Lamarche B (2004): Soy protein favorably affects LDL size independently of isoflavones in hypercholesterolemic men and women. J. Nutr. 134, 574-579.
5. Dreon DM, Fernstrom HA, Miller B & Krauss RM (1994): Low-density lipoprotein subclass patterns and lipoprotein response to a reduced-fat diet in men. FASEB J. 8, 121-126.
6. Hallikainen MA, Sarkkinen ES & Uusitupa MI (2000): Plant stanol esters affect serum cholesterol concentrations of hypercholesterolemic men and women in a dose-dependent manner. J. Nutr. 130, 767-776.
7. Jones PJ, Ntanios FY, Raeini-Sarjaz M & Vanstone CA (1999): Cholesterol-lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men. Am. J. Clin. Nutr. 69, 1144-1150.
8. Jones PJ, Raeini-Sarjaz M, Ntanios FY, Vanstone CA, Feng JY & Parsons WE (2000): Modulation of plasma lipid levels and cholesterol kinetics by phytosterol versus phytostanol esters. J. Lipid Res. 41, 697-705.
9. Jones PJ, Vanstone CA, Raieni-Sarjaz M & St Onge MP (2003): Phytosterols in low-and non-fat beverages as part of a controlled diet fail to lower plasma lipid levels. J. Lipid Res. 44, 1713-1719.
10. Krauss RM & Dreon DM (1995): Low-density-lipoprotein subclasses and response to a low-fat diet in healthy men. Am. J. Clin. Nutr. 62, 478S-487S.
11. Lamarche B, Lemieux I & Despres JP (1999): The small, dense LDL phenotype and the risk of coronary heart disease: epidemiology, patho-physiology and therapeutic aspects. Diabetes Metab. 25, 199-211.
12. Matvienko OA, Lewis DS, Swanson M, Arndt B, Rainwater DL, Stewart J & Alekel DL (2002): A single daily dose of soybean phytosterols in ground beef decreases serum total cholesterol and LDL cholesterol in young, mildly hypercholesterolemic men. Am. J. Clin. Nutr. 76, 57-64.
13. Mensink RP, Ebbing S, Lindhout M, Plat J & van Heugten MM (2002): Effects of plant stanol esters supplied in low-fat yoghurt on serum lipids and lipoproteins, non-cholesterol sterols and fat soluble antioxidant concentrations. Atherosclerosis 160, 205-213.
14. Mifflin MD, St Jeor ST, Hill LA, Scott BJ, Daugherty SA & Koh YO (1990): A new predictive equation for resting energy expenditure in healthy individuals. Am. J. Clin. Nutr. 51, 241-247.
15. Nestel P, Cehum M, Pomeroy S, Abbey M & Weldon G (2001): Cholesterol-lowering effects of plant sterol esters and non-esterified stanols in margarine, butter and low-fat foods. Eur. J. Clin. Nutr. 55, 1084-1090.
16. Pedersen A, Baumstark MW, Marckmann P, Gylling H & Sandstrom B (2000): An olive oil-rich diet results in higher concentrations of LDL cholesterol and a higher number of LDL subfraction particles than rapeseed oil and sunflower oil diets. J. Lipid Res. 41, 1901-1911.
17. St-Pierre AC, Ruel IL, Cantin B, Dagenais GR, Bernard PM, Despres JP & Lamarche B (2001): Comparison of various electrophoretic characteristics of LDL particles and their relationship to the risk of ischemic heart disease. Circulation 104, 2295-2299.
18. Tikkanen MJ, Hogstrom P, Tuomilehto J, Keinanen-Kiukaanniemi S, Sundvall J & Karppanen H (2001): Effect of a diet based on low-fat foods enriched with nonesterified plant sterols and mineral nutrients on serum cholesterol. Am. J. Cardiol. 88, 1157-1162.
19. Vanstone CA, Raeini-Sarjaz M, Parsons WE & Jones PJ (2002): Unesterified plant sterols and stanols lower LDL-cholesterol concentrations equivalently in hypercholesterolemic persons. Am. J. Clin. Nutr. 76, 1272-1278.
20. Volpe R, Niittynen L, Korpela R, Sirtori C, Bucci A, Fraone N & Pazzucconi F (2001): Effects of yoghurt enriched with plant sterols on serum lipids in patients with moderate hypercholesterolaemia. Br. J. Nutr. 86, 233-239.