Serum plant sterols as a potential risk factor for coronary heart disease

Metabolism: Clinical and Experimental

Volumn 51, Issue 12, 2002, Pages 1519-1521

  Sudhop, Thomas ^a   Gottwald, Britta M ^a   Von Bergmann, Klaus ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CAMPESTEROL; CHOLESTANOL; CHOLESTEROL; DESMOSTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LATHOSTEROL; LIPID; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHYTOSTEROL; SITOSTEROL; TRIACYLGLYCEROL;

ARTICLE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY BYPASS GRAFT; FAMILY HISTORY; FEMALE; GENETIC DISORDER; HUMAN; HYPOTHESIS; INBORN ERROR OF METABOLISM; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SITOSTEROLEMIA; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

EID: 0036916821     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1053/meta.2002.36298     Document Type: Article

References (17)

1. Salen G, Ahrens EH Jr, Grundy SM: Metabolism of beta-sitosterol in man. J Clin Invest 49:952-967, 1970
2. Heinemann T, Axtmann G, Von Bergmann K: Comparison of intestinal absorption of cholesterol with different plant sterols in man. Eur J Clin Invest 23:827-831, 1993
3. Lütjohann D, Björkhem I, Beil UF, et al: Sterol absorption and sterol balance in phytosterolemia evaluated by deuterium-labeled sterols: Effect of sitostanol treatment. J Lipid Res 36:1763-1773, 1995
4. Bhattacharyya A, Connor W: Beta-sitosterolemia and xanthromatosis. J Clin Invest 53:1033-1043, 1974
5. Salen G, Shefer S, Nguyen L, et al: Sitosterolemia. J Lipid Res 33:945-955, 1992
6. Björkhem K, Boberg KM, Leitersdorf E: Inborn errors in bile acid biosynthesis and storage of sterols other than cholesterol, in Scriver CR, Beaudet AL, Valle DS, et al (eds): The Metabolic and Molecular Bases of Inherited Disease. New York, NY, McGraw-Hill, 2001, pp 2961-2988
7. Salen G, Shore V, Tint GS, et al: Increased sitosterol absorption, decreased removal, and expanded body pools compensate for reduced cholesterol synthesis in sitosterolemia with xanthomatosis. J Lipid Res 30:1319-1330, 1989
8. Berge KE, Tian H, Graf GA, et al: Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science 290:1771-1775, 2000
9. Lee MH, Lu K, Hazard S, et al: Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption. Nat Genet 27:79-83, 2001
10. Salen G, Horak I, Rothkopf M, et al: Lethal atherosclerosis associated with abnormal plasma and tissue sterol composition in sitosterolemia with xanthomatosis. J Lipid Res 26:1126-1133, 1985
11. Kolovou G, Voudris V, Drogari E, et al: Coronary bypass grafts in a young girl with sitosterolemia. Eur Heart J 17:965-966, 1996 (letter)
12. Watts GF, Mitchell WD: Clinical and metabolic findings in a patient with phytosterolaemia. Ann Clin Biochem 29:231-236, 1992
13. Glueck CJ, Speirs J, Tracy T, et al: Relationships of serum plant sterols (phytosterols) and cholesterol in 595 hypercholesterolemic subjects, and familial aggregation of phytosterols, cholesterol, and premature coronary heart disease in hyperphytosterolemic probands and their first-degree relatives. Metabolism 40:842-848, 1991
14. Miettinen TA, Tilvis RS, Kesaniemi YA: Serum cholestanol and plant sterol levels in relation to cholesterol metabolism in middle-aged men. Metabolism 38:136-140, 1989
15. Kempen HJ, De Knijff P, Boomsma DI, et al: Plasma levels of lathosterol and phytosterols in relation to age, sex, anthropometric parameters, plasma lipids, and apolipoprotein E phenotype, in 160 Dutch families. Metabolism 40:604-611, 1991
16. Nguyen TT, Dale LC, Von Bergmann K, et al: Cholesterol-lowering effect of stanol ester in a US population of mildly hypercholesterolemic men and women: A randomized controlled trial. Mayo Clin Proc 74:1198-1206, 1999
17. Berge KE, Von Bergmann K, Lütjohann D, et al: Heritability of plasma noncholesterol sterols and relationship to DNA sequence polymorphism in ABCG5 and ABCG8. J Lipid Res 43:486-494, 2002