Apoptosis in T Cell Acute Lymphoblastic Leukemia Cells after Cell Cycle Arrest Induced by Pharmacological Inhibition of Notch Signaling

Chemistry and Biology

Volumn 14, Issue 2, 2007, Pages 209-219

  Lewis, Huw D ^a   Leveridge, Matthew ^a   Strack, Peter R ^b   Haldon, Christine D ^a   O'Neil, Jennifer ^c   Kim, Hellen ^b   Madin, Andrew ^a   Hannam, Joanne C ^a   Look, A Thomas ^c   Kohl, Nancy ^b   Draetta, Giulio ^b   Harrison, Timothy ^a   Kerby, Julie A ^a   Shearman, Mark S ^a   Beher, Dirk ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; NOTCH RECEPTOR; SECRETASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL SURVIVAL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; FLOW CYTOMETRY; HUMAN; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; T CELL LEUKEMIA; TUMOR CELL LINE;

AMYLOID PRECURSOR PROTEIN SECRETASES; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; ENZYME INHIBITORS; FLOW CYTOMETRY; HUMANS; LEUKEMIA, T-CELL, ACUTE; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

EID: 33847083871     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2006.12.010     Document Type: Article

References (57)

1. Artavanis-Tsakonas S., Rand M.D., and Lake R.J. Notch signaling: cell fate control and signal integration in development. Science 284 (1999) 770-776
2. Baker N.E. Notch signaling in the nervous system. Pieces still missing from the puzzle. Bioessays 22 (2000) 264-273
3. Yoon K., and Gaiano N. Notch signaling in the mammalian central nervous system: insights from mouse mutants. Nat. Neurosci. 8 (2005) 709-715
4. Mumm J.S., Schroeter E.H., Saxena M.T., Griesemer A., Tian X., Pan D.J., Ray W.J., and Kopan R. A ligand-induced extracellular cleavage regulates γ-secretase-like proteolytic activation of Notch1. Mol. Cell 5 (2000) 197-206
5. Iso T., Kedes L., and Hamamori Y. HES and HERP families: multiple effectors of the Notch signaling pathway. J. Cell. Physiol. 194 (2003) 237-255
6. Jarriault S., Brou C., Logeat F., Schroeter E.H., Kopan R., and Israel A. Signalling downstream of activated mammalian Notch. Nature 377 (1995) 355-358
7. Allenspach E.J., Maillard I., Aster J.C., and Pear W.S. Notch signaling in cancer. Cancer Biol. Ther. 1 (2002) 466-476
8. Nickoloff B.J., Osborne B.A., and Miele L. Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents. Oncogene 22 (2003) 6598-6608
9. Radtke F., and Raj K. The role of Notch in tumorigenesis: oncogene or tumour suppressor?. Nat. Rev. Cancer 3 (2003) 756-767
10. Reynolds T.C., Smith S.D., and Sklar J. Analysis of DNA surrounding the breakpoints of chromosomal translocations involving the β T cell receptor gene in human lymphoblastic neoplasms. Cell 50 (1987) 107-117
11. Ellisen L.W., Bird J., West D.C., Soreng A.L., Reynolds T.C., Smith S.D., and Sklar J. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66 (1991) 649-661
12. Pear W.S., Aster J.C., Scott M.L., Hasserjian R.P., Soffer B., Sklar J., and Baltimore D. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J. Exp. Med. 183 (1996) 2283-2291
13. Dievart A., Beaulieu N., and Jolicoeur P. Involvement of Notch1 in the development of mouse mammary tumors. Oncogene 18 (1999) 5973-5981
14. Brennan K., and Brown A.M. Is there a role for Notch signalling in human breast cancer?. Breast Cancer Res. 5 (2003) 69-75
15. Tonon G., Modi S., Wu L., Kubo A., Coxon A.B., Komiya T., O'Neil K., Stover K., El Naggar A., Griffin J.D., et al. t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. Nat. Genet. 33 (2003) 208-213
16. Klinakis A., Szabolcs M., Politi K., Kiaris H., Artavanis-Tsakonas S., and Efstratiadis A. Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice. Proc. Natl. Acad. Sci. USA 103 (2006) 9262-9267
17. Hubmann R., Schwarzmeier J.D., Shehata M., Hilgarth M., Duechler M., Dettke M., and Berger R. Notch2 is involved in the overexpression of CD23 in B-cell chronic lymphocytic leukemia. Blood 99 (2002) 3742-3747
18. Jundt F., Anagnostopoulos I., Forster R., Mathas S., Stein H., and Dorken B. Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma. Blood 99 (2002) 3398-3403
19. Pece S., Serresi M., Santolini E., Capra M., Hulleman E., Galimberti V., Zurrida S., Maisonneuve P., Viale G., and Di Fiore P.P. Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis. J. Cell Biol. 167 (2004) 215-221
20. Hallahan A.R., Pritchard J.I., Hansen S., Benson M., Stoeck J., Hatton B.A., Russell T.L., Ellenbogen R.G., Bernstein I.D., Beachy P.A., and Olson J.M. The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas. Cancer Res. 64 (2004) 7794-7800
21. De Strooper B., Annaert W., Cupers P., Saftig P., Craessaerts K., Mumm J.S., Schroeter E.H., Schrijvers V., Wolfe M.S., Ray W.J., et al. A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain. Nature 398 (1999) 518-522
22. Levitan D., and Greenwald I. Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377 (1995) 351-354
23. Ye Y., Lukinova N., and Fortini M.E. Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants. Nature 398 (1999) 525-529
24. Miele L., Miao H., and Nickoloff B.J. NOTCH signaling as a novel cancer therapeutic target. Curr. Cancer Drug Targets 6 (2006) 313-323
25. Screpanti I., Bellavia D., Campese A.F., Frati L., and Gulino A. Notch, a unifying target in T-cell acute lymphoblastic leukemia?. Trends Mol. Med. 9 (2003) 30-35
26. Das I., Craig C., Funahashi Y., Jung K.M., Kim T.W., Byers R., Weng A.P., Kutok J.L., Aster J.C., and Kitajewski J. Notch oncoproteins depend on γ-secretase/presenilin activity for processing and function. J. Biol. Chem. 279 (2004) 30771-30780
27. Weng A.P., Ferrando A.A., Lee W., Morris J.P., Silverman L.B., Sanchez-Irizarry C., Blacklow S.C., Look A.T., and Aster J.C. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 306 (2004) 269-271
28. Sparey T., Beher D., Best J., Biba M., Castro J.L., Clarke E., Hannam J., Harrison T., Lewis H., Madin A., et al. Cyclic sulfamide γ-secretase inhibitors. Bioorg. Med. Chem. Lett. 15 (2005) 4212-4216
29. Dovey H.F., John V., Anderson J.P., Chen L.Z., de Saint Andrieu P., Fang L.Y., Freedman S.B., Folmer B., Goldbach E., Holsztynska E.J., et al. Functional γ-secretase inhibitors reduce β-amyloid peptide levels in brain. J. Neurochem. 76 (2001) 173-181
30. Seiffert D., Bradley J.D., Rominger C.M., Rominger D.H., Yang F., Meredith Jr. J.E., Wang Q., Roach A.H., Thompson L.A., Spitz S.M., et al. Presenilin-1 and -2 are molecular targets for γ-secretase inhibitors. J. Biol. Chem. 275 (2000) 34086-34091
31. Lewis H.D., Perez Revuelta B.I., Nadin A., Neduvelil J.G., Harrison T., Pollack S.J., and Shearman M.S. Catalytic site-directed γ-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and β-APP cleavages. Biochemistry 42 (2003) 7580-7586
32. Kopan R., Schroeter E.H., Weintraub H., and Nye J.S. Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain. Proc. Natl. Acad. Sci. USA 93 (1996) 1683-1688
33. Kopan R., and Ilagan M.X. γ-secretase: proteasome of the membrane?. Nat. Rev. Mol. Cell Biol. 5 (2004) 499-504
34. Pollack S.J., and Lewis H. Secretase inhibitors for Alzheimer's disease: challenges of a promiscuous protease. Curr. Opin. Investig. Drugs 6 (2005) 35-47
35. Weng A.P., Nam Y., Wolfe M.S., Pear W.S., Griffin J.D., Blacklow S.C., and Aster J.C. Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Mol. Cell. Biol. 23 (2003) 655-664
36. Balint K., Xiao M., Pinnix C.C., Soma A., Veres I., Juhasz I., Brown E.J., Capobianco A.J., Herlyn M., and Liu Z.J. Activation of Notch1 signaling is required for β-catenin-mediated human primary melanoma progression. J. Clin. Invest. 115 (2005) 3166-3176
37. Haruki N., Kawaguchi K.S., Eichenberger S., Massion P.P., Olson S., Gonzalez A., Carbone D.P., and Dang T.P. Dominant-negative Notch3 receptor inhibits mitogen-activated protein kinase pathway and the growth of human lung cancers. Cancer Res. 65 (2005) 3555-3561
38. Nair P., Somasundaram K., and Krishna S. Activated Notch1 inhibits p53-induced apoptosis and sustains transformation by human papillomavirus type 16 E6 and E7 oncogenes through a PI3K-PKB/Akt-dependent pathway. J. Virol. 77 (2003) 7106-7112
39. Curry C.L., Reed L.L., Golde T.E., Miele L., Nickoloff B.J., and Foreman K.E. γ secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells. Oncogene 24 (2005) 6333-6344
40. Nefedova Y., Cheng P., Alsina M., Dalton W.S., and Gabrilovich D.I. Involvement of Notch-1 signaling in bone marrow stroma-mediated de novo drug resistance of myeloma and other malignant lymphoid cell lines. Blood 103 (2004) 3503-3510
41. Kiaris H., Politi K., Grimm L.M., Szabolcs M., Fisher P., Efstratiadis A., and Artavanis-Tsakonas S. Modulation of notch signaling elicits signature tumors and inhibits hras1-induced oncogenesis in the mouse mammary epithelium. Am. J. Pathol. 165 (2004) 695-705
42. Yang X., Klein R., Tian X., Cheng H.T., Kopan R., and Shen J. Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev. Biol. 269 (2004) 81-94
43. Duechler M., Shehata M., Schwarzmeier J.D., Hoelbl A., Hilgarth M., and Hubmann R. Induction of apoptosis by proteasome inhibitors in B-CLL cells is associated with downregulation of CD23 and inactivation of Notch2. Leukemia 19 (2005) 260-267
44. Girard L., Hanna Z., Beaulieu N., Hoemann C.D., Simard C., Kozak C.A., and Jolicoeur P. Frequent provirus insertional mutagenesis of Notch1 in thymomas of MMTVD/myc transgenic mice suggests a collaboration of c-myc and Notch1 for oncogenesis. Genes Dev. 10 (1996) 1930-1944
45. Feldman B.J., Hampton T., and Cleary M.L. A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice. Blood 96 (2000) 1906-1913
46. Beverly L.J., and Capobianco A.J. Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesis. Cancer Cell 3 (2003) 551-564
47. Capobianco A.J., Zagouras P., Blaumueller C.M., Artavanis-Tsakonas S., and Bishop J.M. Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2. Mol. Cell. Biol. 17 (1997) 6265-6273
48. Weijzen S., Zlobin A., Braid M., Miele L., and Kast W.M. HPV16 E6 and E7 oncoproteins regulate Notch-1 expression and cooperate to induce transformation. J. Cell. Physiol. 194 (2003) 356-362
49. Rangarajan A., Syal R., Selvarajah S., Chakrabarti O., Sarin A., and Krishna S. Activated Notch1 signaling cooperates with papillomavirus oncogenes in transformation and generates resistance to apoptosis on matrix withdrawal through PKB/Akt. Virology 286 (2001) 23-30
50. Weijzen S., Rizzo P., Braid M., Vaishnav R., Jonkheer S.M., Zlobin A., Osborne B.A., Gottipati S., Aster J.C., Hahn W.C., et al. Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nat. Med. 8 (2002) 979-986
51. Bocchetta M., Miele L., Pass H.I., and Carbone M. Notch-1 induction, a novel activity of SV40 required for growth of SV40-transformed human mesothelial cells. Oncogene 22 (2003) 81-89
52. Qin J.Z., Stennett L., Bacon P., Bodner B., Hendrix M.J., Seftor R.E., Seftor E.A., Margaryan N.V., Pollock P.M., Curtis A., et al. p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas. Mol. Cancer Ther. 3 (2004) 895-902
53. Sancho E., Batlle E., and Clevers H. Signaling pathways in intestinal development and cancer. Annu. Rev. Cell Dev. Biol. 20 (2004) 695-723
54. Collins B.J., Kleeberger W., and Ball D.W. Notch in lung development and lung cancer. Semin. Cancer Biol. 14 (2004) 357-364
55. Miyamoto Y., Maitra A., Ghosh B., Zechner U., Argani P., Iacobuzio-Donahue C.A., Sriuranpong V., Iso T., Meszoely I.M., Wolfe M.S., et al. Notch mediates TGF α-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell 3 (2003) 565-576
56. Santagata S., Demichelis F., Riva A., Varambally S., Hofer M.D., Kutok J.L., Kim R., Tang J., Montie J.E., Chinnaiyan A.M., et al. JAGGED1 expression is associated with prostate cancer metastasis and recurrence. Cancer Res. 64 (2004) 6854-6857
57. Purow B.W., Haque R.M., Noel M.W., Su Q., Burdick M.J., Lee J., Sundaresan T., Pastorino S., Park J.K., Mikolaenko I., et al. Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation. Cancer Res. 65 (2005) 2353-2363