Selective targeting of synthetic antioxidants to mitochondria: Towards a mitochondrial medicine for neurodegenerative diseases?

European Journal of Pharmacology

Volumn 447, Issue 2-3, 2002, Pages 155-161

  Dessolin, Jean ^a   Schuler, Marie ^a   Quinart, Alice ^a   De Giorgi, Francesca ^a   Ghosez, Leon ^a   Ichas, François ^a  

^a INSTITUT EUROPÉEN DE CHIMIE ET BIOLOGIE   (France)

Author keywords

Antioxidant; Apoptosis; Drug targeting; Mitochondrion

Indexed keywords

[4 (2,2,6,6 TETRAMETHYLPIPERIDIN 4 YLOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE N OXIDE; ANTIOXIDANT; JD 29; MANGANESE N,N' ETHYLENEBIS(3 METHOXYSALICYLIDENEAMINE); TEMPOL; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG EFFECT; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; HUMAN CELL; LIPOPHILICITY; MEDICINE; MITOCHONDRION; MOLECULE; NERVE CELL NECROSIS; PARKINSON DISEASE; PRIORITY JOURNAL;

ANTIOXIDANTS; APOPTOSIS; HELA CELLS; HUMANS; MITOCHONDRIA; NEURODEGENERATIVE DISEASES;

EID: 0037025274     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)01839-3     Document Type: Article

References (13)

1. Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: A key role for reactive oxygen species in ischemic brain injury
2. The free radical theory of aging matures
3. Mitochondrially targeted antioxidants and thiol reagents
4. The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant
5. Highly enantioselective epoxidation catalysts derived from 1,2-diaminocyclohexane
6. Selective targeting of a redox-active ubiquinone to mitochondria within cells: Antioxidant and antiapoptotic properties
7. Studies of structure-activity relationship of nitroxide free radicals and their precursors as modifiers against oxidative damage
8. Mechanisms of coupling of oxidative phosphorylation and the membrane potential of mitochondria
9. Coenzyme Q 10 administration increases brain mitochondrial concentrations and exerts neuroprotective effects
10. Selective targeting bioactive compounds to mitochondria
11. Superoxide radical-initiated apoptotic signalling pathway in selenite-treated HepG2 cells: Mitochondria serve as the main target
12. Oxidative damage and mitochondrial decay in aging
13. Selective targeting of an antioxidant to mitochondria