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Li J., Moran T., Swanson E., Julian C., Harris J., Bonen D.K., Hedl M., Nicolae D.L., Abraham C., and Cho J.H. Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations. Hum Mol Genet 13 (2004) 1715-1725
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42
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IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism
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Netea M.G., Azam T., Ferwerda G., Girardin S.E., Walsh M., Park J.S., Abraham E., Kim J.M., Yoon D.Y., Dinarello C.A., and Kim S.H. IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism. Proc Natl Acad Sci USA 102 (2005) 16309-16314
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Netea, M.G.1
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Abraham, E.7
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Dinarello, C.A.10
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43
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NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses
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Watanabe T., Kitani A., Murray P.J., and Strober W. NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat Immunol 5 (2004) 800-808
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Watanabe, T.1
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44
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Nucleotide-binding oligomerization domain-2 modulates specific TLR pathways for the induction of cytokine release
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Netea M.G., Ferwerda G., de Jong D.J., Jansen T., Jacobs L., Kramer M., Naber T.H., Drenth J.P., Girardin S.E., Kullberg B.J., et al. Nucleotide-binding oligomerization domain-2 modulates specific TLR pathways for the induction of cytokine release. J Immunol 174 (2005) 6518-6523
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Netea, M.G.1
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45
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NOD2 and Toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis
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This study provides evidence that both TLR and NLR signalling is needed for bacterial recognition.
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Ferwerda G., Girardin S.E., Kullberg B.J., Le Bourhis L., de Jong D.J., Langenberg D.M., van Crevel R., Adema G.J., Ottenhoff T.H., Van der Meer J.W., et al. NOD2 and Toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis. PLoS Pathog 1 (2005) 279-285. This study provides evidence that both TLR and NLR signalling is needed for bacterial recognition.
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Ferwerda, G.1
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46
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TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells
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Rosenstiel P., Fantini M., Brautigam K., Kuhbacher T., Waetzig G.H., Seegert D., and Schreiber S. TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells. Gastroenterology 124 (2003) 1001-1009
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Up-regulation of NOD1 and NOD2 through TLR4 and TNF-alpha in LPS-treated murine macrophages
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Takahashi Y., Isuzugawa K., Murase Y., Imai M., Yamamoto S., Iizuka M., Akira S., Bahr G.M., Momotani E., Hori M., et al. Up-regulation of NOD1 and NOD2 through TLR4 and TNF-alpha in LPS-treated murine macrophages. J Vet Med Sci 68 (2006) 471-478
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48
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A role for Erbin in the regulation of NOD2-dependent NF-kappa B signaling
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McDonald C., Chen F.F., Ollendorff V., Ogura Y., Marchetto S., Lecine P., Borg J.P., and Nunez G. A role for Erbin in the regulation of NOD2-dependent NF-kappa B signaling. J Biol Chem 280 (2005) 40301-40309
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McDonald, C.1
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49
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Analysis of NOD2-mediated proteome response to muramyl dipeptide in HEK293 cells
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Weichart D., Gobom J., Klopfleisch S., Hasler R., Gustavsson N., Billmann S., Lehrach H., Seegert D., Schreiber S., and Rosenstiel P. Analysis of NOD2-mediated proteome response to muramyl dipeptide in HEK293 cells. J Biol Chem 281 (2006) 2380-2389
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Enhancement of endotoxin activity by muramyldipeptide
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Takada H., Yokoyama S., and Yang S. Enhancement of endotoxin activity by muramyldipeptide. J Endotoxin Res 8 (2002) 337-342
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Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo
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Masumoto J., Yang K., Varambally S., Hasegawa M., Tomlins S.A., Qiu S., Fujimoto Y., Kawasaki A., Foster S.J., Horie Y., et al. Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo. J Exp Med 203 (2006) 203-213
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J Exp Med
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Kawasaki, A.8
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Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses
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Damiano J.S., Oliveira V., Welsh K., and Reed J.C. Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses. Biochem J 381 (2004) 213-219
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A short isoform of NOD2/CARD15, NOD2-S, is an endogenous inhibitor of NOD2/receptor-interacting protein kinase 2-induced signaling pathways
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•]
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Rosenstiel, P.1
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54
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NOD1 variation, immunoglobulin E and asthma
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These are the first papers to describe functional implications of Nod splice-variants.
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Hysi P., Kabesch M., Moffatt M.F., Schedel M., Carr D., Zhang Y., Boardman B., von Mutius E., Weiland S.K., Leupold W., et al. NOD1 variation, immunoglobulin E and asthma. Hum Mol Genet 14 (2005) 935-941. These are the first papers to describe functional implications of Nod splice-variants.
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Hum Mol Genet
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Hysi, P.1
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55
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Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms
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Saleh M., Vaillancourt J.P., Graham R.K., Huyck M., Srinivasula S.M., Alnemri E.S., Steinberg M.H., Nolan V., Baldwin C.T., Hotchkiss R.S., et al. Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature 429 (2004) 75-79
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Nature
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Hotchkiss, R.S.10
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56
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20444486755
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GRIM-19 interacts with NOD2 and serves as down-stream effector of anti-bacterial function in intestinal epithelial cells
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Barnich N., Hisamatsu T., Aguirre J.E., Xavier R., Reinecker H.C., and Podolsky D.K. GRIM-19 interacts with NOD2 and serves as down-stream effector of anti-bacterial function in intestinal epithelial cells. J Biol Chem 280 (2005) 40301-40309
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Barnich, N.1
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Xavier, R.4
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Podolsky, D.K.6
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58
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Reciprocal cross-talk between Nod2 and TAK1 signaling pathways
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Chen C.M., Gong Y., Zhang M., and Chen J.J. Reciprocal cross-talk between Nod2 and TAK1 signaling pathways. J Biol Chem 279 (2004) 25876-25882
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Chen, C.M.1
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Chen, J.J.4
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59
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TRIP6 is a RIP2-associated common signaling component of multiple NF-kappaB activation pathways
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Li L., Bin L.H., Li F., Liu Y., Chen D., Zhai Z., and Shu H.B. TRIP6 is a RIP2-associated common signaling component of multiple NF-kappaB activation pathways. J Cell Sci 118 (2005) 555-563
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J Cell Sci
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Li, L.1
Bin, L.H.2
Li, F.3
Liu, Y.4
Chen, D.5
Zhai, Z.6
Shu, H.B.7
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60
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33645757512
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ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions
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Sarkar A., Duncan M., Hart J., Hertlein E., Guttridge D.C., and Wewers M.D. ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions. J Immunol 176 (2006) 4979-4986
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Sarkar, A.1
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Wewers, M.D.6
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61
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33645532087
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NF-kappa B-inducing kinase regulates selected gene expression in the Nod2 signaling pathway
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This study shows that Nod2 is able to activate the alternative NF-κB pathway.
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Pan Q., Kravchenko V., Katz A., Huang S., Ii M., Mathison J.C., Kobayashi K., Flavell R.A., Schreiber R.D., Goeddel D., et al. NF-kappa B-inducing kinase regulates selected gene expression in the Nod2 signaling pathway. Infect Immun 74 (2006) 2121-2127. This study shows that Nod2 is able to activate the alternative NF-κB pathway.
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Infect Immun
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Pan, Q.1
Kravchenko, V.2
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Kobayashi, K.7
Flavell, R.A.8
Schreiber, R.D.9
Goeddel, D.10
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62
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Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition
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Barnich N., Aguirre J.E., Reinecker H.C., Xavier R., and Podolsky D.K. Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition. J Cell Biol 170 (2005) 21-26
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J Cell Biol
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Barnich, N.1
Aguirre, J.E.2
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Xavier, R.4
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63
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Oda K, Kitano H: A comprehensive map of the Toll-like receptor signaling network. Mol Syst Biol 2006, 2:2006.0015. Epub 2006 Apr 18.
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64
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Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival
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This paper provides evidence for a non-redundant function of both Nalp3 and Ipaf in sensing potassium efflux mediated by pore-forming toxins in host cells.
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Gurcel L., Abrami L., Girardin S., Tschopp J., and van der Goot F.G. Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival. Cell 126 (2006) 1135-1145. This paper provides evidence for a non-redundant function of both Nalp3 and Ipaf in sensing potassium efflux mediated by pore-forming toxins in host cells.
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(2006)
Cell
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Gurcel, L.1
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Girardin, S.3
Tschopp, J.4
van der Goot, F.G.5
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