Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin

EMBO Reports

Volumn 6, Issue 12, 2005, Pages 1201-1207

  Magalhaes, Joao Gamelas ^a   Philpott, Dana J ^a   Nahori, Marie Anne ^a   Jéhanno, Muguette ^a   Fritz, Joerg ^a   Le Bourhis, Lionel ^a   Viala, Jérôme ^a   Hugot, Jean Pierre ^b   Giovannini, Marco ^c   Bertin, John ^d   Lepoivre, Michel ^e   Mengin Lecreulx, Dominique ^f   Sansonetti, Philippe J ^a   Girardin, Stephen E ^a  

^a INSTITUT PASTEUR   (France)

^b HÔPITAL ROBERT DEBRÉ   (France)

^c INSERM   (France)

^d Synta Pharmaceuticals Corp   (United States)

^e UNIVERSITÉ PARIS SACLAY   (France)

^f INSTITUTE FOR INTEGRATIVE BIOLOGY OF THE CELL I2BC   (France)

Author keywords

Innate immunity; Nod proteins; Peptidoglycan

Indexed keywords

CYTOKINE; CYTOTOXIN; NITRIC OXIDE; PEPTIDOGLYCAN; PROTEIN NOD1; TETRAPEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL MATURATION; CONTROLLED STUDY; CYTOKINE RELEASE; FLOW CYTOMETRY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VIVO STUDY; INNATE IMMUNITY; MACROPHAGE; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN STRUCTURE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELL LINE; CYTOTOXINS; GENES, REPORTER; HUMANS; IMMUNITY, NATURAL; INJECTIONS, INTRAPERITONEAL; LEUKOCYTES, MONONUCLEAR; LUCIFERASES; MACROPHAGE ACTIVATION; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NOD1 SIGNALING ADAPTOR PROTEIN; PEPTIDOGLYCAN; SPECIES SPECIFICITY; TRACHEA; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; BACTERIA (MICROORGANISMS); BORDETELLA PERTUSSIS; MAMMALIA; MURINAE;

EID: 28544434876     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/sj.embor.7400552     Document Type: Article

References (21)

1. Burroughs M, Rozdzinski E, Geelen S, Tuomanen E (1993) A structure-activity relationship for induction of meningeal inflammation by muramyl peptides. J Clin Invest 92: 297-302
2. Chamaillard M et al (2003) An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat Immunol 4: 702-707
3. Chamaillard M, Inohara N, Nunez G (2004) Battling enteroinvasive bacteria: Nod1 comes to the rescue. Trends Microbiol 12: 529-532
4. Cookson BT, Cho HL, Herwaldt LA, Goldman WE (1989) Biological activities and chemical composition of purified tracheal cytotoxin of Bordetella pertussis. Infect Immun 57: 2223-2229
5. Flak TA, Heiss LN, Engle JT, Goldman WE (2000) Synergistic epithelial responses to endotoxin and a naturally occurring muramyl peptide. Infect Immun 68: 1235-1242
6. Fritz JH, Girardin SE, Fitting C, Werts C, Mengin-Lecreulx D, Caroff M, Cavaillon JM, Philpott DJ, Adib-Conquy M (2005) Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists. Eur J Immunol 35: 2459-2470
7. Girardin SE, Philpott DJ (2004) Mini-review: The role of peptidoglycan recognition in innate immunity. Eur J Immunol 34: 1777-1782
8. Girardin SE et al (2003a) Nod1 detects a unique muropeptide from Gram-negative bacterial peptidoglycan. Science 300: 1584-1587
9. Girardin SE, Boneca IG, Viala J, Chamaillard M, Labigne A, Thomas G, Philpott DJ, Sansonetti PJ (2003b) Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 278: 8869-8872
10. Girardin SE, Travassos LH, Herve M, Blanot D, Boneca IG, Philpott DJ, Sansonetti PJ, Mengin-Lecreulx D (2003c) Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2. J Biol Chem 278: 41702-41708
11. Goldman WE, Klapper DG, Baseman JB (1982) Detection, isolation, and analysis of a released Bordetella pertussis product toxic to cultured tracheal cells. Infect Immun 36: 782-794
12. Inohara N, Ogura Y, Chen FF, Muto A, Nunez G (2001) Human Nod1 confers responsiveness to bacterial lipopolysaccharides. J Biol Chem 276: 2551-2554
13. Inohara N et al (2003) Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J Biol Chem 278: 5509-5512
14. Inohara N, Chamaillard M, McDonald C, Nunez G (2005) NOD-LRR proteins: role in host-microbial interactions and inflammatory disease. Annu Rev Biochem 74: 355-383
15. Kaneko T, Goldman WE, Mellroth P, Steiner H, Fukase K, Kusumoto S, Harley W, Fox A, Golenbock D, Silverman N (2004) Monomeric and polymeric Gram-negative peptidoglycan but not purified LPS stimulate the Drosophila IMD pathway. Immunity 20: 637-649
16. Kim JG, Lee SJ, Kagnoff MF (2004) Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptors. Infect Immun 72: 1487-1495
17. Martin SA, Karnovsky ML, Krueger JM, Pappenheimer JR, Biemann K (1984) Peptidoglycans as promoters of slow-wave sleep. I. Structure of the sleep-promoting factor isolated from human urine. J Biol Chem 259: 12652-12658
18. Melly MA, McGee ZA, Rosenthal RS (1984) Ability of monomeric peptidoglycan fragments from Neisseria gonorrhoeae to damage human fallopian-tube mucosa. J Infect Dis 149: 378-386
19. Rosenthal RS, Nogami W, Cookson BT, Goldman WE, Folkening WJ (1987) Major fragment of soluble peptidoglycan released from growing Bordetella pertussis is tracheal cytotoxin. Infect Immun 55: 2117-2120
20. Stenbak CR et al (2004) Peptidoglycan molecular requirements allowing detection by the Drosophila immune deficiency pathway. J Immunol 173: 7339-7348
21. Travassos LH, Girardin SE, Philpott DJ, Blanot D, Nahori MA, Werts C, Boneca IG (2004) Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition. EMBO Rep 5: 1000-1006