Inhibition of pancreatic stellate cell activation by the hydroxymethylglutaryl coenzyme A reductase inhibitor lovastatin

Biochemical Pharmacology

Volumn 65, Issue 8, 2003, Pages 1295-1303

  Jaster, Robert ^a   Brock, Peter ^a   Sparmann, Gisela ^a   Emmrich, Jörg ^a   Liebe, Stefan ^a  

^a UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Chronic pancreatitis; Fibrosis; Lovastatin; Pancreatic stellate cells; Ras; RhoA

Indexed keywords

ALPHA ACTIN; BROXURIDINE; DNA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PLATELET DERIVED GROWTH FACTOR; RAS PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL ASSAY; CELL CULTURE; CELL PROLIFERATION; CELL STIMULATION; CELL VIABILITY; CHRONIC PANCREATITIS; CONTROLLED STUDY; CYSTIC FIBROSIS; DNA DETERMINATION; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVATION; GROWTH INHIBITION; IMMUNOBLOTTING; MEMBRANE TRANSPORT; NICK END LABELING; NONHUMAN; PANCREAS CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PROCESSING; QUANTITATIVE ANALYSIS; RAT; SIGNAL TRANSDUCTION; SMOOTH MUSCLE; STELLATE CELL;

EID: 0037446216     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(03)00075-3     Document Type: Article

References (49)

1. Longnecker D.S. Pathology and pathogenesis of diseases of the pancreas. Am. J. Pathol. 107:1983;103-121.
2. Etemad B., Whitcomb D.C. Chronic pancreatitis: diagnosis, classification and new genetic developments. Gastroenterology. 120:2001;682-707.
3. Apte M.V., Haber P.S., Applegate T.L., Norton I.D., McCaughan G.W., Korsten M.A., Pirola R.C., Wilson J.S. Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut. 43:1998;128-133.
4. Bachem M.G., Schneider E., Groβ H., Weidenbach H., Schmid R.M., Menke A., Siech M., Beger H., Grünert A., Adler G. Identification, culture, and characterisation of pancreatic stellate cells in rats and humans. Gastroenterology. 115:1998;421-432.
5. Ramadori G. The stellate cell (Ito-cell, fat-storing cell, lipocyte, perisinusoidal cell) of the liver. Virchows Arch. B. Cell Pathol. 61:1991;147-158.
6. Gressner A.M., Bachem M.G. Molecular mechanisms of liver fibrogenesis - a homage to the role of activated fat-storing cells. Digestion. 56:1995;335-346.
7. Gressner A.M. Cytokines and cellular crosstalk involved in the activation of fat-storing cells. J. Hepatol. 22:1995;28-36.
8. Apte M.V., Haber P.S., Darby S.J., Rodgers S.C., McCaughan G.W., Korsten M.A., Pirola R.C., Wilson J.S. Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. Gut. 44:1999;534-541.
9. Apte M.V., Phillips P.A., Fahmy R.G., Darby S.J., Rodgers S.C., McCaughan G.W., Korsten M.A., Pirola R.C., Naidoo D., Wilson J.S. Does alcohol directly stimulate pancreatic fibrogenesis? Gastroenterology. 118:2000;780-794.
10. Haber P.S., Kegh G.W., Apte M.V., Moran C.S., Stewart N.L., Crawford D.H.G., Pirola R.C., McCaughan G.W., Ramm G.A., Wilson J. Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis. Am. J. Pathol. 155:1999;1087-1095.
11. Emmrich J., Weber I., Sparmann G., Liebe S. Activation of pancreatic stellate cells in experimental chronic pancreatitis in rats. Gastroenterology. 118:2000;A166.
12. Wells R.G., Crawford J.M. Pancreatic stellate cells: the new stars of chronic pancreatitis? Gastroenterology. 115:1998;491-493.
13. Luttenberger T., Schmid-Kotsas A., Menke A., Siech M., Beger H., Grünert A., Adler G. Platelet-derived growth factors stimulate proliferation and extracellular matrix synthesis of pancreatic stellate cells: implications in pathogenesis of pancreas fibrosis. Lab Invest. 80:2000;47-55.
14. Kruse M.-L., Hildebrand P.B., Timke C., Fölsch U.R., Schmidt W.E. TGFβ1 autocrine growth control in isolated pancreatic fibroblastoid cells/stellate cells in vitro. Regul. Pept. 90:2000;47-52.
15. Mews P., Phillips P., Fahmy R., Korsten M., Pirola R., Wilson J., Apte M. Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis. Gut. 50:2002;535-541.
16. Jaster R., Sparmann G., Emmrich J., Liebe S. Extracellular signal-regulated kinases are key mediators of mitogenic signals in rat pancreatic stellate cells. Gut. 51:2002;579-584.
17. Marra F., Arrighi M.C., Fazi M., Caligiuri A., Pinzani M., Romanelli R.G., Efsen E., Laffi G., Gentilini P. Extracellular signal-regulated kinase activation differentially regulates platelet-derived growth factor's actions in hepatic stellate cells, and is induced by in vivo liver injury in the rat. Hepatology. 30:1999;951-958.
18. Claesson-Welsh L. Platelet-derived growth factor receptor signals. J. Biol. Chem. 269:1994;32023-32026.
19. Lewis T.S., Shapiro P.S., Ahn S.G. Signal transduction through MAP kinase cascades. Adv. Cancer Res. 74:1998;49-139.
20. Chang L., Karin M. Mammalian MAP kinase signalling cascades. Nature. 410:2001;37-40.
21. Gille H., Kortenjann M., Thomae O., Moomaw C., Slaughter C., Cobb M.H., Shaw P.E. ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO J. 14:1995;951-962.
22. Wasylyk B., Hahn S.J., Giovane A. The Ets family of transcription factors. Eur. J. Biochem. 211:1993;7-18.
23. Griffin J. The biology of signal transduction: basic sciences to novel therapies. Semin. Oncol. 28:2001;3-8.
24. Reuter C.W., Morgan M.A., Bergman L. Targeting the Ras signalling pathway: a rational, mechanism-based treatment for hematological malignancies? Blood. 96:2000;1655-1669.
25. Rebollo A., Martinez-A C. Ras proteins: recent advances and new functions. Blood. 94:1999;2971-2980.
26. Casey P.J., Solski P.A., Der C.J., Buss J.E. p21ras is modified by a farnesyl isoprenoid. Proc. Natl. Acad. Sci. U.S.A. 86:1989;8323-8327.
27. Katayama M., Kawata M., Yoshida Y., Horiuchi H., Yamamoto T., Matsuura Y., Takai Y. The posttranslationally modified C-terminal structure of bovine aortic smooth muscle rhoA p21. J. Biol. Chem. 266:1991;12639-12645.
28. Hall A. Rho GTPases and the actin cytoskeleton. Science. 279:1998;509-514.
29. Goldstein J.L., Brown M.S. Regulation of the mevalonate pathway. Nature. 343:1990;425-430.
30. Johnson M.D., Woodard A., Okediji E.J., Toms S.A., Allen G.S. Lovastatin is a potent inhibitor of meningeoma cell proliferation: evidence for inhibition of a mitogen associated protein kinase. J. Neurooncol. 56:2002;133-142.
31. Vrtovsnik F., Couette S., Prie D., Lallemand D., Friedlander G. Lovastatin-induced inhibition of renal epithelial tubular cell proliferation involves a p21ras activated, AP-1-dependent pathway. Kidney Int. 52:1997;1016-1027.
32. Bouterfa H.L., Sattelmeyer V., Czub S., Vordermark D., Roosen K., Tonn J.C. Inhibition of Ras farnesylation by lovastatin leads to downregulation of proliferation and migration in primary cultured human glioblastoma cells. Anticancer Res. 20:2000;2761-2771.
33. Kusama T., Mukai M., Iwasaki T., Tatsuta M., Matsumoto Y., Akedo H., Inoue M., Nakamura H. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis. Gastroenterology. 122:2002;308-317.
34. Wang I.K., Lin-Shiau S.Y., Lin J.K. Suppression of invasion and MMP-9 expression in NIH 3T3 and v-H-Ras 3T3 fibroblasts by lovastatin through inhibition of ras isoprenylation. Oncology. 59:2000;245-254.
35. Tan A., Levrey H., Dahm C., Polunovsky V.A., Rubins J., Bitterman P.B. Lovastatin induces fibroblast apoptosis in vitro and in vivo. Am. J. Respir. Crit. Care Med. 159:1999;220-227.
36. Lowry O.H., Rosebrough N.J., Farr A.T., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
37. Fenton R.G., Kung H.F., Longo D.L., Smith M.R. Regulation of intracellular actin polymerization by prenylated cellular proteins. J. Cell Biol. 117:1992;347-356.
38. Koch G., Benz C., Schmidt G., Olenik C., Aktories K. Rhole of Rho protein in lovastatin-induced breakdown of actin cytoskeleton. J. Pharmacol. Exp. Ther. 283:1997;901-909.
39. Ghosh P.M., Ghosh-Choudhury N., Moyer M.L., Mott G.E., Thomas C.A., Foster B.A., Greenberg N.M., Kreisberg J.I. Role of Rho activation in the growth and morphology of a murine prostate tumor line. Oncogene. 18:1999;4120-4130.
40. Skaletz-Rorowski A., Muller J.G., Kroke A., Waltenberger J., Pulawski E., Pinkernell K., Breithardt G. Lovastatin blocks fibroblast growth factor-induced mitogen-activated protein kinase signaling in coronary smooth muscle cells via phosphatase inhibition. Eur. J. Cell Biol. 80:2001;207-212.
41. Rosen E.D., Spiegelman B.M. PPARγ: a nuclear regulator of metabolism, differentiation, and cell growth. J. Biol. Chem. 276:2001;37731-37734.
42. Masamune A., Kikuta K., Satoh M., Sakai Y., Satoh A., Shimosegawa T. Ligands of the peroxisome proliferator-activated receptor-γ block activation of pancreatic stellate cells. J. Biol. Chem. 277:2002;141-147.
43. Xia Z., Tan M.M., Wong W.W., Dimitroulakos J., Minden M.D., Penn L.Z. Blocking protein geranylation is essential for lovastatin-induced apoptosis of human acute myeloid cells. Leukemia. 15:2001;1398-1407.
44. Rubins J.B., Greatens T., Kratzke R.A., Tan A.T., Polunovsky V.A., Bitterman P. Lovastatin induces apoptosis in malignant mesothelioma cells. Am. J. Respir. Crit. Care Med. 157:1998;1616-1622.
45. Kelynack K.J., Hewitson T.D., Martic M., McTaggart S., Becker G.J. Lovastatin downregulates renal myofibroblast function in vitro. Nephron. 91:2002;701-707.
46. Jani J.P., Specht S., Stemmler N., Blanock K., Singh S.V., Gupta V., Katoh A. Metastasis of B16F10 mouse melanoma inhibited by lovastatin, an inhibitor of cholesterol biosynthesis. Invasion Metastasis. 13:1993;314-324.
47. Alonso D.F., Farina H.G., Skilton G., Gabri M.R., De Lorenzo M.S., Gomez D.E. Reduction of mouse mammary tumor formation and metastasis by lovastatin, an inhibitor of mevalonate pathway of cholesterol synthesis. Breast Cancer Res. Treat. 50:1998;83-93.
48. Duggan D.E., Vickers S. Physiological disposition of HMG-CoA-reductase inhibitors. Drug Metab. Rev. 22:1990;333-362.
49. Sparmann G., Merkord J., Jaschke A., Nizze H., Jonas L., Lohr M., Liebe S., Emmrich J. Pancreatic fibrosis in experimental pancreatitis induced by dibutyltin dichloride. Gastroenterology. 112:1997;1664-1672.