Chronic Protein Kinase B (PKB/c-akt) activation leads to apoptosis induced by oxidative stress-mediated Foxo3a transcriptional up-regulation

Cancer Research

Volumn 66, Issue 22, 2006, Pages 10760-10769

  Van Gorp, Ankie G M ^a   Pomeranz, Karen M ^b   Birkenkamp, Kim U ^a   Hui, Rosaline C Y ^b   Lam, Eric W F ^b   Coffer, Paul J ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYTAMOXIFEN; ACETYLCYSTEINE; HYDROGEN PEROXIDE; PROTEIN KINASE B; PROTEIN KINASE B ALPHA; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR FKHRL1;

ANIMAL CELL; APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL ACTIVITY; CELL PROLIFERATION; CELL SURVIVAL; CELL TRANSFORMATION; CONTROLLED STUDY; GLYCOLYSIS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION; UPREGULATION;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P27; ENZYME ACTIVATION; FORKHEAD TRANSCRIPTION FACTORS; MEMBRANE PROTEINS; MICE; OXIDATIVE STRESS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 33845340834     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-1111     Document Type: Article

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