Chronic activation of protein kinase Bβ/Akt2 leads to multinucleation and cell fusion in human epithelial kidney cells: Events associated with tumorigenesis

Oncogene

Volumn 24, Issue 35, 2005, Pages 5459-5470

  Jin, Jing ^a,b   Woodgett, James R ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

Author keywords

Akt; Autophagy; Cell fusion; Cytokinesis; Endomitosis endoreplication; Phagocytosis; Pinocytosis; PKB; Tamoxifen induced; Tumorigenesis

Indexed keywords

ESTROGEN RECEPTOR; PROTEIN KINASE B BETA; TAMOXIFEN; 4 HYDROXYTAMOXIFEN; 4-HYDROXYTAMOXIFEN; AKT1 PROTEIN, HUMAN; AKT2 PROTEIN, HUMAN; ANTIESTROGEN; DRUG DERIVATIVE; HYBRID PROTEIN; ONCOPROTEIN; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE;

ANEUPLOIDY; ARTICLE; AUTOPHAGY; CELL FUSION; CELL GROWTH; CELL SIZE; CELL STRAIN HEK293; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; KIDNEY EPITHELIUM; LIGAND BINDING; MITOSIS RATE; MULTINUCLEAR CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INDUCTION; TUMOR CELL; CELL LINE; CELL TRANSFORMATION; DRUG EFFECT; ENZYMOLOGY; EPITHELIUM CELL; METABOLISM; PATHOLOGY; PHYSIOLOGY; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

CELL FUSION; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; ENZYME ACTIVATION; EPITHELIAL CELLS; ESTROGEN ANTAGONISTS; HUMANS; MICROSCOPY, ELECTRON, TRANSMISSION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, ESTROGEN; RECOMBINANT FUSION PROTEINS; TAMOXIFEN;

EID: 24644466501     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1208704     Document Type: Article

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