Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: Functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones

Biochemical Journal

Volumn 351, Issue 1, 2000, Pages 67-77

  Penning, T M ^a   Burczynski, M E ^a   Jez, J M ^a   Hung, C F ^a   Lin, H K ^a   Ma, H ^a   Moore, M ^a   Palackal, N ^a   Ratnam, K ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

5 dihydrotestosterone; Anxiolytic steroids; Steroid hormones; Steroid receptors

Indexed keywords

20ALPHA DIHYDROPROGESTERONE; 3ALPHA HYDROXYSTEROID DEHYDROGENASE; ALDEHYDE REDUCTASE; ANDROGEN; ANDROSTANEDIOL; ANDROSTANOLONE; ANDROSTENEDIONE; ESTRADIOL; ESTROGEN; ESTRONE; GESTAGEN; ISOENZYME; PROGESTERONE; SEX HORMONE; STEROID RECEPTOR; TESTOSTERONE; 3 ALPHA HYDROXYSTEROID DEHYDROGENASE (B SPECIFIC); 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; KETONE; MESSENGER RNA; RECOMBINANT PROTEIN; STEROID;

AROMATIZATION; ARTICLE; BRAIN; ENZYME KINETICS; ENZYME SPECIFICITY; HUMAN; HUMAN TISSUE; LIVER; MAMMARY GLAND; OXIDATION; PRIORITY JOURNAL; PROSTATE; REDUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; STEREOSPECIFICITY; STEROIDOGENESIS; TISSUE DISTRIBUTION; TISSUE SPECIFICITY; UTERUS; ANTIBODY SPECIFICITY; BINDING SITE; BIOSYNTHESIS; CATALYSIS; CHEMISTRY; FEMALE; GENE EXPRESSION PROFILING; GENETICS; ISOLATION AND PURIFICATION; KINETICS; MALE; METABOLISM; MOLECULAR CLONING;

3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (B-SPECIFIC); 3-HYDROXYSTEROID DEHYDROGENASES; ANDROGENS; BINDING SITES; CATALYSIS; CLONING, MOLECULAR; ESTROGENS; FEMALE; GENE EXPRESSION PROFILING; HUMANS; ISOENZYMES; KETONES; KINETICS; MALE; ORGAN SPECIFICITY; PROGESTINS; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STEROIDS; SUBSTRATE SPECIFICITY;

EID: 0034287545     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3510067     Document Type: Article

References (37)

1. Enzymatic mechanisms of hormone metabolism 1. Oxidation and reduction of the steroid nucleus
2. Rat liver 3α-hydroxysteroid dehydrogenase
3. Members of the nuclear factor 1 transcription factor family regulate rat 3α-hydroxysteroid/dihydrodiol dehydrogenase (3α-HSD/DD AKR1C9) gene expression: A member of the a do-keo reductase superfamily
4. Bile-acid metabolism
5. Steroid structure and androgenic activity. Specificities involved in the receptor binding and nuclear retention of various androgens
6. + oxidoreductase of rat ventral prostate
7. Characterization of the 3α-hydroxysteroid dehydrogenase of dog prostate
8. The formation of 5α-androstane-3α,17β-diol by dog prostate
9. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor
10. Neurosteroids: Endogenous bimodal modulators of the GABA(A) receptor. Mechanism of action and physiological significance
11. Neurosteroids and GABA(A) receptor function
12. Effects of progesterone or neuroactive steroid?
13. 5α-Reduced androgens pray a key role in murine parturition
14. The parturition defect in steroid 5α-reductase type 1 knockout mice is due to impaired cervical ripening
15. cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family
16. Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells
17. Molecular cloning of two human liver 3α-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder
18. Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3α-hydroxysteroid dehydrogenases
19. Expression and characterization of recombinant type 2 3α-hydroxysteroid dehydrogenase (HSD) from human prostate: Demonstration of bifunctional 3α/17β-HSD activity and cellular distribution
20. Molecular cloning of human type 3 3α-hydroxysteroid dehydrogenase that differs from 20α-hydroxysteroid dehydrogenase by seven amino acids
21. A new nomenclature for the aldoketo reductase superfamily
22. Comparative anatomy of the aldo-keto reductase superfamily
23. The key role of 17β-hydroxysteroid dehydrogenases in sex steroid biology
24. Characteristics of a highly labile human type 5 17β-hydroxysteroid dehydrogenase
25. Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes
26. Overexpression and mutagenesis of the cDNA for rat liver 3α-hydroxysteroid/dihydrodiol dehydrogenase. Role of cysteines and tyrosines in catalysis
27. Characterization of homogeneous recombinant rat ovarian 20α-hydroxysteroid dehydrogenase: Fluorescent properties and inhibition profile
28. Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: Oxidation of trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to the activated o-quinone metabolite benzo[a]pyrene-7,8-dione
29. Statistical estimations in enzyme kinetics
30. Polycyclic aromatic hydrocarbon trans-dihydrodiol specificity of four recombinant human dihydrodiol dehydrogenase isoforms
31. Expression cloning and characterization of oxidative 17β- and 3α-hydroxysteroid dehydrogenases from rat and human prostate
32. Type 3 3α-hydroxysteroid dehydrogenase (3α-HSD) accumulates 5α-DHT and activates the androgen receptor in human prostate cancer PC3 cells
33. +
34. + bound to 3α-hydroxysteroid/dihydrodiol dehydrogenase
35. Conversion of mammalian 3α-hydroxysteroid dehydrogenase to 20α-hydroxysteroid dehydrogenase using loop chimeras: Changing specificity from androgens to progestins
36. Close kinship of human 20α-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes