Enzyme fragment complementation binding assay for p38α mitogen-activated protein kinase to study the binding kinetics of enzyme inhibitors

Assay and Drug Development Technologies

Volumn 4, Issue 4, 2006, Pages 411-420

  Zaman, Guido J R ^a   van der Lee, Miranda M C ^a   Kok, Jacobus J ^a   Nelissen, Rob L H ^a   Loomans, Elma E M G ^a  

^a NV ORGANON   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BETA GALACTOSIDASE; DORAMAPIMOD; ENZYME INHIBITOR; ISOENZYME; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 ALPHA; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; BINDING KINETICS; CHEMOLUMINESCENCE; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME MECHANISM; ESCHERICHIA COLI; HUMAN; HUMAN CELL; IC 50; INCUBATION TIME; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MONOCYTE; STRUCTURE ANALYSIS; SURFACE PLASMON RESONANCE;

ANIMALS; CELL LINE; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; GREEN FLUORESCENT PROTEINS; HUMANS; IMIDAZOLES; KINETICS; MITOGEN-ACTIVATED PROTEIN KINASE 14; MOLECULAR STRUCTURE; NAPHTHALENES; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN TRANSPORT; PYRAZOLES; PYRIDINES; RECOMBINANT FUSION PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PLASMON RESONANCE;

EID: 33751220802     PISSN: 1540658X     EISSN: None     Source Type: Journal    
DOI: 10.1089/adt.2006.4.411     Document Type: Article

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