A Biacore biosensor method for detailed kinetic binding analysis of small molecule inhibitors of p38α mitogen-activated protein kinase

Analytical Biochemistry

Volumn 325, Issue 1, 2004, Pages 126-136

  Casper, David ^a   Bukhtiyarova, Marina ^a   Springman, Eric B ^a  

^a Locus Pharmaceuticals Inc   (United States)

Author keywords

Assay; Biacore; Binding; Biosensor; E.C.2.7.1. ; Inhibitor; MAP kinase; p38

Indexed keywords

ASSAYS; BINDING ENERGY; BIOASSAY; BIOSENSORS; DISSOCIATION; KINETICS; LIGANDS; MOLECULES; RATE CONSTANTS; SURFACE PLASMON RESONANCE; THERMODYNAMICS;

BIACORE; BINDING; E.C.2.7.1; INHIBITOR; MAP KINASE;

ENZYMES;

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 6 (4 FLUOROPHENYL) 2,3 DIHYDRO 5 (4 PYRIDYL)IMIDAZO[2,1 B]THIAZOLE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; SYNAPTOPHYSIN;

ANALYTIC METHOD; ARTICLE; BIOSENSOR; CONTROLLED STUDY; DISSOCIATION; ENZYME KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN IMMOBILIZATION; PROTEIN INTERACTION; PROTEIN STRUCTURE; SURFACE PLASMON RESONANCE; SURFACE PROPERTY; THERMODYNAMICS;

EID: 0347359115     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ab.2003.10.025     Document Type: Article

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